标题
A multi-scale approach to designing therapeutics for tuberculosis
作者
关键词
-
出版物
Integrative Biology
Volume 7, Issue 5, Pages 591-609
出版商
Royal Society of Chemistry (RSC)
发表日期
2015-04-20
DOI
10.1039/c4ib00295d
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Mass spectrometry imaging of levofloxacin distribution in TB-infected pulmonary lesions by MALDI-MSI and continuous liquid microjunction surface sampling
- (2015) Brendan Prideaux et al. INTERNATIONAL JOURNAL OF MASS SPECTROMETRY
- A computational tool integrating host immunity with antibiotic dynamics to study tuberculosis treatment
- (2015) Elsje Pienaar et al. JOURNAL OF THEORETICAL BIOLOGY
- Vaccine against tuberculosis: what’s new?
- (2014) Carlotta Montagnani et al. BMC INFECTIOUS DISEASES
- Strategies for Efficient Numerical Implementation of Hybrid Multi-scale Agent-Based Models to Describe Biological Systems
- (2014) Nicholas A. Cilfone et al. Cellular and Molecular Bioengineering
- Macrophage Polarization Drives Granuloma Outcome during Mycobacterium tuberculosis Infection
- (2014) Simeone Marino et al. INFECTION AND IMMUNITY
- Microfluidic source-sink model reveals effects of biophysically distinct CXCL12 isoforms in breast cancer chemotaxis
- (2014) S. P. Cavnar et al. Integrative Biology
- Computational Modeling Predicts IL-10 Control of Lesion Sterilization by Balancing Early Host Immunity–Mediated Antimicrobial Responses with Caseation duringMycobacterium tuberculosisInfection
- (2014) Nicholas A. Cilfone et al. JOURNAL OF IMMUNOLOGY
- Recent advances towards tuberculosis control: vaccines and biomarkers
- (2014) J. Weiner et al. JOURNAL OF INTERNAL MEDICINE
- A model of isoniazid treatment of tuberculosis
- (2014) Yolandy Lemmer et al. JOURNAL OF THEORETICAL BIOLOGY
- The path of anti-tuberculosis drugs: from blood to lesions to mycobacterial cells
- (2014) Véronique Dartois NATURE REVIEWS MICROBIOLOGY
- Analysis of Combination Drug Therapy to Develop Regimens with Shortened Duration of Treatment for Tuberculosis
- (2014) George L. Drusano et al. PLoS One
- Exploring the collaboration between antibiotics and the immune response in the treatment of acute, self-limiting infections
- (2014) P. Ankomah et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Tuberculosis vaccines – rethinking the current paradigm
- (2014) Peter Andersen et al. TRENDS IN IMMUNOLOGY
- Harnessing the Heterogeneity of T Cell Differentiation Fate to Fine-Tune Generation of Effector and Memory T Cells
- (2014) Chang Gong et al. Frontiers in Immunology
- The Immune Response in Tuberculosis
- (2013) Anne O'Garra et al. Annual Review of Immunology
- A Physiologically Based Pharmacokinetic Model of Rifampin in Mice
- (2013) Michael A. Lyons et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Radiologic Responses in Cynomolgus Macaques for Assessing Tuberculosis Chemotherapy Regimens
- (2013) Philana Ling Lin et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- The mutation rate of mycobacterial repetitive unit loci in strains of M. tuberculosis from cynomolgus macaque infection
- (2013) Mark N Ragheb et al. BMC GENOMICS
- 13C-Flux Spectral Analysis of Host-Pathogen Metabolism Reveals a Mixed Diet for Intracellular Mycobacterium tuberculosis
- (2013) Dany J.V. Beste et al. CHEMISTRY & BIOLOGY
- Microenvironments in Tuberculous Granulomas Are Delineated by Distinct Populations of Macrophage Subsets and Expression of Nitric Oxide Synthase and Arginase Isoforms
- (2013) J. T. Mattila et al. JOURNAL OF IMMUNOLOGY
- Predicting lymph node output efficiency using systems biology
- (2013) Chang Gong et al. JOURNAL OF THEORETICAL BIOLOGY
- The Mycobacterium tuberculosis regulatory network and hypoxia
- (2013) James E. Galagan et al. NATURE
- Sterilization of granulomas is common in active and latent tuberculosis despite within-host variability in bacterial killing
- (2013) Philana Ling Lin et al. NATURE MEDICINE
- Advances in the development of new tuberculosis drugs and treatment regimens
- (2013) Alimuddin Zumla et al. NATURE REVIEWS DRUG DISCOVERY
- The Roles of Immune Memory and Aging in Protective Immunity and Endogenous Reactivation of Tuberculosis
- (2013) Giorgio Guzzetta et al. PLoS One
- Multi-Scale Modeling Predicts a Balance of Tumor Necrosis Factor-α and Interleukin-10 Controls the Granuloma Environment during Mycobacterium tuberculosis Infection
- (2013) Nicholas A. Cilfone et al. PLoS One
- TB or Not TB: That Is No Longer the Question
- (2013) R. L. Modlin et al. Science Translational Medicine
