Article
Clinical Neurology
Jed W. Smith, Raphae S. Barlas, Mamas A. Mamas, S. Matthijs Boekholdt, Ziad Mallat, Robert N. Luben, Nicholas J. Wareham, Kay-Tee Khaw, Phyo K. Myint
Summary: A nested case-control study found that sPLA2 activity, but not concentration, is associated with an increased risk of future ischaemic stroke. This finding may have implications for risk group stratification and the development of novel therapeutic agents.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Cell Biology
Ashish Jaiswal, Rakhshinda Rehman, Joytri Dutta, Sabita Singh, Archita Ray, Malathy Shridhar, Jaswant Jaisankar, Manas Bhatt, Dikshit Khandelwal, Bandya Sahoo, Arjun Ram, Ulaganathan Mabalirajan
Summary: Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease with a poor prognosis. The expression profile of various secretory Phospholipase A2 (PLA2) isoforms in the lungs of healthy individuals and IPF patients was analyzed. PLA2G2A and PLA2G5 were found to be increased in the fibroblasts of IPF patients.
Article
Chemistry, Physical
Shan Zhang, Weikang Gong, Zhongjie Han, Yang Liu, Chunhua Li
Summary: This study investigates the shared and specific functions of the sPLA2 family members through structural and bioinformatics analyses. The study reveals that critical residues for family functions are highly conserved, while regions associated with calcium ion/membrane binding vary among members. The analysis also shows that specific residues are sensitive to external perturbations, indicating different roles in allosteric modulation, while shared residues play a key role in maintaining structural stability.
JOURNAL OF PHYSICAL CHEMISTRY B
(2021)
Article
Oncology
Jingjin Li, Xiaoping Zhang, Mengxi Yang, Hang Yang, Ning Xu, Xueqiang Fan, Gang Liu, Xintong Jiang, Jiasai Fan, Lifang Zhang, Hu Zhang, Ying Zhou, Rui Li, Si Gao, Jiangli Jin, Zening Jin, Jingang Zheng, Qiang Tu, Jingyi Ren
Summary: Through genome-wide analysis of DNA methylation, it was found that hypomethylation in vulnerable atherosclerotic plaques is associated with genes involved in inflammation, indicating a potential role in driving the progression and destabilization of atherosclerotic cardiovascular disease.
CLINICAL EPIGENETICS
(2021)
Article
Fisheries
Wanghong Xiao, Geng Qin, Yanhong Zhang, Yali Liu, Huixian Zhang, Zelin Chen, Qiang Lin
Summary: This study reveals the important role of seahorse sPLA2-IBs in immune protection, particularly during male pregnancy.
Article
Biochemistry & Molecular Biology
Miguel A. Bermudez, Maria A. Balboa, Jesus Balsinde
Summary: Lipid droplets, previously seen as static storage organelles, are now recognized as dynamic structures involved in key processes like lipid metabolism, cellular homeostasis, and signaling. Circulating monocytes may interact with products released by endothelial cells in atherosclerotic plaques, potentially acquiring a foamy phenotype before differentiating into macrophages. Arachidonic acid, released in significant amounts into the bloodstream, acts as a potent inducer of neutral lipid synthesis and lipid droplet formation in circulating monocytes.
Article
Gastroenterology & Hepatology
Alison L. Halpern, Patrick D. Kohtz, Allana M. White, Anna K. Houk, Jacob F. Rehring, Levent Hanson, Martin D. McCarter, Molishree Joshi, Xianzhong Meng, David A. Fullerton, Michael J. Weyant
Summary: The study found that the inhibition of sPLA2 IIa can reduce the expression of EGFR and HER2 in esophageal adenocarcinoma cells, thereby decreasing cell proliferation. In a mouse model, mice treated with sPLA2 IIa inhibitor had smaller tumors compared to the control group. This suggests the potential of sPLA2 IIa inhibitors as therapeutics in the treatment of esophageal adenocarcinoma.
