Article
Clinical Neurology
Stephanie Schipmann, Michael Muther, Louise Stogbauer, Sebastian Zimmer, Benjamin Brokinkel, Markus Holling, Oliver Grauer, Eric Suero Molina, Nils Warneke, Walter Stummer
Summary: Combining 5-ALA FGR and PDT provides an innovative and safe method of local tumor control resulting in promising progression-free survival (PFS). Further prospective studies are warranted to evaluate long-term therapeutic effects.
JOURNAL OF NEUROSURGERY
(2021)
Article
Biochemistry & Molecular Biology
Martin Kiening, Norbert Lange
Summary: This study compared the efficacy of ALA, ALA-Hex, and PSI-ALA-Hex in inducing fluorescence protoporphyrin IX production in breast cancer cells. The results showed that ALA-Hex and PSI-ALA-Hex were able to produce protoporphyrin IX in all breast cancer cell models, while ALA performed poorly in half of the models. The intravenous administration of PSI-ALA-Hex showed mild efficacy in detecting a wide range of breast tumors, whereas ALA showed higher selectivity.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2023)
Review
Oncology
Harshal A. Shah, Sandra Leskinen, Hamza Khilji, Vinayak Narayan, Netanel Ben-Shalom, Randy S. D'Amico
Summary: The current studies on 5-ALA fluorescence in brain metastases are limited and do not confirm its efficacy in improving the extent of resection or post-operative survival. Fluorescence varies greatly across and within tumor types.
JOURNAL OF NEURO-ONCOLOGY
(2022)
Article
Oncology
Chen Xi, Sun Jinli, Jianyao Mao, Chen Yan, Huijuan Li, Zhongjie Shi, Zhangyu Li, Liwei Zhou, Yukui Li, Sifang Chen, Guowei Tan
Summary: This study investigates the benefits of sodium fluorescein-guided surgery in patients with high-grade glioma. The results show that the use of fluorescein guidance significantly reduces surgery duration, improves gross total resection rates, and reduces postoperative residual tumor volume. This technique is particularly advantageous for tumors located in non-verbal, sensory, motor, and cognitive areas such as the temporal and occipital lobes, without increasing the incidence of postoperative complications.
FRONTIERS IN ONCOLOGY
(2023)
Review
Clinical Neurology
Danielle Golub, Jonathan Hyde, Siddhant Dogra, Joseph Nicholson, Katherine A. Kirkwood, Paulomi Gohel, Stephen Loftus, Theodore H. Schwartz
Summary: The study compared the efficacy of 5-ALA and IMRI in optimizing EOR in HGG, finding both to be superior to conventional neuronavigation. However, no clear difference in effectiveness was found between IMRI and 5-ALA.
JOURNAL OF NEUROSURGERY
(2021)
Review
Neurosciences
Lapo Bonosi, Salvatore Marrone, Umberto Emanuele Benigno, Felice Buscemi, Sofia Musso, Massimiliano Porzio, Manikon Poullay Silven, Fabio Torregrossa, Giovanni Grasso
Summary: This study conducted a systematic review to examine the role of intraoperative imaging techniques in improving the surgical outcomes of glioblastoma multiforme (GBM) patients. The results showed that combining multiple image-guided techniques resulted in better extent of resection, but patients still experienced neurocognitive decline after surgery, leading to a reduced quality of life.
Article
Neurosciences
Pietro Zeppa, Raffaele De Marco, Matteo Monticelli, Armando Massara, Andrea Bianconi, Giuseppe Di Perna, Stefania Greco Crasto, Fabio Cofano, Antonio Melcarne, Michele Maria Lanotte, Diego Garbossa
Summary: This study compared the use of 5-ALA and SF in GBM patients and found no significant differences in terms of resection extent and postoperative functional status. However, the concomitant use of both fluorophores may improve overall survival.
Review
Clinical Neurology
Emily J. Smith, Kavita Gohil, Charee M. Thompson, Anant Naik, Wael Hassaneen
Summary: This meta-analysis demonstrates that fluorescein-guided surgery improves GTR rates of HGGs compared to non-fluorescence guided surgery, while showing similar GTR rates compared to reported 5-ALA-guided resection rates.
