Proteasome Inhibition Alleviates SNARE-Dependent Neurodegeneration

Next-generation proteasome blockers promise safer cancer therapy

(2012) Asher Mullard   NATURE MEDICINE

Mutations in DNAJC5, Encoding Cysteine-String Protein Alpha, Cause Autosomal-Dominant Adult-Onset Neuronal Ceroid Lipofuscinosis

(2011) Lenka Nosková et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Proteasome inhibitors improve the function of mutant lysosomal α-glucosidase in fibroblasts from Pompe disease patient carrying c.546G>T mutation

(2011) Yohta Shimada et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

CSPα knockout causes neurodegeneration by impairing SNAP-25 function

(2011) Manu Sharma et al.   EMBO JOURNAL

Inhibition of Endoplasmic Reticulum-associated Degradation Rescues Native Folding in Loss of Function Protein Misfolding Diseases

(2011) Fan Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mutations associated with Charcot-Marie-Tooth disease cause SIMPLE protein mislocalization and degradation by the proteasome and aggresome-autophagy pathways

(2011) S. M. Lee et al.   JOURNAL OF CELL SCIENCE

Synaptic protein deficits are associated with dementia irrespective of extreme old age

(2011) Michal Schnaider Beeri et al.   NEUROBIOLOGY OF AGING

Exome-Sequencing Confirms DNAJC5 Mutations as Cause of Adult Neuronal Ceroid-Lipofuscinosis

(2011) Bruno A. Benitez et al.   PLoS One

Combination Therapy of Bortezomib with Novel Targeted Agents: An Emerging Treatment Strategy

(2010) J. J. Wright   CLINICAL CANCER RESEARCH

Cysteine String Protein-  Prevents Activity-Dependent Degeneration in GABAergic Synapses

(2010) P. Garcia-Junco-Clemente et al.   JOURNAL OF NEUROSCIENCE

Protein degradation, aggregation, and misfolding

(2010) Ana Maria Cuervo et al.   MOVEMENT DISORDERS

Enhancement of proteasome activity by a small-molecule inhibitor of USP14

(2010) Byung-Hoon Lee et al.   NATURE

CSPα promotes SNARE-complex assembly by chaperoning SNAP-25 during synaptic activity

(2010) Manu Sharma et al.   NATURE CELL BIOLOGY

Proteasome inhibition induces hsp30 and hsp70 gene expression as well as the acquisition of thermotolerance in Xenopus laevis A6 cells

(2009) Jordan T. F. Young et al.   CELL STRESS & CHAPERONES

Prion Protein Misfolding

(2009) L. Kupfer et al.   CURRENT MOLECULAR MEDICINE

Proteasome inhibitors prevent oxidative stress-induced nerve cell death by a novel mechanism

(2008) Pamela Maher   BIOCHEMICAL PHARMACOLOGY

α-Synuclein Misfolding and Neurodegenerative Diseases

(2008) Vladimir Uversky   CURRENT PROTEIN & PEPTIDE SCIENCE

The potential of proteasome inhibitors in cancer therapy

(2008) Jan Sterz et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

A molecular pathway of neurodegeneration linking α-synuclein to ApoE and Aβ peptides

(2008) Gilbert Gallardo et al.   NATURE NEUROSCIENCE

Synaptic proteins, neuropathology and cognitive status in the oldest-old

(2007) Elizabeth Head et al.   NEUROBIOLOGY OF AGING