Autophagy: a potential therapeutic target in lung diseases

Inhibition of mammalian S6 kinase by resveratrol suppresses autophagy

(2016) Sean M. Armour et al.   Aging-US

A method to measure cardiac autophagic flux in vivo

(2014) Eri Iwai-Kanai et al.   Autophagy

Autophagic proteins regulate cigarette smoke induced apoptosis: Protective role of heme oxygenase-1

(2014) Hong Pyo Kim et al.   Autophagy

ATG5 regulates plasma cell differentiation

(2013) Kara L. Conway et al.   Autophagy

Identification of a candidate therapeutic autophagy-inducing peptide

(2013) Sanae Shoji-Kawata et al.   NATURE

Plasma cells require autophagy for sustainable immunoglobulin production

(2013) Niccolò Pengo et al.   NATURE IMMUNOLOGY

Autophagy in Human Health and Disease

(2013) Augustine M.K. Choi et al.   NEW ENGLAND JOURNAL OF MEDICINE

TLR4 deficiency promotes autophagy during cigarette smoke-induced pulmonary emphysema

(2012) Chang Hyeok An et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Cross talk between NADPH oxidase and autophagy in pulmonary artery endothelial cells with intrauterine persistent pulmonary hypertension

(2012) Ru-Jeng Teng et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Insufficient autophagy in idiopathic pulmonary fibrosis

(2012) Jun Araya et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Lc3 Over-Expression Improves Survival and Attenuates Lung Injury Through Increasing Autophagosomal Clearance in Septic Mice

(2012) Steven Lo et al.   ANNALS OF SURGERY

Autophagy and the Immune System

(2012) Petric Kuballa et al.   Annual Review of Immunology

Suppression of basal autophagy reduces lung cancer cell proliferation and enhances caspase-dependent and -independent apoptosis by stimulating ROS formation

(2012) Vitaliy O. Kaminskyy et al.   Autophagy

Guidelines for the use and interpretation of assays for monitoring autophagy

(2012) Daniel J. Klionsky et al.   Autophagy

Host Cell Autophagy Activated by Antibiotics Is Required for Their Effective Antimycobacterial Drug Action

(2012) Jwa-Jin Kim et al.   Cell Host & Microbe

Depletion of the Ubiquitin-binding Adaptor Molecule SQSTM1/p62 from Macrophages HarboringcftrΔF508 Mutation Improves the Delivery ofBurkholderia cenocepaciato the Autophagic Machinery

(2012) Basant A. Abdulrahman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagy plays an essential role in the clearance of Pseudomonas aeruginosa by alveolar macrophages

(2012) K. Yuan et al.   JOURNAL OF CELL SCIENCE

Lymphangioleiomyomatosis — a wolf in sheep’s clothing

(2012) Elizabeth P. Henske et al.   JOURNAL OF CLINICAL INVESTIGATION

Therapeutic targets in cancer cell metabolism and autophagy

(2012) Heesun Cheong et al.   NATURE BIOTECHNOLOGY

Autophagy modulation as a potential therapeutic target for diverse diseases

(2012) David C. Rubinsztein et al.   NATURE REVIEWS DRUG DISCOVERY

Autophagy induced by resveratrol prevents human prion protein-mediated neurotoxicity

(2012) Jae-Kyo Jeong et al.   NEUROSCIENCE RESEARCH

Autophagy Mediates the Delivery of Thrombogenic Tissue Factor to Neutrophil Extracellular Traps in Human Sepsis

(2012) Konstantinos Kambas et al.   PLoS One

Autophagy in Idiopathic Pulmonary Fibrosis

(2012) Avignat S. Patel et al.   PLoS One

Combination Erlotinib-Cisplatin and Atg3-Mediated Autophagy in Erlotinib Resistant Lung Cancer

(2012) Jasmine G. Lee et al.   PLoS One

Inhibition of Autophagy Ameliorates Acute Lung Injury Caused by Avian Influenza A H5N1 Infection

(2012) Y. Sun et al.   Science Signaling

Insufficient autophagy promotes bronchial epithelial cell senescence in chronic obstructive pulmonary disease

(2012) Satoko Fujii et al.   OncoImmunology

TLR4 Activity Is Required in the Resolution of Pulmonary Inflammation and Fibrosis after Acute and Chronic Lung Injury

(2011) Hong-Zhen Yang et al.   AMERICAN JOURNAL OF PATHOLOGY

Critical role of CFTR-dependent lipid rafts in cigarette smoke-induced lung epithelial injury

(2011) Manish Bodas et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Geranylgeranyl transferase 1 modulates autophagy and apoptosis in human airway smooth muscle

(2011) Saeid Ghavami et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Carbon Monoxide Activates Autophagy via Mitochondrial Reactive Oxygen Species Formation

(2011) Seon-Jin Lee et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Hyperoxia-Induced LC3B Interacts with the Fas Apoptotic Pathway in Epithelial Cell Death

(2011) Akihiko Tanaka et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Complete Induction of Autophagy Is Essential for Cardioprotection in Sepsis

