Article
Nanoscience & Nanotechnology
Mrunal Vitthal Wanjale, Vishnu Sunil Jaikumar, K. C. Sivakumar, Riya Ann Paul, Jackson James, G. S. Vinod Kumar
Summary: This study reports the synthesis of a polyester-based supramolecular hydrogel as a brain biocompatible implant for in situ delivery of hydrophobic drugs. The hydrogel showed good biocompatibility and was able to effectively restrict the aggressive regrowth of tumors. The combination of carmustine and curcumin as model hydrophobic drugs demonstrated a synergistic apoptotic effect on glioma cells. This study provides a promising strategy for site-specific drug delivery in brain tumors.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Review
Pharmacology & Pharmacy
Charlotte Berard, Charles Truillet, Benoit Larrat, Frederic Dhermain, Marie-Anne Esteve, Florian Correard, Anthony Novell
Summary: The therapeutic management of gliomas is a difficult task due to the challenges presented by brain tumors, including the presence of blood-brain barriers that prevent effective drug delivery. Focused ultrasound-mediated BBB disruption offers a promising non-invasive method to enhance drug delivery into brain tumors. Clinical trials and preclinical studies have demonstrated the potential of this approach in glioma therapy. However, there are still challenges to overcome for its clinical use.
PHARMACOLOGY & THERAPEUTICS
(2023)
Review
Cell Biology
Ziyi Qiu, Zhenhua Yu, Ting Xu, Liuyou Wang, Nanxin Meng, Huawei Jin, Bingzhe Xu
Summary: This review summarizes the major strategies of novel nano-drug delivery systems for the treatment of brain tumors in recent years, which aim to cross the BBB and enhance brain targeting, and compares the advantages and disadvantages of several strategies.
Review
Pharmacology & Pharmacy
Tobeka Naki, Blessing A. Aderibigbe
Summary: Malignant brain tumor is a life-threatening disease with poor survival rate. Nanomedicines have shown promise in the treatment of brain cancer by overcoming the blood-brain barrier and reducing drug toxicity, leading to improved drug delivery and targeted drug release.
Review
Biochemistry & Molecular Biology
Elza N. Mathew, Bethany C. Berry, Hong Wei Yang, Rona S. Carroll, Mark D. Johnson
Summary: This review addresses the impact of tumor invasion, molecular and cellular heterogeneity, and the blood-brain barrier on drug delivery and distribution in glioblastoma, and introduces potential therapeutic delivery options.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Joji Ishida, Saira Alli, Andrew Bondoc, Brian Golbourn, Nesrin Sabha, Kristina Mikloska, Stacey Krumholtz, Dilakshan Srikanthan, Naohide Fujita, Amanda Luck, Colin Maslink, Christian Smith, Kullervo Hynynen, James Rutka
Summary: Diffuse intrinsic pontine glioma (DIPG) is a devastating tumor in children that cannot be surgically removed, and MRI-guided focused ultrasound (MRgFUS) shows promise in enhancing drug delivery for DIPG treatment.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Engineering, Biomedical
Leonardo Delello Di Filippo, Suzana Goncalves de Carvalho, Jonatas Lobato Duarte, Marcela Tavares Luiz, Jessyca Aparecida Paes Dutra, Geanne Aparecida de Paula, Marlus Chorilli, Joao Conde
Summary: Glioblastoma multiforme (GBM) is the most common and aggressive type of primary brain tumor, accounting for approximately 60% of cases of gliomas. However, the treatment of GBM is challenging due to the presence of the blood-brain barrier (BBB), which limits the delivery of therapeutic drugs to the brain parenchyma. Nanocarriers with nanometric size and surface modifications show promise in improving the bioavailability and targeting of chemotherapeutic drugs to GBM cells. This review provides an overview of the most frequently overexpressed receptors in GBM cells and potential strategies for chemotherapeutic delivery and active targeting using nanocarriers.
MATERIALS TODAY BIO
(2023)
Review
Pharmacology & Pharmacy
Wouter J. F. Vanbilloen, Julian S. Rechberger, Jacob B. Anderson, Leo F. Nonnenbroich, Liang Zhang, David J. Daniels
Summary: Primary brain and central nervous system (CNS) tumors are a diverse group of neoplasms that occur within the brain and spinal cord. The unique challenges presented by the brain-CSF barrier and blood-brain barrier have hindered the translation of advances in understanding CNS tumor progression into effective therapies. Nanoparticles offer a potential solution for targeted CNS tumor therapeutics delivery by bypassing these barriers.
Review
Medicine, Research & Experimental
Li Qiao, Huishu Yang, Xin-xin Shao, Qiuyan Yin, Xian-Jun Fu, Qingcong Wei
Summary: Glioma is the most common and aggressive primary intracranial tumor within the central nervous system. The blood-brain barrier has been a major obstacle for effective glioma treatment. Nanocarrier-mediated drug delivery has emerged as an effective and noninvasive system for treating glioma, showing great potential in glioma therapy.
MOLECULAR PHARMACEUTICS
(2022)
Article
Multidisciplinary Sciences
Rong Sun, Mingzhu Liu, Jianping Lu, Binbin Chu, Yunmin Yang, Bin Song, Houyu Wang, Yao He
Summary: The authors have developed a bacteria-based drug delivery system for the treatment of glioblastoma. This system bypasses the blood-brain barrier and uses photothermal therapy and immune responses to destroy bacteria-infected glioblastoma cells and prolong the survival of mice. The residual bacteria can also be effectively eliminated from the body.
