Harnessing Biomaterials to Engineer the Lymph Node Microenvironment for Immunity or Tolerance

A Biodegradable Nanoparticle Platform for the Induction of Antigen-Specific Immune Tolerance for Treatment of Autoimmune Disease

(2014) Zoe Hunter et al.   ACS Nano

Nanoparticle delivery of donor antigens for transplant tolerance in allogeneic islet transplantation

(2014) Jane Bryant et al.   BIOMATERIALS

Nanomedicine in autoimmunity

(2014) Xavier Clemente-Casares et al.   IMMUNOLOGY LETTERS

Laminins affect T cell trafficking and allograft fate

(2014) Kristi J. Warren et al.   JOURNAL OF CLINICAL INVESTIGATION

Emerging roles of lymphatic endothelium in regulating adaptive immunity

(2014) Catherine M. Card et al.   JOURNAL OF CLINICAL INVESTIGATION

Designing and building the next generation of improved vaccine adjuvants

(2014) Luis A. Brito et al.   JOURNAL OF CONTROLLED RELEASE

Treatment of Experimental Autoimmune Encephalomyelitis by Codelivery of Disease Associated Peptide and Dexamethasone in Acetalated Dextran Microparticles

(2014) Kevin J. Peine et al.   MOLECULAR PHARMACEUTICS

Structure-based programming of lymph-node targeting in molecular vaccines

(2014) Haipeng Liu et al.   NATURE

Therapeutic Inflammatory Monocyte Modulation Using Immune-Modifying Microparticles

(2014) D. R. Getts et al.   Science Translational Medicine

Enhancing Efficacy of Anticancer Vaccines by Targeted Delivery to Tumor-Draining Lymph Nodes

(2014) L. Jeanbart et al.   Cancer Immunology Research

Particle shape dependence of CD8+ T cell activation by artificial antigen presenting cells

(2013) Joel C. Sunshine et al.   BIOMATERIALS

Targeting the tumor-draining lymph node with adjuvanted nanoparticles reshapes the anti-tumor immune response

(2013) Susan N. Thomas et al.   BIOMATERIALS

Antigen-specific tolerization approaches in multiple sclerosis

(2013) Andreas Lutterotti et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Is intralymphatic immunotherapy ready for clinical use in patients with grass pollen allergy?

(2013) Marianne Witten et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Nanogel-based delivery of mycophenolic acid ameliorates systemic lupus erythematosus in mice

(2013) Michael Look et al.   JOURNAL OF CLINICAL INVESTIGATION

PLGA nanoparticles enhance the expression of retinaldehyde dehydrogenase enzymes in dendritic cells and induce FoxP3+ T-cells in vitro

(2013) Chantal Keijzer et al.   JOURNAL OF CONTROLLED RELEASE

Engineering synthetic vaccines using cues from natural immunity

(2013) Darrell J. Irvine et al.   NATURE MATERIALS

Comparison of PLA Microparticles and Alum as Adjuvants for H5N1 Influenza Split Vaccine: Adjuvanticity Evaluation and Preliminary Action Mode Analysis

(2013) Weifeng Zhang et al.   PHARMACEUTICAL RESEARCH

Combinatorial delivery of immunosuppressive factors to dendritic cells using dual-sized microspheres

(2013) Jamal S. Lewis et al.   Journal of Materials Chemistry B

Bioinspired Controlled Release of CCL22 Recruits Regulatory T Cells In Vivo

(2012) Siddharth Jhunjhunwala et al.   ADVANCED MATERIALS

Intralymphatic immunotherapy for cat allergy induces tolerance after only 3 injections

(2012) Gabriela Senti et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Multiple sclerosis

(2012) Alyssa Nylander et al.   JOURNAL OF CLINICAL INVESTIGATION

Manipulation of the surface pegylation in combination with reduced vesicle size of cationic liposomal adjuvants modifies their clearance kinetics from the injection site, and the rate and type of T cell response

(2012) Randip Kaur et al.   JOURNAL OF CONTROLLED RELEASE

Controlled release formulations of IL-2, TGF-β1 and rapamycin for the induction of regulatory T cells

(2012) Siddharth Jhunjhunwala et al.   JOURNAL OF CONTROLLED RELEASE

Engineering DNA Nanoparticles as Immunomodulatory Reagents that Activate Regulatory T Cells

(2012) L. Huang et al.   JOURNAL OF IMMUNOLOGY

Nanoparticle Hydrophobicity Dictates Immune Response

(2012) Daniel F. Moyano et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Vaccine-like Controlled-Release Delivery of an Immunomodulating Peptide To Treat Experimental Autoimmune Encephalomyelitis

(2012) Barlas Büyüktimkin et al.   MOLECULAR PHARMACEUTICS

Microparticles bearing encephalitogenic peptides induce T-cell tolerance and ameliorate experimental autoimmune encephalomyelitis

(2012) Daniel R Getts et al.   NATURE BIOTECHNOLOGY

Synthetic mast-cell granules as adjuvants to promote and polarize immunity in lymph nodes

(2012) Ashley L. St. John et al.   NATURE MATERIALS

Therapies for allergic inflammation: refining strategies to induce tolerance

(2012) Cezmi A Akdis   NATURE MEDICINE

Engineering antigens for in situ erythrocyte binding induces T-cell deletion

(2012) S. Kontos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enhancing humoral responses to a malaria antigen with nanoparticle vaccines that expand Tfh cells and promote germinal center induction

