Tumor cell migration in complex microenvironments

Enzymatic Targeting of the Stroma Ablates Physical Barriers to Treatment of Pancreatic Ductal Adenocarcinoma

(2012) Paolo P. Provenzano et al.   CANCER CELL

EMT and Dissemination Precede Pancreatic Tumor Formation

(2012) Andrew D. Rhim et al.   CELL

Epithelial cell guidance by self-generated EGF gradients

(2012) Cally Scherber et al.   Integrative Biology

Spatial organization of the extracellular matrix regulates cell-cell junction positioning

(2012) Q. Tseng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A micropatterning and image processing approach to simplify measurement of cellular traction forces

(2011) Samuel R. Polio et al.   Acta Biomaterialia

Cooperation Between Integrins and Growth Factor Receptors in Signaling and Endocytosis

(2011) Johanna Ivaska et al.   Annual Review of Cell and Developmental Biology

Microfluidic devices for studying heterotypic cell-cell interactions and tissue specimen cultures under controlled microenvironments

(2011) Ioannis K. Zervantonakis et al.   Biomicrofluidics

Elucidating the Role of Matrix Stiffness in 3D Cell Migration and Remodeling

(2011) M. Ehrbar et al.   BIOPHYSICAL JOURNAL

Micrometer-scale oxygen delivery rearranges cells and prevents necrosis in tumor tissue in vitro

(2011) Bhushan J. Toley et al.   BIOTECHNOLOGY PROGRESS

Tumor Cell Invasion Is Promoted by Interstitial Flow-Induced Matrix Priming by Stromal Fibroblasts

(2011) A. C. Shieh et al.   CANCER RESEARCH

Intravital Imaging

(2011) Mikael J. Pittet et al.   CELL

Cancer Invasion and the Microenvironment: Plasticity and Reciprocity

(2011) Peter Friedl et al.   CELL

Cancer Dormancy: A Model of Early Dissemination and Late Cancer Recurrence

(2011) D. Paez et al.   CLINICAL CANCER RESEARCH

Cell communication networks in cancer invasion

(2011) Fernando Calvo et al.   CURRENT OPINION IN CELL BIOLOGY

Biophysical regulation of tumor cell invasion: moving beyond matrix stiffness

(2011) Amit Pathak et al.   Integrative Biology

Bio-inspired materials for parsing matrix physicochemical control of cell migration: A Review

(2011) Hyung-Do Kim et al.   Integrative Biology

The migration speed of cancer cells influenced by macrophages and myofibroblasts co-cultured in a microfluidic chip

(2011) Tsi-Hsuan Hsu et al.   Integrative Biology

Migration dynamics of breast cancer cells in a tunable 3D interstitial flow chamber

(2011) Ulrike Haessler et al.   Integrative Biology

Matrix stiffening sensitizes epithelial cells to EGF and enables the loss of contact inhibition of proliferation

(2011) J.-H. Kim et al.   JOURNAL OF CELL SCIENCE

Integrins and cadherins join forces to form adhesive networks

(2011) G. F. Weber et al.   JOURNAL OF CELL SCIENCE

Heparan Sulfate Proteoglycans Mediate Interstitial Flow Mechanotransduction Regulating MMP-13 Expression and Cell Motility via FAK-ERK in 3D Collagen

(2011) Zhong-Dong Shi et al.   PLoS One

Fluid Shear Stress Regulates the Invasive Potential of Glioma Cells via Modulation of Migratory Activity and Matrix Metalloproteinase Expression

(2011) Henry Qazi et al.   PLoS One

Tension, Free Space, and Cell Damage in a Microfluidic Wound Healing Assay

(2011) Michael Murrell et al.   PLoS One

Probing the invasiveness of prostate cancer cells in a 3D microfabricated landscape

(2011) L. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interstitial flow influences direction of tumor cell migration through competing mechanisms

(2011) W. J. Polacheck et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanical compression drives cancer cells toward invasive phenotype

(2011) J. M. Tse et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fluid forces control endothelial sprouting

(2011) J. W. Song et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stromal Endothelial Cells Directly Influence Cancer Progression

(2011) J. W. Franses et al.   Science Translational Medicine

Delivery of Molecular and Nanoscale Medicine to Tumors: Transport Barriers and Strategies

