Article
Chemistry, Medicinal
Yuqi Jiang, Jie Xu, Kairui Yue, Chao Huang, Mengting Qin, Dongyu Chi, Qixin Yu, Yue Zhu, Xiaohan Hou, Tongqiang Xu, Min Li, C. James Chou, Xiaoyang Li
Summary: The study focused on modifying HDAC inhibitors to deactivate the Michael reaction in order to improve their potency. Compound 11h showed significant improvements in both HDAC inhibitory activity and cell-based antitumor assay, demonstrating potential for clinical application and efficacy against AML.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Review
Pharmacology & Pharmacy
Shujing Zhang, Menghan Liu, Yongfang Yao, Bin Yu, Hongmin Liu
Summary: Targeted therapy for AML focusing on LSD1 has shown effectiveness, with LSD1 inhibitors such as TCP, ORY-1001, GSK2879552, and IMG-7289 showing promise in clinical trials. Combination therapies with other drugs may enhance treatment outcomes.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Junjie Li, Qi Li, Wentao Wang, Xinran Zhang, Chen Chu, Xintian Tang, Bo Zhu, Lizhong Xiong, Yu Zhao, Dao-Xiu Zhou
Summary: DELLA proteins are important regulators of gibberellic acid signaling and have contributed to grain yield increases in rice and wheat varieties during the green revolution. This study identifies a complex involving the rice DELLA protein SLENDER RICE1 (SLR1), Polycomb-repressive complex 2 (PRC2), and histone deacetylase HDA702, which represses downstream genes through silent chromatin state formation. Disruption of this complex impairs SLR1-dependent histone modification and gene repression, highlighting the importance of chromatin regulators in DELLA-mediated gene regulation.
Article
Biochemistry & Molecular Biology
Yueqing Su, Chao Deng, Xuemei Liu, Jiamei Lian
Summary: The study reveals that betahistine co-treatment can attenuate dyslipidemia and fatty liver caused by chronic olanzapine treatment by modulating hepatic histone methylation. It enhances H3K4me binding on the promoter of Cpt1a gene and inhibits H3K9me binding on the promoter of Pparg gene, leading to inhibition of lipid storage and promotion of fatty acid oxidation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Plant Sciences
Bo Li, Caixian Yang, Bingzhuang An, Hongpan Wang, Mohammed Albaqami, Salah Fatouh Abou-Elwafa, Le Xu, Yanhao Xu
Summary: This study investigated the epigenetic regulation responses to temperature stress in barley. It was found that high temperature stress had greater deleterious effects on barley seedlings' growth compared to mild low temperature stress. High temperature stress caused more DNA demethylation, and higher levels of histone modifications were observed. Transcription factors played important roles in both mild low temperature and high temperature stress.
PHYSIOLOGIA PLANTARUM
(2022)
Article
Pharmacology & Pharmacy
Han Liu, Peng Chen, Yong-Long Yang, Ke-Wei Zhu, Tao Wang, Ling Tang, Yan-Ling Liu, Shan Cao, Gan Zhou, Hui Zeng, Xie-Lan Zhao, Wei Zhang, Xiao-Ping Chen
Summary: The study identified TBC1D16 as a potential predictor for chemosensitivity and prognosis in adult AML patients, with higher methylation and expression of this gene associated with increased risk of incomplete remission and worse overall survival.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Medicine, General & Internal
Yang Sun, Dai Li, Yuqiang Su, Haikang Zhao, Weiwei Pang, Wei Zhao, Shengjun Wu
Summary: Derangements in monoaminergic transmission and disturbed signaling in the hypothalamic-pituitary-adrenal axis are major characteristics of Parkinson's disease (PD). Hydrogen sulfide (H2S) has been reported to have potential therapeutic effects on PD due to its regulatory role in neuronal signals. This study aimed to evaluate the hypothesis that H2S exerts protective action via inhibition of epigenetic histone acetylation.
