Defining the Role of Solid Stress and Matrix Stiffness in Cancer Cell Proliferation and Metastasis

Solid Stress Facilitates Fibroblasts Activation to Promote Pancreatic Cancer Cell Migration

(2018) Maria Kalli et al.   ANNALS OF BIOMEDICAL ENGINEERING

Vasodilator-Stimulated Phosphoprotein (VASP) depletion from breast cancer MDA-MB-231 cells inhibits tumor spheroid invasion through downregulation of Migfilin, β-catenin and urokinase-plasminogen activator (uPA)

(2017) Vasiliki Gkretsi et al.   EXPERIMENTAL CELL RESEARCH

The Solid Mechanics of Cancer and Strategies for Improved Therapy

(2017) Triantafyllos Stylianopoulos   JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME

Single and collective cell migration: the mechanics of adhesions

(2017) Chiara De Pascalis et al.   MOLECULAR BIOLOGY OF THE CELL

Tissue Force Programs Cell Fate and Tumor Aggression

(2017) Jason J. Northey et al.   Cancer Discovery

Identification of Ras suppressor-1 (RSU-1) as a potential breast cancer metastasis biomarker using a three-dimensional in vitro approach

(2017) Vasiliki Gkretsi et al.   Oncotarget

Growth-induced stress enhances epithelial-mesenchymal transition induced by IL-6 in clear cell renal cell carcinoma via the Akt/GSK-3β/β-catenin signaling pathway

(2017) Q Chen et al.   Oncogenesis

Tumour mechanopathology: Cutting the stress out

(2017) Daniele M. Gilkes et al.   Nature Biomedical Engineering

Impact of the physical microenvironment on tumor progression and metastasis

(2016) Fabian Spill et al.   CURRENT OPINION IN BIOTECHNOLOGY

Mechanical signals regulate and activate SNAIL1 protein to control the fibrogenic response of cancer-associated fibroblasts

(2016) Kun Zhang et al.   JOURNAL OF CELL SCIENCE

Regulation of pancreatic cancer aggressiveness by stromal stiffening

(2016) Nicola Rath et al.   NATURE MEDICINE

Measuring cell-generated forces: a guide to the available tools

(2016) William J Polacheck et al.   NATURE METHODS

Hyaluronan-Derived Swelling of Solid Tumors, the Contribution of Collagen and Cancer Cells, and Implications for Cancer Therapy

(2016) Chrysovalantis Voutouri et al.   NEOPLASIA

Solid stress and elastic energy as measures of tumour mechanopathology

(2016) Hadi T. Nia et al.   Nature Biomedical Engineering

Osmotic Regulation Is Required for Cancer Cell Survival under Solid Stress

(2015) Daniel J. McGrail et al.   BIOPHYSICAL JOURNAL

Human breast cancer invasion and aggression correlates with ECM stiffening and immune cell infiltration

(2015) I. Acerbi et al.   Integrative Biology

Mechanical induction of the tumorigenic β-catenin pathway by tumour growth pressure

(2015) María Elena Fernández-Sánchez et al.   NATURE

Matrix stiffness drives epithelial–mesenchymal transition and tumour metastasis through a TWIST1–G3BP2 mechanotransduction pathway

(2015) Spencer C. Wei et al.   NATURE CELL BIOLOGY

Pancreatic stellate cells: A dynamic player of the intercellular communication in pancreatic cancer

(2015) Atsushi Masamune et al.   Clinics and Research in Hepatology and Gastroenterology

The Role of Mechanical Forces in Tumor Growth and Therapy

(2014) Rakesh K. Jain et al.   Annual Review of Biomedical Engineering

Compressive Stress Inhibits Proliferation in Tumor Spheroids through a Volume Limitation

(2014) Morgan Delarue et al.   BIOPHYSICAL JOURNAL

The role of cancer-associated fibroblasts, solid stress and other microenvironmental factors in tumor progression and therapy resistance

