标题
Transgenic Mouse Models in Cancer Research
作者
关键词
-
出版物
Frontiers in Oncology
Volume 8, Issue -, Pages -
出版商
Frontiers Media SA
发表日期
2018-07-20
DOI
10.3389/fonc.2018.00268
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Chemical Control of a CRISPR-Cas9 Acetyltransferase
- (2018) Jonathan H. Shrimp et al. ACS Chemical Biology
- Humanized mice in studying efficacy and mechanisms of PD-1-targeted cancer immunotherapy
- (2018) Minan Wang et al. FASEB JOURNAL
- Partial DNA-guided Cas9 enables genome editing with reduced off-target activity
- (2018) Hao Yin et al. Nature Chemical Biology
- The commensal microbiome is associated with anti–PD-1 efficacy in metastatic melanoma patients
- (2018) Vyara Matson et al. SCIENCE
- The microbiome in cancer immunotherapy: Diagnostic tools and therapeutic strategies
- (2018) Laurence Zitvogel et al. SCIENCE
- Mapping a functional cancer genome atlas of tumor suppressors in mouse liver using AAV-CRISPR–mediated direct in vivo screening
- (2018) Guangchuan Wang et al. Science Advances
- Enhanced red and far-red fluorescent proteins for in vivo imaging
- (2018) Ilya Kelmanson NATURE METHODS
- CRISPR/Cas9 Engineering of Adult Mouse Liver Demonstrates That the Dnajb1 – Prkaca Gene Fusion Is Sufficient to Induce Tumors Resembling Fibrolamellar Hepatocellular Carcinoma
- (2017) Lars H. Engelholm et al. GASTROENTEROLOGY
- Humanized mice (humice) carrying patient-derived xenograft (PDX) as a platform to develop immunotherapy in bladder cancer (BCa).
- (2017) Chong-xian Pan et al. JOURNAL OF CLINICAL ONCOLOGY
- Current status and perspectives of patient-derived xenograft models in cancer research
- (2017) Yunxin Lai et al. Journal of Hematology & Oncology
- Mouse Genome Database (MGD)-2018: knowledgebase for the laboratory mouse
- (2017) Cynthia L Smith et al. NUCLEIC ACIDS RESEARCH
- Gut microbiome influences efficacy of PD-1–based immunotherapy against epithelial tumors
- (2017) Bertrand Routy et al. SCIENCE
- Gene Therapy with the Sleeping Beauty Transposon System
- (2017) Partow Kebriaei et al. TRENDS IN GENETICS
- Effect of siRNA‑mediated gene silencing of transketolase on A549 lung cancer cells
- (2017) Huan Lu et al. Oncology Letters
- Somatic chromosomal engineering identifies BCAN-NTRK1 as a potent glioma driver and therapeutic target
- (2017) Peter J. Cook et al. Nature Communications
- Clinical responses to adoptive T-cell transfer can be modeled in an autologous immune-humanized mouse model
- (2017) Henrik Jespersen et al. Nature Communications
- In Vivo Imaging Sheds Light on Immune Cell Migration and Function in Cancer
- (2017) Tommaso Torcellan et al. Frontiers in Immunology
- Models of Models: A Translational Route for Cancer Treatment and Drug Development
- (2017) Lesley A. Ogilvie et al. Frontiers in Oncology
- Nanoparticle delivery of Cas9 ribonucleoprotein and donor DNA in vivo induces homology-directed DNA repair
- (2017) Kunwoo Lee et al. Nature Biomedical Engineering
- Efficient and rapid generation of large genomic variants in rats and mice using CRISMERE
- (2017) Marie-Christine Birling et al. Scientific Reports
- CRISPR/Cas9-derived models of ovarian high grade serous carcinoma targeting Brca1, Pten and Nf1, and correlation with platinum sensitivity
- (2017) Josephine B. Walton et al. Scientific Reports
- Patient-derived xenograft (PDX) models in basic and translational breast cancer research
- (2016) Lacey E. Dobrolecki et al. CANCER AND METASTASIS REVIEWS
- Regulatory T cells in cancer immunotherapy
- (2016) Atsushi Tanaka et al. CELL RESEARCH
- Genetically engineered mouse models in oncology research and cancer medicine
- (2016) Kelly Kersten et al. EMBO Molecular Medicine
- Establishment of a tamoxifen-inducible Cre-driver mouse strain for widespread and temporal genetic modification in adult mice
- (2016) Hirotake Ichise et al. EXPERIMENTAL ANIMALS
- Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage
- (2016) Alexis C. Komor et al. NATURE
- Repurposing the CRISPR-Cas9 system for targeted DNA methylation
- (2016) Aleksandar Vojta et al. NUCLEIC ACIDS RESEARCH
- Versatile in vivo regulation of tumor phenotypes by dCas9-mediated transcriptional perturbation
- (2016) Christian J. Braun et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Post-translational Regulation of Cas9 during G1 Enhances Homology-Directed Repair
- (2016) Tony Gutschner et al. Cell Reports
- Restricting retrotransposons: a review
- (2016) John L. Goodier Mobile DNA
- Development of Patient Derived Xenograft Models of Overt Spontaneous Breast Cancer Metastasis: A Cautionary Note
- (2016) Marta Paez-Ribes et al. PLoS One
- Improvement of the reverse tetracycline transactivator by single amino acid substitutions that reduce leaky target gene expression to undetectable levels
- (2016) Ian J. Roney et al. Scientific Reports
- Efficient Production of Fluorescent Transgenic Rats using the piggyBac Transposon
- (2016) Tianda Li et al. Scientific Reports
- Optimizing tamoxifen-inducible Cre/loxp system to reduce tamoxifen effect on bone turnover in long bones of young mice
- (2015) Zhendong A. Zhong et al. BONE
- Genome-wide CRISPR Screen in a Mouse Model of Tumor Growth and Metastasis
- (2015) Sidi Chen et al. CELL
- Pancreatic cancer modeling using retrograde viral vector delivery and in vivo CRISPR/Cas9-mediated somatic genome editing
- (2015) Shin-Heng Chiou et al. GENES & DEVELOPMENT
- Efficient CRISPR/Cas9-Mediated Genome Editing in Mice by Zygote Electroporation of Nuclease
- (2015) Wenning Qin et al. GENETICS
- Engineered CRISPR-Cas9 nucleases with altered PAM specificities
- (2015) Benjamin P. Kleinstiver et al. NATURE
- Broadening the targeting range of Staphylococcus aureus CRISPR-Cas9 by modifying PAM recognition
- (2015) Benjamin P Kleinstiver et al. NATURE BIOTECHNOLOGY
- Inducible in vivo genome editing with CRISPR-Cas9
- (2015) Lukas E Dow et al. NATURE BIOTECHNOLOGY
- Orthogonal gene knockout and activation with a catalytically active Cas9 nuclease
- (2015) James E Dahlman et al. NATURE BIOTECHNOLOGY
- Combined inhibition of BET family proteins and histone deacetylases as a potential epigenetics-based therapy for pancreatic ductal adenocarcinoma
- (2015) Pawel K Mazur et al. NATURE MEDICINE
- Cas9 gRNA engineering for genome editing, activation and repression
- (2015) Samira Kiani et al. NATURE METHODS
- CRISPR/Cas9 somatic multiplex-mutagenesis for high-throughput functional cancer genomics in mice
- (2015) Julia Weber et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Commensal Bifidobacterium promotes antitumor immunity and facilitates anti-PD-L1 efficacy
- (2015) A. Sivan et al. SCIENCE
- Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota
- (2015) M. Vetizou et al. SCIENCE
- Somatic CRISPR/Cas9-mediated tumour suppressor disruption enables versatile brain tumour modelling
- (2015) Marc Zuckermann et al. Nature Communications
- An Inducible Lentiviral Guide RNA Platform Enables the Identification of Tumor-Essential Genes and Tumor-Promoting Mutations In Vivo
- (2015) Brandon J. Aubrey et al. Cell Reports
- Modeling of the Human Alveolar Rhabdomyosarcoma Pax3-Foxo1 Chromosome Translocation in Mouse Myoblasts Using CRISPR-Cas9 Nuclease
- (2015) Irina V. Lagutina et al. PLoS Genetics
- Efficient CRISPR/Cas9-Mediated Genome Editing in Mice by Zygote Electroporation of Nuclease
- (2015) Wenning Qin et al. GENETICS
- Electroporation enables the efficient mRNA delivery into the mouse zygotes and facilitates CRISPR/Cas9-based genome editing
- (2015) Masakazu Hashimoto et al. Scientific Reports
- Green to red photoconversion of GFP for protein tracking in vivo
- (2015) Amirali Sattarzadeh et al. Scientific Reports
- Genetically Engineered Mouse Models for Drug Development and Preclinical Trials
