Article
Behavioral Sciences
Ana Paula Mendes-Silva, Erica Leandro Marciano Vieira, Gabriela Xavier, Lucelia Scarabeli Silva Barroso, Laiss Bertola, Efrem Augusto Ribeiro Martins, Elisa Macedo Brietzke, Sintia Iole Nogueira Belangero, Breno Satler Diniz
Summary: The study found that older adults with late-life depression have shorter telomeres compared to healthy controls, especially those with more severe depressive symptoms. There was a negative correlation between telomere length and the severity of depressive symptoms and medical burden, but no significant correlation with cognitive performance.
BRAIN AND BEHAVIOR
(2021)
Article
Medicine, General & Internal
Chong Zhang, Xiaolin Liang
Summary: This study investigated the association between WeChat use and the mental health of middle-aged and older adults. The results showed a negative correlation between WeChat use and depression, as well as WeChat Moments sharing and depression. WeChat use is found to empower middle-aged and elderly individuals in maintaining close social relationships and trust, contributing to their mental health.
Article
Psychiatry
Melusine Durand, Nicolas Nagot, Laurent Michel, Sao Mai Le, Huong Thi Duong, Roselyne Vallo, Amelie Vizeneux, Delphine Rapoud, Hoang Thi Giang, Catherine Quillet, Nham Thi Tuyet Thanh, Khuat Thi Hai Oanh, Vu Hai Vinh, Jonathan Feelemyer, Philippe Vande Perre, Khue Pham Minh, Didier Laureillard, Don Des Jarlais, Jean-Pierre Moles
Summary: Premature biological aging, as indicated by shorter telomere length, is associated with mental disorders among people who inject drugs, particularly those with multiple episodes of major depressive disorders. However, no association was found with mitochondrial DNA alterations. This suggests that individuals with mental disorders in this population may be at a higher risk for age-related diseases.
FRONTIERS IN PSYCHIATRY
(2022)
Review
Cell Biology
Pedro A. Pousa, Raquel M. Souza, Paulo Henrique M. Melo, Bernardo H. M. Correa, Tamires S. C. Mendonca, Ana Cristina Simoes-e-Silva, Debora M. Miranda
Summary: Through a systematic review of 56 studies, it was found that mental disorders related to psychological distress are negatively associated with telomere length, indicating a potential link between psychological stress and physiological aging. The possible underlying molecular mechanisms causing telomere shortening in psychiatric diseases include oxidative stress, inflammation, and mitochondrial dysfunction.
Article
Cell Biology
Jeong-Hwa Jin, Hyuk Sung Kwon, Seong Hye Choi, Seong-Ho Koh, Eun-Hye Lee, Jee Hyang Jeong, Jae-Won Jang, Kyung Won Park, Eun-Joo Kim, Hee Jin Kim, Jin Yong Hong, Soo Jin Yoon, Bora Yoon, Hyun-Hee Park, Jungsoon Ha, Jong Eun Park, Myung Hoon Han
Summary: This study found a relationship between sleep parameters and longitudinal shortening of leukocyte telomere length (LTL). Poor sleep quality, specifically short sleep duration, long sleep latency, and low sleep efficiency were associated with faster longitudinal shortening of LTL.
Article
Veterinary Sciences
Jessica Quimby, Andrea Erickson, Shannon Mcleland, Rachel Cianciolo, David Maranon, Katharine Lunn, Jonathan Elliott, Jack Lawson, Ann Hess, Rene Paschall, Susan Bailey
Summary: This study found significantly increased renal cell senescence, telomere shortening, and nitrosative stress in cats with CKD, suggesting that these patients may benefit from senolytic therapy.
