标题
CRISPR/Cascade 9-Mediated Genome Editing-Challenges and Opportunities
作者
关键词
-
出版物
Frontiers in Genetics
Volume 9, Issue -, Pages -
出版商
Frontiers Media SA
发表日期
2018-07-05
DOI
10.3389/fgene.2018.00240
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Partial DNA-guided Cas9 enables genome editing with reduced off-target activity
- (2018) Hao Yin et al. Nature Chemical Biology
- CRISPR/Cas9-mediated somatic and germline gene correction to restore hemostasis in hemophilia B mice
- (2017) Cong Huai et al. HUMAN GENETICS
- Liver cyst gene knockout in cholangiocytes inhibits cilium formation and Wnt signaling
- (2017) Edgar S Wills et al. HUMAN MOLECULAR GENETICS
- CRISPR-Mediated Base Editing Enables Efficient Disruption of Eukaryotic Genes through Induction of STOP Codons
- (2017) Pierre Billon et al. MOLECULAR CELL
- Gene Targeting by Homology-Directed Repair in Rice Using a Geminivirus-Based CRISPR/Cas9 System
- (2017) Mugui Wang et al. Molecular Plant
- RNA targeting with CRISPR–Cas13
- (2017) Omar O. Abudayyeh et al. NATURE
- Programmable base editing of A•T to G•C in genomic DNA without DNA cleavage
- (2017) Nicole M. Gaudelli et al. NATURE
- Correction of a pathogenic gene mutation in human embryos
- (2017) Hong Ma et al. NATURE
- CRISPR-STOP: gene silencing through base-editing-induced nonsense mutations
- (2017) Cem Kuscu et al. NATURE METHODS
- Delivery technologies for genome editing
- (2017) Hao Yin et al. NATURE REVIEWS DRUG DISCOVERY
- Generation of stable nulliplex autopolyploid lines of Arabidopsis thaliana using CRISPR/Cas9 genome editing
- (2017) Peter Ryder et al. PLANT CELL REPORTS
- Evolutionarily conserved TRH neuropeptide pathway regulates growth inCaenorhabditis elegans
- (2017) Elien Van Sinay et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Inactivation of porcine endogenous retrovirus in pigs using CRISPR-Cas9
- (2017) Dong Niu et al. SCIENCE
- Nrl knockdown by AAV-delivered CRISPR/Cas9 prevents retinal degeneration in mice
- (2017) Wenhan Yu et al. Nature Communications
- A Scalable Epitope Tagging Approach for High Throughput ChIP-Seq Analysis
- (2017) Xiong Xiong et al. ACS Synthetic Biology
- CRISPR/Cas9-mediated targeted gene correction in amyotrophic lateral sclerosis patient iPSCs
- (2017) Lixia Wang et al. Protein & Cell
- CRISPR/Cas9 mediated chicken Stra8 gene knockout and inhibition of male germ cell differentiation
- (2017) Yani Zhang et al. PLoS One
- Enhancing Targeted Genomic DNA Editing in Chicken Cells Using the CRISPR/Cas9 System
- (2017) Ling Wang et al. PLoS One
- Targeted RP9 ablation and mutagenesis in mouse photoreceptor cells by CRISPR-Cas9
- (2017) Ji-Neng Lv et al. Scientific Reports
- Small molecules enhance CRISPR/Cas9-mediated homology-directed genome editing in primary cells
- (2017) Guoling Li et al. Scientific Reports
- CRISPR/Cas9 in Genome Editing and Beyond
- (2016) Haifeng Wang et al. Annual Review of Biochemistry
- Myostatin gene knockout mediated by Cas9-D10A nickase in chicken DF1 cells without off-target effect
- (2016) Jeong Hyo Lee et al. ASIAN-AUSTRALASIAN JOURNAL OF ANIMAL SCIENCES
- Efficient generation of Rosa26 knock-in mice using CRISPR/Cas9 in C57BL/6 zygotes
- (2016) Van Trung Chu et al. BMC BIOTECHNOLOGY
- S100A4 accelerates the proliferation and invasion of endometrioid carcinoma and is associated with the “MELF” pattern
- (2016) Shinichiro Tahara et al. CANCER SCIENCE
- Establishment of MAGEC2-knockout cells and functional investigation of MAGEC2 in tumor cells