(2011) Vikash P. Chauhan et al.   Annual Review of Chemical and Biomolecular Engineering

Inhibition of epithelial to mesenchymal transition in metastatic breast carcinoma cells by c-Src suppression

(2010) Xiang Liu et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Latest Developments in Microfluidic Cell Biology and Analysis Systems

(2010) Georgette B. Salieb-Beugelaar et al.   ANALYTICAL CHEMISTRY

Engineering systems for the generation of patterned co-cultures for controlling cell–cell interactions

(2010) Hirokazu Kaji et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Pore size variable type I collagen gels and their interaction with glioma cells

(2010) Ya-li Yang et al.   BIOMATERIALS

Pericellular Conditions Regulate Extent of Cell-Mediated Compaction of Collagen Gels

(2010) Mark D. Stevenson et al.   BIOPHYSICAL JOURNAL

Cancer Cell Stiffness: Integrated Roles of Three-Dimensional Matrix Stiffness and Transforming Potential

(2010) Erin L. Baker et al.   BIOPHYSICAL JOURNAL

An Off-Lattice Hybrid Discrete-Continuum Model of Tumor Growth and Invasion

(2010) Junhwan Jeon et al.   BIOPHYSICAL JOURNAL

Molecular mechanisms underlying tumor dormancy

(2010) Nava Almog   CANCER LETTERS

Stretchy Proteins on Stretchy Substrates: The Important Elements of Integrin-Mediated Rigidity Sensing

(2010) Simon W. Moore et al.   DEVELOPMENTAL CELL

A new chemotaxis device for cell migration studies

(2010) Waseem Khan Raja et al.   Integrative Biology

Determinants of leader cells in collective cell migration

(2010) Antoine A. Khalil et al.   Integrative Biology

Transition to invasion in breast cancer: a microfluidic in vitro model enables examination of spatial and temporal effects

(2010) Kyung Eun Sung et al.   Integrative Biology

Integrins stimulate E-cadherin-mediated intercellular adhesion by regulating Src-kinase activation and actomyosin contractility

(2010) C. Martinez-Rico et al.   JOURNAL OF CELL SCIENCE

Crossing barriers: The new dimension of 2D cell migration assays

(2010) Remco van Horssen et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Carcinoma-associated fibroblasts promoted tumor spheroid invasion on a microfluidic 3D co-culture device

(2010) Tingjiao Liu et al.   LAB ON A CHIP

Nanoscale architecture of integrin-based cell adhesions

(2010) Pakorn Kanchanawong et al.   NATURE

Competition amongst Eph receptors regulates contact inhibition of locomotion and invasiveness in prostate cancer cells

(2010) Jonathan W. Astin et al.   NATURE CELL BIOLOGY

Ligand-independent activation of c-Met by fibronectin and α5β1-integrin regulates ovarian cancer invasion and metastasis

(2010) A K Mitra et al.   ONCOGENE

Regulation of cell motile behavior by crosstalk between cadherin- and integrin-mediated adhesions

(2010) N. Borghi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Substrate Elasticity Regulates Skeletal Muscle Stem Cell Self-Renewal in Culture

(2010) P. M. Gilbert et al.   SCIENCE

Interstitial flow promotes vascular fibroblast, myofibroblast, and smooth muscle cell motility in 3-D collagen I via upregulation of MMP-1

(2009) Zhong-Dong Shi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Probing cellular mechanobiology in three-dimensional culture with collagen–agarose matrices

(2009) Theresa A. Ulrich et al.   BIOMATERIALS

Adaptive-Control Model for Neutrophil Orientation in the Direction of Chemical Gradients

(2009) Daniel Irimia et al.   BIOPHYSICAL JOURNAL

Extracellular Matrix Stiffness and Architecture Govern Intracellular Rheology in Cancer

(2009) Erin L. Baker et al.   BIOPHYSICAL JOURNAL

Electrotaxis of lung cancer cells in a multiple-electric-field chip

(2009) Ching-Wen Huang et al.   BIOSENSORS & BIOELECTRONICS

Staged stromal extracellular 3D matrices differentially regulate breast cancer cell responses through PI3K and beta1-integrins

(2009) Remedios Castelló-Cros et al.   BMC CANCER

The Mechanical Rigidity of the Extracellular Matrix Regulates the Structure, Motility, and Proliferation of Glioma Cells

