Review
Biochemistry & Molecular Biology
Sylwia Smolinska, Dario Antolin-Amerigo, Florin-Dan Popescu, Marek Jutel
Summary: TSLP is a critical cytokine in allergy and asthma development, primarily produced by epithelial cells. It functions as a potent immune system activator through interaction with its receptor complex. Understanding the interplay between TSLP and dysfunctional epithelium provides insights into allergy and asthma pathogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Immunology
Si-Hang Wang, Ya-Gang Zuo
Summary: TSLP, particularly the long form, plays a crucial role in immune-mediated skin diseases, driving Th2 and Th17 immune responses, inducing itch, and being associated with skin fibrosis and epidermal hyperplasia. Targeting TSLP may have significant implications for the treatment of these diseases in the future.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, Research & Experimental
Na-Ra Han, Seong-Gyu Ko, Phil-Dong Moon, Hi-Joon Park
Summary: Chloroquine (CQ) exhibits anti-inflammatory effects by modulating TSLP levels in mast cells and reducing ear edema thickness, as well as TSLP levels in ear tissue and serum. The down-regulation of CASP1, NF-kappa B, and other signaling cascades by CQ contributes to its protective role against TSLP-mediated inflammatory disorders.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Respiratory System
Changhui Yu, Wufeng Huang, Zicong Zhou, Shixiu Liang, Zili Zhou, Jieyi Liu, Haijing Zhao, Laiyu Liu, Hangming Dong, Fei Zou, Shaoxi Cai
Summary: The short isoform of TSLP (sTSLP) inhibits airway inflammation in asthma by occupying the binding site of the long isoform of TSLP (lTSLP) in the TSLPR and IL-7R receptor complex, thereby reducing aerobic glycolysis and inflammatory cytokine production.
RESPIRATORY RESEARCH
(2022)
Article
Respiratory System
Pierre-Alexandre Gagnon, Martin Klein, John De Vos, Sabrina Biardel, Andreanne Cote, Krystelle Godbout, Michel Laviolette, Catherine Laprise, Said Assou, Jamila Chakir
Summary: Bronchial thermoplasty may improve asthma control by downregulating epithelial-derived S100A family expression and related downstream signaling pathways.
RESPIRATORY RESEARCH
(2023)
Article
Oncology
Ranya Guennoun, Jennet Hojanazarova, Kathryn E. Trerice, Marjan Azin, Matthew T. McGoldrick, Erik B. Schiferle, Michael P. Stover, Shadmehr Demehri
Summary: This study demonstrates the potential of immunotherapy for lung cancer by examining the impact of Thymic Stromal Lymphopoietin (TSLP) cytokine induction on early lung cancer development. TSLP induction suppresses the development of invasive lung tumors, dependent on CD4(+) T cells. This highlights the importance of adaptive immune response in protecting against lung cancer progression.
Article
Biochemistry & Molecular Biology
An-nan Zhang, Nan Li, Zhuo-chang Chen, Ya-li Guo, Cui-jie Tian, Dong-jun Cheng, Xue-yi Tang, Xiao-yu Zhang
Summary: Objective of this study was to investigate the effect of amygdalin, an active ingredient in bitter almonds, on TGF-beta-induced EMT in bronchial epithelial cells and elucidate the underlying mechanisms. The results showed that amygdalin treatment relieved airway wall remodeling and decreased the expressions of EMT markers. Furthermore, amygdalin inhibited TGF-beta-induced EMT through regulating the expression of HPSE.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Review
Allergy
Lorenzo Salvati, Laura Maggi, Francesco Annunziato, Lorenzo Cosmi
Summary: Epithelial cytokines, particularly TSLP, play a crucial role in asthma outcomes, and the anti-TSLP monoclonal antibody tezepelumab has proven to be an effective alternative treatment. Biomarker identification will help predict responders and personalize asthma treatment.
CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Christiana Magkrioti, Georgia Antonopoulou, Dionysios Fanidis, Vaia Pliaka, Theodore Sakellaropoulos, Leonidas G. Alexopoulos, Christoph Ullmer, Vassilis Aidinis
Summary: This study investigated the response of human proximal tubular epithelial cells to LPA and other pathological stimuli, identifying signaling pathways and inflammatory factors that may play a role in the pathogenesis of CKD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Wanlin Li, Chenghui Liao, Jing Du, Jing Hu, Lu Wang, Xun Song, Zhendan He, Xiaohua Xiao, Liang Ye
Summary: Two isoforms of TSLP, lTSLP and sTSLP, exist in rheumatoid arthritis (RA), with lTSLP being predominant in active RA and sTSLP in inactive RA and healthy controls. lTSLP expression is associated with disease activity and proinflammatory cytokine expression. lTSLP promotes the expression of proinflammatory cytokines in PBMCs of RA, while inhibiting the expression of anti-inflammatory cytokines.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Takeshi Nitta, Hiroshi Takayanagi
Summary: The stromal microenvironment in the thymus is crucial for generating a functional T cell repertoire, with thymic epithelial cells (TECs) being the most prominent type. Besides TECs, other stromal cell types of mesenchymal origin also play important roles in controlling TEC development. The recently discovered functional effect of thymic fibroblasts on T cell repertoire selection is highlighted as a significant advancement in our understanding of thymic organogenesis and T cell development.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Critical Care Medicine
Xingnan Li, Stefano Guerra, Julie G. Ledford, Monica Kraft, Huashi Li, Annette T. Hastie, Mario Castro, Loren C. Denlinger, Serpil C. Erzurum, John Fahy, Benjamin Gaston, Elliot Israel, Nizar N. Jarjour, Bruce D. Levy, David T. Mauger, Wendy C. Moore, Joe Zein, Naftali Kaminski, Sally E. Wenzel, Prescott G. Woodruff, Deborah A. Meyers, Eugene R. Bleecker
Summary: This study investigated the association between CC16 mRNA expression levels in nonciliated bronchial epithelial cells (BECs) and asthma severity. The results showed that low CC16 mRNA expression levels were significantly associated with asthma susceptibility, severity, exacerbations, and T2 inflammation biomarkers. Additionally, CC16 mRNA expression levels were correlated with the expression levels of Th2, Th1, and inflammation genes. A combination of CC16 and IL-6 could identify different asthma endotypes.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Yuhao Zhao, Yeping Zhang, Zongsheng Guo, Zheng Ma, Ye Liu, Chunming Han, Xinchun Yang, Lei Zhao
Summary: Plasma TSLP levels were higher in AMI patients compared to UA patients, and lower TSLP levels were associated with MACE after AMI. Follow-up analysis showed that TSLP was a negative predictor of MACE in AMI patients.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Allergy
Adrien Brulefert, Astrid Hoste, Quentin Muller, Jean-Daniel Fauny, Christopher G. Mueller, Vincent Flacher
Summary: Our study found that vitamin D3 can induce skin dendritic cells to differentiate into Th2 cells producing IL-4 and IL-13, while also triggering the release of TSLP. Blocking the TSLP receptor in some donors eliminated IL-13 production but had no effect on IL-4+ Th2 cells. Vitamin D3-elicited CD14+ dendritic cells were able to promote IL-4+ Th2 cells in a TSLP-independent manner.
Article
Nutrition & Dietetics
Shu-Ju Wu, Wen-Chung Huang, Ching-Yi Cheng, Meng-Chun Wang, Shu-Chen Cheng, Chian-Jiun Liou
Summary: The study shows that fisetin can reduce the inflammatory response and oxidative stress in bronchial epithelial cells, and improve airway hyperresponsiveness in asthmatic mice. Fisetin decreases the levels of inflammatory cytokines and chemokines, as well as intercellular adhesion molecule-1 expression. It also suppresses monocyte adhesion and reduces eosinophil numbers. Moreover, fisetin promotes glutathione levels and decreases malondialdehyde levels in the lungs.