(2014) Gvantsa Kharaishvili et al.   Cancer Cell International

Role of Constitutive Behavior and Tumor-Host Mechanical Interactions in the State of Stress and Growth of Solid Tumors

(2014) Chrysovalantis Voutouri et al.   PLoS One

Coevolution of Solid Stress and Interstitial Fluid Pressure in Tumors During Progression: Implications for Vascular Collapse

(2013) Triantafyllos Stylianopoulos et al.   CANCER RESEARCH

Integrins in mechanotransduction

(2013) Tyler D Ross et al.   CURRENT OPINION IN CELL BIOLOGY

Microenvironmental regulation of tumor progression and metastasis

(2013) Daniela F Quail et al.   NATURE MEDICINE

Mechanical Stress Impairs Mitosis Progression in Multi-Cellular Tumor Spheroids

(2013) Annaïck Desmaison et al.   PLoS One

Cellular capsules as a tool for multicellular spheroid production and for investigating the mechanics of tumor progression in vitro

(2013) K. Alessandri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tuning three-dimensional collagen matrix stiffness independently of collagen concentration modulates endothelial cell behavior

(2012) Brooke N. Mason et al.   Acta Biomaterialia

Tumor cell migration in complex microenvironments

(2012) William J. Polacheck et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Cancer-Associated Fibroblasts Drive the Progression of Metastasis through both Paracrine and Mechanical Pressure on Cancer Tissue

(2012) G. S. Karagiannis et al.   MOLECULAR CANCER RESEARCH

Causes, consequences, and remedies for growth-induced solid stress in murine and human tumors

(2012) T. Stylianopoulos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Controlling matrix stiffness and topography for the study of tumor cell migration

(2012) Casey M. Kraning-Rush et al.   Cell Adhesion & Migration

3D in vitro bioengineered tumors based on collagen I hydrogels

(2011) Christopher S. Szot et al.   BIOMATERIALS

Actomyosin-Mediated Cellular Tension Drives Increased Tissue Stiffness and β-Catenin Activation to Induce Epidermal Hyperplasia and Tumor Growth

(2011) Michael S. Samuel et al.   CANCER CELL

Mechanical compression drives cancer cells toward invasive phenotype

(2011) J. M. Tse et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gene Expression Profiles in 3D Tumor Analogs Indicate Compressive Strain Differentially Enhances Metastatic Potential

(2010) Zoe N. Demou   ANNALS OF BIOMEDICAL ENGINEERING

Dynamic interplay between the collagen scaffold and tumor evolution

(2010) Mikala Egeblad et al.   CURRENT OPINION IN CELL BIOLOGY

The Mechanical Rigidity of the Extracellular Matrix Regulates the Structure, Motility, and Proliferation of Glioma Cells

(2009) T. A. Ulrich et al.   CANCER RESEARCH

Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling

(2009) Kandice R. Levental et al.   CELL

Matrix Architecture Dictates Three-Dimensional Migration Modes of Human Macrophages: Differential Involvement of Proteases and Podosome-Like Structures

(2009) E. Van Goethem et al.   JOURNAL OF IMMUNOLOGY

Filamin A–β1 Integrin Complex Tunes Epithelial Cell Response to Matrix Tension

(2009) Scott Gehler et al.   MOLECULAR BIOLOGY OF THE CELL

Micro-Environmental Mechanical Stress Controls Tumor Spheroid Size and Morphology by Suppressing Proliferation and Inducing Apoptosis in Cancer Cells

(2009) Gang Cheng et al.   PLoS One

Mechanically Activated Integrin Switch Controls  5 1 Function

(2009) J. C. Friedland et al.   SCIENCE

Cancer-Associated Stromal Fibroblasts Promote Pancreatic Tumor Progression

(2008) R. F. Hwang et al.   CANCER RESEARCH

Expression of p21waf1/Cip1 in stromal fibroblasts of primary breast tumors

(2008) G. Trimis et al.   HUMAN MOLECULAR GENETICS

Mechanotransduction - a field pulling together?

(2008) C. S. Chen   JOURNAL OF CELL SCIENCE