Peptides Come Round: Using SICLOPPS Libraries for Early Stage Drug Discovery

Directed Evolution of Bicyclic Peptides for Therapeutic Application

(2014) Philippe Diderich et al.   CHIMIA

Synthesis of bicyclic organo-peptide hybrids via oxime/intein-mediated macrocyclization followed by disulfide bond formation

(2014) Jessica M. Smith et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

In Vitro Selection of Multiple Libraries Created by Genetic Code Reprogramming To Discover Macrocyclic Peptides That Antagonize VEGFR2 Activity in Living Cells

(2013) Takashi Kawakami et al.   ACS Chemical Biology

Allosteric Lariat Peptide Inhibitors of Abl Kinase

(2013) V. M. Bharathikumar et al.   CHEMBIOCHEM

Flexizyme-Mediated Genetic Reprogramming As a Tool for Noncanonical Peptide Synthesis and Drug Discovery

(2013) Toby Passioura et al.   CHEMISTRY-A EUROPEAN JOURNAL

Emerging Strategies to Access Peptide Macrocycles from Genetically Encoded Polypeptides

(2013) Jessica M. Smith et al.   JOURNAL OF ORGANIC CHEMISTRY

Bicyclic Peptide Ligands Pulled out of Cysteine-Rich Peptide Libraries

(2013) Shiyu Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Cyclic Peptide Inhibitor of HIF-1 Heterodimerization That Inhibits Hypoxia Signaling in Cancer Cells

(2013) Elena Miranda et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cyclic Peptide Inhibitors of the β-Sliding Clamp in Staphylococcus aureus

(2013) Susanne Kjelstrup et al.   PLoS One

A cyclic peptide inhibitor of C-terminal binding protein dimerization links metabolism with mitotic fidelity in breast cancer cells

(2013) Charles N. Birts et al.   Chemical Science

In Vitro Selection of Anti-Akt2 Thioether-Macrocyclic Peptides Leading to Isoform-Selective Inhibitors

(2012) Yuuki Hayashi et al.   ACS Chemical Biology

Discovery of Macrocyclic Peptides Armed with a Mechanism-Based Warhead: Isoform-Selective Inhibition of Human Deacetylase SIRT2

(2012) Jumpei Morimoto et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Intracellular Detection and Evolution of Site-Specific Proteases Using a Genetic Selection System

(2012) Kathryn D. Verhoeven et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

Targeting Tumour Proliferation with a Small-Molecule Inhibitor of AICAR Transformylase Homodimerization

(2012) Ian B. Spurr et al.   CHEMBIOCHEM

Protein–protein interaction inhibitors get into the groove

(2012) Asher Mullard   NATURE REVIEWS DRUG DISCOVERY

Modular Assembly of Macrocyclic Organo-Peptide Hybrids Using Synthetic and Genetically Encoded Precursors

(2011) Jessica M. Smith et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Diverse organo-peptide macrocyclesvia a fast and catalyst-free oxime/intein-mediated dual ligation

(2011) Maragani Satyanarayana et al.   CHEMICAL COMMUNICATIONS

Small-molecule discovery from DNA-encoded chemical libraries

(2011) Ralph E. Kleiner et al.   CHEMICAL SOCIETY REVIEWS

Macrocycles Are Great Cycles: Applications, Opportunities, and Challenges of Synthetic Macrocycles in Drug Discovery

(2011) Eric Marsault et al.   JOURNAL OF MEDICINAL CHEMISTRY

Contemporary strategies for peptide macrocyclization

(2011) Christopher J. White et al.   Nature Chemistry

Evolution of cyclic peptide protease inhibitors

(2011) T. S. Young et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intein-Mediated Cyclization of Randomized Peptides in the Periplasm ofEscherichia coliand Their Extracellular Secretion

(2010) Geneviève Deschuyteneer et al.   ACS Chemical Biology

Functional profiling of p53-binding sites in Hdm2 and Hdmx using a genetic selection system

(2010) Shreya Datta et al.   BIOORGANIC & MEDICINAL CHEMISTRY

A Genetic Screen for Isolating “Lariat” Peptide Inhibitors of Protein Function

(2009) Kris Barreto et al.   CHEMISTRY & BIOLOGY

Diverse backbone-cyclized peptides via codon reprogramming

(2009) Takashi Kawakami et al.   Nature Chemical Biology

Rapid selection of cyclic peptides that reduce α-synuclein toxicity in yeast and animal models

(2009) Joshua A Kritzer et al.   Nature Chemical Biology

Phage-encoded combinatorial chemical libraries based on bicyclic peptides

(2009) Christian Heinis et al.   Nature Chemical Biology

Inhibition of HIV Budding by a Genetically Selected Cyclic Peptide Targeting the Gag−TSG101 Interaction

(2008) Ali Tavassoli et al.   ACS Chemical Biology

Inhibition of transcription factors with small organic molecules

(2008) Thorsten Berg   CURRENT OPINION IN CHEMICAL BIOLOGY

The exploration of macrocycles for drug discovery — an underexploited structural class

(2008) Edward M. Driggers et al.   NATURE REVIEWS DRUG DISCOVERY

Genetic Selection of Cyclic Peptide Dam Methyltransferase Inhibitors

(2007) Todd A. Naumann et al.   CHEMBIOCHEM