期刊
NEUROBIOLOGY OF AGING
卷 32, 期 9, 页码 1725-1729出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2009.09.002
关键词
Alzheimer's; AICD; APP; Fe65; Electroencephalogram; Seizure
资金
- Alzheimer's Association
- CART-Rotary funds
- [R01AG026146]
- [5T32HD007104-31]
Alterations in the processing of the amyloid precursor protein (APP) lead to familial Alzheimer's disease (AD). AD patients exhibit increased seizure susceptibility and alterations in their EEGs, which suggests that APP and its metabolites may modulate neuronal networks. Here we demonstrate that transgenic mice overexpressing APP intracellular domain (AICD) and its binding partner Fe65 exhibit abnormal spiking events and a susceptibility to induced seizures. These abnormalities are not observed in PDAPP (D664A) mice, which express high A beta levels but harbor a mutation in the APP intracellular domain. These data suggest that alterations in the levels of AICD contribute to network dysfunction in AD. (C) 2009 Elsevier Inc. All rights reserved.
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