(2011) Chi-Hsun Hsieh et al.   ANNALS OF SURGERY

The Role of Atg Proteins in Autophagosome Formation

(2011) Noboru Mizushima et al.   Annual Review of Cell and Developmental Biology

The Inflammasome NLRs in Immunity, Inflammation, and Associated Diseases

(2011) Beckley K. Davis et al.   Annual Review of Immunology

Autophagy in Pulmonary Diseases

(2011) Stefan W. Ryter et al.   Annual Review of Physiology

Characterization of macroautophagic flux in vivo using a leupeptin-based assay

(2011) Jeffrey Haspel et al.   Autophagy

Autophagy stimulation by rapamycin suppresses lung inflammation and infection byBurkholderia cenocepaciain a model of cystic fibrosis

(2011) Basant A. Abdulrahman et al.   Autophagy

Liver autophagy contributes to the maintenance of blood glucose and amino acid levels

(2011) Junji Ezaki et al.   Autophagy

Combining an EGFR directed tyrosine kinase inhibitor with autophagy-inducing drugs: A beneficial strategy to combat non-small cell lung cancer

(2011) Yaara Gorzalczany et al.   CANCER LETTERS

Autophagy: Renovation of Cells and Tissues

(2011) Noboru Mizushima et al.   CELL

Beclin1 Controls the Levels of p53 by Regulating the Deubiquitination Activity of USP10 and USP13

(2011) Junli Liu et al.   CELL

Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis

(2011) J. Y. Guo et al.   GENES & DEVELOPMENT

Autophagy-deficient mice develop multiple liver tumors

(2011) A. Takamura et al.   GENES & DEVELOPMENT

Heme oxygenase-1-mediated autophagy protects against hepatocyte cell death and hepatic injury from infection/sepsis in mice

(2011) Evie H. Carchman et al.   HEPATOLOGY

Azithromycin blocks autophagy and may predispose cystic fibrosis patients to mycobacterial infection

(2011) Maurizio Renna et al.   JOURNAL OF CLINICAL INVESTIGATION

Blocking IL-17A Promotes the Resolution of Pulmonary Inflammation and Fibrosis Via TGF- 1-Dependent and -Independent Mechanisms

(2011) S. Mi et al.   JOURNAL OF IMMUNOLOGY

Autophagy-Mediated Dendritic Cell Activation Is Essential for Innate Cytokine Production and APC Function with Respiratory Syncytial Virus Responses

(2011) Susan Morris et al.   JOURNAL OF IMMUNOLOGY

Human Adenovirus Type 5 Induces Cell Lysis through Autophagy and Autophagy-Triggered Caspase Activity

(2011) H. Jiang et al.   JOURNAL OF VIROLOGY

Human Rhinovirus 2 Induces the Autophagic Pathway and Replicates More Efficiently in Autophagic Cells

(2011) K. A. Klein et al.   JOURNAL OF VIROLOGY

High-dose vitamin D3 during intensive-phase antimicrobial treatment of pulmonary tuberculosis: a double-blind randomised controlled trial

(2011) Adrian R Martineau et al.   LANCET

Chloroquine for influenza prevention: a randomised, double-blind, placebo controlled trial

(2011) Nicholas I Paton et al.   LANCET INFECTIOUS DISEASES

The Role of Autophagy in Cancer: Therapeutic Implications

(2011) Z. J. Yang et al.   MOLECULAR CANCER THERAPEUTICS

Complex Inhibitory Effects of Nitric Oxide on Autophagy

(2011) Sovan Sarkar et al.   MOLECULAR CELL

Autophagy in immunity and inflammation

(2011) Beth Levine et al.   NATURE

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

Azithromycin for Prevention of Exacerbations of COPD

(2011) Richard K. Albert et al.   NEW ENGLAND JOURNAL OF MEDICINE

Efficacy and Safety of Sirolimus in Lymphangioleiomyomatosis

(2011) Francis X. McCormack et al.   NEW ENGLAND JOURNAL OF MEDICINE

BH3 mimetics activate multiple pro-autophagic pathways

(2011) S A Malik et al.   ONCOGENE

EGFR Tyrosine Kinase Inhibitors Activate Autophagy as a Cytoprotective Response in Human Lung Cancer Cells

(2011) Weidong Han et al.   PLoS One

Tumorigenesis in tuberous sclerosis complex is autophagy and p62/sequestosome 1 (SQSTM1)-dependent

(2011) A. Parkhitko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chaperone-Mediated Autophagy Is Required for Tumor Growth

(2011) M. Kon et al.   Science Translational Medicine

A functionalized single-walled carbon nanotube-induced autophagic cell death in human lung cells through Akt–TSC2-mTOR signaling

(2011) H-L Liu et al.   Cell Death & Disease

Autophagic Protein LC3B Confers Resistance against Hypoxia-induced Pulmonary Hypertension

(2010) Seon-Jin Lee et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Investigating autophagy: Quantitative morphometric analysis using electron microscopy

(2010) Jamie M. Swanlund et al.   Autophagy

Beta2-adrenergic receptor regulates cardiac fibroblast autophagy and collagen degradation

