A need for NAD+ in muscle development, homeostasis, and aging

A conserved NAD + binding pocket that regulates protein-protein interactions during aging

(2017) Jun Li et al.   SCIENCE

Nicotinamide riboside kinases display redundancy in mediating nicotinamide mononucleotide and nicotinamide riboside metabolism in skeletal muscle cells

(2017) Rachel S. Fletcher et al.   Molecular Metabolism

NAD + Replenishment Improves Lifespan and Healthspan in Ataxia Telangiectasia Models via Mitophagy and DNA Repair

(2016) Evandro Fei Fang et al.   Cell Metabolism

Loss of NAD Homeostasis Leads to Progressive and Reversible Degeneration of Skeletal Muscle

(2016) David W. Frederick et al.   Cell Metabolism

Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice

(2016) Kathryn F. Mills et al.   Cell Metabolism

Loss of fibronectin from the aged stem cell niche affects the regenerative capacity of skeletal muscle in mice

(2016) Laura Lukjanenko et al.   NATURE MEDICINE

NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice

(2016) H. Zhang et al.   SCIENCE

NAD+ repletion improves muscle function in muscular dystrophy and counters global PARylation

(2016) D. Ryu et al.   Science Translational Medicine

Dysregulation of SIRT-1 in aging mice increases skeletal muscle fatigue by a PARP-1-dependent mechanism

(2016) Junaith S. Mohamed et al.   Aging-US

NAD+ Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus

(2015) Carles Cantó et al.   Cell Metabolism

The NAD+-Dependent SIRT1 Deacetylase Translates a Metabolic Switch into Regulatory Epigenetics in Skeletal Muscle Stem Cells

(2015) James G. Ryall et al.   Cell Stem Cell

Hanging on for the ride: Adhesion to the extracellular matrix mediates cellular responses in skeletal muscle morphogenesis and disease

(2015) Michelle F. Goody et al.   DEVELOPMENTAL BIOLOGY

Mitochondrial reticulum for cellular energy distribution in muscle

(2015) Brian Glancy et al.   NATURE

In vivo NAD assay reveals the intracellular NAD contents and redox state in healthy human brain and their age dependences

(2015) Xiao-Hong Zhu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nicotinamide phosphorybosiltransferase overexpression in thyroid malignancies and its correlation with tumor stage and with survivin/survivin DEx3 expression

(2015) Nadia Sawicka-Gutaj et al.   TUMOR BIOLOGY

Age affects the contraction-induced mitochondrial redox response in skeletal muscle

(2015) Dennis R. Claflin et al.   Frontiers in Physiology

Differentiation-Associated Downregulation of Poly(ADP-Ribose) Polymerase-1 Expression in Myoblasts Serves to Increase Their Resistance to Oxidative Stress

(2015) Gábor Oláh et al.   PLoS One

SRT2104 extends survival of male mice on a standard diet and preserves bone and muscle mass

(2014) Evi M. Mercken et al.   AGING CELL

MicroRNA-149 Inhibits PARP-2 and Promotes Mitochondrial Biogenesis via SIRT-1/PGC-1α Network in Skeletal Muscle

(2014) Junaith S. Mohamed et al.   DIABETES

Evidence for a Direct Effect of the NAD+Precursor Acipimox on Muscle Mitochondrial Function in Humans

(2014) Tineke van de Weijer et al.   DIABETES

Increasing NAD Synthesis in Muscle via Nicotinamide Phosphoribosyltransferase Is Not Sufficient to Promote Oxidative Metabolism

(2014) David W. Frederick et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial flashes: new insights into mitochondrial ROS signalling and beyond

(2014) Tingting Hou et al.   JOURNAL OF PHYSIOLOGY-LONDON

Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging

(2013) Ana P. Gomes et al.   CELL

The NAD+/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling

(2013) Laurent Mouchiroud et al.   CELL

Resveratrol Induces a Mitochondrial Complex I-dependent Increase in NADH Oxidation Responsible for Sirtuin Activation in Liver Cells