(2012) J. J. Moon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nanoparticle-mediated codelivery of myelin antigen and a tolerogenic small molecule suppresses experimental autoimmune encephalomyelitis

(2012) A. Yeste et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Engineering Approaches to Immunotherapy

(2012) M. A. Swartz et al.   Science Translational Medicine

Lymph node targeting of BCG vaccines amplifies CD4 and CD8 T-cell responses and protection against Mycobacterium tuberculosis

(2012) Ying Waeckerle-Men et al.   VACCINE

Nanoparticle Delivery of Mycophenolic Acid Upregulates PD-L1 on Dendritic Cells to Prolong Murine Allograft Survival

(2011) A. C. Shirali et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Induction of potent anti-tumor responses while eliminating systemic side effects via liposome-anchored combinatorial immunotherapy

(2011) Brandon Kwong et al.   BIOMATERIALS

Predicting biomaterial property-dendritic cell phenotype relationships from the multivariate analysis of responses to polymethacrylates

(2011) Peng Meng Kou et al.   BIOMATERIALS

Intra-Lymph Node Prime-Boost Vaccination against Melan A and Tyrosinase for the Treatment of Metastatic Melanoma: Results of a Phase 1 Clinical Trial

(2011) A. Ribas et al.   CLINICAL CANCER RESEARCH

Immunopathogenesis of multiple sclerosis

(2011) Manuel Comabella et al.   CLINICAL IMMUNOLOGY

Programming the magnitude and persistence of antibody responses with innate immunity

(2011) Sudhir Pai Kasturi et al.   NATURE

Germinal center B and follicular helper T cells: siblings, cousins or just good friends?

(2011) Stephen L Nutt et al.   NATURE IMMUNOLOGY

Interbilayer-crosslinked multilamellar vesicles as synthetic vaccines for potent humoral and cellular immune responses

(2011) James J. Moon et al.   NATURE MATERIALS

PLGA, PLGA-TMC and TMC-TPP Nanoparticles Differentially Modulate the Outcome of Nasal Vaccination by Inducing Tolerance or Enhancing Humoral Immunity

(2011) Chantal Keijzer et al.   PLoS One

In situ engineering of the lymph node microenvironment via intranodal injection of adjuvant-releasing polymer particles

(2011) C. M. Jewell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dendritic cell responses to surface properties of clinical titanium surfaces

(2010) Peng Meng Kou et al.   Acta Biomaterialia

Polylactide-cyclosporin A nanoparticles for targeted immunosuppression

(2010) Jamil Azzi et al.   FASEB JOURNAL

Reversal of Autoimmunity by Boosting Memory-like Autoregulatory T Cells

(2010) Sue Tsai et al.   IMMUNITY

T cells and follicular dendritic cells in germinal center B-cell formation and selection

(2010) Carola G. Vinuesa et al.   IMMUNOLOGICAL REVIEWS

Administration routes affect the quality of immune responses: A cross-sectional evaluation of particulate antigen-delivery systems

(2010) Deepa Mohanan et al.   JOURNAL OF CONTROLLED RELEASE

Modulation of CD4+ T Lymphocyte Lineage Outcomes with Targeted, Nanoparticle-Mediated Cytokine Delivery

(2010) Jason Park et al.   MOLECULAR PHARMACEUTICS

Therapeutic cell engineering with surface-conjugated synthetic nanoparticles

(2010) Matthias T Stephan et al.   NATURE MEDICINE

Lymph Node-Targeted Immunotherapy Mediates Potent Immunity Resulting in Regression of Isolated or Metastatic Human Papillomavirus-Transformed Tumors

(2009) K. A. Smith et al.   CLINICAL CANCER RESEARCH

Intralymphatic immunotherapy

(2009) Gabriela Senti et al.   Current Opinion in Allergy and Clinical Immunology

Antigen-Specific Suppression of Inflammatory Arthritis Using Liposomes

(2009) C. Capini et al.   JOURNAL OF IMMUNOLOGY

Secondary Lymphoid Organs: Responding to Genetic and Environmental Cues in Ontogeny and the Immune Response

(2009) N. H. Ruddle et al.   JOURNAL OF IMMUNOLOGY

Chitin Is a Size-Dependent Regulator of Macrophage TNF and IL-10 Production

(2009) C. A. Da Silva et al.   JOURNAL OF IMMUNOLOGY

Virus-like Particle (VLP) Lymphatic Trafficking and Immune Response Generation After Immunization by Different Routes

(2009) Rafael Cubas et al.   JOURNAL OF IMMUNOTHERAPY

Intranodal Immunization With a Vaccinia Virus Encoding Multiple Antigenic Epitopes and Costimulatory Molecules in Metastatic Melanoma

(2009) Michel Adamina et al.   MOLECULAR THERAPY

Uptake of particulate vaccine adjuvants by dendritic cells activates the NALP3 inflammasome

(2009) Fiona A. Sharp et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enhancing DNA vaccination by sequential injection of lymph nodes with plasmid vectors and peptides

(2009) Kent A. Smith et al.   VACCINE

Inflammasome-activating nanoparticles as modular systems for optimizing vaccine efficacy

(2009) Stacey L. Demento et al.   VACCINE

Antigen kinetics determines immune reactivity

(2008) Pål Johansen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intralymphatic allergen administration renders specific immunotherapy faster and safer: A randomized controlled trial

(2008) G. Senti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA