Sialic Acid Metabolism: A Key Player in Breast Cancer Metastasis Revealed by Metabolomics

The PLAG1-GDH1 Axis Promotes Anoikis Resistance and Tumor Metastasis through CamKK2-AMPK Signaling in LKB1-Deficient Lung Cancer

(2018) Lingtao Jin et al.   MOLECULAR CELL

Metabolism in cancer metastasis: bioenergetics, biosynthesis, and beyond

(2017) Shao Thing Teoh et al.   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

Proline metabolism supports metastasis formation and could be inhibited to selectively target metastasizing cancer cells

(2017) Ilaria Elia et al.   Nature Communications

Protein Sialylation Regulates a Gene Expression Signature that Promotes Breast Cancer Cell Pathogenicity

(2016) Rebecca A. Kohnz et al.   ACS Chemical Biology

Environment Impacts the Metabolic Dependencies of Ras-Driven Non-Small Cell Lung Cancer

(2016) Shawn M. Davidson et al.   Cell Metabolism

Effect of alpha 2,6 sialylation on integrin-mediated adhesion of breast cancer cells to fibronectin and collagen IV

(2016) Ye Yuan et al.   LIFE SCIENCES

ST3Gal III modulates breast cancer cell adhesion and invasion by altering the expression of invasion-related molecules

(2016) Hong-Xia Cui et al.   ONCOLOGY REPORTS

Precision glycocalyx editing as a strategy for cancer immunotherapy

(2016) Han Xiao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Early and multiple origins of metastatic lineages within primary tumors

(2016) Zi-Ming Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional roles of sialylation in breast cancer progression through miR-26a/26b targeting ST8SIA4

(2016) Xiaolu Ma et al.   Cell Death & Disease

Tumor sialylation impedes T cell mediated anti-tumor responses while promoting tumor associated-regulatory T cells

(2016) Maurizio Perdicchio et al.   Oncotarget

Elevation of β-galactoside α2,6-sialyltransferase 1 in a fructoseresponsive manner promotes pancreatic cancer metastasis

(2016) Chi-Che Hsieh et al.   Oncotarget

Breast Cancer-Derived Lung Metastases Show Increased Pyruvate Carboxylase-Dependent Anaplerosis

(2016) Stefan Christen et al.   Cell Reports

In vivo cancer metabolism is defined by the nutrient microenvironment

(2016) Ilaria Elia et al.   Translational Cancer Research

Targeted Delivery of a Sialic Acid-Blocking Glycomimetic to Cancer Cells Inhibits Metastatic Spread

(2015) Christian Büll et al.   ACS Nano

Metabolic control of signalling pathways and metabolic auto-regulation

(2015) Doriane Lorendeau et al.   BIOLOGY OF THE CELL

Metabolic changes associated with tumor metastasis, part 2: Mitochondria, lipid and amino acid metabolism

(2015) Paolo E. Porporato et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Metabolic changes associated with tumor metastasis, part 1: tumor pH, glycolysis and the pentose phosphate pathway

(2015) Valéry L. Payen et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Epigenetics and Metabolism

(2015) S. T. Keating et al.   CIRCULATION RESEARCH

LC–MS/MS glycomic analyses of free and conjugated forms of the sialic acids, Neu5Ac, Neu5Gc and KDN in human throat cancers

(2015) Fang Wang et al.   GLYCOBIOLOGY

Metabolism in cancer metastasis

(2015) Georg F. Weber   INTERNATIONAL JOURNAL OF CANCER

Dynamic Sialylation in Transforming Growth Factor-β (TGF-β)-induced Epithelial to Mesenchymal Transition

(2015) Jun Du et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genomic landscape of carcinogen-induced and genetically induced mouse skin squamous cell carcinoma

(2015) Dany Nassar et al.   NATURE MEDICINE

Sialic Acids Sweeten a Tumor's Life

(2014) C. Bull et al.   CANCER RESEARCH

Easy quantitative assessment of genome editing by sequence trace decomposition

(2014) Eva K. Brinkman et al.   NUCLEIC ACIDS RESEARCH

Aberrant Glycosylation Promotes Lung Cancer Metastasis through Adhesion to Galectins in the Metastatic Niche

