Article
Pharmacology & Pharmacy
Laura Lucia Trebucq, Georgina Alexandra Cardama, Pablo Lorenzano Menna, Diego Andres Golombek, Juan Jose Chiesa, Luciano Marpegan
Summary: The study revealed circadian modulation in the efficacy of 1A-116, likely through RAC1 pathway rhythmicity, suggesting that a chronopharmacological approach is a feasible strategy to improve glioblastoma treatment.
Review
Biochemistry & Molecular Biology
Safwan Alomari, Irma Zhang, Adrian Hernandez, Caitlin Y. Kraft, Divyaansh Raj, Jayanidhi Kedda, Betty Tyler
Summary: Glioblastoma is a common malignant brain tumor with poor prognosis, and there is a need for effective therapeutics. Drug repurposing is a potential strategy, with some drugs showing efficacy against GBM cell lines. However, the blood-brain barrier may limit their effectiveness.
Review
Chemistry, Multidisciplinary
Shuangqi Yu, Lijie Chen, Hongyu Xu, Shengrong Long, Jiazhi Jiang, Wei Wei, Xing Niu, Xiang Li
Summary: The diagnosis and treatment of glioblastoma face several obstacles, but combining multiple methods can provide benefits. Nanomaterials and drug combinations can improve treatment outcomes and reduce side effects. This review discusses the progress and challenges of glioblastoma diagnosis and treatment, as well as the potential of nanomedicine in this field.
FRONTIERS IN CHEMISTRY
(2022)
Article
Clinical Neurology
Ian E. McCutcheon, Mark C. Preul
Summary: The treatment of glioblastoma has evolved from early brain surgery in the nineteenth century to the introduction of modern chemotherapeutics, leading to incremental improvements in survival outcomes. Advances in surgical techniques, adjuvant therapies, and imaging have contributed to improved outcomes over the past century.
WORLD NEUROSURGERY
(2021)
Review
Immunology
Angeliki Datsi, Ruediger V. Sorg
Summary: Dendritic cell vaccination (DCV) is a promising immunotherapy for treating glioblastomas, with numerous trials showing potential but some controlled studies failing to detect a survival benefit. Further exploration is needed to fully understand the potential of this therapeutic approach.
FRONTIERS IN IMMUNOLOGY
(2021)
Editorial Material
Clinical Neurology
Ben A. Strickland, Gabriel Zada
Summary: Glioblastoma multiforme is the most common primary brain tumor in adults, often treated with maximal safe resection, chemotherapy, and radiation. Intraoperative use of blue light endoscopy can enhance tumor fluorescence visualization, aiding in achieving a more accurate resection.
WORLD NEUROSURGERY
(2021)
Review
Cell Biology
Jed de Ruiter Swain, Evdokia Michalopoulou, Evan K. Noch, Michael J. Lukey, Linda Van Aelst
Summary: This review discusses the mechanisms of intercellular metabolite exchange in the healthy brain and how it is exploited by glioblastoma for tumor growth and modulation of the tumor microenvironment. The authors highlight the potential of targeting metabolic dependencies as a therapeutic avenue against this aggressive brain cancer.
GENES & DEVELOPMENT
(2023)
Review
Pharmacology & Pharmacy
Nikhil Pandey, Pavlos Anastasiadis, Christine P. Carney, Pranjali P. Kanvinde, Graeme F. Woodworth, Jeffrey A. Winkles, Anthony J. Kim
Summary: This review focuses on drug delivery strategies and nanotherapeutic technologies targeting brain-invading cancer cells and highlights the importance of treatments for invasive cells.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Article
Oncology
Simone Pacioni, Quintino Giorgio D'Alessandris, Stefano Giannetti, Giuseppe Maria Della Pepa, Martina Offi, Martina Giordano, Valerio Maria Caccavella, Maria Laura Falchetti, Liverana Lauretti, Roberto Pallini
Summary: In this study, fluorescence microscopy analysis was used to assess the number of fluorescence-positive tumor cells induced by 5-aminolevulinic acid (5-ALA) in both low-grade and high-grade gliomas. The ability of 5-ALA to cross the blood-brain barrier (BBB) was also investigated. It was found that 32.7-75.5 percent of cells in high-grade gliomas displayed 5-ALA induced fluorescence, while low-grade gliomas did not show fluorescence following 5-ALA. Immunofluorescence analysis suggested that 5-ALA does not cross the BBB. These findings have important implications for the neurosurgical resection of gliomas.
Review
Cell Biology
Emily E. S. Brettschneider, Masaki Terabe
Summary: Glioblastoma is an aggressive and deadly cancer, and immunotherapies have not made significant progress. NKT cells may play a key immunoregulatory role in glioblastoma, but their specific function is still unclear.
Article
Neurosciences
Siqi Xia, Huaijun Chen, Tianchi Tang
Summary: This study found that patients with brain tumors, gliomas, and glioblastomas have a lower risk of Alzheimer's disease (AD) compared to patients with other tumors. Glioblastoma was significantly associated with a lower risk of AD compared to other tumors.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Oncology
Melodie Davy, Laurie Genest, Christophe Legrand, Oceane Pelouin, Guillaume Froget, Vincent Castagne, Tristan Rupp
Summary: Grade 4 gliomas and glioblastomas are the most common and aggressive brain tumors. Temozolomide, the current standard treatment, has varying responses depending on the tumor type, while Fingolimod, an immunomodulatory drug, may need further evaluation for its potential activity. The study highlights the need for new therapies to improve survival and quality of life for glioblastoma patients.
