The multifaceted nature of amyloid precursor protein and its proteolytic fragments: friends and foes

Focusing the amyloid cascade hypothesis on N-truncated Abeta peptides as drug targets against Alzheimer’s disease

(2014) Thomas A. Bayer et al.   ACTA NEUROPATHOLOGICA

A Death Receptor 6-Amyloid Precursor Protein Pathway Regulates Synapse Density in the Mature CNS But Does Not Contribute to Alzheimer's Disease-Related Pathophysiology in Murine Models

(2014) D. Y. Kallop et al.   JOURNAL OF NEUROSCIENCE

Genetic Analysis Reveals that Amyloid Precursor Protein and Death Receptor 6 Function in the Same Pathway to Control Axonal Pruning Independent of  -Secretase

(2014) O. Olsen et al.   JOURNAL OF NEUROSCIENCE

The Intersection of Amyloid Beta and Tau at Synapses in Alzheimer’s Disease

(2014) Tara L. Spires-Jones et al.   NEURON

Death Receptor 6 Regulates Adult Experience-Dependent Cortical Plasticity

(2013) S. A. Marik et al.   JOURNAL OF NEUROSCIENCE

A DR6/p75NTR complex is responsible for β-amyloid-induced cortical neuron death

(2013) Y Hu et al.   Cell Death & Disease

Tyr682 in the Aβ-precursor protein intracellular domain regulates synaptic connectivity, cholinergic function, and cognitive performance

(2012) Carmela Matrone et al.   AGING CELL

Identification of a novel amyloid precursor protein processing pathway that generates secreted N-terminal fragments

(2012) Laura J. Vella et al.   FASEB JOURNAL

Cross-Linking of Cell Surface Amyloid Precursor Protein Leads to Increased  -Amyloid Peptide Production in Hippocampal Neurons: Implications for Alzheimer's Disease

(2012) R. Lefort et al.   JOURNAL OF NEUROSCIENCE

Elimination of APP caspase cleavage site D664 attenuates Aβ-mediated synaptic depression

(2011) Brea Midthune et al.   Alzheimers & Dementia

APP physiological and pathophysiological functions: insights from animal models

(2011) Qinxi Guo et al.   CELL RESEARCH

Extracellular phosphorylation of the amyloid β-peptide promotes formation of toxic aggregates during the pathogenesis of Alzheimer's disease

(2011) Sathish Kumar et al.   EMBO JOURNAL

A Single Tyrosine Residue in the Amyloid Precursor Protein Intracellular Domain Is Essential for Developmental Function

(2011) Alessia P. M. Barbagallo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functions of Aβ, sAPPα and sAPPβ : similarities and differences

(2011) Stéphanie Chasseigneaux et al.   JOURNAL OF NEUROCHEMISTRY

Biology and pathophysiology of the amyloid precursor protein

(2011) Hui Zheng et al.   Molecular Neurodegeneration

Neuronal activity regulates the regional vulnerability to amyloid-β deposition

(2011) Adam W Bero et al.   NATURE NEUROSCIENCE

Nitration of Tyrosine 10 Critically Enhances Amyloid β Aggregation and Plaque Formation

(2011) Markus P. Kummer et al.   NEURON

The roles of amyloid precursor protein (APP) in neurogenesis

(2011) Zhi-dong Zhou et al.   Cell Adhesion & Migration

Behavioural phenotype of APPC100.V717F transgenic mice over-expressing a mutant Aβ-bearing fragment is associated with reduced NMDA receptor density

(2010) Wah Chin Boon et al.   BEHAVIOURAL BRAIN RESEARCH

Effects of Synaptic Modulation on  -Amyloid, Synaptophysin, and Memory Performance in Alzheimer's Disease Transgenic Mice

(2010) D. Tampellini et al.   JOURNAL OF NEUROSCIENCE

Many Neuronal and Behavioral Impairments in Transgenic Mouse Models of Alzheimer's Disease Are Independent of Caspase Cleavage of the Amyloid Precursor Protein

(2010) J. A. Harris et al.   JOURNAL OF NEUROSCIENCE

Aging and excitotoxic stress exacerbate neural circuit reorganization in amyloid precursor protein intracellular domain transgenic mice

