The Rho Kinase Isoforms ROCK1 and ROCK2 Each Contribute to the Development of Experimental Pulmonary Fibrosis

ROCK insufficiency attenuates ozone-induced airway hyperresponsiveness in mice

(2015) David I. Kasahara et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Activated alveolar epithelial cells initiate fibrosis through autocrine and paracrine secretion of connective tissue growth factor

(2014) Jibing Yang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

A Phase 3 Trial of Pirfenidone in Patients with Idiopathic Pulmonary Fibrosis

(2014) Talmadge E. King et al.   NEW ENGLAND JOURNAL OF MEDICINE

Efficacy and Safety of Nintedanib in Idiopathic Pulmonary Fibrosis

(2014) Luca Richeldi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Fibrosis of two: Epithelial cell-fibroblast interactions in pulmonary fibrosis

(2013) Norihiko Sakai et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

LPA1-induced cytoskeleton reorganization drives fibrosis through CTGF-dependent fibroblast proliferation

(2013) Norihiko Sakai et al.   FASEB JOURNAL

Hyperoxia increases the elastic modulus of alveolar epithelial cells through Rho kinase

(2013) Kristina R. Wilhelm et al.   FEBS Journal

ROCKing pulmonary fibrosis

(2013) Dean Sheppard   JOURNAL OF CLINICAL INVESTIGATION

Inhibition of mechanosensitive signaling in myofibroblasts ameliorates experimental pulmonary fibrosis

(2013) Yong Zhou et al.   JOURNAL OF CLINICAL INVESTIGATION

Long-term treatment with fasudil improves bleomycin-induced pulmonary fibrosis and pulmonary hypertension via inhibition of Smad2/3 phosphorylation

(2013) Yihua Bei et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Matrix Stiffness–Induced Myofibroblast Differentiation Is Mediated by Intrinsic Mechanotransduction

(2012) Xiangwei Huang et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Fasudil, a Rho-Kinase Inhibitor, Attenuates Bleomycin-Induced Pulmonary Fibrosis in Mice

(2012) Chunguo Jiang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Delayed stress fiber formation mediates pulmonary myofibroblast differentiation in response to TGF-β

(2011) Nathan Sandbo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

The Lysophosphatidic Acid Receptor LPA1Promotes Epithelial Cell Apoptosis after Lung Injury

(2011) Manuela Funke et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Role of Rho kinase isoforms in murine allergic airway responses

(2011) M. Zhu et al.   EUROPEAN RESPIRATORY JOURNAL

Prolonged Exposure to Sphingosine 1–Phosphate Receptor-1 Agonists Exacerbates Vascular Leak, Fibrosis, and Mortality after Lung Injury

(2010) Barry S. Shea et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Targeted Injury of Type II Alveolar Epithelial Cells Induces Pulmonary Fibrosis

(2009) Thomas H. Sisson et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Critical Role of Serum Response Factor in Pulmonary Myofibroblast Differentiation Induced by TGF-β

(2009) Nathan Sandbo et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

ROCK Isoform Regulation of Myosin Phosphatase and Contractility in Vascular Smooth Muscle Cells

(2009) Yuepeng Wang et al.   CIRCULATION RESEARCH

MMP expression and abnormal lung permeability are important determinants of outcome in IPF

(2008) S. McKeown et al.   EUROPEAN RESPIRATORY JOURNAL