WORLD NEUROSURGERY
(2021)
Article
Oncology
Evgenii Belykh, Liudmila Bardonova, Irakliy Abramov, Vadim A. A. Byvaltsev, Talgat Kerymbayev, Kwanha Yu, Debbie R. R. Healey, Ernesto Luna-Melendez, Benjamin Deneen, Shwetal Mehta, James K. K. Liu, Mark C. C. Preul
Summary: Surgical resection is the primary treatment for gliomas, but there is a lack of comparative effectiveness information for different fluorescent dyes used for intraoperative tumor visualization. This study analyzed the effectiveness of fluorescein sodium (FNa), 5-aminolevulinic acid (5-ALA)-induced protoporphyrin IX (PpIX), and indocyanine green (ICG) fluorescence in various glioma models and found that wide-field imaging is equally efficient for highly malignant gliomas with all three dyes, while confocal microscopy improves diagnostic accuracy and can better detect low concentrations of PpIX and FNa in low-intermediate grade gliomas.
FRONTIERS IN ONCOLOGY
(2023)
Editorial Material
Clinical Neurology
Ben A. Strickland, Gabriel Zada
Summary: Glioblastoma multiforme is the most common primary brain tumor in adults, often treated with maximal safe resection, chemotherapy, and radiation. Intraoperative use of blue light endoscopy can enhance tumor fluorescence visualization, aiding in achieving a more accurate resection.
WORLD NEUROSURGERY
(2021)
Review
Oncology
Linda M. Wang, Matei A. Banu, Peter Canoll, Jeffrey N. Bruce
Summary: The current standard of care for glioblastoma includes surgical resection followed by temozolomide chemotherapy and radiation. Recent studies suggest that over 95% extent of resection is associated with better outcomes. The goal of surgery is maximal safe resection, extending into the contrast-enhancing tumor margins for improved prognosis.
FRONTIERS IN ONCOLOGY
(2021)
Article
Pharmacology & Pharmacy
Martin Hsiu-Chu Lin, Li-Ching Chang, Chiu-Yen Chung, Wei-Chao Huang, Ming-Hsueh Lee, Kuo-Tai Chen, Ping-Shan Lai, Jen-Tsung Yang
Summary: The study conducted phototherapy using the PCI technique on a human GBM cell-line, showing that the formulation Etop/PpIX-PAMAM(G5) Ns had higher cellular uptake and exhibited a synergistic effect compared to free PpIX. Furthermore, phototherapy with light illumination resulted in increased oxidative stress and apoptosis, indicating a potential therapeutic strategy for GBM treatment.
Review
Oncology
Jeffrey Traylor, Mark N. Pernik, Alex C. Sternisha, Samuel K. McBrayer, Kalil G. Abdullah
Summary: 5-aminolevulinic acid (5-ALA) is a medication that can produce fluorescence in certain cancers by converting to protoporphyrin IX (PpIX). This fluorescence assists surgeons in visualizing tumor margins during surgery, particularly in high-grade gliomas like glioblastoma. However, some low-grade gliomas do not readily accumulate PpIX and fluorescence with 5-ALA administration, making complete resection challenging. Targeting the heme synthesis pathway may offer potential strategies to enhance fluorescence and improve surgical outcomes for these tumors.
Review
Clinical Neurology
Anant Naik, Emily J. Smith, Ariana Barreau, Mark Nyaeme, Samuel W. Cramer, Daniel Najafali, David T. Krist, Paul M. Arnold, Wael Hassaneen
Summary: A network meta-analysis comparing 5-ALA, IMRI, and FS as intraoperative navigation methods for high-grade glioma resection showed that IMRI, FS, and 5-ALA all led to higher rates of gross total resection and improved overall survival and progression-free survival.
JOURNAL OF CLINICAL NEUROSCIENCE
(2022)
Review
Oncology
Lasse Cramer Ahrens, Mathias Green Krabbenhoft, Rasmus Wuergler Hansen, Nikola Mikic, Christian Bonde Pedersen, Frantz Rom Poulsen, Anders Rosendal Korshoej
Summary: Surgery is crucial in treating high-grade gliomas (HGG) as gross total resection (GTR) can increase overall survival and progression-free survival. Fluorescence-guided surgery using 5-aminolevulinic acid (5-ALA) has shown to significantly increase GTR compared to white light surgery. Sodium fluorescein (SF), an off-label fluorophore, has gained popularity due to its cost-effectiveness, non-toxicity, and ease of administration during surgery, although its level of evidence in HGG surgery is lower than that of 5-ALA.
