Article
Biochemistry & Molecular Biology
Tiina Lehtola, Elina Nummenmaa, Lauri Tuure, Mari Hamalainen, Riina M. Nieminen, Teemu Moilanen, Antti Pemmari, Eeva Moilanen
Summary: Dexamethasone attenuates MMP-13 expression in chondrocytes through MKP-1 and p38 MAP kinase-dependent mechanisms, suggesting MKP-1 as a protective factor and a potential drug target for treating OA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Morena Scotece, Mari Haemaelaeinen, Tiina Leppaenen, Katriina Vuolteenaho, Eeva Moilanen
Summary: MKP-1 has a potential protective role in scleroderma by suppressing inflammation and fibrosis. MKP-1 deficiency enhances collagen accumulation and expression of inflammatory and profibrotic factors. Enhancing the expression or activity of MKP-1 could be a potential treatment for scleroderma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Cory Langreck, Eric Wauson, Dakota Nerland, Brad Lamb, Tyler Folkerts, Lori Winter, Eileen Lu, Sarah Tague, Kenneth E. McCarson, Jonathan E. Ploski, Mounira Banasr, Ronald S. Duman, Miranda M. Roland, Victor Babich, Francesca Di Sole, Vanja Duric
Summary: The study indicates that hippocampal mitogen-activated protein kinase phosphatase-1 (MKP-1) plays a crucial role in connecting brain dysfunction with systemic illness under stress. Chronic corticosterone (CORT) treatment results in behavioral emotionality and systemic pathophysiological effects, including elevated renal inflammation protein markers.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Chouhui Xuan, Haixia Cui, Zhengyong Jin, Yuyang Yue, Shuxia Cao, Songbiao Cui, Dongyuan Xu
Summary: Glutamine treatment can effectively alleviate hyp-induced brain injury and improve learning and memory impairment in neonatal rats. This neuroprotective effect may be related to the regulation of MKP-1 expression and inhibition of MAPK signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yinghui Li, Marc W. Halterman
Summary: Defects in neurogenesis can lead to neurodevelopmental disorders and neurodegenerative conditions, with MAPKs and the family of MAPK dual-specificity phosphatases (DUSPs) playing crucial roles in regulating neural stem cell differentiation. Studies suggest that the canonical DUSP, MAP Kinase Phosphatase-1 (MKP-1), exerts a pro-neurogenic bias during a critical window in neural stem cell differentiation by regulating BNIP3 and basal autophagy levels.
Article
Biochemistry & Molecular Biology
Madhuri Basak, Kiran Das, Tarun Mahata, Dinesh Kumar, Nupur Nagar, Krishna Mohan Poluri, Pranesh Kumar, Priyadip Das, Adele Stewart, Biswanath Maity
Summary: Cardiotoxicity is a major drawback of anthracycline chemotherapeutics. This study demonstrates that upregulation of RGS7 and inflammatory markers in the hearts of chemotherapy patients, especially those with reduced left-ventricular function. Knockdown of RGS7 protects against doxorubicin-induced oxidative stress, NF-κB activation, inflammatory cytokine production, and cell death. RGS7 forms a complex with Tip60 and SIRT1, controls the acetylation status of NF-κB, and modulates cellular acetylation capacity, making it a potential therapeutic target for chemotherapy-induced cardiotoxicity.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Immunology
Monica Dominguez, Verena Truemper, Ana Carolina Mota, Bernhard Bruene, Dmitry Namgaladze
Summary: ATP-citrate lyase (ACLY) is a key enzyme involved in metabolic and epigenetic gene regulation. This study investigated the impact of ACLY phosphorylation on its function in human myeloid cells and found that phosphorylation at serine 455 does not affect the enzymatic activity of ACLY. Additionally, loss of ACLY activity may trigger long-term adaptive mechanisms that increase inflammatory responses.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Neurosciences
Junhua Li, Lin Wang, Qinhua Zeng, Jing He, Qing Tang, Kejian Wang, Guiqiong He