NATURE COMMUNICATIONS
(2022)
Article
Polymer Science
Martin Studenovsky, Anna Rumlerova, Libor Kostka, Tomas Etrych
Summary: The study focuses on the design, synthesis, and physico-chemical properties of polymer-mebendazole nanomedicines for repurposing in cancer therapy, aiming to enhance their bioavailability. Multiple low-molecular-weight mebendazole derivatives and polymer conjugates were successfully synthesized, with potential applications beyond mebendazole to other benzimidazole-based anthelmintics. The methodology described in this study may also be applicable for conjugation of other biologically active compounds containing a heterocyclic N-H group in their molecules.
Review
Oncology
Wen Jiang, Jin-Wei Hu, Xu-Ran He, Wei-Lin Jin, Xin-Yang He
Summary: Statins, as HMG-CoA reductase inhibitors, not only lower cholesterol and improve cardiovascular risk, but also show potential as anti-cancer drugs. However, evidence on their anti-cancer efficacy is inconsistent, with further research needed to determine if they are more effective against certain molecular subtypes of cancer.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Review
Oncology
Randy S. D'Amico, Manish K. Aghi, Michael A. Vogelbaum, Jeffrey N. Bruce
Summary: Convection-enhanced delivery (CED) is a method of targeted, local drug delivery to the central nervous system that shows promise for treating glioblastoma (GBM), although the long-term efficacy of the agents studied remains difficult to assess at present.
JOURNAL OF NEURO-ONCOLOGY
(2021)
Article
Engineering, Biomedical
Fawad Ur Rehman, Yang Liu, Meng Zheng, Bingyang Shi
Summary: Exosome application is a promising nanotechnology discipline for disease therapy and diagnosis. Due to their natural properties, such as efficient drug delivery and blood-brain barrier traversing ability, exosomes have gained attention in clinical translation for brain diseases treatment.
Review
Biochemistry & Molecular Biology
Diana Araujo, Eduarda Ribeiro, Irina Amorim, Nuno Vale
Summary: Gastric cancer is a leading cause of death worldwide, and most patients are diagnosed at an advanced stage with poor prognosis. Current treatment options include endoscopic detection, surgery, and chemotherapy or chemoradiotherapy. Drug repurposing, exploring new therapeutic indications for approved drugs, is an important approach to drug development.
Review
Biochemistry & Molecular Biology
Andrew M. Hersh, Safwan Alomari, Betty M. Tyler
Summary: This article provides a review of the potential of nanoparticles (NPs) in improving drug delivery to brain tumors. The unique physical and chemical properties of NPs and the mechanisms of NP transport across the blood-brain barrier are discussed, along with the major types of NPs investigated for brain tumor treatment. In addition, the use of NPs as imaging contrast agents and their conjugation with imaging probes for visualization and treatment monitoring are explored. Finally, the limitations of NPs for brain tumor treatment are discussed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Morgane Le Bras, Noah Gorelick, Sylvain Pautet, Betty Tyler, Stephane Manenti, Nicolas Skuli, Stefania Millevoi, Anne Cammas
Summary: This study investigates the molecular mechanisms underlying protein synthesis deregulation in glioblastoma (GBM) and its impact on tumor progression and resistance to therapy. The results reveal the crucial role of RNA-binding proteins hnRNP H/F in controlling protein synthesis in GBM through overlapping mechanisms. Furthermore, hnRNP H/F are shown to potentiate cellular processes that contribute to the aggressive and resistant phenotype of GBMs, indicating their potential as therapeutic targets.
Review
Chemistry, Medicinal
Sarah J. Skuli, Safwan Alomari, Hallie Gaitsch, A'ishah Bakayoko, Nicolas Skuli, Betty M. Tyler
Summary: Metformin, as a drug, not only reduces the risk of cancer in type 2 diabetics but also inhibits cell growth in various cancers. However, its mechanism of action in cancer cells and its effect on cancer metabolism are still unclear.
Review
Polymer Science
Chad A. Caraway, Hallie Gaitsch, Elizabeth E. Wicks, Anita Kalluri, Navya Kunadi, Betty M. Tyler
Summary: Translating novel therapies for brain cancer is crucial for improving survival rates. Polymeric nanoparticles show promise in delivering chemotherapy drugs to tumor cells and have the potential to be effective in brain tumor therapy.
Review
Oncology
Andrew M. Hersh, Hallie Gaitsch, Safwan Alomari, Daniel Lubelski, Betty M. Tyler
Summary: Glioblastoma stem cells (GSCs) are a unique population of tumor cells that play a key role in tumor growth and treatment resistance. Dysregulation of critical signaling pathways and epigenomic changes in GSCs have been identified as potential therapeutic targets. A multi-pronged therapeutic approach targeting multiple pathways and molecules may be necessary for effective treatment. Further research on GSCs and treatment methods is crucial as the outcomes for GSCs remain poor.
Review
Oncology
Andrew M. Hersh, Meghana Bhimreddy, Carly Weber-Levine, Kelly Jiang, Safwan Alomari, Nicholas Theodore, Amir Manbachi, Betty M. Tyler
Summary: Glioblastoma (GBM) is a difficult-to-treat brain tumor, but focused ultrasound (FUS) shows promise as a new therapeutic approach. FUS can penetrate the skull and non-invasively ablate tumor tissue. It can also disrupt the blood-brain barrier, allowing chemotherapy drugs to penetrate the tumor. Other research includes stimulating the immune system and increasing tumor sensitivity to radiation therapy.
Review
Oncology
Hallie Gaitsch, Andrew M. Hersh, Safwan Alomari, Betty M. Tyler
Summary: Gliomas are challenging primary brain tumors due to resistance to treatment and anatomical barriers. Dendrimers, nanomaterials with a branching structure, have shown potential for targeted delivery to gliomas. This review discusses the physical characteristics of dendrimers, strategies for targeting glioma cells, and novel applications in glioma models.