Review
Nanoscience & Nanotechnology
Zulal Ozdemir, Nonappa, Zdenek Wimmer
Summary: Naturally abundant plant triterpenoids have gained attention in biological application due to their renewable and sustainable nature. However, their limited solubility in aqueous media poses a challenge. Recent studies have focused on designing derivatives with improved bioavailability and self-assembly properties for applications in soft functional materials. Triterpenoid-based supramolecular gels exhibit unique properties such as rapid self-healing, thixotropic behaviors, aging-induced transition, as well as anticancer and antimicrobial properties. This review provides an overview of the structural and functional properties, self-assembly and gelation properties, rationally designed derivatives, structural transition in aqueous media, and biological effects of natural triterpenoids.
ACS APPLIED NANO MATERIALS
(2022)
Review
Chemistry, Multidisciplinary
Jamie M. Cameron, Geoffroy Guillemot, Theodor Galambos, Sharad S. Amin, Elizabeth Hampson, Kevin Mall Haidaraly, Graham N. Newton, Guillaume Izzet
Summary: Hybrid polyoxometalates (POMs) have emerged as promising building blocks for the construction of new nanomaterials, offering a range of attractive properties and design opportunities. Their ability to be covalently coupled to a variety of organic moieties allows for the rational design of complex molecular architectures with unique functionalities, showing great potential for applications in catalysis, energy-storage, and molecular biology.
CHEMICAL SOCIETY REVIEWS
(2022)
Article
Chemistry, Medicinal
Sameer Dhawan, Hanuman Singh, Souvik Dutta, V. Haridas
Summary: This article presents selected examples of self-assembling peptides and pseudopeptides, which can form various nanostructures and have a wide range of applications.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2022)
Review
Chemistry, Multidisciplinary
Yinzhou Ma, Xiaocen Duan, Jianyong Huang
Summary: With the remarkable development of DNA nanotechnology, DNA hydrogels have emerged as a unique branch of biomaterials with broad biocompatibility, precise programmability, and tunable mechanical properties. By combining with functional nucleic acids, DNA hydrogels can provide additional target recognition, therapeutic potential, and catalytic activities, making them ideal for biosensing and medical applications. This review provides an up-to-date overview of synthetic strategies, applications, and future challenges of biomedical DNA hydrogels, highlighting their significant contributions to various fields in biomedicine.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Review
Chemistry, Multidisciplinary
Ying Pei, Lu Wang, Keyong Tang, David L. Kaplan
Summary: Biopolymers from biomass offer sustainability, biodegradability, and unique properties, with a hierarchical structure for toughness and adaptability. By using nano-structural assemblies as building blocks, a top-down processing strategy has been employed to construct new biopolymer-based materials.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Review
Biochemistry & Molecular Biology
Jingyao Li, Fuzhong Zhang
Summary: Amyloids are self-assembled protein aggregates with cross-beta fibrillar morphology. They are not only associated with diseases like Alzheimer's and Parkinson's, but also play important functional roles in diverse organisms. Amyloid fibrils' rigidity, chemical stability, high aspect ratio, and sequence programmability make them attractive for functional materials in environmental sciences, material engineering, and translational medicines.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Engineering, Biomedical
Xuejiao Yang, Zeyuan Cao, Honglei Lu, Huaimin Wang
Summary: Peptide-based materials show great potential for biomedical applications, but manipulating peptide assemblies in living cells is still a challenge. Recent research has focused on using endogenous triggers to construct peptide assemblies in vivo, with a particular emphasis on advancements in cancer therapy.
ADVANCED HEALTHCARE MATERIALS
(2021)
Review
Chemistry, Multidisciplinary
Yi Shen, Aviad Levin, Ayaka Kamada, Zenon Toprakcioglu, Marc Rodriguez-Garcia, Yufan Xu, Tuomas P. J. Knowles
Summary: Proteins are essential for building high-performance materials in nature, which can serve structural roles or generate active structures. The focus is increasingly on utilizing protein nanofibrils to form new supramolecular architectures for various applications.
