Article
Cell Biology
Ariel Caviedes, Barbara Maturana, Katherina Corvalan, Alexander Engler, Felipe Gordillo, Manuel Varas-Godoy, Karl-Heinz Smalla, Luis Federico Batiz, Carlos Lafourcade, Thilo Kaehne, Ursula Wyneken
Summary: This study reveals that NMDA receptor overstimulation leads to neuronal death, with NF-kappa B activity selectively enhanced in hippocampal neurons and inhibited through S-nitrosylation in resistant neurons. S-nitrosylation influences different biological processes in susceptible and resistant neurons.
CELL DEATH & DISEASE
(2021)
Article
Medicine, Research & Experimental
Yuan Zhang, Zhiyuan Qian, Dongsheng Jiang, Yufang Sun, Shangshang Gao, Xinghong Jiang, Hua Wang, Jin Tao
Summary: The study revealed that Nmb stimulates Cav3.2 channels through NmbR via a G(beta gamma)-dependent AMPK/PKA pathway, leading to hyperexcitability of TG neurons and pain hypersensitivity in mouse models.
Review
Biochemistry & Molecular Biology
Elliott M. Thompson, Andrew W. Stoker
Summary: Dual specificity phosphatases are crucial in regulating intracellular signaling pathways, with DUSP26 being an atypical member implicated in a range of human diseases, particularly cancer. DUSP26 displays both tumor-suppressive and tumor-promoting properties in cancer, depending on the context.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Ailin Cao, Weiqi Gao, Takeshi Sawada, Reiko U. Yoshimoto, Reona Aijima, Yasuyoshi Ohsaki, Mizuho A. Kido
Summary: Allergic inflammation in the bronchi can cause hypersensitive skin in the facial skin, potentially leading to mechanical hypersensitivity. This hypersensitivity may be the result of TRPV1-mediated neuronal plasticity and glial activation in the trigeminal ganglion.
LABORATORY INVESTIGATION
(2023)
Article
Medicine, Research & Experimental
Yong Li, Jing Li, Sheng-sheng Wei, Jing Du
Summary: This study aimed to investigate the effect of lipopolysaccharide (LPS) on the loss of corneal nerve fibers in cultured trigeminal ganglion (TG) cells and the underlying mechanism. The length of neurites in TG cells was examined after LPS treatment, revealing a significant decrease. It was found that LPS inhibited autophagy, leading to the degeneration of TG neurites.
CURRENT MEDICAL SCIENCE
(2023)
Article
Multidisciplinary Sciences
Renfei Qi, Junping Cao, Yufang Sun, Yanping Li, Zitong Huang, Dongsheng Jiang, Xing-Hong Jiang, Terrance P. Snutch, Yuan Zhang, Jin Tao
Summary: In neuropathic pain, miR-32-5p plays a functional role by regulating Cav3.2 channels. Nerve injury-induced histone methylation decreases miR-32-5p expression, leading to increased Cav3.2 protein expression and pain-related behaviors.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Neurosciences
Vasiliki Tellios, Matthew J. E. Maksoud, Wei-Yang Lu
Summary: This study is the first to characterize BG morphology and GLAST expression during development in nNOS(-/-) mice using immunohistochemistry and western blotting. The results showed that BG in nNOS(-/-) mice exhibited abnormal morphology and decreased GLAST expression compared with wildtype (WT) mice across postnatal development. It was also found that nNOS/NO signaling regulates BG development through a PKG-mediated mechanism.
Article
Clinical Neurology
Yuan Zhang, Hua Wang, Yufang Sun, Zitong Huang, Yu Tao, Yiru Wang, Xinghong Jiang, Jin Tao
Summary: This study reveals the crucial role of tyramine in regulating membrane excitability and pain sensitivity. Tyramine decreases the A-type K+ current in trigeminal ganglion neurons through TAAR1-mediated Gβγ-dependent PKCθ signaling cascade, leading to enhanced neuronal excitability and mechanical pain sensitivity.
JOURNAL OF HEADACHE AND PAIN
(2023)
Article
Chemistry, Multidisciplinary
Mengyu Liang, Zhichao Liu, Zhonghui Zhang, Yuxiao Mei, Yang Tian
Summary: A novel tool for real-time imaging and quantification of nitric oxide (NO) was developed, which was successfully applied to neural stem cells and different regions of mouse brain tissue. The role of NO in the regulation of stem cells and its correlation with different brain regions were investigated.
Article
Multidisciplinary Sciences
Kenichiro Shimazaki, Takehiro Yajima, Hiroyuki Ichikawa, Tadasu Sato
Summary: The study demonstrated the presence of GAL-immunoreactive cells and nerve fibers in the rat dura mater, suggesting a potential role of GAL in nociceptive transmission or modulation as well as immune mechanisms of the dura mater. GAL was commonly expressed in the cerebral falx and cerebellar dura mater, with co-expression of CGRP-immunoreactivity, and in a substantial proportion of sensory neurons innervating the dura mater in the trigeminal ganglion.