- (2016) Jingjing Wang et al. CANCER SCIENCE
- Structure and Engineering of Francisella novicida Cas9
- (2016) Hisato Hirano et al. CELL
- Generation of porcine fetal fibroblasts expressing the tetracycline-inducible Cas9 gene by somatic cell nuclear transfer
- (2016) Guoqian Liu et al. Molecular Medicine Reports
- Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage
- (2016) Alexis C. Komor et al. NATURE
- High-fidelity CRISPR–Cas9 nucleases with no detectable genome-wide off-target effects
- (2016) Benjamin P. Kleinstiver et al. NATURE
- Therapeutic genome editing by combined viral and non-viral delivery of CRISPR system components in vivo
- (2016) Hao Yin et al. NATURE BIOTECHNOLOGY
- Directed evolution using dCas9-targeted somatic hypermutation in mammalian cells
- (2016) Gaelen T Hess et al. NATURE METHODS
- Knock-in of large reporter genes in human cells via CRISPR/Cas9-induced homology-dependent and independent DNA repair
- (2016) Xiangjun He et al. NUCLEIC ACIDS RESEARCH
- Effective knockdown ofDrosophilalong non-coding RNAs by CRISPR interference
- (2016) Sanjay Ghosh et al. NUCLEIC ACIDS RESEARCH
- pKAMA-ITACHI Vectors for Highly Efficient CRISPR/Cas9-Mediated Gene Knockout inArabidopsis thaliana
- (2016) Hiroki Tsutsui et al. PLANT AND CELL PHYSIOLOGY
- Generation of a heterozygous knockout human embryonic stem cell line for the OCIAD1 locus using CRISPR/CAS9 mediated targeting: BJNhem20-OCIAD1-CRISPR-20
- (2016) Deeti K. Shetty et al. Stem Cell Research
- ssODN-mediated knock-in with CRISPR-Cas for large genomic regions in zygotes
- (2016) Kazuto Yoshimi et al. Nature Communications
- Homology Directed Knockin of Point Mutations in the Zebrafish tardbp and fus Genes in ALS Using the CRISPR/Cas9 System
- (2016) Gary Alan Barclay Armstrong et al. PLoS One
- Genome-Wide Assessment of Efficiency and Specificity in CRISPR/Cas9 Mediated Multiple Site Targeting in Arabidopsis
- (2016) Brenda A. Peterson et al. PLoS One
- Deep Brain Photoreceptor (val-opsin) Gene Knockout Using CRISPR/Cas Affects Chorion Formation and Embryonic Hatching in the Zebrafish
- (2016) Chong Yee Hang et al. PLoS One
- CRISPR/Cas9-mediated gene knockout in the mouse brain using in utero electroporation
- (2016) Yohei Shinmyo et al. Scientific Reports
- CRISPR/cas9, a novel genomic tool to knock down microRNA in vitro and in vivo
- (2016) Hong Chang et al. Scientific Reports
- Knockout of Zebrafish Ovarian Aromatase Gene (cyp19a1a) by TALEN and CRISPR/Cas9 Leads to All-male Offspring Due to Failed Ovarian Differentiation
- (2016) Esther Shuk-Wa Lau et al. Scientific Reports
- Cpf1 Is a Single RNA-Guided Endonuclease of a Class 2 CRISPR-Cas System
- (2015) Bernd Zetsche et al. CELL
- Intron targeting-mediated and endogenous gene integrity-maintaining knockin in zebrafish using the CRISPR/Cas9 system
- (2015) Jia Li et al. CELL RESEARCH
- Heritable CRISPR/Cas9-mediated targeted integration in Xenopus tropicalis
- (2015) Zhaoying Shi et al. FASEB JOURNAL
- Targeted Chromosomal Translocations and Essential Gene Knockout Using CRISPR/Cas9 Technology in Caenorhabditis elegans
- (2015) X. Chen et al. GENETICS
- Multiplex Conditional Mutagenesis Using Transgenic Expression of Cas9 and sgRNAs
- (2015) Linlin Yin et al. GENETICS
- Error-Prone Repair of DNA Double-Strand Breaks
- (2015) Kasey Rodgers et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Functional analysis of Bombyx Wnt1 during embryogenesis using the CRISPR/Cas9 system
- (2015) Zhongjie Zhang et al. JOURNAL OF INSECT PHYSIOLOGY