(2010) Pablo Aránguiz-Urroz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Mitochondria Supply Membranes for Autophagosome Biogenesis during Starvation

(2010) Dale W. Hailey et al.   CELL

Rilmenidine attenuates toxicity of polyglutamine expansions in a mouse model of Huntington's disease

(2010) C. Rose et al.   HUMAN MOLECULAR GENETICS

PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy

(2010) Noriyuki Matsuda et al.   JOURNAL OF CELL BIOLOGY

Identification of an Autophagy Defect in Smokers' Alveolar Macrophages

(2010) M. M. Monick et al.   JOURNAL OF IMMUNOLOGY

Plasma membrane contributes to the formation of pre-autophagosomal structures

(2010) Brinda Ravikumar et al.   NATURE CELL BIOLOGY

Defective CFTR induces aggresome formation and lung inflammation in cystic fibrosis through ROS-mediated autophagy inhibition

(2010) Alessandro Luciani et al.   NATURE CELL BIOLOGY

The origin of the autophagosomal membrane

(2010) Sharon A. Tooze et al.   NATURE CELL BIOLOGY

Chemical modulators of autophagy as biological probes and potential therapeutics

(2010) Angeleen Fleming et al.   Nature Chemical Biology

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

(2010) Kiichi Nakahira et al.   NATURE IMMUNOLOGY

Autophagy gone awry in neurodegenerative diseases

(2010) Esther Wong et al.   NATURE NEUROSCIENCE

Mechanisms of mitophagy

(2010) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Regulation of Mammalian Autophagy in Physiology and Pathophysiology

(2010) Brinda Ravikumar et al.   PHYSIOLOGICAL REVIEWS

Autophagy protein microtubule-associated protein 1 light chain-3B (LC3B) activates extrinsic apoptosis during cigarette smoke-induced emphysema

(2010) Z.-H. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Statin-induced autophagy by inhibition of geranylgeranyl biosynthesis in prostate cancer PC3 cells

(2010) Ankur Parikh et al.   PROSTATE

Autophagy and Metabolism

(2010) J. D. Rabinowitz et al.   SCIENCE

PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin

(2010) Derek P. Narendra et al.   PLOS BIOLOGY

Tamoxifen and AEBS ligands induced apoptosis and autophagy in breast cancer cells through the stimulation of sterol accumulation

(2009) Philippe de Medina et al.   Autophagy

Autophagy as the main means of cytotoxicity by glucocorticoids in hematological malignancies

(2009) Dan Grandér et al.   Autophagy

The inositol 1,4,5-trisphosphate receptor regulates autophagy through its interaction with Beclin 1

(2009) J M Vicencio et al.   CELL DEATH AND DIFFERENTIATION

Cell death induced by dexamethasone in lymphoid leukemia is mediated through initiation of autophagy

(2009) E Laane et al.   CELL DEATH AND DIFFERENTIATION

Vitamin D3 Induces Autophagy in Human Monocytes/Macrophages via Cathelicidin

(2009) Jae-Min Yuk et al.   Cell Host & Microbe

An ATP-competitive Mammalian Target of Rapamycin Inhibitor Reveals Rapamycin-resistant Functions of mTORC1

(2009) Carson C. Thoreen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagy regulates lipid metabolism

(2009) Rajat Singh et al.   NATURE

Induction of autophagy by spermidine promotes longevity

(2009) Tobias Eisenberg et al.   NATURE CELL BIOLOGY

Autophagy enhances the efficacy of BCG vaccine by increasing peptide presentation in mouse dendritic cells

(2009) Chinnaswamy Jagannath et al.   NATURE MEDICINE

Screen for Chemical Modulators of Autophagy Reveals Novel Therapeutic Inhibitors of mTORC1 Signaling

(2009) Aruna D. Balgi et al.   PLoS One

PINK1-dependent recruitment of Parkin to mitochondria in mitophagy

(2009) C. Vives-Bauza et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PAMAM Nanoparticles Promote Acute Lung Injury by Inducing Autophagic Cell Death through the Akt-TSC2-mTOR Signaling Pathway

(2009) C. Li et al.   Journal of Molecular Cell Biology

Active-Site Inhibitors of mTOR Target Rapamycin-Resistant Outputs of mTORC1 and mTORC2

(2009) Morris E Feldman et al.   PLOS BIOLOGY

Akt inhibition promotes autophagy and sensitizes PTEN-null tumors to lysosomotropic agents

(2008) Michael Degtyarev et al.   JOURNAL OF CELL BIOLOGY

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

(2008) Derek Narendra et al.   JOURNAL OF CELL BIOLOGY

Novel targets for Huntington's disease in an mTOR-independent autophagy pathway

(2008) Andrea Williams et al.   Nature Chemical Biology

Egr-1 Regulates Autophagy in Cigarette Smoke-Induced Chronic Obstructive Pulmonary Disease

(2008) Zhi-Hua Chen et al.   PLoS One

Autophagy induced by suberoylanilide hydroxamic acid in Hela S3 cells involves inhibition of protein kinase B and up-regulation of Beclin 1

(2007) Qi Cao et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY