PPARG2 Pro12Ala and ADAMTS9 rs4607103 as “insulin resistance loci” and “insulin secretion loci” in Italian individuals. The GENFIEV study and the Verona Newly Diagnosed Type 2 Diabetes Study (VNDS) 4

Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes

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Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways

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Impaired early- but not late-phase insulin secretion in subjects with impaired fasting glucose

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Variants of GCKR Affect Both  -Cell and Kidney Function in Patients With Newly Diagnosed Type 2 Diabetes: The Verona Newly Diagnosed Type 2 Diabetes Study 2

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Survival of pancreatic beta cells is partly controlled by a TCF7L2-p53-p53INP1-dependent pathway

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Brain PPAR-γ promotes obesity and is required for the insulin–sensitizing effect of thiazolidinediones

(2011) Min Lu et al.   NATURE MEDICINE

Genetics of Type 2 Diabetes

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Association of indices of liver and adipocyte insulin resistance with 19 confirmed susceptibility loci for type 2 diabetes in 6,733 non-diabetic Finnish men

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Piragliatin (RO4389620), a Novel Glucokinase Activator, Lowers Plasma Glucose Both in the Postabsorptive State and after a Glucose Challenge in Patients with Type 2 Diabetes Mellitus: A Mechanistic Study

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Variants and Haplotypes ofTCF7L2Are Associated with β-Cell Function in Patients with Newly Diagnosed Type 2 Diabetes: The Verona Newly Diagnosed Type 2 Diabetes Study (VNDS) 1

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Gene Variants in the Novel Type 2 Diabetes Loci CDC123/CAMK1D, THADA, ADAMTS9, BCL11A, and MTNR1B Affect Different Aspects of Pancreatic  -Cell Function

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The vascular actions of insulin control its delivery to muscle and regulate the rate-limiting step in skeletal muscle insulin action

(2009) E. J. Barrett et al.   DIABETOLOGIA

Lack of Significant Effects of the Type 2 Diabetes Susceptibility LociJAZF1,CDC123/CAMK1D,NOTCH2,ADAMTS9,THADA, andTSPAN8/LGR5on Diabetes and Quantitative Metabolic Traits

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Testing the association of novel meta-analysis-derived diabetes risk genes with type II diabetes and related metabolic traits in Asian Indian Sikhs

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The Pro12Ala polymorphism of the PPARγ2 gene is associated with hepatic glucose uptake during hyperinsulinemia in subjects with type 2 diabetes mellitus

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Variant near ADAMTS9 Known to Associate with Type 2 Diabetes Is Related to Insulin Resistance in Offspring of Type 2 Diabetes Patients—EUGENE2 Study

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Association Testing of Novel Type 2 Diabetes Risk Alleles in the JAZF1, CDC123/CAMK1D, TSPAN8, THADA, ADAMTS9, and NOTCH2 Loci With Insulin Release, Insulin Sensitivity, and Obesity in a Population-Based Sample of 4,516 Glucose-Tolerant Middle-Aged Danes

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Newly identified loci highlight beta cell dysfunction as a key cause of type 2 diabetes: Where are the insulin resistance genes?

(2008) J. C. Florez   DIABETOLOGIA

Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes

(2008) Eleftheria Zeggini et al.   NATURE GENETICS

Hyperinsulinemia and insulin resistance are independently associated with plasma lipids, uric acid and blood pressure in non-diabetic subjects. The GISIR database

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Novel Meta-Analysis-Derived Type 2 Diabetes Risk Loci Do Not Determine Prediabetic Phenotypes

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