ARCHIVES OF MEDICAL SCIENCE
(2023)
Review
Immunology
Liangjie Xu, Cuicui Zhou, Yi Liang, Tinpan Fan, Fen Zhang, Xinxin Chen, Wei Yuan
Summary: This article reviews the interaction between epigenetic modifications and the functions of myeloid-derived suppressor cells (MDSCs), and briefly introduces how the accumulation and function of MDSCs caused by epigenetic modifications impact disease development, providing a promising therapeutic strategy for related disorders.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Oncology
Md Sahab Uddin, Abdullah Al Mamun, Badrah S. Alghamdi, Devesh Tewari, Philippe Jeandet, Md Shahid Sarwar, Ghulam Md Ashraf
Summary: Research has shown that glioma progression is closely linked to different types of epigenetic phenomena, such as chromatin modifications, DNA methylation, chromatin remodeling, and aberrant microRNA. Targeting the genes and proteins that control these alterations can be an effective way to treat GBM. Treatment approaches include histone deacetylase inhibitors and DNA methyltransferase inhibitors.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Luxi Wang, Yong Joo Ahn, Reto Asmis
Summary: Inhibition of histone deacetylase 2 can prevent nutrient stress-induced protein S-glutathionylation and monocyte dysfunction, reducing atherosclerosis development in male mice but not female mice. Specific histone deacetylase 2 inhibitors may represent a potential novel therapeutic strategy for atherosclerosis prevention and treatment, with potential sexual dimorphic effects.
Article
Multidisciplinary Sciences
Wanlin Jiang, Megan E. Block, Chandra S. Boosani
Summary: This study investigates the role of TNF-alpha and IGF-1 in regulating the epigenetic mechanisms that promote VSMCs proliferation, and identifies a novel molecular mechanism involving DNMT1, HDAC10, and HDAC2. Results reveal the inter-dependence of epigenetic mediators in VSMCs proliferation.
Article
Oncology
Warren Fiskus, Christopher P. Mill, Behnam Nabet, Dimuthu Perera, Christine Birdwell, Taghi Manshouri, Bernardo Lara, Tapan M. Kadia, Courtney DiNardo, Koichi Takahashi, Naval Daver, Prithviraj Bose, Lucia Masarova, Naveen Pemmaraju, Steven Kornblau, Gautam Borthakur, Guillermo Montalban-Bravo, Guillermo Garcia Manero, Sunil Sharma, Matthew Stubbs, Xiaoping Su, Michael R. Green, Cristian Coarfa, Srdan Verstovsek, Joseph D. Khoury, Christopher R. Vakoc, Kapil N. Bhalla
Summary: The study demonstrates the potential of targeting GFI1/LSD1, BRD4, MOZ, HDAC3, and DOT1L to improve outcomes in AML and MPN sAML cells. Combination therapy of LSD1i and JAKi ruxolitinib shows synergistic lethality in post-MPN sAML cells, with LSD1i pre-treatment overcoming nongenetic resistance to ruxolitinib or BETi. This highlights the importance of LSD1i-based combination therapy in overcoming nongenetic therapy-resistance in AML and post-MPN sAML.
BLOOD CANCER JOURNAL
(2021)
Article
Oncology
Zhiyong Zhang, Xin Zhang, Aimin Huang
Summary: This study revealed differential expression of HDAC6 in a pan-cancer analysis, highlighting its role in tumor metabolism and immunity. Low expression of HDAC6 was associated with poor prognosis in pancreatic adenocarcinoma, thymoma, and uveal melanoma. Furthermore, HDAC6 was linked to tumor immune infiltration and immune checkpoint gene expression profiles.
FRONTIERS IN ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Carlos Rivera, Hun-Goo Lee, Anna Lappala, Danni Wang, Veronica Noches, Montserrat Olivares-Costa, Marcela Sjoberg-Herrera, Jeannie T. Lee, Maria Estela Andres
Summary: RCOR1 is paradoxically enriched in transcriptionally active chromatin and represses transcription through two mechanisms.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
William J. Lu-Culligan, Leah J. Connor, Yixuan Xie, Babatunde E. Ekundayo, Brendan T. Rose, Martin Machyna, Andreas P. Pintado-Urbanc, Joshua T. Zimmer, Isaac W. Vock, Natarajan V. Bhanu, Megan C. King, Benjamin A. Garcia, Franziska Bleichert, Matthew D. Simon
Summary: Lysine residues can be modified by both methylation and acetylation to form N epsilon-acetyl-N epsilon-methyllysine (Kacme). Kacme is found on histone H4 across species and mammalian tissues and is associated with active chromatin.