DIGESTIVE DISEASES AND SCIENCES
(2021)
Article
Hematology
Lasse G. Lorentzen, Gorm M. Hansen, Kasper K. Iversen, Henning Bundgaard, Michael J. Davies
Summary: Proteomic analysis of proteins captured on angioplasty balloons during percutaneous coronary interventions can provide information on coronary artery lesion protein profiles and distinguish between different types of coronary artery disease.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Article
Clinical Neurology
Yuan Wang, Gang Liu, Haiqing Song, Catherine Cao, Xunming Ji, Guodong Cao
Summary: This study found that elevated levels of Lp-PLA2 were associated with intracranial artery stenosis in patients with acute ischemic stroke, suggesting it may serve as a promising biomarker and potential therapeutic target for intracranial artery stenosis.
FRONTIERS IN NEUROLOGY
(2022)
Article
Medicine, Research & Experimental
Evangelos Falidas, Eirini Kitsiouli, Despoina Spyropoulou, Evangelos Tsiambas, Asimina Kalogirou, George Tsouvelas, Stylianos Papadopoulos, Michail Mitsis, Marilena Lekka, Sofianiki Mastronikoli, Dimitrios Peschos, Odysseas Dimas, Konstantinos Vlachos
Summary: This study investigated the expression of SPLA2 in colon adenocarcinoma (CA) and found that SPLA2 over-expression was significantly associated with increased tumor diameter. This suggests that SPLA2 may influence endogenous cell responses through its enzymatic activity, and it has the potential to be a biomarker for monitoring CA patients.
Article
Pathology
Lucas R. Massoth, Niyati Desai, Annamaria Szabolcs, Cynthia K. Harris, Azfar Neyaz, Rory Crotty, Ivan Chebib, Miguel N. Rivera, Lynette M. Sholl, James R. Stone, David T. Ting, Vikram Deshpande
Summary: The study evaluated the use of ISH and IHC technologies to detect the SARS-CoV-2 virus in tissue samples from COVID-19 patients and compared the results with qRT-PCR. The study found that viral protein and RNA in lung tissue were predominantly extracellular, with some cases showing predominant presence within hyaline membranes.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Su Duy Nguyen, Emilia A. Korhonen, Martina B. Lorey, Laura Hakanpaa, Mikko I. Mayranpaa, Petri T. Kovanen, Pipsa Saharinen, Kari Alitalo, Katariina Oorni
Summary: The study demonstrated that PLA(2)-LDL is a potent agonist of endothelial WPB exocytosis, leading to increased secretion of Ang2 and translocation of P-selectin. These findings provide mechanistic insights into how PLA(2)-LDL promotes vascular inflammation and atherosclerosis.
Review
Integrative & Complementary Medicine
Lu-ming Wang, Wen-lan Zhang, Nuan Lyu, Yan-rong Suo, Lin Yang, Bin Yu, Xi-juan Jiang
Summary: This paper reviews the research on Chinese medicine in treating atherosclerosis, focusing on reducing levels of lipoprotein-associated phospholipase A2 to guide future experimental studies and clinical applications related to atherosclerosis.
CHINESE JOURNAL OF INTEGRATIVE MEDICINE
(2023)
Article
Oncology
Zhangxiao Peng, Yanxin Chang, Jianhui Fan, Weidan Ji, Changqing Su
Summary: Phospholipase A2 enzymes are a superfamily consisting of six subfamilies, playing important roles in inflammation-related diseases and cancer. Among them, sPLA2-IIA may have conflicting roles depending on cancer type, while cPLA2alpha and iPLA28 generally play a protumorigenic role in most cancers.
Article
Clinical Neurology
Yuan Liu, Jinhua Zhu, Xuhui Deng, Zhi Yang, Chunchun Chen, Shuxuan Huang, Lue Chen, Ying Ma, Weifeng Lin, Feiqi Zhu
Summary: This study found that the serum marker Lp-PLA2 is an independent risk factor for the occurrence and progression of VBD to posterior circulation ischemic stroke. Age and serum level of Lp-PLA2 were significantly associated with VBD and VBD with ischemic stroke.
NEUROLOGICAL SCIENCES
(2021)