Summary: This study investigates the role of MKP-1 in regulating microglia phenotype and inflammatory factor release in Alzheimer's disease (AD). The findings suggest that MKP-1 can modulate microglia phenotype and inflammatory factor release in AD through the p38 signaling pathway.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Review
Biochemistry & Molecular Biology
Hyunju Kang
Summary: Atherosclerosis is a chronic metabolic disorder that leads to cardiovascular diseases. Nutrients like carotenoids, polyphenols, and vitamins can prevent atherosclerosis by regulating gene acetylation states through histone deacetylases. These nutrients also activate sirtuins to regulate epigenetic states related to atherosclerosis. However, gaps in knowledge still exist regarding the effective prevention of atherosclerosis through the epigenetic regulation by nutrients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Wentong Hao, Kecheng Li, Xiangyun Ge, Haoyue Yang, Chaojie Xu, Song Liu, Huahua Yu, Pengcheng Li, Ronge Xing
Summary: This study investigates the effect of degree of acetylation (DA) on the anti-inflammatory activity of chitooligosaccharides (COS). It found that COS with a DA of 12% exhibits the highest anti-inflammatory activity and is able to alleviate the damage caused by endotoxemia, providing a foundation for the development of COS as an anti-endotoxemia drug.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Hongbing Liu, Nguyen Yen Nhi Ngo, Kyra F. Herzberger, Manasi Gummaraju, Sylvia Hilliard, Chao-Hui Chen
Summary: Our studies demonstrated the critical role of Histone deacetylases (HDACs) in the regulation of nephrogenesis. Through ChIP-Seq analysis, we found that HDAC1 and HDAC2 have redundant functions in early nephrogenesis and regulate genes associated with nephron morphogenesis, chromatin assembly or disassembly, as well as other DNA checkpoints. HDAC1 and HDAC2 also simultaneously activate or repress the expression of different genes to maintain the cellular state of nephron progenitors.
BIOCHEMICAL PHARMACOLOGY
(2022)
Review
Cell Biology
Vincenza Capone, Laura Della Torre, Daniela Carannante, Mehrad Babaei, Lucia Altucci, Rosaria Benedetti, Vincenzo Carafa
Summary: Histone modifications play a crucial role in the pathogenesis of diseases, including cancer, and acetylation is a reversible epigenetic process with important functions in cell life. HAT1 has been found to regulate molecular pathways, including those involved in cancer. This review summarizes the current knowledge and recent advances of HAT1 in the pathogenesis of cancer.
Review
Cell Biology
Charles L. Evavold, Jonathan C. Kagan
Summary: This review discusses the current understanding of the mechanisms of IL-1 family cytokine synthesis, processing, and release. Recent research has shown that inflammasomes play a dominant role in the release of IL-1 family cytokines. Furthermore, the host metabolic state is proposed to determine the route of IL-1β secretion, with implications for microbial infection and sterile inflammation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Editorial Material
Cell Biology
Xinyi Wang, Boran Li, Qiming Sun
Summary: It has been discovered that RETREG1 (reticulophagy regulator 1) is a reticulophagy receptor that catalyzes the fragmentation of the endoplasmic reticulum (ER) to facilitate the formation of reticulophagosomes. Additionally, phosphorylation and acetylation of RETREG1 stimulate its oligomerization, facilitating ER fragmentation and reticulophagy. This study provides further insight into how reticulophagy receptors transmit cellular signals to fine-tune ER homeostasis.
Article
Environmental Sciences
Wei Zhang, Xiaoli Guo, Jing Ren, Yujiao Chen, Jingyu Wang, Ai Gao
Summary: This study reveals the involvement of the PKM2/pStat3/IL-17A axis in the hematotoxicity of benzene and highlights the potential therapeutic implications of targeting PKM2 in hematologic diseases.
