期刊
ACS NANO
卷 15, 期 4, 页码 5819-5837出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.0c08510
关键词
protein; biomaterial; gel; fiber; film; microfluidic; self-assembly; drug delivery; condensate
类别
资金
- Welcome Trust
- ERC
- BBSRC
- Cambridge Centre for Misfolding Diseases
Proteins are essential for building high-performance materials in nature, which can serve structural roles or generate active structures. The focus is increasingly on utilizing protein nanofibrils to form new supramolecular architectures for various applications.
Proteins are the fundamental building blocks for high-performance materials in nature. Such materials fulfill structural roles, as in the case of silk and collagen, and can generate active structures including the cytoskeleton. Attention is increasingly turning to this versatile class of molecules for the synthesis of next-generation green functional materials for a range of applications. Protein nanofibrils are a fundamental supramolecular unit from which many macroscopic protein materials are formed. In this Review, we focus on the multiscale assembly of such protein nanofibrils formed from naturally occurring proteins into new supramolecular architectures and discuss how they can form the basis of material systems ranging from bulk gels, films, fibers, micro/nanogels, condensates, and active materials. We review current and emerging approaches to process and assemble these building blocks in a manner which is different to their natural evolutionarily selected role but allows the generation of tailored functionality, with a focus on microfluidic approaches. We finally discuss opportunities and challenges for this class of materials, including applications that can be involved in this material system which consists of fully natural, biocompatible, and biodegradable feedstocks yet has the potential to generate materials with performance and versatility rivalling that of the best synthetic polymers.
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