(2013) Valérie Desquiret-Dumas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AMP-activated protein kinase regulates nicotinamide phosphoribosyl transferase expression in skeletal muscle

(2013) Josef Brandauer et al.   JOURNAL OF PHYSIOLOGY-LONDON

Mitonuclear protein imbalance as a conserved longevity mechanism

(2013) Riekelt H. Houtkooper et al.   NATURE

Satellite Cells and the Muscle Stem Cell Niche

(2013) Hang Yin et al.   PHYSIOLOGICAL REVIEWS

Skeletal muscle aging and the mitochondrion

(2013) Matthew L. Johnson et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Laminins in basement membrane assembly

(2013) Erhard Hohenester et al.   Cell Adhesion & Migration

NAD+/NADH and skeletal muscle mitochondrial adaptations to exercise

(2012) Amanda T. White et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The diverse roles and clinical relevance of PARPs in DNA damage repair: Current state of the art

(2012) Mike De Vos et al.   BIOCHEMICAL PHARMACOLOGY

On PAR with PARP: cellular stress signaling through poly(ADP-ribose) and PARP-1

(2012) X. Luo et al.   GENES & DEVELOPMENT

Age-Associated Changes In Oxidative Stress and NAD+ Metabolism In Human Tissue

(2012) Hassina Massudi et al.   PLoS One

Skeletal muscle transcriptional coactivator PGC-1  mediates mitochondrial, but not metabolic, changes during calorie restriction

(2012) L. W. S. Finley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NAD+ Biosynthesis Ameliorates a Zebrafish Model of Muscular Dystrophy

(2012) Michelle F. Goody et al.   PLOS BIOLOGY

Fibrotic response induced by angiotensin-II requires NAD(P)H oxidase-induced reactive oxygen species (ROS) in skeletal muscle cells

(2011) Claudio Cabello-Verrugio et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

PARP-1 Inhibition Increases Mitochondrial Metabolism through SIRT1 Activation

(2011) Péter Bai et al.   Cell Metabolism

Compartmentation of NAD+ -dependent signalling

(2011) Friedrich Koch-Nolte et al.   FEBS LETTERS

P2X7 purinoceptor alterations in dystrophic mdx mouse muscles: relationship to pathology and potential target for treatment

(2011) Christopher N. J. Young et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Resveratrol Ameliorates Muscular Pathology in the Dystrophic mdx Mouse, a Model for Duchenne Muscular Dystrophy

(2011) Y. S. Hori et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Age Related Changes in NAD+ Metabolism Oxidative Stress and Sirt1 Activity in Wistar Rats

(2011) Nady Braidy et al.   PLoS One

Mitochondrial metabolic function assessed in vivo and in vitro

(2010) Ian R Lanza et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Nrk2b-mediated NAD+ production regulates cell adhesion and is required for muscle morphogenesis in vivo

(2010) Michelle F. Goody et al.   DEVELOPMENTAL BIOLOGY

Muscle type-specific responses to NAD+ salvage biosynthesis promote muscle function in Caenorhabditis elegans

(2010) Tracy L. Vrablik et al.   DEVELOPMENTAL BIOLOGY

NAMPT overexpression in prostate cancer and its contribution to tumor cell survival and stress response

(2010) B Wang et al.   ONCOGENE

Nicotinamide adenine dinucleotide extends the lifespan of Caenorhabditis elegans mediated by sir-2.1 and daf-16

(2009) Teppei Hashimoto et al.   BIOGERONTOLOGY

Exercise alters SIRT1, SIRT6, NAD and NAMPT levels in skeletal muscle of aged rats

(2009) Erika Koltai et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Role of NADH/NAD+ transport activity and glycogen store on skeletal muscle energy metabolism during exercise: in silico studies

(2008) Yanjun Li et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Superoxide Flashes in Single Mitochondria

(2008) Wang Wang et al.   CELL

Glucose Restriction Inhibits Skeletal Myoblast Differentiation by Activating SIRT1 through AMPK-Mediated Regulation of Nampt

(2008) Marcella Fulco et al.   DEVELOPMENTAL CELL