- Ethics of embryo editing divides scientists
- (2015) David Cyranoski NATURE
- Don’t edit the human germ line
- (2015) Edward Lanphier et al. NATURE
- Engineered CRISPR-Cas9 nucleases with altered PAM specificities
- (2015) Benjamin P. Kleinstiver et al. NATURE
- A CRISPR-Cas9 gene drive system targeting female reproduction in the malaria mosquito vector Anopheles gambiae
- (2015) Andrew Hammond et al. NATURE BIOTECHNOLOGY
- MMP21 is mutated in human heterotaxy and is required for normal left-right asymmetry in vertebrates
- (2015) Anne Guimier et al. NATURE GENETICS
- MMEJ-assisted gene knock-in using TALENs and CRISPR-Cas9 with the PITCh systems
- (2015) Tetsushi Sakuma et al. Nature Protocols
- Highly efficient Cas9-mediated gene drive for population modification of the malaria vector mosquitoAnopheles stephensi
- (2015) Valentino M. Gantz et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Improved Hematopoietic Differentiation Efficiency of Gene-Corrected Beta-Thalassemia Induced Pluripotent Stem Cells by CRISPR/Cas9 System
- (2015) Bing Song et al. STEM CELLS AND DEVELOPMENT
- In-Yeast Engineering of a Bacterial Genome Using CRISPR/Cas9
- (2015) Iason Tsarmpopoulos et al. ACS Synthetic Biology
- Systematic Evaluation of Drosophila CRISPR Tools Reveals Safe and Robust Alternatives to Autonomous Gene Drives in Basic Research
- (2015) Fillip Port et al. G3-Genes Genomes Genetics
- Multiplex Conditional Mutagenesis Using Transgenic Expression of Cas9 and sgRNAs
- (2015) Linlin Yin et al. GENETICS
- Efficient generation of genome-modified mice via offset-nicking by CRISPR/Cas system
- (2014) Wataru Fujii et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- CRISPR-Cas9 Knockin Mice for Genome Editing and Cancer Modeling
- (2014) Randall J. Platt et al. CELL
- Generation of Gene-Modified Cynomolgus Monkey via Cas9/RNA-Mediated Gene Targeting in One-Cell Embryos
- (2014) Yuyu Niu et al. CELL
- Oligonucleotide-based targeted gene editing in C. elegans via the CRISPR/Cas9 system
- (2014) Pei Zhao et al. CELL RESEARCH
- Heritable/conditional genome editing in C. elegans using a CRISPR-Cas9 feeding system
- (2014) Pengpeng Liu et al. CELL RESEARCH
- Making designer mutants in model organisms
- (2014) Y. Peng et al. DEVELOPMENT
- Precise and efficient genome editing in zebrafish using the CRISPR/Cas9 system
- (2014) U. Irion et al. DEVELOPMENT
- Conditional Knockouts Generated by Engineered CRISPR-Cas9 Endonuclease Reveal the Roles of Coronin in C. elegans Neural Development
- (2014) Zhongfu Shen et al. DEVELOPMENTAL CELL
- Highly efficient multiplex targeted mutagenesis and genomic structure variation in Bombyx mori cells using CRISPR/Cas9
- (2014) Yuanyuan Liu et al. INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY
- CRISPR/Cas9 mediated genome engineering in Drosophila
- (2014) Andrew Bassett et al. METHODS
- Structural basis of PAM-dependent target DNA recognition by the Cas9 endonuclease
- (2014) Carolin Anders et al. NATURE
- Dimeric CRISPR RNA-guided FokI nucleases for highly specific genome editing
- (2014) Shengdar Q Tsai et al. NATURE BIOTECHNOLOGY
- Genome editing with Cas9 in adult mice corrects a disease mutation and phenotype
- (2014) Hao Yin et al. NATURE BIOTECHNOLOGY
- Multigene Knockout Utilizing Off-Target Mutations of the CRISPR/Cas9 System in Rice
- (2014) Masaki Endo et al. PLANT AND CELL PHYSIOLOGY
- Variation, Evolution, and Correlation Analysis of C+G Content and Genome or Chromosome Size in Different Kingdoms and Phyla
- (2014) Xiu-Qing Li et al. PLoS One
