Review
Biotechnology & Applied Microbiology
Willem van Eden
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2020)
Article
Cell Biology
Qingkang Lyu, Irene S. Ludwig, Peter J. S. Kooten, Alice J. A. M. Sijts, Victor P. M. G. Rutten, Willem van Eden, Femke Broere
CELL STRESS & CHAPERONES
(2020)
Article
Microbiology
Md Aminul Islam, Michihiro Takagi, Kohtaro Fukuyama, Ryoya Komatsu, Leonardo Albarracin, Tomonori Nochi, Yoshihito Suda, Wakako Ikeda-Ohtsubo, Victor Rutten, Willem van Eden, Julio Villena, Hisashi Aso, Haruki Kitazawa
Article
Immunology
Robin H. G. A. van den Biggelaar, Willem van Eden, Victor P. M. G. Rutten, Christine A. Jansen
Article
Biochemistry & Molecular Biology
Qingkang Lyu, Magdalena Wawrzyniuk, Victor P. M. G. Rutten, Willem van Eden, Alice J. A. M. Sijts, Femke Broere
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Review
Nutrition & Dietetics
Josep Bassaganya-Riera, Elliot M. Berry, Ellen E. Blaak, Barbara Burlingame, Johannes le Coutre, Willem van Eden, Ahmed El-Sohemy, J. Bruce German, Dietrich Knorr, Christophe Lacroix, Maurizio Muscaritoli, David C. Nieman, Michael Rychlik, Andrew Scholey, Mauro Serafini
Summary: In the past five years, significant progress has been made in nutrition science, such as the integration of Sustainable Development Goals and nutritional science, as well as research on the Human Microbiome. Looking ahead to the next five years, emphasis on health and sustainability will be the main focus of nutrition science.
FRONTIERS IN NUTRITION
(2021)
Article
Chemistry, Medicinal
Chun Yin Jerry Lau, Naomi Benne, Bo Lou, Danielle ter Braake, Esmeralda Bosman, Nicky E. van Kronenburg, Marcel H. Fens, Femke Broere, Wim E. Hennink, Enrico Mastrobattista
Summary: The induction of antigen-specific immune tolerance is crucial for the treatment of autoimmune disorders. This study investigates the use of supramolecular peptide nanofibers to induce immune tolerance. The surface charges of the nanofibers were modified to enhance the antigen-specific tolerogenic response. This molecular approach may contribute to the design of future immunotherapies.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Danielle ter Braake, Naomi Benne, Chun Yin Jerry Lau, Enrico Mastrobattista, Femke Broere
Summary: By utilizing liposomes containing specific antigens to encapsulate RA, the proportion of antigen-associated tolDCs can be increased, leading to a more targeted induction of antigen-specific tolerance in mice. This study highlights the importance of co-delivering antigens and immunomodulators to minimize off-target effects and systemic side effects.
Review
Microbiology
Adil Ijaz, Edwin J. A. Veldhuizen, Femke Broere, Victor P. M. G. Rutten, Christine A. Jansen
Summary: Salmonellosis is a common infection in poultry that causes economic losses and poses a threat to public health. Antibiotics as feed additives have been effective, but due to resistance issues, alternative strategies such as enhancing innate immunity in young chickens are being explored. Identifying key players in the innate immune response in the intestine is crucial for designing targeted immune modulation approaches.
Article
Infectious Diseases
Nico van Os, Ali Javed, Femke Broere, Albert van Dijk, Melanie D. Balhuizen, Martin van Eijk, Suzan H. M. Rooijakkers, Bart W. Bardoel, Dani A. C. Heesterbeek, Henk P. Haagsman, Edwin Veldhuizen
Summary: CR-163 and CR-172 exhibit broad-spectrum antimicrobial activity by disrupting bacterial membranes. Additionally, PepBiotics can bind to LPS and LTA, replacing the role of polymyxin B. The study also demonstrates that bacteria killed by PepBiotics are less likely to stimulate immune cells compared to gentamicin and heat-killed bacteria, which still elicit a strong immune response.
JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE
(2022)
Article
Orthopedics
M. Teunissen, B. P. Meij, L. Snel, K. Coeleveld, J. Popov-Celeketic, I. S. Ludwig, F. Broere, F. P. J. G. Lafeber, M. A. Tryfonidou, S. C. Mastbergen
Summary: This study investigated the effects of knee joint distraction (KJD) on osteoarthritic joints in dogs at two consecutive timepoints. The results showed that although the cartilage was still in a catabolic state directly after KJD, there were signs of healing at 10 weeks of follow-up. The signaling pathways involved in the healing process, including TGF-beta and Notch pathways, were explored.
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2023)
Article
Virology
Sandra Vreman, Elisabeth M. D. L. van der Heijden, Lars Ravesloot, Irene S. Ludwig, Judith M. A. van den Brand, Frank Harders, Andries A. Kampfraath, Herman F. Egberink, Jose L. Gonzales, Nadia Oreshkova, Femke Broere, Wim H. M. van der Poel, Nora M. Gerhards
Summary: Several reports demonstrated domestic cats' susceptibility to SARS-CoV-2 infection. In this study, the immune responses in cats after experimental inoculation were investigated, along with infection kinetics and pathological lesions. Infected cats showed mild lung changes and viral antigen expression, but no clinical signs. Viral RNA was present in nasal and throat swabs until day 7, and infectious virus could be isolated from nose, trachea, and lungs until day 7. Cats developed a humoral immune response from day 7 onwards, with limited cellular immune responses on day 7.
Article
Chemistry, Medicinal
Ali Javed, Melanie D. Balhuizen, Arianne Pannekoek, Floris J. Bikker, Dani A. C. Heesterbeek, Henk P. Haagsman, Femke Broere, Markus Weingarth, Edwin J. A. Veldhuizen
Summary: This study systematically investigates the influence of O-antigen and Lipid A composition on the antibacterial and anti-endotoxin activity of four HDPs. The results show that O-antigen does not affect antibacterial activity, while Lipid A modification can affect the immunomodulatory role of HDPs. The findings have important implications for the application of HDPs in the treatment of infectious diseases.
Article
Immunology
Robin H. G. A. van den Biggelaar, Willem van Eden, Victor P. M. G. Rutten, Christine A. Jansen