- (2014) Ho Lee Biomolecules & Therapeutics
- Sleeping Beautytransposon system for genetic etiological research and gene therapy of cancers
- (2014) Xiaomei Hou et al. CANCER BIOLOGY & THERAPY
- Mouse Models of Human Cancer
- (2014) Barbara C. Böck et al. CANCER RESEARCH
- CRISPR-Cas9 Knockin Mice for Genome Editing and Cancer Modeling
- (2014) Randall J. Platt et al. CELL
- Development and Applications of CRISPR-Cas9 for Genome Engineering
- (2014) Patrick D. Hsu et al. CELL
- Efficient Ablation of Genes in Human Hematopoietic Stem and Effector Cells using CRISPR/Cas9
- (2014) Pankaj K. Mandal et al. Cell Stem Cell
- Low Incidence of Off-Target Mutations in Individual CRISPR-Cas9 and TALEN Targeted Human Stem Cell Clones Detected by Whole-Genome Sequencing
- (2014) Adrian Veres et al. Cell Stem Cell
- A Mouse Geneticist's Practical Guide to CRISPR Applications
- (2014) P. Singh et al. GENETICS
- Gene disruption by cell-penetrating peptide-mediated delivery of Cas9 protein and guide RNA
- (2014) S. Ramakrishna et al. GENOME RESEARCH
- Dynamic Treg interactions with intratumoral APCs promote local CTL dysfunction
- (2014) Christian A. Bauer et al. JOURNAL OF CLINICAL INVESTIGATION
- DRAGO (KIAA0247), a New DNA Damage–Responsive, p53-Inducible Gene That Cooperates With p53 as Oncosuppressor
- (2014) Federica Polato et al. JNCI-Journal of the National Cancer Institute
- In vivo engineering of oncogenic chromosomal rearrangements with the CRISPR/Cas9 system
- (2014) Danilo Maddalo et al. NATURE
- CRISPR-mediated direct mutation of cancer genes in the mouse liver
- (2014) Wen Xue et al. NATURE
- Generation of mouse models of myeloid malignancy with combinatorial genetic lesions using CRISPR-Cas9 genome editing
- (2014) Dirk Heckl et al. NATURE BIOTECHNOLOGY
- Generating genetically modified mice using CRISPR/Cas-mediated genome engineering
- (2014) Hui Yang et al. Nature Protocols
- Immune Humanization of Immunodeficient Mice Using Diagnostic Bone Marrow Aspirates from Carcinoma Patients
- (2014) Melanie Werner-Klein et al. PLoS One
- Mouse models of cancer: Sleeping Beauty transposons for insertional mutagenesis screens and reverse genetic studies
- (2014) Barbara R. Tschida et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- Targeted genomic rearrangements using CRISPR/Cas technology
- (2014) Peter S. Choi et al. Nature Communications
- Recent Technological Advances in Using Mouse Models to Study Ovarian Cancer
- (2014) Carrie Danielle House et al. Frontiers in Oncology
- Genetically Engineered Mouse Models of Pituitary Tumors
- (2014) David A. Cano et al. Frontiers in Oncology
- The human NPM1 mutation A perturbs megakaryopoiesis in a conditional mouse model
- (2013) P. Sportoletti et al. BLOOD
- One-Step Generation of Mice Carrying Mutations in Multiple Genes by CRISPR/Cas-Mediated Genome Engineering
- (2013) Haoyi Wang et al. CELL
- Repurposing CRISPR as an RNA-Guided Platform for Sequence-Specific Control of Gene Expression
- (2013) Lei S. Qi et al. CELL
- One-Step Generation of Mice Carrying Reporter and Conditional Alleles by CRISPR/Cas-Mediated Genome Engineering
- (2013) Hui Yang et al. CELL
- Reporter Mouse Lines for Fluorescence Imaging
- (2013) Takaya Abe et al. DEVELOPMENT GROWTH & DIFFERENTIATION
- Evaluation of p21 promoter for interleukin 12 radiation induced transcriptional targeting in a mouse tumor model
- (2013) Urska Kamensek et al. Molecular Cancer
- Cancer Gene Discovery: Exploiting Insertional Mutagenesis
- (2013) Marco Ranzani et al. MOLECULAR CANCER RESEARCH
- Knockout mice created by TALEN-mediated gene targeting
- (2013) Young Hoon Sung et al. NATURE BIOTECHNOLOGY
- High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells
- (2013) Yanfang Fu et al. NATURE BIOTECHNOLOGY
- CRISPR RNA–guided activation of endogenous human genes
- (2013) Morgan L Maeder et al. NATURE METHODS
