Secreted phospholipase A2, lipoprotein hydrolysis, and atherosclerosis: integration with lipidomics

Group X Secretory Phospholipase A 2 Negatively Regulates ABCA1 and ABCG1 Expression and Cholesterol Efflux in Macrophages

(2010) Preetha Shridas et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Group X secretory phospholipase A2 augments angiotensin II-induced inflammatory responses and abdominal aortic aneurysm formation in apoE-deficient mice

(2010) Melissa Zack et al.   ATHEROSCLEROSIS

Emerging roles of secreted phospholipase A2 enzymes: Lessons from transgenic and knockout mice

(2010) Makoto Murakami et al.   BIOCHIMIE

Bioactive products generated by Group V sPLA2 hydrolysis of LDL activate macrophages to secrete pro-inflammatory cytokines

(2010) Boris B. Boyanovsky et al.   CYTOKINE

A novel anti-inflammatory role for secretory phospholipase A2in immune complex-mediated arthritis

(2010) Eric Boilard et al.   EMBO Molecular Medicine

The Capacity of Group V sPLA 2 to Increase Atherogenicity of ApoE −/− and LDLR −/− Mouse LDL In Vitro Predicts its Atherogenic Role In Vivo

(2009) Boris Boyanovsky et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Phospholipase A 2 –Modified Low-Density Lipoprotein Activates Macrophage Peroxisome Proliferator–Activated Receptors

(2009) Dmitry Namgaladze et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Metabolism and atherogenic disease association of lysophosphatidylcholine

(2009) Gerd Schmitz et al.   ATHEROSCLEROSIS

Group III secreted phospholipase A2transgenic mice spontaneously develop inflammation

(2009) Hiroyasu Sato et al.   BIOCHEMICAL JOURNAL

Varespladib (A-002), a Secretory Phospholipase A2 Inhibitor, Reduces Atherosclerosis and Aneurysm Formation in ApoE−/− Mice

(2009) Heather Fraser et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Molecular and functional characterization of polymorphisms in the secreted phospholipase A2 group X gene: relevance to coronary artery disease

(2009) Sarah Gora et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Effects of 1-H-indole-3-glyoxamide (A-002) on concentration of secretory phospholipase A2 (PLASMA study): a phase II double-blind, randomised, placebo-controlled trial

(2009) Robert S Rosenson et al.   LANCET

Secretory phospholipase A2-IID is an effector molecule of CD4+CD25+regulatory T cells

(2009) Caroline E. von Allmen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biochemistry and Physiology of Mammalian Secreted Phospholipases A2

(2008) Gérard Lambeau et al.   Annual Review of Biochemistry

Analyses of Group III Secreted Phospholipase A2Transgenic Mice Reveal Potential Participation of This Enzyme in Plasma Lipoprotein Modification, Macrophage Foam Cell Formation, and Atherosclerosis

(2008) Hiroyasu Sato et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Increased lipolysis by secretory phospholipase A2group V of lipoproteins in diabetic dyslipidaemia

(2008) C. Pettersson et al.   JOURNAL OF INTERNAL MEDICINE

The synergistic inhibition of atherogenesis in apoE−/−mice between pravastatin and the sPLA2inhibitor varespladib (A-002)

(2008) Zory Shaposhnik et al.   JOURNAL OF LIPID RESEARCH

Expression of secretory phospholipase A2s in human atherosclerosis development

(2007) Masayo Kimura-Matsumoto et al.   ATHEROSCLEROSIS