VETERINARY SCIENCES
(2021)
Article
Endocrinology & Metabolism
Racha Ghoussaini, Hani Tamim, Martine Elbejjani, Maha Makki, Lara Nasreddine, Hussain Ismaeel, Mona P. P. Nasrallah, Nathalie K. K. Zgheib
Summary: This longitudinal study found that age, gender, and baseline C-peptide level were associated with telomere shortening, indicating the potential role of metabolic dysregulation in early aging. Further understanding and addressing high C-peptide levels are important for preventing premature aging.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Cell Biology
Xin Zhang, Mengting Shi, Xi Zhao, Ennan Bin, Yucheng Hu, Nan Tang, Huaping Dai, Chen Wang
Summary: This study aimed to investigate the regeneration capacity of AT2 cells with short telomeres. It was found that short telomeres in AT2 cells result in reduced expression level of TPPP3, thereby limiting the differentiation and regeneration capacity of AT2 cells.
CELL PROLIFERATION
(2022)
Article
Cell Biology
Xiaotong Yang, Paula A. Benny, Elorri Cervera-Marzal, Biyu Wu, Cameron B. Lassiter, Joshua Astern, Lana X. Garmire
Summary: Variations in telomere length have been linked to aging, stress, and diseases. This study investigated the association between placental telomere length and preeclampsia. The results suggest that placental telomere length is not significantly different between severe preeclampsia cases and healthy controls, but it is negatively correlated with gestational age and influenced by race.
Review
Biochemistry & Molecular Biology
Andy Ruiz, Julio Flores-Gonzalez, Ivette Buendia-Roldan, Leslie Chavez-Galan
Summary: This article discusses the important role of telomere shortening (TS) in lung diseases. In addition to age, other factors can induce TS and increase the risk of lung diseases. In an infectious environment, immune cells with TS are associated with severe lymphopenia and death, while in a non-infectious context, naive T cells with TS are related to cancer progression and enhanced inflammatory processes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Judith E. Carroll, Richard Olmstead, Reina Haque, Michael R. Irwin
Summary: Depression history and the number of depressive episodes are associated with accelerated biological aging in breast cancer survivors.
Review
Clinical Neurology
Dario Moreno-Agostino, Yu-Tzu Wu, Christina Daskalopoulou, M. Tasdik Hasan, Martijn Huisman, Matthew Prina
Summary: Evidence suggests that there is an increasing trend in the likelihood of experiencing depression over time in the general population, with no significant impact from factors such as gender, age, and type of prevalence. Moreover, the high heterogeneity across studies was not explained by any of the design variables considered, and no evidence for publication bias was found.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Letter
Clinical Neurology
Joseph M. Simonett, Akbar Shakoor, Paul S. Bernstein
Summary: Self-inflicted damage to the retina using handheld lasers is a growing and underrecognized form of self-harm, which can ultimately result in legal blindness. Patients with histories of major depressive disorder and self-harm behaviors are more susceptible to this type of harm. Mental health providers should be vigilant in screening for laser pointer access and preventing permanent vision loss in at-risk individuals.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Editorial Material
Cell Biology
Pawel Kordowitzki
Summary: Research has shown that the pool of oocytes in females starts to decline before birth, and as women age, characteristics such as chromosomal abnormalities, decreased mitochondrial function, and telomere shortening become more common. This may contribute to higher rates of miscarriage and chromosomal non-disjunction in older women who choose to delay pregnancy.
Article
Genetics & Heredity
Alessio Squassina, Anna Meloni, Donatella Congiu, Panagiotis Bosganas, George P. Patrinos, Rixing Lin, Gustavo Turecki, Giovanni Severino, Raffaella Ardau, Caterina Chillotti, Claudia Pisanu
Summary: This study used patients-derived lymphoblastoid cell lines to investigate the role of lithium in bipolar disorder (BD). The results showed no difference in telomere length between patients and controls after lithium treatment, suggesting that patients-derived lymphoblastoid cell lines may not be suitable for studying telomere dynamics in BD.
Article
Biochemistry & Molecular Biology
Till F. M. Andlauer, Jose Guzman-Parra, Fabian Streit, Jana Strohmaier, Maria Jose Gonzalez, Susana Gil Flores, Francisco J. Cabaleiro Fabeiro, Francisco del Rio Noriega, Fermin Perez Perez, Jesus Haro Gonzalez, Guillermo Orozco Diaz, Yolanda de Diego-Otero, Berta Moreno-Kustner, Georg Auburger, Franziska Degenhardt, Stefanie Heilmann-Heimbach, Stefan Herms, Per Hoffmann, Josef Frank, Jerome C. Foo, Jens Treutlein, Stephanie H. Witt, Sven Cichon, Manolis Kogevinas, Fabio Rivas, Fermin Mayoral, Bertram Mueller-Myhsok, Andreas J. Forstner, Markus M. Nothen, Marcella Rietschel
Summary: This study analyzed whether the risk for bipolar disorder in BD multiplex families is influenced by common genetic variants. The results showed that familial BD cases and unaffected family members had higher PRS for all three psychiatric disorders, indicating a high baseline risk in the families; familial BD cases had significantly higher BD PRS than unaffected family members and unrelated BD cases, suggesting that development of BD in these families is attributable to common variants with specific risk for BD.
MOLECULAR PSYCHIATRY
(2021)
Review
Geriatrics & Gerontology
David T. Turner, Mandy X. Hu, Ellen Generaal, Daniel Bos, M. Kamran Ikram, Alis Heshmatollah, Lana Fani, M. Arfan Ikram, Brenda W. J. H. Penninx, Pim Cuijpers
Summary: Through a review of 11 meta-analyses, it was found that exercise may improve overall cognitive functioning in disease-free older adults, but high-quality evidence is needed to determine if there is improvement in specific cognitive domains. In patients with MCI, exercise was found to have significant benefits on overall cognitive functioning, but limited evidence is available across most cognitive domains.
JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Lisa de las Fuentes, Yun Ju Sung, Raymond Noordam, Thomas Winkler, Mary F. Feitosa, Karen Schwander, Amy R. Bentley, Michael R. Brown, Xiuqing Guo, Alisa Manning, Daniel I. Chasman, Hugues Aschard, Traci M. Bartz, Lawrence F. Bielak, Archie Campbell, Ching-Yu Cheng, Rajkumar Dorajoo, Fernando P. Hartwig, A. R. V. R. Horimoto, Changwei Li, Ruifang Li-Gao, Yongmei Liu, Jonathan Marten, Solomon K. Musani, Ioanna Ntalla, Tuomo Rankinen, Melissa Richard, Xueling Sim, Albert V. Smith, Salman M. Tajuddin, Bamidele O. Tayo, Dina Vojinovic, Helen R. Warren, Deng Xuan, Maris Alver, Mathilde Boissel, Jin-Fang Chai, Xu Chen, Kaare Christensen, Jasmin Divers, Evangelos Evangelou, Chuan Gao, Giorgia Girotto, Sarah E. Harris, Meian He, Fang-Chi Hsu, Brigitte Kuehnel, Federica Laguzzi, Xiaoyin Li, Leo-Pekka Lyytikainen, Ilja M. Nolte, Alaitz Poveda, Rainer Rauramaa, Muhammad Riaz, Rico Rueedi, Xiao-ou Shu, Harold Snieder, Tamar Sofer, Fumihiko Takeuchi, Niek Verweij, Erin B. Ware, Stefan Weiss, Lisa R. Yanek, Najaf Amin, Dan E. Arking, Donna K. Arnett, Sven Bergmann, Eric Boerwinkle, Jennifer A. Brody, Ulrich Broeckel, Marco Brumat, Gregory Burke, Claudia P. Cabrera, Mickael Canouil, Miao Li Chee, Yii-Der Ida Chen, Massimiliano Cocca, John Connell, H. Janaka de Silva, Paul S. de Vries, Gudny Eiriksdottir, Jessica D. Faul, Virginia Fisher, Terrence Forrester, Ervin F. Fox, Yechiel Friedlander, He Gao, Bruna Gigante, Franco Giulianini, Chi Charles Gu, Dongfeng Gu, Tamara B. Harris, Jiang He, Sami Heikkinen, Chew-Kiat Heng, Steven Hunt, M. Arfan Ikram, Marguerite R. Irvin, Mika Kahonen, Maryam Kavousi, Chiea Chuen Khor, Tuomas O. Kilpelainen, Woon-Puay Koh, Pirjo Komulainen, Aldi T. Kraja, J. E. Krieger, Carl D. Langefeld, Yize Li, Jingjing Liang, David C. M. Liewald, Ching-Ti Liu, Jianjun Liu, Kurt K. Lohman, Reedik Magi, Colin A. McKenzie, Thomas Meitinger, Andres Metspalu, Yuri Milaneschi, Lili Milani, Dennis O. Mook-Kanamori, Mike A. Nalls, Christopher P. Nelson, Jill M. Norris, Jeff O'Connell, Adesola Ogunniyi, Sandosh Padmanabhan, Nicholette D. Palmer, Nancy L. Pedersen, Thomas Perls, Annette Peters, Astrid Petersmann, Patricia A. Peyser, Ozren Polasek, David J. Porteous, Leslie J. Raffel, Treva K. Rice, Jerome I. Rotter, Igor Rudan, Oscar-Leonel Rueda-Ochoa, Charumathi Sabanayagam, Babatunde L. Salako, Pamela J. Schreiner, James M. Shikany, Stephen S. Sidney, Mario Sims, Colleen M. Sitlani, Jennifer A. Smith, John M. Starr, Konstantin Strauch, Morris A. Swertz, Alexander Teumer, Yih Chung Tham, Andre G. Uitterlinden, Dhananjay Vaidya, M. Yldau van der Ende, Melanie Waldenberger, Lihua Wang, Ya-Xing Wang, Wen-Bin Wei, David R. Weir, Wanqing Wen, Jie Yao, Bing Yu, Caizheng Yu, Jian-Min Yuan, Wei Zhao, Alan B. Zonderman, Diane M. Becker, Donald W. Bowden, Ian J. Deary, Marcus Doerr, Tonu Esko, Barry I. Freedman, Philippe Froguel, Paolo Gasparini, Christian Gieger, Jost Bruno Jonas, Candace M. Kammerer, Norihiro Kato, Timo A. Lakka, Karin Leander, Terho Lehtimaki, Patrik K. E. Magnusson, Pedro Marques-Vidal, Brenda W. J. H. Penninx, Nilesh J. Samani, Pim van der Harst, Lynne E. Wagenknecht, Tangchun Wu, Wei Zheng, Xiaofeng Zhu, Claude Bouchard, Richard S. Cooper, Adolfo Correa, Michele K. Evans, Vilmundur Gudnason, Caroline Hayward, Bernardo L. Horta, Tanika N. Kelly, Stephen B. Kritchevsky, Daniel Levy, Walter R. Palmas, A. C. Pereira, Michael M. Province, Bruce M. Psaty, Paul M. Ridker, Charles N. Rotimi, E. Shyong Tai, Rob M. van Dam, Cornelia M. van Duijn, Tien Yin Wong, Kenneth Rice, W. James Gauderman, Alanna C. Morrison, Kari E. North, Sharon L. R. Kardia, Mark J. Caulfield, Paul Elliott, Patricia B. Munroe, Paul W. Franks, Dabeeru C. Rao, Myriam Fornage
Summary: Educational attainment is widely used as a surrogate for socioeconomic status in studies on hypertension and high blood pressure. Through multi-ancestry meta-analyses, researchers identified 84 known and 18 novel blood pressure loci, suggesting a potential role of educational attainment or SES in the genetic architecture of blood pressure.
MOLECULAR PSYCHIATRY
(2021)
Article
Biochemistry & Molecular Biology
Azmeraw T. Amare, Klaus Oliver Schubert, Liping Hou, Scott R. Clark, Sergi Papiol, Micah Cearns, Urs Heilbronner, Franziska Degenhardt, Fasil Tekola-Ayele, Yi-Hsiang Hsu, Tatyana Shekhtman, Mazda AdIi, Nirmala Akula, Kazufumi Akiyama, Raffaella Ardau, Barbara Arias, Jean-Michel Aubry, Lena Backlund, Kumar Bhattacharjee, Frank Bellivier, Antonio Benabarre, Susanne Bengesser, Joanna M. Biernacka, Armin Birner, Clara Brichant-Petitjean, Pablo Cervantes, Hsi-Chung Chen, Caterina Chillotti, Sven Cichon, Cristiana Cruceanu, Piotr M. Czerski, Nina Dalkner, Alexandre Dayer, Maria Del Zompo, J. Raymond DePaulo, Bruno Etain, Stephane Jamain, Peter Falkai, Andreas J. Forstner, Louise Frisen, Mark A. Frye, Janice M. Fullerton, Sebastien Gard, Julie S. Garnham, Fernando S. Goes, Maria Grigoroiu-Serbanescu, Paul Grof, Ryota Hashimoto, Joanna Hauser, Stefan Herms, Per Hoffmann, Andrea Hofmann, Esther Jimenez, Jean-Pierre Kahn, Layla Kassem, Po-Hsiu Kuo, Tadafumi Kato, John R. Kelsoe, Sarah Kittel-Schneider, Sebastian Kliwicki, Barbara Koenig, Ichiro Kusumi, Gonzalo Laje, Mikael Landen, Catharina Lavebratt, Marion Leboyer, Susan G. Leckband, Alfonso Tortorella, Mirko Manchia, Lina Martinsson, Michael J. McCarthy, Susan L. McElroy, Francesc Colom, Marina Mitjans, Francis M. Mondimore, Palmiero Monteleone, Caroline M. Nievergelt, Markus M. Noethen, Tomas Novak, Claire O'Donovan, Norio Ozaki, Urban Osby, Andrea Pfennig, James B. Potash, Andreas Reif, Eva Reininghaus, Guy A. Rouleau, Janusz K. Rybakowski, Martin Schalling, Peter R. Schofield, Barbara W. Schweizer, Giovanni Severino, Paul D. Shilling, Katzutaka Shimoda, Christian Simhandl, Claire M. Slaney, Alessio Squassina, Thomas Stamm, Pavla Stopkova, Mario Maj, Gustavo Turecki, Eduard Vieta, Julia Veeh, Stephanie H. Witt, Adam Wright, Peter P. Zandi, Philip B. Mitchell, Michael Bauer, Martin Alda, Marcella Rietschel, Francis J. McMahon, Thomas G. Schulze, Bernhard T. Baune
Summary: The study found a significant association between polygenic susceptibility to major depression and response to lithium treatment in patients with bipolar disorder. Patients with a lower polygenic load for depression were more likely to respond well to lithium. This highlights the genetic contribution to lithium response in bipolar disorder and supports the concept of a lithium-responsive biotype.
MOLECULAR PSYCHIATRY
(2021)
Article
Biochemistry & Molecular Biology
Laura K. M. Han, Richard Dinga, Tim Hahn, Christopher R. K. Ching, Lisa T. Eyler, Lyubomir Aftanas, Moji Aghajani, Andre Aleman, Bernhard T. Baune, Klaus Berger, Ivan Brak, Geraldo Busatto Filho, Angela Carballedo, Colm G. Connolly, Baptiste Couvy-Duchesne, Kathryn R. Cullen, Udo Dannlowski, Christopher G. Davey, Danai Dima, Fabio L. S. Duran, Verena Enneking, Elena Filimonova, Stefan Frenzel, Thomas Frodl, Cynthia H. Y. Fu, Beata R. Godlewska, Ian H. Gotlib, Hans J. Grabe, Nynke A. Groenewold, Dominik Grotegerd, Oliver Gruber, Geoffrey B. Hall, Ben J. Harrison, Sean N. Hatton, Marco Hermesdorf, Ian B. Hickie, Tiffany C. Ho, Norbert Hosten, Andreas Jansen, Claas Kaehler, Tilo Kircher, Bonnie Klimes-Dougan, Bernd Kraemer, Axel Krug, Jim Lagopoulos, Ramona Leenings, Frank P. MacMaster, Glenda MacQueen, Andrew McIntosh, Quinn McLellan, Katie L. McMahon, Sarah E. Medland, Bryon A. Mueller, Benson Mwangi, Evgeny Osipov, Maria