ENVIRONMENTAL POLLUTION
(2022)
Article
Cardiac & Cardiovascular Systems
Jacob Amersfoort, Frank H. Schaftenaar, Hidde Douna, Peter J. van Santbrink, Gijs H. M. van Puijvelde, Bram Slutter, Amanda C. Foks, Amy Harms, Estefania Moreno-Gordaliza, Yanyan Wang, Thomas Hankemeier, Ilze Bot, Hongbo Chi, Johan Kuiper
Summary: The study found that dyslipidemia affects the migration of Treg cells, leading to inadequate immunosuppression in atherosclerotic lesions. This condition alters the migration capacity and cellular metabolism of Treg cells, increasing their migration to lymphoid tissues and influencing infiltration into atherosclerotic lesions.
CARDIOVASCULAR RESEARCH
(2021)
Editorial Material
Cell Biology
Jana L. Raynor, Hongbo Chi
Summary: Amino acids are essential for T cells to meet their metabolic and biosynthetic demands, and a recent study has shown that LCK can sense intracellular asparagine to support T cell receptor-mediated CD8(+) T cell activation.
NATURE CELL BIOLOGY
(2021)
Article
Hematology
Wenting Zheng, Jun Wei, Caitlin C. Zebley, Lindsay L. Jones, Yogesh Dhungana, Yong-Dong Wang, Jayadev Mavuluri, Lingyun Long, Yiping Fan, Ben Youngblood, Hongbo Chi, Terrence L. Geiger
Summary: This study demonstrates that the deficiency of Regnase-1 enhances CAR-T cell expansion and memory-like cell formation, leading to improved tumor clearance and sustained remission. Regnase-1 deficiency also reduces exhaustion and enhances the activity of CAR-T cells.
Article
Biochemistry & Molecular Biology
Hongling Huang, Peipei Zhou, Jun Wei, Lingyun Long, Hao Shi, Yogesh Dhungana, Nicole M. Chapman, Guotong Fu, Jordy Saravia, Jana L. Raynor, Shaofeng Liu, Gustavo Palacios, Yong-Dong Wang, Chenxi Qian, Jiyang Yu, Hongbo Chi
Summary: This study reveals that amino acid transporters play a role in dampening T-MEM differentiation, while Pofut1 is a key regulator for terminal effector differentiation of T-EFF cells. These findings highlight the importance of nutrient uptake and signaling in determining T cell fate.
Article
Multidisciplinary Sciences
Seon Ah Lim, Jun Wei, Thanh-Long M. Nguyen, Hao Shi, Wei Su, Gustavo Palacios, Yogesh Dhungana, Nicole M. Chapman, Lingyun Long, Jordy Saravia, Peter Vogel, Hongbo Chi
Summary: Regulatory T cells play a crucial role in immune tolerance and immunosuppression in the tumor microenvironment. Inhibiting lipid synthesis dependent on SREBPs in T-reg cells can enhance antitumor immune responses without autoimmune toxicity, and deletion of SCAP in these cells inhibits tumor growth and enhances immunotherapy. SCAP and SREBPs signaling regulate lipid synthesis and inhibitory receptor signaling in T-reg cells, pointing to new ways of targeting these cells for cancer therapy.
Review
Biochemical Research Methods
Jun Wei, Wenting Zheng, Nicole M. Chapman, Terrence L. Geiger, Hongbo Chi
Summary: T cells play vital roles in cancer immunity, and cellular metabolism dynamically adjusts to impact T cell function. The balance between effector T cells and T-regulatory cells is crucial for immune homeostasis.
CURRENT OPINION IN BIOTECHNOLOGY
(2021)
Editorial Material
Immunology
Hongbo Chi
CELLULAR & MOLECULAR IMMUNOLOGY
(2022)
Review
Immunology
Nicole M. Chapman, Hongbo Chi
Summary: Adaptive immune responses mediated by T cells and B cells are crucial for protective immunity against pathogens and tumors. Understanding how metabolic plasticity and adaptation dictate functional specialization of immune cells is fundamental to our understanding and therapeutic modulation of the immune system. Extensive progress has been made in characterizing the effects of metabolic networks on immune cell fate and function in different immunological contexts.
