NAD+ repletion improves muscle function in muscular dystrophy and counters global PARylation

Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents

(2016) Dongryeol Ryu et al.   NATURE MEDICINE

NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice

(2016) H. Zhang et al.   SCIENCE

Systems proteomics of liver mitochondria function

(2016) E. G. Williams et al.   SCIENCE

NAD+ Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus

(2015) Carles Cantó et al.   Cell Metabolism

Fat deposition and accumulation in the damaged and inflamed skeletal muscle: cellular and molecular players

(2015) Clara Sciorati et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Eliciting the mitochondrial unfolded protein response by nicotinamide adenine dinucleotide repletion reverses fatty liver disease in mice

(2015) Karim Gariani et al.   HEPATOLOGY

Fasting and refeeding differentially regulate NLRP3 inflammasome activation in human subjects

(2015) Javier Traba et al.   JOURNAL OF CLINICAL INVESTIGATION

Tetracyclines Disturb Mitochondrial Function across Eukaryotic Models: A Call for Caution in Biomedical Research

(2015) Norman Moullan et al.   Cell Reports

Multilayered Genetic and Omics Dissection of Mitochondrial Activity in a Mouse Reference Population

(2014) Yibo Wu et al.   CELL

A SIRT7-Dependent Acetylation Switch of GABPβ1 Controls Mitochondrial Function

(2014) Dongryeol Ryu et al.   Cell Metabolism

Pharmacological Inhibition of Poly(ADP-Ribose) Polymerases Improves Fitness and Mitochondrial Function in Skeletal Muscle

(2014) Eija Pirinen et al.   Cell Metabolism

Asynchronous remodeling is a driver of failed regeneration in Duchenne muscular dystrophy

(2014) Sherry Dadgar et al.   JOURNAL OF CELL BIOLOGY

Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity

(2014) Daniel Kraus et al.   NATURE

Muscle-Specific SIRT1 Gain-of-Function Increases Slow-Twitch Fibers and Ameliorates Pathophysiology in a Mouse Model of Duchenne Muscular Dystrophy

(2014) Angeliki Chalkiadaki et al.   PLoS Genetics

Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging

(2013) Ana P. Gomes et al.   CELL

The NAD+/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling

(2013) Laurent Mouchiroud et al.   CELL

Type 2 Innate Signals Stimulate Fibro/Adipogenic Progenitors to Facilitate Muscle Regeneration

(2013) Jose E. Heredia et al.   CELL

Newborn bloodspot screening for Duchenne Muscular Dystrophy: 21 years experience in Wales (UK)

(2013) Stuart J Moat et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Poly (ADP-ribose) polymerase-1 is a key mediator of liver inflammation and fibrosis

(2013) Partha Mukhopadhyay et al.   HEPATOLOGY

SIRT1 Protein, by Blocking the Activities of Transcription Factors FoxO1 and FoxO3, Inhibits Muscle Atrophy and Promotes Muscle Growth

(2013) Donghoon Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Intracellular redox state revealed by in vivo31P MRS measurement of NAD+and NADH contents in brains

(2013) Ming Lu et al.   MAGNETIC RESONANCE IN MEDICINE

Role of sirtuins in lifespan regulation is linked to methylation of nicotinamide

(2013) Kathrin Schmeisser et al.   Nature Chemical Biology

Therapy for Duchenne muscular dystrophy: renewed optimism from genetic approaches

(2013) Rebecca J. Fairclough et al.   NATURE REVIEWS GENETICS

Nitric Oxide Controls Fat Deposition in Dystrophic Skeletal Muscle by Regulating Fibro-Adipogenic Precursor Differentiation

(2013) Nicoletta Cordani et al.   STEM CELLS

Evidence-based path to newborn screening for duchenne muscular dystrophy

(2012) Jerry R. Mendell et al.   ANNALS OF NEUROLOGY

Guidelines for the use and interpretation of assays for monitoring autophagy

(2012) Daniel J. Klionsky et al.   Autophagy

Systems Genetics of Metabolism: The Use of the BXD Murine Reference Panel for Multiscalar Integration of Traits

(2012) Pénélope A. Andreux et al.   CELL

The NAD+ Precursor Nicotinamide Riboside Enhances Oxidative Metabolism and Protects against High-Fat Diet-Induced Obesity

(2012) Carles Cantó et al.   Cell Metabolism

Cellular and molecular mechanisms of muscle atrophy

(2012) P. Bonaldo et al.   Disease Models & Mechanisms

Impaired adaptability of in vivo mitochondrial energetics to acute oxidative insult in aged skeletal muscle

(2012) Michael P. Siegel et al.   MECHANISMS OF AGEING AND DEVELOPMENT

NAD+ Biosynthesis Ameliorates a Zebrafish Model of Muscular Dystrophy

(2012) Michelle F. Goody et al.   PLOS BIOLOGY

NCoR1 Is a Conserved Physiological Modulator of Muscle Mass and Oxidative Function

(2011) Hiroyasu Yamamoto et al.   CELL

Nicotinamide Mononucleotide, a Key NAD+ Intermediate, Treats the Pathophysiology of Diet- and Age-Induced Diabetes in Mice

(2011) Jun Yoshino et al.   Cell Metabolism

PARP-1 Inhibition Increases Mitochondrial Metabolism through SIRT1 Activation

(2011) Péter Bai et al.   Cell Metabolism

PARP inhibitors: New tools to protect from inflammation

(2010) Vincenzo Giansanti et al.   BIOCHEMICAL PHARMACOLOGY

The Secret Life of NAD+: An Old Metabolite Controlling New Metabolic Signaling Pathways

(2010) Riekelt H. Houtkooper et al.   ENDOCRINE REVIEWS

Muscle injury activates resident fibro/adipogenic progenitors that facilitate myogenesis

(2010) Aaron W. B. Joe et al.   NATURE CELL BIOLOGY

Telomere shortening is associated to TRF1 and PARP1 overexpression in Duchenne muscular dystrophy

(2010) M’Hammed Aguennouz et al.   NEUROBIOLOGY OF AGING

Intracellular NAD levels regulate tumor necrosis factor protein synthesis in a sirtuin-dependent manner

(2009) Frédéric Van Gool et al.   NATURE MEDICINE

Genetic background determines metabolic phenotypes in the mouse

(2008) Marie-France Champy et al.   MAMMALIAN GENOME