(2010) Kaushik Ghosal et al.   NEUROBIOLOGY OF AGING

Transgenic Expression of the Amyloid-β Precursor Protein-Intracellular Domain Does Not Induce Alzheimer's Disease–Like Traits In Vivo

(2010) Luca Giliberto et al.   PLoS One

APP Processing Induced by Herpes Simplex Virus Type 1 (HSV-1) Yields Several APP Fragments in Human and Rat Neuronal Cells

(2010) Giovanna De Chiara et al.   PLoS One

Tyr682 in the Intracellular Domain of APP Regulates Amyloidogenic APP Processing In Vivo

(2010) Alessia P. M. Barbagallo et al.   PLoS One

Mechanism of cytotoxicity mediated by the C31 fragment of the amyloid precursor protein

(2009) Sun Ah Park et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Identification of novel N-terminal fragments of amyloid precursor protein in cerebrospinal fluid

(2009) Erik Portelius et al.   EXPERIMENTAL NEUROLOGY

α-secretase mediated conversion of the amyloid precursor protein derived membrane stub C99 to C83 limits Aβ generation

(2009) Sebastian Jäger et al.   JOURNAL OF NEUROCHEMISTRY

Synaptic NMDA Receptor Activation Stimulates  -Secretase Amyloid Precursor Protein Processing and Inhibits Amyloid-  Production

(2009) S. E. Hoey et al.   JOURNAL OF NEUROSCIENCE

Amyloid β Protein: Aβ40 Inhibits Aβ42 Oligomerization

(2009) Megan M. Murray et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Neurodegeneration in Alzheimer's disease: caspases and synaptic element interdependence

(2009) Dale E. Bredesen   Molecular Neurodegeneration

APP binds DR6 to trigger axon pruning and neuron death via distinct caspases

(2009) Anatoly Nikolaev et al.   NATURE

Amyloid-β as a positive endogenous regulator of release probability at hippocampal synapses

(2009) Efrat Abramov et al.   NATURE NEUROSCIENCE

Abnormal neuronal networks and seizure susceptibility in mice overexpressing the APP intracellular domain

(2009) D.L. Vogt et al.   NEUROBIOLOGY OF AGING

Alzheimer's disease-like pathological features in transgenic mice expressing the APP intracellular domain

(2009) K. Ghosal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

γ-Secretase in biology and medicine

(2009) Michael S. Wolfe   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Long-term prevention of Alzheimer's disease-like behavioral deficits in PDAPP mice carrying a mutation in Asp664

(2008) Veronica Galvan et al.   BEHAVIOURAL BRAIN RESEARCH

Amyloid Precursor Protein Is a Primary Androgen Target Gene That Promotes Prostate Cancer Growth

(2008) K.-i. Takayama et al.   CANCER RESEARCH

Aβ40 promotes neuronal cell fate in neural progenitor cells

(2008) Y Chen et al.   CELL DEATH AND DIFFERENTIATION

A Closer Look at α-Secretase

(2008) Rolf Postina   Current Alzheimer Research

p3 peptide, a truncated form of Aβ devoid of synaptotoxic effect, does not assemble into soluble oligomers

(2008) Fabienne Dulin et al.   FEBS LETTERS

Evidence that the Amyloid beta Precursor Protein-intracellular domain lowers the stress threshold of neurons and has a "regulated" transcriptional role

(2008) Luca Giliberto et al.   Molecular Neurodegeneration

Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

(2008) Ganesh M Shankar et al.   NATURE MEDICINE

Endogenous secreted amyloid precursor protein-α regulates hippocampal NMDA receptor function, long-term potentiation and spatial memory

(2008) Chanel J. Taylor et al.   NEUROBIOLOGY OF DISEASE

Endocytosis Is Required for Synaptic Activity-Dependent Release of Amyloid-β In Vivo

(2008) John R. Cirrito et al.   NEURON

The amyloid precursor protein intracellular domain (AICD) as modulator of gene expression, apoptosis, and cytoskeletal dynamics—Relevance for Alzheimer's disease

(2008) Thorsten Müller et al.   PROGRESS IN NEUROBIOLOGY

The FE65 proteins and Alzheimer's disease

(2007) Declan M. McLoughlin et al.   JOURNAL OF NEUROSCIENCE RESEARCH