Article
Biochemistry & Molecular Biology
Samy Eljamel
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2015)
Article
Oncology
Omar Aboumarzouk, Ronan Valentine, Ron Buist, Sarfraz Ahmad, Ghulam Nabi, Sam Eljamel, Harry Moseley, Slawomir Grzegorz Kata
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2015)
Article
Acoustics
Yun Jiang, Zhen Qiu, Rachael McPhillips, Carl Meggs, Syed Osama Mahboob, Han Wang, Robyn Duncan, Daniel Rodriguez-Sanmartin, Ye Zhang, Giuseppe Schiavone, Roos Eisma, Marc P. Y. Desmulliez, Sam Eljamel, Sandy Cochran, Tim W. Button, Christine E. M. Demore
IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL
(2016)
Article
Engineering, Electrical & Electronic
Giuseppe Schiavone, Thomas Jones, Dennis Price, Rachael McPhillips, Yun Jiang, Zhen Qiu, Carl Meggs, Syed O. Mahboob, Sam Eljamel, Tim W. Button, Christine E. M. Demore, Sandy Cochran, Marc P. Y. Desmulliez
MICROSYSTEM TECHNOLOGIES-MICRO-AND NANOSYSTEMS-INFORMATION STORAGE AND PROCESSING SYSTEMS
(2017)
Article
Oncology
Naomi Foster, Sam Eljamel
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2016)
Article
Clinical Neurology
Kate Miller, Sam Eljamel
WORLD NEUROSURGERY
(2016)
Article
Clinical Neurology
Walter Stummer, Floriano Rodrigues, Philippe Schucht, Matthias Preuss, Dorothee Wiewrodt, Ulf Nestler, Marco Stein, Jose Manuel Cabezudo Artero, Nunzio Platania, Jane Skjoth-Rasmussen, Alessandro Della Puppa, John Caird, Soren Cortnum, Sam Eljamel, Christian Ewald, Laura Gonzalez-Garcia, Andrew J. Martin, Ante Melada, Aurelia Peraud, Angela Brentrup, Thomas Santarius, Hans Herbert Steiner
ACTA NEUROCHIRURGICA
(2014)
Article
Clinical Neurology
David Christmas, J. Douglas Steele, Serenella Tolomeo, M. Sam Eljamel, Keith Matthews
JOURNAL OF AFFECTIVE DISORDERS
(2013)
Article
Clinical Neurology
Bart Nuttin, Hemmings Wu, Helen Mayberg, Marwan Hariz, Loes Gabriels, Thorsten Galert, Reinhard Merkel, Cynthia Kubu, Osvaldo Vilela-Filho, Keith Matthews, Takaomi Taira, Andres M. Lozano, Gaston Schechtmann, Paresh Doshi, Giovanni Broggi, Jean Regis, Ahmed Alkhani, Bomin Sun, Sam Eljamel, Michael Schulder, Michael Kaplitt, Emad Eskandar, Ali Rezai, Joachim K. Krauss, Paulien Hilven, Rick Schuurman, Pedro Ruiz, Jin Woo Chang, Paul Cosyns, Nir Lipsman, Juergen Voges, Rees Cosgrove, Yongjie Li, Thomas Schlaepfer
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2014)
Article
Clinical Neurology
Greg D. Guthrie, Sam Eljamel
JOURNAL OF NEUROSURGERY
(2013)
Article
Clinical Neurology
Hon Tang, Francisco Falcone, Sam Eljamel
JOURNAL OF NEUROSURGERY
(2013)
Article
Oncology
Ivan Wong Hin Chung, Sam Eljamel
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2013)
Article
Oncology
Max Petterssen, Sarah Eljamel
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2014)
Article
Urology & Nephrology
Slawomir G. Kata, Ghulam Nabi, Sam Eljamel, Piotr Chlosta, Harry Moseley, Omar M. Aboumarzouk
UROLOGIA INTERNATIONALIS
(2014)