Immune mechanisms linked to depression via oxidative stress and neuroprogression

NRROS negatively regulates reactive oxygen species during host defence and autoimmunity

(2014) Rajkumar Noubade et al.   NATURE

The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response

(2014) Alberto Baroja-Mazo et al.   NATURE IMMUNOLOGY

Regulated necrosis: the expanding network of non-apoptotic cell death pathways

(2014) Tom Vanden Berghe et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Lipid Peroxidation: Production, Metabolism, and Signaling Mechanisms of Malondialdehyde and 4-Hydroxy-2-Nonenal

(2014) Antonio Ayala et al.   Oxidative Medicine and Cellular Longevity

Lipid peroxidation and antioxidant protection in patients during acute depressive episodes and in remission after fluoxetine treatment

(2014) Piotr Gałecki et al.   Pharmacological Reports

Identification and characterization of a unique leucine-rich repeat protein (LRRC33) that inhibits Toll-like receptor-mediated NF-κB activation

(2013) Jingyi Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Redox activation of Nrf2 & NF-κB: A double end sword?

(2013) Mabel Buelna-Chontal et al.   CELLULAR SIGNALLING

Modulatory mechanisms controlling the NLRP3 inflammasome in inflammation: recent developments

(2013) Moritz Haneklaus et al.   CURRENT OPINION IN IMMUNOLOGY

Redox regulation of protein kinases

(2013) Aoife Corcoran et al.   FEBS Journal

Oxidative Stress and Neurodegenerative Disorders

(2013) Jie Li et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Enhanced Phosphatidylinositol 3-kinase (PI3K)/Akt Signaling Has Pleiotropic Targets in Hippocampal Neurons Exposed to Iron-induced Oxidative Stress

(2013) Romina María Uranga et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Major depressive disorder and accelerated cellular aging: results from a large psychiatric cohort study

(2013) J E Verhoeven et al.   MOLECULAR PSYCHIATRY

A review of peripheral biomarkers in major depression: The potential of inflammatory and oxidative stress biomarkers

(2013) Adrian L. Lopresti et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Nrf2 participates in depressive disorders through an anti-inflammatory mechanism

(2013) María Dolores Martín-de-Saavedra et al.   PSYCHONEUROENDOCRINOLOGY

Depression and Oxidative Stress

(2013) Priya Palta et al.   PSYCHOSOMATIC MEDICINE

The plasma membrane channel ORAI1 mediates detrimental calcium influx caused by endogenous oxidative stress

(2013) N Henke et al.   Cell Death & Disease

Redox-Regulated Growth Factor Survival Signaling

(2012) John F. Woolley et al.   ANTIOXIDANTS & REDOX SIGNALING

The innate immune response to products of phospholipid peroxidation

(2012) David Weismann et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

The Involvement of Cleavage of Neural Cell Adhesion Molecule in Neuronal Death under Oxidative Stress Conditions in Cultured Cortical Neurons

(2012) Wakako Fujita-Hamabe et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Dysregulated relationship of inflammation and oxidative stress in major depression

(2012) B.J. Rawdin et al.   BRAIN BEHAVIOR AND IMMUNITY

Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling

(2012) Paul D. Ray et al.   CELLULAR SIGNALLING

The relevance of oxidative stress status in first episode and recurrent depression

(2012) Cristinel Stefanescu et al.   JOURNAL OF AFFECTIVE DISORDERS

Increased autoimmune responses against auto-epitopes modified by oxidative and nitrosative damage in depression: Implications for the pathways to chronic depression and neuroprogression

(2012) Michael Maes et al.   JOURNAL OF AFFECTIVE DISORDERS

The neuroprogressive nature of major depressive disorder: pathways to disease evolution and resistance and therapeutic implications

(2012) S Moylan et al.   MOLECULAR PSYCHIATRY

Unmedicated, remitted patients with major depression have decreased serum immunoglobulin A

(2012) Philip W. Gold et al.   NEUROSCIENCE LETTERS

Preclinical and Clinical Evidence of Antioxidant Effects of Antidepressant Agents: Implications for the Pathophysiology of Major Depressive Disorder

(2012) Guilherme A. Behr et al.   Oxidative Medicine and Cellular Longevity

Mechanism of Oxidative Stress in Neurodegeneration

(2012) Sonia Gandhi et al.   Oxidative Medicine and Cellular Longevity

Adult Neurogenesis Transiently Generates Oxidative Stress

(2012) Noah M. Walton et al.   PLoS One

Oxidative/nitrosative stress and antidepressants: Targets for novel antidepressants

(2012) Seung-Yup Lee et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Increased oxidative stress in patients with depression and its relationship to treatment

(2012) Cecilia P. Chung et al.   PSYCHIATRY RESEARCH

Redox regulation of cell migration and adhesion

(2012) Thomas Ryan Hurd et al.   TRENDS IN CELL BIOLOGY

New drug targets in depression: inflammatory, cell-mediated immune, oxidative and nitrosative stress, mitochondrial, antioxidant, and neuroprogressive pathways. And new drug candidates—Nrf2 activators and GSK-3 inhibitors