Article
Biochemistry & Molecular Biology
Andrea A. Lebel, Michee Kisembo, Marie-France N. Soucy, Mathieu P. A. Hebert, Pier Morin, Luc H. Boudreau
Summary: Glioblastoma multiforme (GBM) is a common form of malignant glioma with limited treatment options, highlighting the importance of developing new therapeutic approaches. This study found that bee venom and its components exhibit anti-cancer activities in human glioma cells by impacting apoptosis, necrosis, and the expression levels of certain genes, suggesting potential value in the treatment of GBM.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Nanoscience & Nanotechnology
Mrunal Vitthal Wanjale, Vishnu Sunil Jaikumar, K. C. Sivakumar, Riya Ann Paul, Jackson James, G. S. Vinod Kumar
Summary: This study reports the synthesis of a polyester-based supramolecular hydrogel as a brain biocompatible implant for in situ delivery of hydrophobic drugs. The hydrogel showed good biocompatibility and was able to effectively restrict the aggressive regrowth of tumors. The combination of carmustine and curcumin as model hydrophobic drugs demonstrated a synergistic apoptotic effect on glioma cells. This study provides a promising strategy for site-specific drug delivery in brain tumors.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Neurosciences
Pietro Zeppa, Raffaele De Marco, Matteo Monticelli, Armando Massara, Andrea Bianconi, Giuseppe Di Perna, Stefania Greco Crasto, Fabio Cofano, Antonio Melcarne, Michele Maria Lanotte, Diego Garbossa
Summary: This study compared the use of 5-ALA and SF in GBM patients and found no significant differences in terms of resection extent and postoperative functional status. However, the concomitant use of both fluorophores may improve overall survival.
Article
Oncology
Omar Aboumarzouk, Ronan Valentine, Ron Buist, Sarfraz Ahmad, Ghulam Nabi, Sam Eljamel, Harry Moseley, Slawomir Grzegorz Kata
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2015)
Article
Acoustics
Yun Jiang, Zhen Qiu, Rachael McPhillips, Carl Meggs, Syed Osama Mahboob, Han Wang, Robyn Duncan, Daniel Rodriguez-Sanmartin, Ye Zhang, Giuseppe Schiavone, Roos Eisma, Marc P. Y. Desmulliez, Sam Eljamel, Sandy Cochran, Tim W. Button, Christine E. M. Demore
IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL
(2016)
Article
Engineering, Electrical & Electronic
Giuseppe Schiavone, Thomas Jones, Dennis Price, Rachael McPhillips, Yun Jiang, Zhen Qiu, Carl Meggs, Syed O. Mahboob, Sam Eljamel, Tim W. Button, Christine E. M. Demore, Sandy Cochran, Marc P. Y. Desmulliez
MICROSYSTEM TECHNOLOGIES-MICRO-AND NANOSYSTEMS-INFORMATION STORAGE AND PROCESSING SYSTEMS
(2017)
Review
Oncology
M. Sam Eljamel, Syed Osama Mahboob
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2016)
Article
Oncology
Naomi Foster, Sam Eljamel
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2016)
Article
Clinical Neurology
Kate Miller, Sam Eljamel
WORLD NEUROSURGERY
(2016)
Article
Clinical Neurology
Walter Stummer, Floriano Rodrigues, Philippe Schucht, Matthias Preuss, Dorothee Wiewrodt, Ulf Nestler, Marco Stein, Jose Manuel Cabezudo Artero, Nunzio Platania, Jane Skjoth-Rasmussen, Alessandro Della Puppa, John Caird, Soren Cortnum, Sam Eljamel, Christian Ewald, Laura Gonzalez-Garcia, Andrew J. Martin, Ante Melada, Aurelia Peraud, Angela Brentrup, Thomas Santarius, Hans Herbert Steiner
ACTA NEUROCHIRURGICA
(2014)
Article
Clinical Neurology
A. G. Kolias, W. J. Scotton, A. Belli, A. T. King, P. M. Brennan, D. O. Bulters, M. S. Eljamel, M. H. Wilson, M. C. Papadopoulos, A. D. Mendelow, D. K. Menon, P. J. Hutchinson
BRITISH JOURNAL OF NEUROSURGERY
(2013)
Article
Clinical Neurology
Bart Nuttin, Hemmings Wu, Helen Mayberg, Marwan Hariz, Loes Gabriels, Thorsten Galert, Reinhard Merkel, Cynthia Kubu, Osvaldo Vilela-Filho, Keith Matthews, Takaomi Taira, Andres M. Lozano, Gaston Schechtmann, Paresh Doshi, Giovanni Broggi, Jean Regis, Ahmed Alkhani, Bomin Sun, Sam Eljamel, Michael Schulder, Michael Kaplitt, Emad Eskandar, Ali Rezai, Joachim K. Krauss, Paulien Hilven, Rick Schuurman, Pedro Ruiz, Jin Woo Chang, Paul Cosyns, Nir Lipsman, Juergen Voges, Rees Cosgrove, Yongjie Li, Thomas Schlaepfer
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2014)
Article
Clinical Neurology
Hon Tang, Francisco Falcone, Sam Eljamel
JOURNAL OF NEUROSURGERY
(2013)
Article
Oncology
Ivan Wong Hin Chung, Sam Eljamel
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2013)
Article
Oncology
Sarah Eljamel, Max Petersen, Ronan Valentine, Ron Buist, Carol Goodman, Harry Moseley, Sam Eljamel
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2013)
Article
Oncology
Max Petterssen, Sarah Eljamel
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2014)
Article
Urology & Nephrology
Slawomir G. Kata, Ghulam Nabi, Sam Eljamel, Piotr Chlosta, Harry Moseley, Omar M. Aboumarzouk
UROLOGIA INTERNATIONALIS
(2014)