PACAP-induced ERK activation in HEK cells expressing PAC1 receptors involves both receptor internalization and PKC signaling

The three α1-adrenoceptor subtypes show different spatio-temporal mechanisms of internalization and ERK1/2 phosphorylation

(2013) M. Perez-Aso et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Pituitary Adenylate Cyclase 1 Receptor Internalization and Endosomal Signaling Mediate the Pituitary Adenylate Cyclase Activating Polypeptide-Induced Increase in Guinea Pig Cardiac Neuron Excitability

(2013) L. A. Merriam et al.   JOURNAL OF NEUROSCIENCE

Conformational biosensors reveal GPCR signalling from endosomes

(2013) Roshanak Irannejad et al.   NATURE

Pharmacology and functions of receptors for vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide: IUPHAR Review 1

(2012) Anthony J Harmar et al.   BRITISH JOURNAL OF PHARMACOLOGY

Persistent cAMP signaling by internalized TSH receptors occurs in thyroid but not in HEK293 cells

(2012) Ruth C. Werthmann et al.   FASEB JOURNAL

Signaling through the neuropeptide GPCR PAC1 induces neuritogenesis via a single linear cAMP- and ERK-dependent pathway using a novel cAMP sensor

(2012) Andrew C. Emery et al.   FASEB JOURNAL

ERK1/2 MAP kinases: Structure, function, and regulation

(2012) Robert Roskoski   PHARMACOLOGICAL RESEARCH

PACAP-deficient mice show attenuated corticosterone secretion and fail to develop depressive behavior during chronic social defeat stress

(2012) Michael L. Lehmann et al.   PSYCHONEUROENDOCRINOLOGY

Regulation of GPCR activity, trafficking and localization by GPCR-interacting proteins

(2011) Ana C Magalhaes et al.   BRITISH JOURNAL OF PHARMACOLOGY

Role of the Clathrin Terminal Domain in Regulating Coated Pit Dynamics Revealed by Small Molecule Inhibition

(2011) Lisa von Kleist et al.   CELL

Molecular mechanism and physiological functions of clathrin-mediated endocytosis

(2011) Harvey T. McMahon et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

α1A-Adrenergic Receptor Induces Activation of Extracellular Signal-Regulated Kinase 1/2 through Endocytic Pathway

(2011) Fei Liu et al.   PLoS One

Pituitary Adenylate Cyclase-activating Polypeptide (PACAP)/PAC1HOP1 Receptor Activation Coordinates Multiple Neurotrophic Signaling Pathways

(2010) Victor May et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Imaging of persistent cAMP signaling by internalized G protein-coupled receptors

(2010) Davide Calebiro et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

The endocytic matrix

(2010) Giorgio Scita et al.   NATURE

Beyond Desensitization: Physiological Relevance of Arrestin-Dependent Signaling

(2010) L. M. Luttrell et al.   PHARMACOLOGICAL REVIEWS

Signaling by internalized G-protein-coupled receptors

(2010) Davide Calebiro et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

G protein-coupled receptors: the inside story

(2009) Kees Jalink et al.   BIOESSAYS

Sustained cyclic AMP production by parathyroid hormone receptor endocytosis

(2009) Sébastien Ferrandon et al.   Nature Chemical Biology

Persistent signaling induced by FTY720-phosphate is mediated by internalized S1P1 receptors

(2009) Florian Mullershausen et al.   Nature Chemical Biology

Chronic stress increases pituitary adenylate cyclase-activating peptide (PACAP) and brain-derived neurotrophic factor (BDNF) mRNA expression in the bed nucleus of the stria terminalis (BNST): Roles for PACAP in anxiety-like behavior

(2009) Sayamwong E. Hammack et al.   PSYCHONEUROENDOCRINOLOGY

Persistent cAMP-Signals Triggered by Internalized G-Protein–Coupled Receptors

(2009) Davide Calebiro et al.   PLOS BIOLOGY

Activation of protein kinase C enhances NMDA-induced currents in primary cultured cerebellar granule cells: Effect of temperature and NMDA NR2 subunit composition

(2008) R. Lisa Popp et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

β-Arrestin 1 Is Required for PAC1Receptor-mediated Potentiation of Long-lasting ERK1/2 Activation by Glucose in Pancreatic β-Cells

(2008) Christophe Broca et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rapid and modifiable neurotransmitter receptor dynamics at a neuronal synapse in vivo

(2008) Corey M McCann et al.   NATURE NEUROSCIENCE