(2009) T. A. Ulrich et al.   CANCER RESEARCH

Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling

(2009) Kandice R. Levental et al.   CELL

Spontaneous migration of cancer cells under conditions of mechanical confinement

(2009) Daniel Irimia et al.   Integrative Biology

Cells in 3D matrices under interstitial flow: Effects of extracellular matrix alignment on cell shear stress and drag forces

(2009) John A. Pedersen et al.   JOURNAL OF BIOMECHANICS

FAK alters invadopodia and focal adhesion composition and dynamics to regulate breast cancer invasion

(2009) Keefe T. Chan et al.   JOURNAL OF CELL BIOLOGY

Protease-dependent versus -independent cancer cell invasion programs: three-dimensional amoeboid movement revisited

(2009) Farideh Sabeh et al.   JOURNAL OF CELL BIOLOGY

One-dimensional topography underlies three-dimensional fibrillar cell migration

(2009) Andrew D. Doyle et al.   JOURNAL OF CELL BIOLOGY

Src kinases as therapeutic targets for cancer

(2009) Lori C. Kim et al.   Nature Reviews Clinical Oncology

Random versus directionally persistent cell migration

(2009) Ryan J. Petrie et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Matrix density-induced mechanoregulation of breast cell phenotype, signaling and gene expression through a FAK–ERK linkage

(2009) P P Provenzano et al.   ONCOGENE

Micro-Environmental Mechanical Stress Controls Tumor Spheroid Size and Morphology by Suppressing Proliferation and Inducing Apoptosis in Cancer Cells

(2009) Gang Cheng et al.   PLoS One

Chemoattractant Signaling between Tumor Cells and Macrophages Regulates Cancer Cell Migration, Metastasis and Neovascularization

(2009) Chad E. Green et al.   PLoS One

Differential Matrix Rigidity Response in Breast Cancer Cell Lines Correlates with the Tissue Tropism

(2009) Ana Kostic et al.   PLoS One

The Extracellular Matrix: Not Just Pretty Fibrils

(2009) R. O. Hynes   SCIENCE

Mechanically Activated Integrin Switch Controls  5 1 Function

(2009) J. C. Friedland et al.   SCIENCE

Guiding cell migration in 3D: A collagen matrix with graded directional stiffness

(2009) Ektoras Hadjipanayi et al.   CELL MOTILITY AND THE CYTOSKELETON

Contact Guidance Mediated Three-Dimensional Cell Migration is Regulated by Rho/ROCK-Dependent Matrix Reorganization

(2008) Paolo P. Provenzano et al.   BIOPHYSICAL JOURNAL

The Inhibition of Tumor Cell Intravasation and Subsequent Metastasis via Regulation of In Vivo Tumor Cell Motility by the Tetraspanin CD151

(2008) Andries Zijlstra et al.   CANCER CELL

Tube Travel: The Role of Proteases in Individual and Collective Cancer Cell Invasion

(2008) P. Friedl et al.   CANCER RESEARCH

Vascular Endothelial Growth Factor-C and C-C Chemokine Receptor 7 in Tumor Cell-Lymphatic Cross-talk Promote Invasive Phenotype

(2008) A. Issa et al.   CANCER RESEARCH

Extracellular Matrix Rigidity Promotes Invadopodia Activity

(2008) Nelson R. Alexander et al.   CURRENT BIOLOGY

Dynamic imaging of cancer growth and invasion: a modified skin-fold chamber model

(2008) Stephanie Alexander et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Stromal myofibroblasts are drivers of invasive cancer growth

(2008) Olivier De Wever et al.   INTERNATIONAL JOURNAL OF CANCER

Modelling cell migration strategies in the extracellular matrix

(2008) K. J. Painter   JOURNAL OF MATHEMATICAL BIOLOGY

Controlled cocultures of HeLa cells and human umbilical vein endothelial cells on detachable substrates

(2008) Hirokazu Kaji et al.   LAB ON A CHIP

Cell migration into scaffolds under co-culture conditions in a microfluidic platform

(2008) Seok Chung et al.   LAB ON A CHIP

Identification of genes that regulate epithelial cell migration using an siRNA screening approach

(2008) Kaylene J. Simpson et al.   NATURE CELL BIOLOGY