期刊
CHEMBIOCHEM
卷 10, 期 1, 页码 34-53出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbic.200800438
关键词
antibiotics; biosynthesis; natural products; nonribosomal peptides; ribosomal peptides
资金
- NIH [GM20011, GM49338]
The conventional notion that peptides are poor candidates for orally available drugs because of protease-sensitive peptide bonds, intrinsic hydrophilicity, and ionic charges contrasts with the diversity of antibiotic natural products with peptide-based frameworks that are synthesized and utilized by Nature. Several of these antibiotics, including penicillin and vancomycin, are employed to treat bacterial infections in humans and have been best-selling therapeutics for decades. Others might provide new platforms for the design of novel therapeutics to combat emering antibiotic-resistant bacterial pathogens.
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