Article
Chemistry, Multidisciplinary
Syed Pavel Afrose, Chiranjit Mahato, Pooja Sharma, Lisa Roy, Dibyendu Das
Summary: In this research, we showed the generation of catalytic supramolecular assemblies from a simple heterocycle melamine driven by a thermodynamically activated ester. The nonequilibrium assemblies were also capable of modulating the photophysical properties of a hydrophobic guest through binding.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Analytical
Tomasz Wasilewski, Bartosz Szulczynski, Dominik Dobrzyniewski, Weronika Jakubaszek, Jacek Gebicki, Wojciech Kamysz
Summary: Cleaning a quartz crystal microbalance (QCM) is crucial for regenerating biosensors. This article compares three methods (electrochemical, oxygen plasma, and Piranha solution) for cleaning QCM, and evaluates their effectiveness through resonant frequency measurements. The results show that all methods are suitable for cleaning peptide-based biosensors, but Piranha method is the most invasive.
Review
Chemistry, Analytical
Emre Ozan Polat, M. Mustafa Cetin, Ahmet Fatih Tabak, Ebru Bilget Guven, Bengu Ozugur Uysal, Taner Arsan, Anas Kabbani, Houmeme Hamed, Sumeyye Berfin Gul
Summary: The development of new biosensor technologies and their use as wearable devices have revolutionized western medicine and personal fitness tracking. Transducers, combined with bio-receptors and miniaturized readout electronics, play a key role in constructing wearable devices for personal health control. The digital health transformation induced by the pandemic has accelerated the research and industrial interest in new transducer technologies for point-of-care and wearable bio-detection.
Review
Engineering, Biomedical
Mei-chen Wan, Wen Qin, Chen Lei, Qi-hong Li, Meng Meng, Ming Fang, Wen Song, Ji-hua Chen, Franklin Tay, Li-na Niu
Summary: Marine resources hold great potential for developing high-value biomaterials, with materials such as chitin, marine-derived collagen, and more showcasing excellent biocompatibility, biodegradability, and bioactive characteristics. These marine biomaterials find important applications in medical, antimicrobial, drug delivery, rehabilitation, and industrial areas.
BIOACTIVE MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Qing Sun, Christian Dolle, Chantal Kurpiers, Kristian Kraft, Monsur Islam, Ruth Schwaiger, Peter Gumbsch, Yolita M. M. Eggeler
Summary: This study presents a novel in situ electron microscopy approach for investigating the shrinkage dynamics of 3D-printed nanoarchitectures during isothermal pyrolysis. The results reveal significant changes in the kinetic parameters and morphological textures of the 3D objects under different temperatures and atmospheric conditions. Understanding and controlling pyrolysis in 3D structures enables precise modification of shrinkage, creation of tensegrity structures, and promotes development of pyrolytic carbon with custom architectures and properties.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Review
Polymer Science
Nidhi C. Dubey, Divya Gaur, Bijay P. Tripathi
Summary: Microgels are soft particles with excellent colloidal stability, large surface area, and fluid-like transport characteristics, making them ideal for enzyme immobilization and reaction regulation. The use of microgels in enzyme processes has rapidly increased in recent years. This review provides a comprehensive overview of microgel synthesis strategies, practical aspects of microgel-enzyme conjugate formation, and the effects of microgel on enzyme stabilization and activities. The review also discusses important biocatalytic applications of microgel and enzyme.
JOURNAL OF POLYMER SCIENCE
(2023)
Review
Agriculture, Multidisciplinary
Hai Chen, Liang Ma, Hongjie Dai, Yu Fu, Hongxia Wang, Yuhao Zhang
Summary: This article discusses the application of protein biomolecules in food-related areas and highlights the importance of rational protein design in overcoming the limitations of natural proteins. It provides an overview of the strategies and principles of rational protein engineering, and focuses on recent progress in the field of food science.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Chemistry, Analytical
Cristina Adrover-Jaume, Alejandra Alba-Patino, Antonio Clemente, Giulia Santopolo, Andreu Vaquer, Steven M. Russell, Enrique Baron, Maria del Mar Gonzalez del Campo, Joana M. Ferrer, Maria Berman-Riu, Mercedes Garcia-Gasalla, Maria Aranda, Marcio Borges, Roberto de la Rica
Summary: Decentralizing COVID-19 care through the use of biosensors for detecting severe cases in decentralized healthcare settings allows for low limit of detection and semi-quantitative measurements of IL-6 in blood and respiratory samples. This enables stratification of COVID-19 patients based on IL-6 levels and potential adaptation for detecting other cytokines.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Chemistry, Analytical
Antonio Clemente, Alejandra Alba-Patino, Giulia Santopolo, Estrella Rojo-Molinero, Antonio Oliver, Marcio Borges, Maria Aranda, Alberto del Castillo, Roberto de la Rica
Summary: This study introduces an enzymatic method that uses O-2 bubbles generated by endogenous catalase enzymes to liquefy respiratory samples more efficiently, without damaging antibody structures. By detecting antibodies in bronchial aspirate specimens from COVID-19 patients, it was found that the enzymatic detection significantly improves the sensitivity for IgG and IgM detection compared to traditional methods.