- Genome engineering using the CRISPR-Cas9 system
- (2013) F Ann Ran et al. Nature Protocols
- Differential Mechanisms Associated with Vascular Disrupting Action of Electrochemotherapy: Intravital Microscopy on the Level of Single Normal and Tumor Blood Vessels
- (2013) Bostjan Markelc et al. PLoS One
- Multiplex Genome Engineering Using CRISPR/Cas Systems
- (2013) L. Cong et al. SCIENCE
- Humanized Mice as a Model to Study Human Hematopoietic Stem Cell Transplantation
- (2013) Anne Tanner et al. STEM CELLS AND DEVELOPMENT
- RNA-programmed genome editing in human cells
- (2013) Martin Jinek et al. eLife
- Life in the Fast Lane: Mammalian Disease Models in the Genomics Era
- (2012) Lukas E. Dow et al. CELL
- Xenogeneic Graft-versus-Host-Disease in NOD-scid IL-2Rγnull Mice Display a T-Effector Memory Phenotype
- (2012) Niwa Ali et al. PLoS One
- Rapid validation of cancer genes in chimeras derived from established genetically engineered mouse models
- (2011) Ivo J. Huijbers et al. BIOESSAYS
- Endogenous T Cell Responses to Antigens Expressed in Lung Adenocarcinomas Delay Malignant Tumor Progression
- (2011) Michel DuPage et al. CANCER CELL
- BRCA1 RING Function Is Essential for Tumor Suppression but Dispensable for Therapy Resistance
- (2011) Rinske Drost et al. CANCER CELL
- The Sleeping Beauty transposon system: a non-viral vector for gene therapy
- (2011) E. L. Aronovich et al. HUMAN MOLECULAR GENETICS
- The construction of transgenic and gene knockout/knockin mouse models of human disease
- (2011) Alfred Doyle et al. TRANSGENIC RESEARCH
- Guidelines for the welfare and use of animals in cancer research
- (2010) P Workman et al. BRITISH JOURNAL OF CANCER
- Illuminating Insights into Firefly Luciferase and Other Bioluminescent Reporters Used in Chemical Biology
- (2010) Natasha Thorne et al. CHEMISTRY & BIOLOGY
- Targeted Genome Modification in Mice Using Zinc-Finger Nucleases
- (2010) I. D. Carbery et al. GENETICS
- Comparative Analysis of Transposable Element Vector Systems in Human Cells
- (2010) Ivana Grabundzija et al. MOLECULAR THERAPY
- Good planning and serendipity: exploiting the Cre/Lox system in the testis
- (2010) Lee Smith REPRODUCTION
- PiggyBac Transposon Mutagenesis: A Tool for Cancer Gene Discovery in Mice
- (2010) R. Rad et al. SCIENCE
- A CreER-Based Random Induction Strategy for Modeling Translocation-Associated Sarcomas in Mice
- (2009) M. Haldar et al. CANCER RESEARCH
- Mouse models of human AML accurately predict chemotherapy response
- (2009) J. Zuber et al. GENES & DEVELOPMENT
- Response and resistance to MEK inhibition in leukaemias initiated by hyperactive Ras
- (2009) Jennifer O. Lauchle et al. NATURE
- Chimeric mouse tumor models reveal differences in pathway activation between ERBB family– and KRAS-dependent lung adenocarcinomas
- (2009) Yinghui Zhou et al. NATURE BIOTECHNOLOGY
- A conditional transposon-based insertional mutagenesis screen for genes associated with mouse hepatocellular carcinoma
- (2009) Vincent W Keng et al. NATURE BIOTECHNOLOGY
- Transposon-mediated genome manipulation in vertebrates
- (2009) Zoltán Ivics et al. NATURE METHODS
- Conditional mouse lung cancer models using adenoviral or lentiviral delivery of Cre recombinase
- (2009) Michel DuPage et al. Nature Protocols
- Cautionary insights on knockout mouse studies: The gene or not the gene?
- (2008) Amy F. Eisener-Dorman et al. BRAIN BEHAVIOR AND IMMUNITY
- Induction of Abnormal Proliferation by Nonmyelinating Schwann Cells Triggers Neurofibroma Formation
- (2008) Huarui Zheng et al. CANCER CELL
- Generalized tetracycline induced Cre recombinase expression through the ROSA26 locus of recombinant mice
- (2008) Cristina M. Bäckman et al. JOURNAL OF NEUROSCIENCE METHODS
- Kras regulatory elements and exon 4A determine mutation specificity in lung cancer
- (2008) Minh D To et al. NATURE GENETICS
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now