(2012) Michael Maes et al.   INFLAMMOPHARMACOLOGY

The cytoprotective role of the Keap1–Nrf2 pathway

(2011) Liam Baird et al.   ARCHIVES OF TOXICOLOGY

Lipid peroxidation modifies the picture of membranes from the “Fluid Mosaic Model” to the “Lipid Whisker Model”

(2011) Angel Catalá   BIOCHIMIE

Measuring and Modeling Apoptosis in Single Cells

(2011) Sabrina L. Spencer et al.   CELL

Autophagic activity in cortical neurons under acute oxidative stress directly contributes to cell death

(2011) Gavin C. Higgins et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Pre- and post-treatments with escitalopram protect against experimental ischemic neuronal damage via regulation of BDNF expression and oxidative stress

(2011) Choong Hyun Lee et al.   EXPERIMENTAL NEUROLOGY

Interleukin-1β: A New Regulator of the Kynurenine Pathway Affecting Human Hippocampal Neurogenesis

(2011) Patricia A Zunszain et al.   NEUROPSYCHOPHARMACOLOGY

Mechanistic explanations how cell-mediated immune activation, inflammation and oxidative and nitrosative stress pathways and their sequels and concomitants play a role in the pathophysiology of unipolar depression

(2011) Brian Leonard et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Crosstalk of reactive oxygen species and NF-κB signaling

(2010) Michael J Morgan et al.   CELL RESEARCH

Depression gets old fast: do stress and depression accelerate cell aging?

(2010) Owen M. Wolkowitz et al.   DEPRESSION AND ANXIETY

Pyroptosis - a cell death modality of its kind?

(2010) Oliver Kepp et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Comorbidity between common mental disorders and chronic somatic diseases in primary care patients

(2010) Margalida Gili et al.   GENERAL HOSPITAL PSYCHIATRY

Increased plasma peroxides and serum oxidized low density lipoprotein antibodies in major depression: Markers that further explain the higher incidence of neurodegeneration and coronary artery disease

(2010) Michael Maes et al.   JOURNAL OF AFFECTIVE DISORDERS

The possible role of the kynurenine pathway in adolescent depression with melancholic features

(2010) Vilma Gabbay et al.   JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY

Altered expression of genes involved in inflammation and apoptosis in frontal cortex in major depression

(2010) R C Shelton et al.   MOLECULAR PSYCHIATRY

Neural mechanisms of ageing and cognitive decline

(2010) Nicholas A. Bishop et al.   NATURE

Chronic mild stress damages mitochondrial ultrastructure and function in mouse brain

(2010) Yu Gong et al.   NEUROSCIENCE LETTERS

The new ‘5-HT’ hypothesis of depression: Cell-mediated immune activation induces indoleamine 2,3-dioxygenase, which leads to lower plasma tryptophan and an increased synthesis of detrimental tryptophan catabolites (TRYCATs), both of which contribute to the onset of depression

(2010) M. Maes et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

A review on the oxidative and nitrosative stress (O&NS) pathways in major depression and their possible contribution to the (neuro)degenerative processes in that illness

(2010) Michael Maes et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Depression and oxidative damage to lipids

(2010) Sarah Yager et al.   PSYCHONEUROENDOCRINOLOGY

Phospholipase A2 and Cyclooxygenase 2 Genes Influence the Risk of Interferon-α–Induced Depression by Regulating Polyunsaturated Fatty Acids Levels

(2009) Kuan-Pin Su et al.   BIOLOGICAL PSYCHIATRY

NCAM-mimetic, FGL peptide, restores disrupted fibroblast growth factor receptor (FGFR) phosphorylation and FGFR mediated signaling in neural cell adhesion molecule (NCAM)-deficient mice

(2009) Anu Aonurm-Helm et al.   BRAIN RESEARCH

The Nrf2-Antioxidant Response Element Signaling Pathway and Its Activation by Oxidative Stress

(2009) Truyen Nguyen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Allostatic load biomarkers of chronic stress and impact on health and cognition

(2009) Robert-Paul Juster et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

The Nrf2/ARE Pathway as a Potential Therapeutic Target in Neurodegenerative Disease

(2008) Marcus J. Calkins et al.   ANTIOXIDANTS & REDOX SIGNALING

Reactive oxygen species: Destroyers or messengers?

(2008) Grzegorz Bartosz   BIOCHEMICAL PHARMACOLOGY

Nrf2-induced antioxidant protection: A promising target to counteract ROS-mediated damage in neurodegenerative disease?

(2008) Helga E. de Vries et al.   FREE RADICAL BIOLOGY AND MEDICINE

The inflammatory & neurodegenerative (I&ND) hypothesis of depression: leads for future research and new drug developments in depression

(2008) Michael Maes et al.   METABOLIC BRAIN DISEASE

Environmental-induced oxidative stress in neurodegenerative disorders and aging

(2008) Lucia Migliore et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Increased plasma levels of 8-iso-PGF2α and IL-6 in an elderly population with depression

(2008) Nikolaos Dimopoulos et al.   PSYCHIATRY RESEARCH