ANALYTICAL CHEMISTRY
(2021)
Review
Chemistry, Analytical
Alejandra Alba-Patino, Andreu Vaquer, Enrique Baron, Steven M. Russell, Marcio Borges, Roberto de la Rica
Summary: This article reviews recent advances in diagnostic tools for managing sepsis based on micro- and nanostructured materials. It discusses popular biomarkers and detection methods for sepsis diagnosis, and highlights the role of micro- and nanostructured materials in developing biosensors to meet the specific needs of different points of sepsis care. The article also summarizes the most utilized materials and points out future challenges for development.
Article
Chemistry, Multidisciplinary
Andreu Vaquer, Enrique Baron, Roberto de la Rica
Summary: This article presents a chrono-sampling method for fabricating wearable devices made entirely of filter paper. The method uses dried polymers as valves to control the flow of liquids for sequential measurements. The concept was demonstrated with a paper multisensor capable of performing nine consecutive pH measurements and a urea biosensor. The proposed analytical platform can monitor the pH of sweat with accuracy and precision comparable to a laboratory-based method.
Article
Chemistry, Analytical
Steven M. Russell, Alejandra Alba-Patino, Andreu Vaquer, Antonio Clemente, Roberto de la Rica
Summary: This study introduces a minimal reader prototype composed of open-source hardware and software that can automatically measure colorimetric signals in rapid tests. It avoids interoperability issues associated with closed-source readers and utilizes an image-processing algorithm to automatically select an optimal region of interest and measure pixel intensity. The results obtained with the proposed algorithm for detecting antibodies against SARS-CoV-2 were comparable to manual methods but showed improved precision and accuracy in quantifying small spots or faint and patchy signals.
Article
Chemistry, Analytical
Maria del Mar Gonzalez del Campo, Alejandra Alba-Patino, Carlos Palomino, Marta Bauza, Estrella Rojo-Molinero, Antonio Oliver, Gemma Turnes, Roberto de la Rica
Summary: This study explored the impact of polymer modifications on the storage and release of reagents in paper-based biosensors, revealing that different polymers can enhance reagent concentration and release efficiency. By modifying polymers, the sensitivity of biosensors can be significantly improved and the detection limits can be lowered.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Review
Materials Science, Multidisciplinary
Mariadel Mar Gonzalez del Campo, Andreu Vaquer, Roberto de la Rica
Summary: In recent years, paper has become a widely used material for developing various types of sensors, and a polymer-based toolbox has emerged to enhance the functionalities of these devices. This article compiles examples from recent literature on microfluidic systems and polymer-based transducers implemented in paper-based analytical platforms. The use of printing methods to pattern polymers allows for mass production of these advanced paper-based devices without requiring specialized facilities.
ADVANCED MATERIALS TECHNOLOGIES
(2022)
Article
Chemistry, Analytical
Giulia Santopolo, Antonio Clemente, Estrella Rojo-Molinero, Antonio Oliver, Camilla Noe, Roberto de la Rica
Summary: Infections caused by bacteria that produce β-lactamases are a major problem in hospitals. Current methods for detecting these bacteria rely on culturing samples, which is time-consuming. This study proposes a multisensor technology that can rapidly identify different types of β-lactamase-producing pathogens within 90 minutes, without the need for sample culturing. The technology concentrates bacterial cells on a paper-based multisensor and performs 12 parallel assays to determine if the pathogens produce specific enzymes. The proposed technology is fast, simple, and cost-effective, making it promising for developing fully automated platforms for clinical diagnosis.
