The Molecular Machinery of Neurotransmitter Release (Nobel Lecture)

Signaling through C2 domains: More than one lipid target

(2014) Senena Corbalan-Garcia et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Microsecond Dissection of Neurotransmitter Release: SNARE-Complex Assembly Dictates Speed and Ca2+ Sensitivity

(2014) Claudio Acuna et al.   NEURON

Complexin Activates Exocytosis of Distinct Secretory Vesicles Controlled by Different Synaptotagmins

(2013) P. Cao et al.   JOURNAL OF NEUROSCIENCE

A molecular machine for neurotransmitter release: synaptotagmin and beyond

(2013) Thomas C Südhof   NATURE MEDICINE

Synaptotagmin-1 and Synaptotagmin-7 Trigger Synchronous and Asynchronous Phases of Neurotransmitter Release

(2013) Taulant Bacaj et al.   NEURON

Dynamic Control of Synaptic Vesicle Replenishment and Short-Term Plasticity by Ca2+-Calmodulin-Munc13-1 Signaling

(2013) Noa Lipstein et al.   NEURON

Lipid-Anchored SNAREs Lacking Transmembrane Regions Fully Support Membrane Fusion during Neurotransmitter Release

(2013) Peng Zhou et al.   NEURON

Neurotransmitter Release: The Last Millisecond in the Life of a Synaptic Vesicle

(2013) Thomas C. Südhof   NEURON

Deconstructing complexin function in activating and clamping Ca2+-triggered exocytosis by comparing knockout and knockdown phenotypes

(2013) X. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Membrane Fusion Enigma: SNAREs, Sec1/Munc18 Proteins, and Their Accomplices—Guilty as Charged?

(2012) Josep Rizo et al.   Annual Review of Cell and Developmental Biology

Munc18-1 mutations that strongly impair SNARE-complex binding support normal synaptic transmission

(2012) Marieke Meijer et al.   EMBO JOURNAL

Syntaxin-1 N-peptide and Habc-domain perform distinct essential functions in synaptic vesicle fusion

(2012) Peng Zhou et al.   EMBO JOURNAL

RIM Promotes Calcium Channel Accumulation at Active Zones of the Drosophila Neuromuscular Junction

(2012) E. R. Graf et al.   JOURNAL OF NEUROSCIENCE

C-Terminal Complexin Sequence Is Selectively Required for Clamping and Priming But Not for Ca2+ Triggering of Synaptic Exocytosis

(2012) Y. J. Kaeser-Woo et al.   JOURNAL OF NEUROSCIENCE

The Presynaptic Active Zone

(2012) Thomas C. Südhof   NEURON

Postsynaptic Complexin Controls AMPA Receptor Exocytosis during LTP

(2012) Mohiuddin Ahmad et al.   NEURON

Distinct Neuronal Coding Schemes in Memory Revealed by Selective Erasure of Fast Synchronous Synaptic Transmission

(2012) Wei Xu et al.   NEURON

RIM genes differentially contribute to organizing presynaptic release sites

(2012) P. S. Kaeser et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proteasome Inhibition Alleviates SNARE-Dependent Neurodegeneration

(2012) M. Sharma et al.   Science Translational Medicine

Short-Term Presynaptic Plasticity

(2012) W. G. Regehr   Cold Spring Harbor Perspectives in Biology

Activity-Dependent IGF-1 Exocytosis Is Controlled by the Ca2+-Sensor Synaptotagmin-10

(2011) Peng Cao et al.   CELL

RIM Proteins Tether Ca2+ Channels to Presynaptic Active Zones via a Direct PDZ-Domain Interaction

(2011) Pascal S. Kaeser et al.   CELL

CSPα knockout causes neurodegeneration by impairing SNAP-25 function

(2011) Manu Sharma et al.   EMBO JOURNAL

Munc13 mediates the transition from the closed syntaxin–Munc18 complex to the SNARE complex

(2011) Cong Ma et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

RIM Proteins Activate Vesicle Priming by Reversing Autoinhibitory Homodimerization of Munc13

(2011) Lunbin Deng et al.   NEURON

RIM Determines Ca2+ Channel Density and Vesicle Docking at the Presynaptic Active Zone

(2011) Yunyun Han et al.   NEURON

Rab3B protein is required for long-term depression of hippocampal inhibitory synapses and for normal reversal learning

(2011) T. Tsetsenis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RIM-Binding Protein, a Central Part of the Active Zone, Is Essential for Neurotransmitter Release

(2011) K. S. Y. Liu et al.   SCIENCE

CSPα promotes SNARE-complex assembly by chaperoning SNAP-25 during synaptic activity

(2010) Manu Sharma et al.   NATURE CELL BIOLOGY

Munc13 C2B domain is an activity-dependent Ca2+ regulator of synaptic exocytosis

(2010) Ok-Ho Shin et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Complexin Clamps Asynchronous Release by Blocking a Secondary Ca2+ Sensor via Its Accessory α Helix

(2010) Xiaofei Yang et al.   NEURON

Distinct roles for two synaptotagmin isoforms in synchronous and asynchronous transmitter release at zebrafish neuromuscular junction

(2010) H. Wen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Syntaxin N-terminal peptide motif is an initiation factor for the assembly of the SNARE-Sec1/Munc18 membrane fusion complex

(2010) S. S. Rathore et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

 -Synuclein Promotes SNARE-Complex Assembly in Vivo and in Vitro

(2010) J. Burre et al.   SCIENCE

Synaptotagmin-1 Docks Secretory Vesicles to Syntaxin-1/SNAP-25 Acceptor Complexes

(2009) Heidi de Wit et al.   CELL

Munc18-1 binding to the neuronal SNARE complex controls synaptic vesicle priming

(2009) Ferenc Deák et al.   JOURNAL OF CELL BIOLOGY

Synaptotagmin-7 is a principal Ca2+sensor for Ca2+-induced glucagon exocytosis in pancreas

(2009) Natalia Gustavsson et al.   JOURNAL OF PHYSIOLOGY-LONDON

Synaptotagmin-1 functions as a Ca2+ sensor for spontaneous release

(2009) Jun Xu et al.   NATURE NEUROSCIENCE

Differential but convergent functions of Ca2+ binding to synaptotagmin-1 C2 domains mediate neurotransmitter release

(2009) O.-H. Shin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Complexin Controls the Force Transfer from SNARE Complexes to Membranes in Fusion

(2009) A. Maximov et al.   SCIENCE

Membrane Fusion: Grappling with SNARE and SM Proteins

(2009) T. C. Sudhof et al.   SCIENCE

Direct interactions between C. elegans RAB-3 and Rim provide a mechanism to target vesicles to the presynaptic density

(2008) Elena O. Gracheva et al.   NEUROSCIENCE LETTERS

Synaptotagmin-1 and -7 are functionally overlapping Ca2+ sensors for exocytosis in adrenal chromaffin cells

(2008) J.-S. Schonn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic analysis of synaptotagmin-7 function in synaptic vesicle exocytosis

(2008) A. Maximov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Impaired insulin secretion and glucose intolerance in synaptotagmin-7 null mutant mice

(2008) N. Gustavsson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conformational Switch of Syntaxin-1 Controls Synaptic Vesicle Fusion

(2008) Stefan H. Gerber et al.   SCIENCE