(2014) Nathan E. Reticker-Flynn et al.   Cancer Discovery

Altered Tumor-Cell Glycosylation Promotes Metastasis

(2014) Irina Häuselmann et al.   Frontiers in Oncology

Involvement of a Non-Human Sialic Acid in Human Cancer

(2014) Annie N. Samraj et al.   Frontiers in Oncology

LC–MS/MS quantification of N-acetylneuraminic acid, N-glycolylneuraminic acid and ketodeoxynonulosonic acid levels in the urine and potential relationship with dietary sialic acid intake and disease in 3- to 5-year-old children

(2013) Yue Chen et al.   BRITISH JOURNAL OF NUTRITION

Binding of the Sialic Acid-binding Lectin, Siglec-9, to the Membrane Mucin, MUC1, Induces Recruitment of β-Catenin and Subsequent Cell Growth

(2013) Shuhei Tanida et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting Aberrant Sialylation in Cancer Cells Using a Fluorinated Sialic Acid Analog Impairs Adhesion, Migration, and In Vivo Tumor Growth

(2013) C. Bull et al.   MOLECULAR CANCER THERAPEUTICS

Glycocalyx engineering reveals a Siglec-based mechanism for NK cell immunoevasion

(2013) Jason E Hudak et al.   Nature Chemical Biology

Roadblocks to translational advances on metastasis research

(2013) Thomas Brabletz et al.   NATURE MEDICINE

Cell Surface Sialic Acid Modulates Extracellular Matrix Adhesion and Migration in Pancreatic Adenocarcinoma Cells

(2013) Sònia Bassagañas et al.   PANCREAS

Metabolic Regulation of Epigenetics

(2012) Chao Lu et al.   Cell Metabolism

Occurrence of free deaminoneuraminic acid (KDN)-containing complex-type N-glycans in human prostate cancers

(2012) Masahiko Yabu et al.   GLYCOBIOLOGY

Metabolic Flux Increases Glycoprotein Sialylation: Implications for Cell Adhesion and Cancer Metastasis

(2012) Ruben T. Almaraz et al.   MOLECULAR & CELLULAR PROTEOMICS

Signaling in Control of Cell Growth and Metabolism

(2012) P. S. Ward et al.   Cold Spring Harbor Perspectives in Biology

Proinvasion Metastasis Drivers in Early-Stage Melanoma Are Oncogenes

(2011) Kenneth L. Scott et al.   CANCER CELL

Human Xeno-Autoantibodies against a Non-Human Sialic Acid Serve as Novel Serum Biomarkers and Immunotherapeutics in Cancer

(2011) V. Padler-Karavani et al.   CANCER RESEARCH

Selectin Ligand Sialyl-Lewis x Antigen Drives Metastasis of Hormone-Dependent Breast Cancers

(2011) S. Julien et al.   CANCER RESEARCH

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Metabolomic Analysis and Visualization Engine for LC−MS Data

(2010) Eugene Melamud et al.   ANALYTICAL CHEMISTRY

Assessment of Tumor Metastasis by the Direct Determination of Cell-Membrane Sialic Acid Expression

(2010) Akira Matsumoto et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Metabolism strikes back: metabolic flux regulates cell signaling

(2010) C. M. Metallo et al.   GENES & DEVELOPMENT

Metabolomic Changes Accompanying Transformation and Acquisition of Metastatic Potential in a Syngeneic Mouse Mammary Tumor Model

(2010) Xin Lu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tradeoff between enzyme and metabolite efficiency maintains metabolic homeostasis upon perturbations in enzyme capacity

(2010) Sarah-Maria Fendt et al.   Molecular Systems Biology

α2,3-Sialyltransferase ST3Gal III Modulates Pancreatic Cancer Cell Motility and Adhesion In Vitro and Enhances Its Metastatic Potential In Vivo

(2010) Marta Pérez-Garay et al.   PLoS One

An online survival analysis tool to rapidly assess the effect of 22,277 genes on breast cancer prognosis using microarray data of 1,809 patients

(2009) Balazs Györffy et al.   BREAST CANCER RESEARCH AND TREATMENT

Gene expression profiles and breast cancer metastasis: a genetic perspective

(2009) Kent W. Hunter et al.   CLINICAL & EXPERIMENTAL METASTASIS