Molecular determinants of ovarian cancer chemoresistance: new insights into an old conundrum

Regulation of p53: a collaboration between Mdm2 and Mdmx

(2015) Dongsheng Pei et al.   Oncotarget

In vitro binding properties of tumor suppressor p53 with PUMA and NOXA

(2012) So Young Park et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The p53 network: cellular and systemic DNA damage responses in aging and cancer

(2012) H. Christian Reinhardt et al.   TRENDS IN GENETICS

Oncogenic phosphatase Wip1 is a novel prognostic marker for lung adenocarcinoma patient survival

(2011) Naoyuki Satoh et al.   CANCER SCIENCE

Wip1 contributes to cell homeostasis maintained by the steady-state level of Wtp53

(2011) Hwan Ki Park et al.   CELL CYCLE

Novel role of Wip1 in p53-mediated cell homeostasis under non-stress conditions

(2011) Jin Zhang et al.   CELL CYCLE

Calpain-mediated Processing of p53-associated Parkin-like Cytoplasmic Protein (PARC) Affects Chemosensitivity of Human Ovarian Cancer Cells by Promoting p53 Subcellular Trafficking

(2011) Michael G. Woo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Wip1 over-expression correlated with TP53/p14ARF pathway disruption in human astrocytomas

(2011) Peng Wang et al.   JOURNAL OF SURGICAL ONCOLOGY

The oncogenic phosphatase PPM1D confers cisplatin resistance in ovarian carcinoma cells by attenuating checkpoint kinase 1 and p53 activation

(2011) A Y Ali et al.   ONCOGENE

A protein phosphatase feedback mechanism regulates the basal phosphorylation of Chk2 kinase in the absence of DNA damage

(2010) Luigi Carlessi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Wip1 Directly Dephosphorylates  -H2AX and Attenuates the DNA Damage Response

(2010) H. Cha et al.   CANCER RESEARCH

Luteolin Inhibits Protein Kinase C  and c-Src Activities and UVB-Induced Skin Cancer

(2010) S. Byun et al.   CANCER RESEARCH

Dephosphorylation of γ-H2AX by WIP1: An important homeostatic regulatory event in DNA repair and cell cycle control

(2010) Sung-Hwan Moon et al.   CELL CYCLE

Examination of the expanding pathways for the regulation of p21 expression and activity

(2010) Yong-Sam Jung et al.   CELLULAR SIGNALLING

The oncogenic phosphatase WIP1 negatively regulates nucleotide excision repair

(2010) Thuy-Ai Nguyen et al.   DNA REPAIR

UV-induced histone H2AX phosphorylation and DNA damage related proteins accumulate and persist in nucleotide excision repair-deficient XP-B cells

(2010) Kyu-Seon Oh et al.   DNA REPAIR

Expression of a Homeostatic Regulator, Wip1 (Wild-type p53-induced Phosphatase), Is Temporally Induced by c-Jun and p53 in Response to UV Irradiation

(2010) Ji-young Song et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PPM1D gene amplification and overexpression in breast cancer: a qRT-PCR and chromogenic in situ hybridization study

(2010) Maryou B Lambros et al.   MODERN PATHOLOGY

Wip1 phosphatase is associated with chromatin and dephosphorylates γH2AX to promote checkpoint inhibition

(2010) L Macůrek et al.   ONCOGENE

Phosphorylation and Degradation of MdmX Is Inhibited by Wip1 Phosphatase in the DNA Damage Response

(2009) X. Zhang et al.   CANCER RESEARCH

PPM1D Is a Potential Therapeutic Target in Ovarian Clear Cell Carcinomas

(2009) D. S.P. Tan et al.   CLINICAL CANCER RESEARCH

Nuclear Factor-κB (NF-κB) Is a Novel Positive Transcriptional Regulator of the Oncogenic Wip1 Phosphatase

(2009) Julie M. Lowe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Estrogen Receptor   Pathway Induces Oncogenic Wip1 Phosphatase Gene Expression

(2009) H.-S. Han et al.   MOLECULAR CANCER RESEARCH

Akt promotes chemoresistance in human ovarian cancer cells by modulating cisplatin-induced, p53-dependent ubiquitination of FLICE-like inhibitory protein

(2009) M R Abedini et al.   ONCOGENE

The type 2C phosphatase Wip1: An oncogenic regulator of tumor suppressor and DNA damage response pathways

(2008) Xiongbin Lu et al.   CANCER AND METASTASIS REVIEWS

Cisplatin Induces p53-Dependent FLICE-Like Inhibitory Protein Ubiquitination in Ovarian Cancer Cells

(2008) M. R. Abedini et al.   CANCER RESEARCH

PPM1D430, a Novel Alternative Splicing Variant of the Human PPM1D, can Dephosphorylate p53 and Exhibits Specific Tissue Expression

(2008) Y. Chuman et al.   JOURNAL OF BIOCHEMISTRY

Arsenic Trioxide Augments Chk2/p53-mediated Apoptosis by Inhibiting Oncogenic Wip1 Phosphatase

(2008) Akinori Yoda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Induction of PPM1D following DNA-damaging treatments through a conserved p53 response element coincides with a shift in the use of transcription initiation sites

(2008) Matteo Rossi et al.   NUCLEIC ACIDS RESEARCH