Editorial Material
Immunology
Jordy Saravia, Hongbo Chi
Summary: This study reveals that mTORC2 plays a crucial role in supporting the long-term survival of memory CD4(+) T cells by protecting them from a specific form of regulated cell death known as ferroptosis.
Review
Biochemistry & Molecular Biology
Seon Ah Lim, Wei Su, Nicole M. Chapman, Hongbo Chi
Summary: T cells play a crucial role in immune response and can regulate the development of cancer and autoimmune diseases. Lipid metabolism is a key regulator of T cell function and fate decision, integrating environmental signals and intracellular signaling processes. This article discusses the roles of extracellular, de novo synthesized and membrane lipids in T cell biology, as well as their role as regulators of intracellular signaling. Therapeutic targeting of lipid metabolism and signaling is also summarized, with important future directions discussed.
NATURE CHEMICAL BIOLOGY
(2022)
Editorial Material
Multidisciplinary Sciences
Xiang Sun, Hongbo Chi
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Hematology
Yizhen Li, Xu Yang, Yu Sun, Zhenhua Li, Wenjian Yang, Bensheng Ju, John Easton, Deqing Pei, Cheng Cheng, Shawn Lee, Ching-Hon Pui, Jiyang Yu, Hongbo Chi, Jun J. Yang
Summary: T-cell immunity plays a pivotal role in maintaining long-term remission of acute lymphoblastic leukemia (ALL) and the interplay between host immunity and drug resistance can be harnessed to improve chemotherapy outcomes for ALL.
Article
Multidisciplinary Sciences
Ao Guo, Hongling Huang, Zhexin Zhu, Mark J. Chen, Hao Shi, Sujing Yuan, Piyush Sharma, Jon P. Connelly, Swantje Liedmann, Yogesh Dhungana, Zhenrui Li, Dalia Haydar, Mao Yang, Helen Beere, Jason T. Yustein, Christopher DeRenzo, Shondra M. Pruett-Miller, Jeremy Chase Crawford, Giedre Krenciute, Charles W. M. Roberts, Hongbo Chi, Douglas R. Green
Summary: This study identifies components of the cBAF complex as negative regulators of T-mem cell generation and provides insights into the asymmetric distribution of cBAF and MYC during the division of activated CD8+ T cells. Manipulation of cBAF early in T cell differentiation has the potential to improve cancer immunotherapy, as demonstrated in a mouse solid tumor model.
Article
Cell Biology
Daniel Bastardo Blanco, Nicole M. Chapman, Jana L. Raynor, Chengxian Xu, Wei Su, K. C. Anil, Wei Li, Seon Ah Lim, Stefan Schattgen, Hao Shi, Isabel Risch, Yu Sun, Yogesh Dhungana, Yunjung Kim, Jun Wei, Sherri Rankin, Geoffrey Neale, Paul G. Thomas, Kai Yang, Hongbo Chi
Summary: PTEN loss leads to the accumulation of type-17 innate-like T cells through altered metabolic reprogramming and the involvement of mTOR, Foxo1, and IL-23-Stat3 signaling.
NATURE CELL BIOLOGY
(2022)
Article
Immunology
Govindarajan Thangavelu, Gabriela Andrejeva, Sara Bolivar-Wagers, Sujeong Jin, Michael C. Zaiken, Michael Loschi, Ethan G. Aguilar, Scott N. Furlan, Chrysothemis C. Brown, Yu-Chi Lee, Cameron McDonald Hyman, Colby J. Feser, Angela Panoskaltsis-Mortari, Keli L. Hippen, Kelli P. MacDonald, William J. Murphy, Ivan Maillard, Geoffrey R. Hill, David H. Munn, Robert Zeiser, Leslie S. Kean, Jeffrey C. Rathmell, Hongbo Chi, Randolph J. Noelle, Bruce R. Blazar
Summary: This study investigated how RA receptor signaling in Tregs influences their function and stability in vivo. The results indicate that RA signaling acts as a rheostat to balance Treg function in inflammatory and noninflammatory conditions.
CELLULAR & MOLECULAR IMMUNOLOGY
(2022)