GATA2 and Lmo2 control angiogenesis and lymphangiogenesis via direct transcriptional regulation of neuropilin-2

GATA-2 anomaly and clinical phenotype of a sporadic case of lymphedema, dendritic cell, monocyte, B- and NK-cell (DCML) deficiency, and myelodysplasia

(2012) Hiroyuki Ishida et al.   EUROPEAN JOURNAL OF PEDIATRICS

Conditional Gata2 inactivation results in HSC loss and lymphatic mispatterning

(2012) Kim-Chew Lim et al.   JOURNAL OF CLINICAL INVESTIGATION

Cis-element mutated in GATA2-dependent immunodeficiency governs hematopoiesis and vascular integrity

(2012) Kirby D. Johnson et al.   JOURNAL OF CLINICAL INVESTIGATION

Angiopoietin-2 Is a Direct Transcriptional Target of TAL1, LYL1 and LMO2 in Endothelial Cells

(2012) Virginie Deleuze et al.   PLoS One

Loss-of-function germline GATA2 mutations in patients with MDS/AML or MonoMAC syndrome and primary lymphedema reveal a key role for GATA2 in the lymphatic vasculature

(2011) J. Kazenwadel et al.   BLOOD

Mutations in GATA2 cause primary lymphedema associated with a predisposition to acute myeloid leukemia (Emberger syndrome)

(2011) Pia Ostergaard et al.   NATURE GENETICS

Hypoxia induces tumor and endothelial cell migration in a Semaphorin 3F- and VEGF-dependent manner via transcriptional repression of their common receptor Neuropilin 2

(2011) Silvia Coma et al.   Cell Adhesion & Migration

Lymphangiogenesis: Molecular Mechanisms and Future Promise

(2010) Tuomas Tammela et al.   CELL

Neuropilin-2 mediates VEGF-C–induced lymphatic sprouting together with VEGFR3

(2010) Yunling Xu et al.   JOURNAL OF CELL BIOLOGY

Direct transcriptional regulation of neuropilin-2 by COUP-TFII modulates multiple steps in murine lymphatic vessel development

(2010) Fu-Jung Lin et al.   JOURNAL OF CLINICAL INVESTIGATION

A Mutated Soluble Neuropilin-2 B Domain Antagonizes Vascular Endothelial Growth Factor Bioactivity and Inhibits Tumor Progression

(2010) E. Geretti et al.   MOLECULAR CANCER RESEARCH

Role of Class 3 Semaphorins and Their Receptors in Tumor Growth and Angiogenesis

(2009) P. Gaur et al.   CLINICAL CANCER RESEARCH

A mechanosensitive transcriptional mechanism that controls angiogenesis

(2009) Akiko Mammoto et al.   NATURE

Neuropilin structure governs VEGF and semaphorin binding and regulates angiogenesis

(2008) Elena Geretti et al.   ANGIOGENESIS

Neuropilin-1 in regulation of VEGF-induced activation of p38MAPK and endothelial cell organization

(2008) H. Kawamura et al.   BLOOD

Blocking Neuropilin-2 Function Inhibits Tumor Cell Metastasis

(2008) Maresa Caunt et al.   CANCER CELL

Calcification of Multipotent Prostate Tumor Endothelium

(2008) Andrew C. Dudley et al.   CANCER CELL

Molecular and developmental biology of the hemangioblast

(2008) Jing-Wei Xiong   DEVELOPMENTAL DYNAMICS