期刊
REDOX BIOLOGY
卷 2, 期 -, 页码 963-970出版社
ELSEVIER
DOI: 10.1016/j.redox.2014.08.002
关键词
Ketogenic diet; Oxidative stress; Cancer therapy
资金
- Carver Research Program of Excellence in Redox Biology and Medicine [R01CA133114, R21CA161182, R01182804-01, R21CA139182, P30CA086862, UL1TR000442]
- RSNA Research and Educational Foundation [RR1020]
Cancer cells, relative to normal cells, demonstrate significant alterations in metabolism that are proposed to result in increased steady-state levels of mitochonclrial-derived reactive oxygen species (ROS) such as O-2(center dot-) and H2O2. It has also been proposed that cancer cells increase glucose and hydroperoxide metabolism to compensate for increased levels of ROS. Given this theoretical construct, it is reasonable to propose that forcing cancer cells to use mitochondrial oxidative metabolism by feeding ketogenic diets that are high in fats and low in glucose and other carbohydrates, would selectively cause metabolic oxidative stress in cancer versus normal cells. Increased metabolic oxidative stress in cancer cells would in turn be predicted to selectively sensitize cancer cells to conventional radiation and chemotherapies. This review summarizes the evidence supporting the hypothesis that ketogenic diets may be safely used as an adjuvant therapy to conventional radiation and chemotherapies and discusses the proposed mechanisms by which ketogenic diets may enhance cancer cell therapeutic responses. (C) 2014 The Authors. Published by Elsevier B.V.
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