- Tuberculosis vaccines: Time to think about the next generation
- (2013) Stefan H.E. Kaufmann SEMINARS IN IMMUNOLOGY
- Updating and curating metabolic pathways of TB
- (2013) Richard A. Slayden et al. TUBERCULOSIS
- Mining large-scale response networks reveals ‘topmost activities’ in Mycobacterium tuberculosis infection
- (2013) Awanti Sambarey et al. Scientific Reports
- Targeting Persisters for Tuberculosis Control
- (2012) Ying Zhang et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Metabolic network analysis predicts efficacy of FDA-approved drugs targeting the causative agent of a neglected tropical disease
- (2012) Arvind K Chavali et al. BMC Systems Biology
- Mycobacterium tuberculosis Inhibits Neutrophil Apoptosis, Leading to Delayed Activation of Naive CD4 T cells
- (2012) Robert Blomgran et al. Cell Host & Microbe
- Population Pharmacokinetics and its Role in Anti-Tuberculosis Drug Development and Optimization of Treatment
- (2012) Eric Free Egelund et al. CURRENT PHARMACEUTICAL DESIGN
- Mechanistic systems modeling to guide drug discovery and development
- (2012) Brian J. Schmidt et al. DRUG DISCOVERY TODAY
- Cytokine Response Is Determined by Duration of Receptor and Signal Transducers and Activators of Transcription 3 (STAT3) Activation
- (2012) David A. Braun et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Differential Risk of Tuberculosis Reactivation among Anti-TNF Therapies Is Due to Drug Binding Kinetics and Permeability
- (2012) M. Fallahi-Sichani et al. JOURNAL OF IMMUNOLOGY
- SOCS3 Deficiency Promotes M1 Macrophage Polarization and Inflammation
- (2012) H. Qin et al. JOURNAL OF IMMUNOLOGY
- Metronidazole prevents reactivation of latent Mycobacterium tuberculosis infection in macaques
- (2012) P. L. Lin et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A metabolic network approach for the identification and prioritization of antimicrobial drug targets
- (2012) Arvind K. Chavali et al. TRENDS IN MICROBIOLOGY
- NF-κB Signaling Dynamics Play a Key Role in Infection Control in Tuberculosis
- (2012) Mohammad Fallahi-Sichani et al. Frontiers in Physiology
- High-Sensitivity MALDI-MRM-MS Imaging of Moxifloxacin Distribution in Tuberculosis-Infected Rabbit Lungs and Granulomatous Lesions
- (2011) Brendan Prideaux et al. ANALYTICAL CHEMISTRY
- Regulation and Functions of the IL-10 Family of Cytokines in Inflammation and Disease
- (2011) Wenjun Ouyang et al. Annual Review of Immunology
- A Physiologically Based Pharmacokinetic Model for Capreomycin
- (2011) B. Reisfeld et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Pharmacokinetic Evaluation of the Penetration of Antituberculosis Agents in Rabbit Pulmonary Lesions
- (2011) Maria C. Kjellsson et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Variability in the population pharmacokinetics of isoniazid in South African tuberculosis patients
- (2011) Justin J. Wilkins et al. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
- Latent tuberculosis: what the host “sees”?
- (2011) Hannah P. Gideon et al. IMMUNOLOGIC RESEARCH
- The multistage vaccine H56 boosts the effects of BCG to protect cynomolgus macaques against active tuberculosis and reactivation of latent Mycobacterium tuberculosis infection
- (2011) Philana Ling Lin et al. JOURNAL OF CLINICAL INVESTIGATION
- Multiscale Computational Modeling Reveals a Critical Role for TNF- Receptor 1 Dynamics in Tuberculosis Granuloma Formation
- (2011) M. Fallahi-Sichani et al. JOURNAL OF IMMUNOLOGY
- Mathematical modeling of pulmonary tuberculosis therapy: Insights from a prototype model with rifampin
- (2011) Sylvain Goutelle et al. JOURNAL OF THEORETICAL BIOLOGY
- A hybrid multi-compartment model of granuloma formation and T cell priming in Tuberculosis
- (2011) Simeone Marino et al. JOURNAL OF THEORETICAL BIOLOGY
- The role of IL-10 in immune regulation during M. tuberculosis infection
- (2011) P S Redford et al. Mucosal Immunology
- A multistage tuberculosis vaccine that confers efficient protection before and after exposure
- (2011) Claus Aagaard et al. NATURE MEDICINE
- 13C Metabolic Flux Analysis Identifies an Unusual Route for Pyruvate Dissimilation in Mycobacteria which Requires Isocitrate Lyase and Carbon Dioxide Fixation
- (2011) Dany J. V. Beste et al. PLoS Pathogens
- In SilicoChildren and the Glass Mouse Model: Clinical Trial Simulations To Identify and Individualize Optimal Isoniazid Doses in Children with Tuberculosis
- (2010) Prakash M. Jeena et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Time-kill kinetics of anti-tuberculosis drugs, and emergence of resistance, in relation to metabolic activity of Mycobacterium tuberculosis