Editorial Material
Critical Care Medicine
Josalyn L. Cho, Benjamin D. Medoff
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2015)
Article
Immunology
Benjamin Causton, Ravisankar A. Ramadas, Josalyn L. Cho, Khristianna Jones, Ana Pardo-Saganta, Jayaraj Rajagopal, Ramnik J. Xavier, Benjamin D. Medoff
JOURNAL OF IMMUNOLOGY
(2015)
Article
Biology
Bernard Khor, John D. Gagnon, Gautam Goel, Marly I. Roche, Kara L. Conway, Khoa Tran, Leslie N. Aldrich, Thomas B. Sundberg, Alison M. Paterson, Scott Mordecai, David Dombkowski, Melanie Schirmer, Pauline H. Tan, Atul K. Bhan, Rahul Roychoudhuri, Nicholas P. Restifo, John J. O'Shea, Benjamin D. Medoff, Alykhan F. Shamji, Stuart L. Schreiber, Arlene H. Sharpe, Stanley Y. Shaw, Ramnik J. Xavier
Article
Biochemical Research Methods
Katja Kleinsteuber, Bjoern Corleis, Narges Rashidi, Nzuekoh Nchinda, Antonella Lisanti, Josalyn L. Cho, Benjamin D. Medoff, Douglas Kwon, Bruce D. Walker
Article
Cell Biology
Josalyn L. Cho, Morris F. Ling, David C. Adams, Lucas Faustino, Sabina A. Islam, Roshi Afshar, Jason W. Griffith, Robert S. Harris, Aylwin Ng, Giorgia Radicioni, Amina A. Ford, Andre K. Han, Ramnik Xavier, William W. Kwok, Richard Boucher, James J. Moon, Daniel L. Hamilos, Mehmet Kesimer, Melissa J. Suter, Benjamin D. Medoff, Andrew D. Luster
SCIENCE TRANSLATIONAL MEDICINE
(2016)
Article
Cell Biology
David C. Adams, Lida P. Hariri, Alyssa J. Miller, Yan Wang, Josalyn L. Cho, Martin Villiger, Jasmin A. Holz, Margit V. Szabari, Daniel L. Hamilos, R. Scott Harris, Jason W. Griffith, Brett E. Bouma, Andrew D. Luster, Benjamin D. Medoff, Melissa J. Suter
SCIENCE TRANSLATIONAL MEDICINE
(2016)
Article
Biochemical Research Methods
David C. Adams, Hamid Pahlevaninezhad, Margit V. Szabari, Josalyn L. Cho, Daniel L. Hamilos, Mehmet Kesimer, Richard C. Boucher, Andrew D. Luster, Benjamin D. Medoff, Melissa J. Suter
BIOMEDICAL OPTICS EXPRESS
(2017)
Editorial Material
Critical Care Medicine
Josalyn L. Cho, Benjamin D. Medoff
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2018)
Article
Biochemistry & Molecular Biology
Rachel S. Knipe, Clemens K. Probst, David Lagares, Alicia Franklin, Jillian J. Spinney, Patricia L. Brazee, Paula Grasberger, Linlin Zhang, Katharine E. Black, Norihiko Sakai, Barry S. Shea, James K. Liao, Benjamin D. Medoff, Andrew M. Tager
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Benjamin Causton, Ana Pardo-Saganta, Jacob Gillis, Katherine Discipio, Tristan Kooistra, Jayaraj Rajagopal, Ramnik J. Xavier, Josalyn L. Cho, Benjamin D. Medoff
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2018)
Article
Allergy
Roshi Afshar, James P. Strassner, Edward Seung, Benjamin Causton, Josalyn L. Cho, R. Scott Harris, Daniel L. Hamilos, Benjamin D. Medoff, Andrew D. Luster
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2013)
Article
Multidisciplinary Sciences
Purushothama Rao Tata, Hongmei Mou, Ana Pardo-Saganta, Rui Zhao, Mythili Prabhu, Brandon M. Law, Vladimir Vinarsky, Josalyn L. Cho, Sylvie Breton, Amar Sahay, Benjamin D. Medoff, Jayaraj Rajagopal
Article
Multidisciplinary Sciences
Vanessa J. Kelly, Tilo Winkler, Jose G. Venegas, Mamary Kone, Daniel L. Hamilos, Roshi Afshar, Josalyn L. Cho, Andrew D. Luster, Benjamin D. Medoff, R. Scott Harris
Letter
Critical Care Medicine
David R. Ziehr, Jehan Alladina, Camille R. Petri, Jason H. Maley, Ari Moskowitz, Benjamin D. Medoff, Kathryn A. Hibbert, B. Taylor Thompson, C. Corey Hardin
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2020)
Article
Cell Biology
Christine R. Fisher, Felix Mba Medie, Rebeccah J. Luu, Robert B. Gaibler, Thomas J. Mulhern, Caitlin R. Miller, Chelsea J. Zhang, Logan D. Rubio, Elizabeth E. Marr, Vidhya Vijayakumar, Elizabeth P. Gabriel, Landys Lopez Quezada, Chun-Hui Zhang, Karen S. Anderson, William L. Jorgensen, Jehan W. Alladina, Benjamin D. Medoff, Jeffrey T. Borenstein, Ashley L. Gard
Summary: This study reports SARS-CoV-2 infection and robust viral replication in the high-throughput, human primary cell-based organ-on-chip platform called PREDICT96-ALI. The unique infection kinetic profiles of lung tissue from three human donors were evaluated using immunofluorescence, RT-qPCR, and plaque assays. The antiviral efficacy of Remdesivir and MPro61 was also investigated in this system.