- Heritable Genome Editing with CRISPR/Cas9 in the Silkworm, Bombyx mori
- (2014) Wei Wei et al. PLoS One
- Optimized CRISPR/Cas tools for efficient germline and somatic genome engineering in Drosophila
- (2014) F. Port et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- CRISPR/Cas9 mediated multiplex genome editing and heritable mutagenesis of BmKu70 in Bombyx mori
- (2014) Sanyuan Ma et al. Scientific Reports
- Efficient Gene Knock-out and Knock-in with Transgenic Cas9 in Drosophila
- (2014) Zhaoyu Xue et al. G3-Genes Genomes Genetics
- Conditional targeting of Ispd using paired Cas9 nickase and a single DNA template in mice
- (2014) Angus Yiu-fai Lee et al. FEBS Open Bio
- Repurposing CRISPR as an RNA-Guided Platform for Sequence-Specific Control of Gene Expression
- (2013) Lei S. Qi et al. CELL
- One-Step Generation of Mice Carrying Reporter and Conditional Alleles by CRISPR/Cas-Mediated Genome Engineering
- (2013) Hui Yang et al. CELL
- Double Nicking by RNA-Guided CRISPR Cas9 for Enhanced Genome Editing Specificity
- (2013) F. Ann Ran et al. CELL
- CRISPR-Mediated Modular RNA-Guided Regulation of Transcription in Eukaryotes
- (2013) Luke A. Gilbert et al. CELL
- Generating rats with conditional alleles using CRISPR/Cas9
- (2013) Yuanwu Ma et al. CELL RESEARCH
- The CRISPR/Cas System mediates efficient genome engineering in Bombyx mori
- (2013) Yueqiang Wang et al. CELL RESEARCH
- Genetic correction using engineered nucleases for gene therapy applications
- (2013) Hongmei Lisa Li et al. DEVELOPMENT GROWTH & DIFFERENTIATION
- Heritable Gene Knockout in Caenorhabditis elegans by Direct Injection of Cas9–sgRNA Ribonucleoproteins
- (2013) Seung Woo Cho et al. GENETICS
- Highly efficient CRISPR/Cas9-mediated knock-in in zebrafish by homology-independent DNA repair
- (2013) T. O. Auer et al. GENOME RESEARCH
- Analysis of off-target effects of CRISPR/Cas-derived RNA-guided endonucleases and nickases
- (2013) S. W. Cho et al. GENOME RESEARCH
- Processing-Independent CRISPR RNAs Limit Natural Transformation in Neisseria meningitidis
- (2013) Yan Zhang et al. MOLECULAR CELL
- DNA targeting specificity of RNA-guided Cas9 nucleases
- (2013) Patrick D Hsu et al. NATURE BIOTECHNOLOGY
- Targeted genome engineering in human cells with the Cas9 RNA-guided endonuclease
- (2013) Seung Woo Cho et al. NATURE BIOTECHNOLOGY
- Multiplex and homologous recombination–mediated genome editing in Arabidopsis and Nicotiana benthamiana using guide RNA and Cas9
- (2013) Jian-Feng Li et al. NATURE BIOTECHNOLOGY
- High-throughput profiling of off-target DNA cleavage reveals RNA-programmed Cas9 nuclease specificity
- (2013) Vikram Pattanayak et al. NATURE BIOTECHNOLOGY
- Demonstration of CRISPR/Cas9/sgRNA-mediated targeted gene modification in Arabidopsis, tobacco, sorghum and rice
- (2013) Wenzhi Jiang et al. NUCLEIC ACIDS RESEARCH
- Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells
- (2013) Ophir Shalem et al. SCIENCE
- Multiplex Genome Engineering Using CRISPR/Cas Systems
- (2013) L. Cong et al. SCIENCE
- Highly Efficient Targeted Mutagenesis of Drosophila with the CRISPR/Cas9 System
- (2013) Andrew R. Bassett et al. Cell Reports
- Mutagenesis and homologous recombination in Drosophila cell lines using CRISPR/Cas9
- (2013) A. R. Bassett et al. Biology Open
- Meganucleases and Other Tools for Targeted Genome Engineering: Perspectives and Challenges for Gene Therapy
- (2011) George Silva et al. CURRENT GENE THERAPY
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