- (2010) J. E. M. de Steenwinkel et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- The potent bactericidal activity of streptomycin in the guinea pig model of tuberculosis ceases due to the presence of persisters
- (2010) Z. Ahmad et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- Characterizing the Dynamics of CD4+ T Cell Priming within a Lymph Node
- (2010) J. J. Linderman et al. JOURNAL OF IMMUNOLOGY
- Understanding Latent Tuberculosis: A Moving Target
- (2010) P. L. Lin et al. JOURNAL OF IMMUNOLOGY
- TNF and IL-10 are major factors in modulation of the phagocytic cell environment in lung and lymph node in tuberculosis: A next-generation two-compartmental model
- (2010) Simeone Marino et al. JOURNAL OF THEORETICAL BIOLOGY
- Single-cell NF-κB dynamics reveal digital activation and analogue information processing
- (2010) Savaş Tay et al. NATURE
- Nanobead-based interventions for the treatment and prevention of tuberculosis
- (2010) Gareth Griffiths et al. NATURE REVIEWS MICROBIOLOGY
- Treatment of tuberculosis and optimal dosing schedules
- (2010) K. C. Chang et al. THORAX
- Inhaled drug therapy for treatment of tuberculosis
- (2010) Amit Misra et al. TUBERCULOSIS
- Identification of Key Processes that Control Tumor Necrosis Factor Availability in a Tuberculosis Granuloma
- (2010) Mohammad Fallahi-Sichani et al. PLoS Computational Biology
- New old challenges in tuberculosis: Potentially effective nanotechnologies in drug delivery
- (2009) Alejandro Sosnik et al. ADVANCED DRUG DELIVERY REVIEWS
- Population Modeling and Monte Carlo Simulation Study of the Pharmacokinetics and Antituberculosis Pharmacodynamics of Rifampin in Lungs
- (2009) S. Goutelle et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Prediction of Tumour Tissue Diffusion Coefficients of Hypoxia-Activated Prodrugs from Physicochemical Parameters
- (2009) Frederik B. Pruijn et al. AUSTRALIAN JOURNAL OF CHEMISTRY
- The Role of the Granuloma in Expansion and Dissemination of Early Tuberculous Infection
- (2009) J. Muse Davis et al. CELL
- Advances in Immunotherapy for Tuberculosis Treatment
- (2009) Gavin J. Churchyard et al. CLINICS IN CHEST MEDICINE
- Quantitative Comparison of Active and Latent Tuberculosis in the Cynomolgus Macaque Model
- (2009) P. L. Lin et al. INFECTION AND IMMUNITY
- Synergy between Individual TNF-Dependent Functions Determines Granuloma Performance for Controlling Mycobacterium tuberculosis Infection
- (2009) J. C. J. Ray et al. JOURNAL OF IMMUNOLOGY
- A systems perspective of host–pathogen interactions: predicting disease outcome in tuberculosis
- (2009) Karthik Raman et al. Molecular BioSystems
- A modeling analysis of the effects of molecular size and binding affinity on tumor targeting
- (2009) M. M. Schmidt et al. MOLECULAR CANCER THERAPEUTICS
- Inhaled Drug Delivery for Tuberculosis Therapy
- (2009) Pavan Muttil et al. PHARMACEUTICAL RESEARCH
- A simple in vitro PK/PD model system to determine time–kill curves of drugs against Mycobacteria
- (2009) Nageshwar R. Budha et al. TUBERCULOSIS
- Lack of IL-10 alters inflammatory and immune responses during pulmonary Mycobacterium tuberculosis infection
- (2009) David M. Higgins et al. TUBERCULOSIS
- Population Pharmacokinetics of Rifampin in Pulmonary Tuberculosis Patients, Including a Semimechanistic Model To Describe Variable Absorption
- (2008) J. J. Wilkins et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Tumor Necrosis Factor Blockade in Chronic Murine Tuberculosis Enhances Granulomatous Inflammation and Disorganizes Granulomas in the Lungs
- (2008) S. D. Chakravarty et al. INFECTION AND IMMUNITY
- Tuberculous Granulomas Are Hypoxic in Guinea Pigs, Rabbits, and Nonhuman Primates
- (2008) L. E. Via et al. INFECTION AND IMMUNITY
- Mathematical modeling of drug delivery
- (2008) J. Siepmann et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Tumor Necrosis Factor Blockers Influence Macrophage Responses toMycobacterium tuberculosis
- (2008) James Harris et al. JOURNAL OF INFECTIOUS DISEASES
- Modelling the effects of pre-exposure and post-exposure vaccines in tuberculosis control
- (2008) C.P. Bhunu et al. JOURNAL OF THEORETICAL BIOLOGY
- A methodology for performing global uncertainty and sensitivity analysis in systems biology
- (2008) Simeone Marino et al. JOURNAL OF THEORETICAL BIOLOGY
Create your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create NowBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started