SCIENTIFIC REPORTS
(2022)
Article
Clinical Neurology
Yuan Zhang, Yuan Wei, Tingting Zheng, Yu Tao, Yufang Sun, Dongsheng Jiang, Jin Tao
Summary: This study reveals that adiponectin plays a crucial role in regulating membrane excitability and pain sensitivity by activating Cav3.2 channels in trigeminal ganglion neurons.
JOURNAL OF HEADACHE AND PAIN
(2023)
Article
Endocrinology & Metabolism
Ran Yang, Shanzi Yu, Lu Chen, Jiahui Ma, Zhenxing Li, Dong Huang
Summary: This study aimed to investigate the role and mechanism of action of Alkbh5 on trigeminal neuralgia. The results showed that the relative expression level of Alkbh5 was negatively correlated with the mechanical pain threshold in rats. Alkbh5 alleviated the mechanical hyperalgesia of the trigeminal neuralgia rat model by negatively regulating the expression of p-ERK.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Neurosciences
Yuhui Luo, Abbie Suttle, Qiaojuan Zhang, Peng Wang, Yong Chen
Summary: Orofacial pain, affecting millions of Americans, is influenced by transient receptor potential (TRP) ion channels. The orofacial sensory system differs from the spinal sensory system in pain processing and sensitivities. TRPs in trigeminally-mediated pain have not been extensively documented compared to spinally-mediated pain.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Microbiology
Mohamed F. Hamed, Glauber Ribeiro de Sousa Araujo, Melissa E. Munzen, Marta Reguera-Gomez, Carly Epstein, Hiu Ham Lee, Susana Frases, Luis R. Martinez
Summary: Cn is a pathogenic fungus that causes severe meningoencephalitis, especially in countries with high HIV prevalence. PLB1 is an important virulence factor that causes brain tissue damage and alters glial cell functions during cryptococcal disease. These findings may help in understanding cerebral cryptococcosis and provide new research avenues in Cn pathogenesis.
Article
Neurosciences
Yi-Ke Li, Yan-Yan Zhang, Jiu Lin, Ya-Jing Liu, Yue-Ling Li, Yu-Heng Feng, Jia-Shuo Zhao, Cheng Zhou, Fei Liu, Jie-Fei Shen
Summary: By regulating K+ homeostasis in neurons and glia, Kir4.1 and mGluR5 play a critical role in neuropathic pain. Activation of mGluR5 in the trigeminal ganglion contributes to orofacial ectopic mechanical allodynia by suppressing Kir4.1 via the PKC signaling pathway.
JOURNAL OF NEUROSCIENCE RESEARCH
(2023)
Article
Neurosciences
Yang He, Jun Tang, Meng Zhang, Junjie Ying, Dezhi Mu
Summary: This study investigated the protective effects and mechanisms of human placenta derived mesenchymal stem cells (hPMSCs) transplantation in a rat model of hypoxic-ischemic encephalopathy (HIE). The results showed that hPMSCs transplantation reduced apoptosis and improved long-term neurological prognosis. Furthermore, the downregulation of Sema 3A/NRP-1 expression and activation of the PI3K/Akt/mTOR signaling pathway played a key role in the protective effects of hPMSCs.
Article
Neurosciences
Emily L. Isenstein, Edward G. Freedman, Jiayi Xu, Ian A. DeAndrea-Lazarus, John J. Foxe
Summary: This study evaluated electrophysiological discrimination of parametric somatosensory stimuli in healthy young adults to understand how the brain processes the duration of tactile information. The results showed that participants did not electrophysiologically discriminate between 100 and 115 ms, but they exhibited distinct electrophysiological responses when the deviant stimuli were 130, 145, and 160 ms. These findings contribute to a better understanding of tactile sensitivity in different clinical conditions.
Article
Neurosciences
Juliana R. Souza, Ludmila Lima-Silveira, Daniela Accorsi-Mendonca, Benedito H. Machado
Summary: This study demonstrates that A2A receptors play a crucial role in modulating synaptic transmission in the NTS neurons and are required for the enhancement of glutamatergic transmission observed under short-term sustained hypoxia conditions.
Article
Neurosciences
Miki Hashizume, Rina Ito, Rie Suge, Yasushi Hojo, Gen Murakami, Takayuki Murakoshi
Summary: The basolateral amygdaloid complex (BLA) is closely involved in the formation of emotional memories, including both aversive memory and contextual fear memory. Acute sleep deprivation (SD) disrupts the acquisition of tone-associated fear memory in juvenile rats, but has no significant effect on contextual fear memory. Slow network oscillation in the amygdala contributes to the formation of amygdala-dependent fear memory in relation to sleep.
Article
Neurosciences
Qunxian Wang, Shipeng Guo, Dongjie Hu, Xiangjun Dong, Zijun Meng, Yanshuang Jiang, Zijuan Feng, Weihui Zhou, Weihong Song
Summary: GSDME plays a crucial role in the pathogenesis of Alzheimer's disease by regulating the switch from apoptosis to pyroptosis and participating in neuroinflammatory response. Knockdown of GSDME has been shown to improve cognitive impairments, indicating that GSDME could be a therapeutic target for Alzheimer's disease.