J. Portella, Elena Pozzi, Liesbeth Reneman, Jonathan Repple, Pedro G. P. Rosa, Matthew D. Sacchet, Philipp G. Saemann, Knut Schnell, Anouk Schrantee, Egle Simulionyte, Jair C. Soares, Jens Sommer, Dan J. Stein, Olaf Steinstraeter, Lachlan T. Strike, Sophia I. Thomopoulos, Marie-Jose van Tol, Ilya M. Veer, Robert R. J. M. Vermeiren, Henrik Walter, Nic J. A. van der Wee, Steven J. A. van der Werff, Heather Whalley, Nils R. Winter, Katharina Wittfeld, Margaret J. Wright, Mon-Ju Wu, Henry Voelzke, Tony T. Yang, Vasileios Zannias, Greig I. de Zubicaray, Giovana B. Zunta-Soares, Christoph Abe, Martin Alda, Ole A. Andreassen, Erlend Boen, Caterina M. Bonnin, Erick J. Canales-Rodriguez, Dara Cannon, Xavier Caseras, Tiffany M. Chaim-Avancini, Torbjorn Elvsashagen, Pauline Favre, Sonya F. Foley, Janice M. Fullerton, Jose M. Goikolea, Bartholomeus C. M. Haarman, Tomas Hajek, Chantal Henry, Josselin Houenou, Fleur M. Howells, Martin Ingvar, Rayus Kuplicki, Beny Lafer, Mikael Landen, Rodrigo Machado-Vieira, Ulrik F. Malt, Colm McDonald, Philip B. Mitchell, Leila Nabulsi, Maria Concepcion Garcia Otaduy, Bronwyn J. Overs, Mircea Polosan, Edith Pomarol-Clotet, Joaquim Radua, Maria M. Rive, Gloria Roberts, Henricus G. Ruhe, Raymond Salvador, Salvador Sarro, Theodore D. Satterthwaite, Jonathan Savitz, Aart H. Schene, Peter R. Schofield, Mauricio H. Serpa, Kang Sim, Marcio Gerhardt Soeiro-de-Souza, Ashley N. Sutherland, Henk S. Temmingh, Garrett M. Timmons, Anne Uhlmann, Eduard Vieta, Daniel H. Wolf, Marcus V. Zanetti, Neda Jahanshad, Paul M. Thompson, Dick J. Veltman, Brenda W. J. H. Penninx, Andre F. Marquand, James H. Cole, Lianne Schmaal
Summary: Major depressive disorder is associated with increased risk of brain atrophy, aging-related diseases, and mortality. This study found that MDD patients showed a higher brain-predicted age difference compared to controls, but this difference did not seem to be driven by specific clinical characteristics. Subtle patterns of age-related structural brain abnormalities in MDD were observed, highlighting the need for further longitudinal studies to assess the clinical value of these findings.
MOLECULAR PSYCHIATRY
(2021)
Article
Clinical Neurology
Wendela G. ter Meulen, Stasja Draisma, Albert M. van Hemert, Robert A. Schoevers, Ralph W. Kupka, Aartjan T. F. Beekman, Brenda W. J. H. Penninx
Summary: Comorbidity of depressive and anxiety disorders is common, with anxiety disorders often preceding depressive disorders. Comorbid patients have higher severity and worse course, with risk factors including childhood trauma, neuroticism, and early age of onset. Functional, somatic, and mental health indicators are generally higher in comorbid patients, warranting specific attention in treatment settings.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Biochemistry & Molecular Biology
Heming Wang, Raymond Noordam, Brian E. Cade, Karen Schwander, Thomas W. Winkler, Jiwon Lee, Yun Ju Sung, Amy R. Bentley, Alisa K. Manning, Hugues Aschard, Tuomas O. Kilpelainen, Marjan Ilkov, Michael R. Brown, Andrea R. Horimoto, Melissa Richard, Traci M. Bartz, Dina Vojinovic, Elise Lim, Jovia L. Nierenberg, Yongmei Liu, Kumaraswamynaidu Chitrala, Tuomo Rankinen, Solomon K. Musani, Nora Franceschini, Rainer Rauramaa, Maris Alver, Phyllis C. Zee, Sarah E. Harris, Peter J. van Der Most, Ilja M. Nolte, Patricia B. Munroe, Nicholette D. Palmer, Brigitte Kuhnel, Stefan