Effector mechanisms of sunitinib-induced G1 cell cycle arrest, differentiation, and apoptosis in human acute myeloid leukaemia HL60 and KG-1 cells

Apoptosis: why and how does it occur in biology?

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The role of Bcl-2 and its pro-survival relatives in tumourigenesis and cancer therapy

(2011) P N Kelly et al.   CELL DEATH AND DIFFERENTIATION

Understanding the molecular-based mechanism of action of the tyrosine kinase inhibitor: sunitinib

(2010) Alfredo Carrato Mena et al.   ANTI-CANCER DRUGS

Is there a role for differentiating therapy in non-APL AML?

(2010) H. Phillip Koeffler   BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY

Identification of known drugs that act as inhibitors of NF-κB signaling and their mechanism of action

(2010) Susanne C. Miller et al.   BIOCHEMICAL PHARMACOLOGY

Synergistic antitumor effect of TRAIL in combination with sunitinib in vitro and in vivo

(2010) Wanjing Ding et al.   CANCER LETTERS

Cdks and cyclins link G1length and differentiation of embryonic, neural and hematopoietic stem cells

(2010) Christian Lange et al.   CELL CYCLE

Sunitinib Induces Apoptosis and Growth Arrest of Medulloblastoma Tumor Cells by Inhibiting STAT3 and AKT Signaling Pathways

(2010) F. Yang et al.   MOLECULAR CANCER RESEARCH

Sunitinib Inhibits MEK/ERK and SAPK/JNK Pathways and Increases Sodium/Iodide Symporter Expression in Papillary Thyroid Cancer

(2010) Mike S. Fenton et al.   THYROID

Sunitinib can enhance BCG mediated cytotoxicity to transitional cell carcinoma through apoptosis pathway

(2010) Szu-Yuan Ping et al.   UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS

Sunitinib Inhibition of Stat3 Induces Renal Cell Carcinoma Tumor Cell Apoptosis and Reduces Immunosuppressive Cells

(2009) H. Xin et al.   CANCER RESEARCH

Differentiation therapy of acute myeloid leukemia: past, present and future

(2009) Kevin Petrie et al.   CURRENT OPINION IN HEMATOLOGY

Sunitinib, an orally available receptor tyrosine kinase inhibitor, induces monocytic differentiation of acute myelogenous leukemia cells that is enhanced by 1,25-dihydroxyvitamin D3

(2009) C Nishioka et al.   LEUKEMIA

Management of acute promyelocytic leukemia: recommendations from an expert panel on behalf of the European LeukemiaNet

(2008) M. A. Sanz et al.   BLOOD

Addition of receptor tyrosine kinase inhibitor to radiation increases tumour control in an orthotopic murine model of breast cancer metastasis in bone

(2008) Pawel Zwolak et al.   EUROPEAN JOURNAL OF CANCER

Sunitinib malate is active against human urothelial carcinoma and enhances the activity of cisplatin in a preclinical model

(2008) Guru Sonpavde et al.   UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS

Blockade of MEK/ERK signaling enhances sunitinib-induced growth inhibition and apoptosis of leukemia cells possessing activating mutations of the FLT3 gene

(2007) Chie Nishioka et al.   LEUKEMIA RESEARCH