Generation of a Genetically Encoded, Photoactivatable Intein for the Controlled Production of Cyclic Peptides

The Chemistry and Biology of Theta Defensins

(2014) Anne C. Conibear et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

An Atypical Naturally Split Intein Engineered for Highly Efficient Protein Labeling

(2014) Ilka V. Thiel et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Selection-Based Discovery of Druglike Macrocyclic Peptides

(2014) Toby Passioura et al.   Annual Review of Biochemistry

Genetic Encoding of Caged Cysteine and Caged Homocysteine in Bacterial and Mammalian Cells

(2014) Rajendra Uprety et al.   CHEMBIOCHEM

Peptides Come Round: Using SICLOPPS Libraries for Early Stage Drug Discovery

(2014) Katherine R. Lennard et al.   CHEMISTRY-A EUROPEAN JOURNAL

Genetic Encoding of Photocaged Cysteine Allows Photoactivation of TEV Protease in Live Mammalian Cells

(2014) Duy P. Nguyen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Butelase 1 is an Asx-specific ligase enabling peptide macrocyclization and synthesis

(2014) Giang K T Nguyen et al.   Nature Chemical Biology

Chemical Bypass of Intein-Catalyzed N-S Acyl Shift in Protein Splicing

(2013) Jens Binschik et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Expression of Fluorescent Cyclotides using Protein Trans-Splicing for Easy Monitoring of Cyclotide-Protein Interactions

(2013) Krishnappa Jagadish et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Internal Disulfide Bond Acts as a Switch for Intein Activity

(2013) Michael C. Nicastri et al.   BIOCHEMISTRY

Cyclotide biosynthesis

(2013) David J Craik et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Discovery of Macrocyclic Peptides Armed with a Mechanism-Based Warhead: Isoform-Selective Inhibition of Human Deacetylase SIRT2

(2012) Jumpei Morimoto et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Unprecedented Rates and Efficiencies Revealed for New Natural Split Inteins from Metagenomic Sources

(2012) Patricia Carvajal-Vallejos et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Discovering the Bacterial Circular Proteins: Bacteriocins, Cyanobactins, and Pilins

(2012) Manuel Montalbán-López et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

In Vitro Selection of Highly Modified Cyclic Peptides That Act as Tight Binding Inhibitors

(2012) Yollete V. Guillen Schlippe et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Photocontrol of Tyrosine Phosphorylation in Mammalian Cells via Genetic Encoding of Photocaged Tyrosine

(2012) Eyal Arbely et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Modular Assembly of Macrocyclic Organo-Peptide Hybrids Using Synthetic and Genetically Encoded Precursors

(2011) Jessica M. Smith et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Photocontrol of Protein Activity Mediated by the Cleavage Reaction of a Split Intein

(2011) Jens Binschik et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Highly Efficient and More Generalcis- andtrans-Splicing Inteins through Sequential Directed Evolution

(2011) Julia H. Appleby-Tagoe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure of catalytically competent intein caught in a redox trap with functional and evolutionary implications

(2011) Brian P Callahan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Intein-Mediated Cyclization of Randomized Peptides in the Periplasm ofEscherichia coliand Their Extracellular Secretion

(2010) Geneviève Deschuyteneer et al.   ACS Chemical Biology

Adding New Chemistries to the Genetic Code

(2010) Chang C. Liu et al.   Annual Review of Biochemistry

Photomodulation of Protein Trans-Splicing Through Backbone Photocaging of the DnaE Split Intein

(2010) Luis Berrade et al.   CHEMBIOCHEM

The naturally splitNpuDnaE intein exhibits an extraordinarily high rate in the proteintrans-splicing reaction

(2009) Joachim Zettler et al.   FEBS LETTERS

A Straight Path to Circular Proteins

(2009) John M. Antos et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Splicing of the Mycobacteriophage Bethlehem DnaB Intein

(2009) Kazuo Tori et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Diverse backbone-cyclized peptides via codon reprogramming

(2009) Takashi Kawakami et al.   Nature Chemical Biology

Rapid selection of cyclic peptides that reduce α-synuclein toxicity in yeast and animal models

(2009) Joshua A Kritzer et al.   Nature Chemical Biology

Phage-encoded combinatorial chemical libraries based on bicyclic peptides

(2009) Christian Heinis et al.   Nature Chemical Biology

Activation of Protein Splicing by Protease- or Light-Triggered O to N Acyl Migration

(2008) Miquel Vila-Perelló et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

How Nature Morphs Peptide Scaffolds into Antibiotics

(2008) Elizabeth M. Nolan et al.   CHEMBIOCHEM

Ribosomal Synthesis of Bicyclic Peptides via Two Orthogonal Inter-Side-Chain Reactions

(2008) Yusuke Sako et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The exploration of macrocycles for drug discovery — an underexploited structural class

(2008) Edward M. Driggers et al.   NATURE REVIEWS DRUG DISCOVERY