ANALYTICAL CHEMISTRY
(2022)
Article
Biochemical Research Methods
Giulia Santopolo, Antonio Clemente, Estrella Rojo-Molinero, Sara Fernandez, Maria Concepcion Alvarez, Antonio Oliver, Roberto de la Rica
Summary: The proposed enzymatic liquefaction method is superior to traditional methods in terms of liquefaction efficiency, cell viability, and retention of in vivo functional characteristics. This method is applicable for flow cytometry analysis of respiratory samples and provides valuable insights into the cellular basis of pathological processes in the lungs.
BIOLOGICAL PROCEDURES ONLINE
(2022)
Article
Chemistry, Analytical
Giulia Santopolo, Antonio Clemente, Marta Gonzalez-Freire, Steven M. Russell, Andreu Vaquer, Enrique Baron, Maria Aranda, Antonia Socias, Alberto del Castillo, Marcio Borges, Roberto de la Rica
Summary: This manuscript demonstrates the use of a nanoparticle aggregation test to classify COVID-19 patients according to disease severity, which can help optimize the utilization of hospital resources.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Chemistry, Analytical
Andreu Vaquer, Cristina Adrover-Jaume, Antonio Clemente, Amanda Iglesias, Meritxell Lopez, Rocio Martinez, Isabel M. Roig, Borja G. Cosio, Roberto de la Rica
Summary: A new method for infusing porous materials with concentrated polymers is proposed, which solves the issue of high viscosity during conventional printing methods and reduces manufacturing variability of biosensors. Immunosenors for detecting cytokines IL-6 and IL-5 were developed using this method and showed promising results.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Chemistry, Multidisciplinary
Manuel Gutierrez-Capitan, Ana Sanchis, Estela O. Carvalho, Antonio Baldi, Lluisa Vilaplana, Vanessa F. Cardoso, Alvaro Calleja, Mingxing Wei, Roberto de la Rica, Javier Hoyo, Arnau Bassegoda, Tzanko Tzanov, Maria-Pilar Marco, Senentxu Lanceros-Mendez, Cesar Fernandez-Sanchez
Summary: This study demonstrates a unique and easily deployable multiplex device that can simultaneously measure interleukin-8, tumor necrosis factor-α, and myeloperoxidase biomarkers in sputum, aiming to facilitate the timely detection of acute exacerbations of chronic obstructive pulmonary disease.
Article
Chemistry, Analytical
David Delgado-Cano, Antonio Clemente, Cristina Adrover-Jaume, Andreu Vaquer, Meritxell Lopez, Rocio Martinez, Isabel M. Roig, Amanda Iglesias, Borja G. Cosio, Roberto de la Rica
Summary: Rapid detection and treatment of Pseudomonas aeruginosa (P. aeruginosa) infections in the respiratory tract of patients with chronic lung diseases is crucial. In this study, an alternative diagnosis approach based on analyzing breath aerosols was proposed. The use of nanoparticle immunosensors on the polypropylene layer of surgical facemasks worn by patients allowed for the detection of chronic and acute P. aeruginosa lung infections.
Article
Chemistry, Analytical
Giulia Santopolo, Antonio Clemente, Estrella Rojo-Molinero, Antonio Oliver, Camilla Noe, Roberto de la Rica
Summary: In this study, a multisensor was proposed for the rapid detection of bacterial pathogens carrying different types of β-lactamases. The sensor can generate colored spots that can be quantified and interpreted to identify the presence of specific enzymes.
ANALYTICAL CHEMISTRY
(2022)
Proceedings Paper
Engineering, Biomedical
Antonio Clemente, Alejandra Alba-Patino, Roberto de la Rica
Summary: A paper biosensor based on nanoparticles has been introduced for the rapid detection of Pseudomonas aeruginosa in respiratory samples. The innovative sample treatment with hydrogen peroxide allows sputum samples to be used, disrupting bacterial biofilms quickly. This diagnostic kit offers high sensitivity, quick turnaround time, and automated real-time densitometry for efficient screening of P. aeruginosa infections.
2021 IEEE 2ND INTERNATIONAL CONGRESS OF BIOMEDICAL ENGINEERING AND BIOENGINEERING (CI-IB&BI 2021)
(2021)