Weiss, Wanqing Wen, Kelly A. Hall, Leo-Pekka Lyytikainen, Jeff O. Connell, Gudny Eiriksdottir, Lenore J. Launer, Paul S. de Vries, Dan E. Arking, Han Chen, Eric Boerwinkle, Jose E. Krieger, Pamela J. Schreiner, Stephen Sidney, James M. Shikany, Kenneth Rice, Yii-Der Ida Chen, Sina A. Gharib, Joshua C. Bis, Annemarie Luik, M. Arfan Ikram, Andre G. Uitterlinden, Najaf Amin, Hanfei Xu, Daniel Levy, Jiang He, Kurt K. Lohman, Alan B. Zonderman, Treva K. Rice, Mario Sims, Gregory Wilson, Tamar Sofer, Stephen S. Rich, Walter Palmas, Jie Yao, Xiuqing Guo, Jerome Rotter, Nienke R. Biermasz, Dennis O. Mook-Kanamori, Lisa W. Martin, Ana Barac, Robert B. Wallace, Daniel J. Gottlieb, Pirjo Komulainen, Sami Heikkinen, Reedik Magi, Lili Milani, Andres Metspalu, John M. Starr, Yuri Milaneschi, R. J. Waken, Chuan Gao, Melanie Waldenberger, Annette Peters, Konstantin Strauch, Thomas Meitinger, Till Roenneberg, Uwe Volker, Marcus Dorr, Xiao-Ou Shu, Sutapa Mukherjee, David R. Hillman, Mika Kahonen, Lynne E. Wagenknecht, Christian Gieger, Hans J. Grabe, Wei Zheng, Lyle J. Palmer, Terho Lehtimaki, Vilmundur Gudnason, Alanna C. Morrison, Alexandre C. Pereira, Myriam Fornage, Bruce M. Psaty, Cornelia M. van Duijn, Ching-Ti Liu, Tanika N. Kelly, Michele K. Evans, Claude Bouchard, Ervin R. Fox, Charles Kooperberg, Xiaofeng Zhu, Timo A. Lakka, Tonu Esko, Kari E. North, Ian J. Deary, Harold Snieder, Brenda W. J. H. Penninx, W. James Gauderman, Dabeeru C. Rao, Susan Redline, Diana van Heemst
Summary: Long and short sleep durations are associated with elevated blood pressure, and genetic factors may play a role in this relationship. Interactions between specific genes and sleep duration were identified, with some genes increasing blood pressure in long sleepers and others increasing blood pressure in short sleepers. This study suggests that the mechanisms regulating blood pressure may be influenced by sleep, providing novel insights into the regulation of sleep-related blood pressure.
MOLECULAR PSYCHIATRY
(2021)
Article
Multidisciplinary Sciences
Joanna Martin, Kimiya Asjadi, Leon Hubbard, Kimberley Kendall, Antonio F. Pardinas, Bradley Jermy, Cathryn M. Lewis, Bernhard T. Baune, Dorret Boomsma, Steven P. Hamilton, Susanne Lucae, Patrik K. Magnusson, Nicholas G. Martin, Andrew M. McIntosh, Divya Mehta, Ole Mors, Niamh Mullins, Brenda W. J. H. Penninx, Martin Preisig, Marcella Rietschel, Ian Jones, James T. R. Walters, Frances Rice, Anita Thapar, Michael O'Donovan
Summary: The study investigated sex differences in genetic risk burden for individuals with anxiety and depression, finding that females were more likely to report a family history of neurodevelopmental and psychiatric disorders. However, there was no strong evidence of sex differences in neurodevelopmental genetic risk burden in adults with anxiety and depression.
Article
Psychiatry
Ilja M. J. Saris, Moji Aghajani, Lianne M. Reus, Pieter-Jelle Visser, Yolande Pijnenburg, Nic J. A. van der Wee, Amy C. Bilderbeck, Andreea Raslescu, Asad Malik, Maarten Mennes, Sanne Koops, Celso Arrango, Jose Luis Ayuso-Mateos, Gerard R. Dawson, Hugh Marston, Martien J. Kas, Brenda W. J. H. Penninx
Summary: The study found a correlation between social dysfunction and reduced DMN connectivity, with the combined effect of both being more pronounced, independent of diagnostic status and not confounded by key clinical or sociodemographic effects.
WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
(2022)
Article
Immunology
Yuri Milaneschi, Kelly A. Allers, Aartjan T. F. Beekman, Erik J. Giltay, Sascha Keller, Robert A. Schoevers, Sigurd D. Suessmuth, Heiko G. Niessen, Brenda W. J. H. Penninx
Summary: The study revealed that TRYCATs levels were associated with specific features of depression, including symptom profiles and inflammatory markers, indicating a potential benefit of modulating the kynurenine pathway for certain subsets of depressed patients. Further clinical studies should focus on patients with clear evidence of kynurenine pathway dysregulation.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Clinical Neurology
Alejandro De la Torre-Luque, Alba Viera-Campos, Amy C. Bilderbeck, Maria Teresa Carreras, Jose Vivancos, Covadonga M. Diaz-Caneja, Moji Aghajani, Ilja M. J. Saris, Andreea Raslescu, Asad Malik, Jenna Clark, Brenda W. J. H. Penninx, Nic van der Wee, Inge Winter-van Rossum, Bernd Sommer, Hugh Marston, Gerard R. Dawson, Martien J. Kas, Jose Luis Ayuso-Mateos, Celso Arango
Summary: This study investigated the role of social withdrawal in neuropsychiatric patients and found that they showed poorer performance in detecting facial emotions compared to healthy individuals. Social withdrawal was associated with higher accuracy in negative emotion detection and lower misclassification of positive emotions. These findings suggest that social withdrawal may lead to heightened sensitivity to negative emotions and impact social functioning in people with severe mental illness.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2022)
Article
Psychiatry
Nathaly Rius Ottenheim, Kuan-Yu Pan, Almar A. L. Kok, Frederike Jorg, Merijn Eikelenboom, Melany Horsfall, Rob A. Luteijn, Patricia van Oppen, Didi Rhebergen, Robert A. Schoevers, Brenda W. J. H. Penninx, Erik J. Giltay
Summary: The study found neuroticism to be a robust predictor of adverse changes in mental health, and identified additional sociodemographic and COVID-19-related predictors that explain longitudinal variability in mental health during the COVID-19 pandemic.
Article
Biochemistry & Molecular Biology
Tina Drincic, Jens H. van Dalfsen, Jeanine Kamphuis, Mike C. Jentsch, Sjoerd M. van Belkum, Marcus J. M. Meddens, Brenda W. J. H. Penninx, Robert A. Schoevers
Summary: Insomnia has a clinically relevant relationship with major depressive disorder (MDD), as it is associated with neurobiological alterations similar to the pathophysiology of MDD. This study aimed to investigate the relationship between insomnia and the main mechanisms of MDD in a clinical sample of MDD individuals.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Psychiatry
Ekaterina Protsenko, Owen M. Wolkowitz, Kristine Yaffe
Summary: Psychiatry has shown increasing interest in the concept of biological aging, and research has explored the relationship between stress, psychiatric illness, and accelerated biological aging. Epigenetic clocks, specifically the GrimAge clock, have been used to estimate biological age based on DNA methylation data. Several studies have examined the associations between stress, PTSD, MDD, and GrimAge acceleration, but the results are mixed, possibly due to variations in analytic methods and covariate selection. To address this issue, a systematic framework for covariate selection and an approach to results reporting are proposed to improve analytic consensus.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Psychology, Clinical
Margreet ten Have, Marlous Tuithof, Saskia van Dorsselaer, Marloes Kleinjan, Brenda W. J. H. Penninx, Neeltje M. Batelaan, Ron de Graaf
Summary: Research on anxiety disorders in the general population shows that the disorder tends to have a chronic course, with a significant proportion of patients not recovering after 12 months. Risk factors for longer episode duration include older age, lack of paid job, higher neuroticism, more physical disorders, and worse physical functioning.
DEPRESSION AND ANXIETY
(2021)