In Vitro Exposure to Prostratin but Not Bryostatin-1 Improves Natural Killer Cell Functions Including Killing of CD4+ T Cells Harboring Reactivated Human Immunodeficiency Virus

NK cells of HIV-1-infected patients with poor CD4 + T-cell reconstitution despite suppressive HAART show reduced IFN-γ production and high frequency of autoreactive CD56 bright cells

(2017) Erica Giuliani et al.   IMMUNOLOGY LETTERS

The histone deacetylase inhibitor SAHA simultaneously reactivates HIV-1 from latency and up-regulates NKG2D ligands sensitizing for natural killer cell cytotoxicity

(2017) Maria Giovanna Desimio et al.   VIROLOGY

Bryostatin-1 for latent virus reactivation in HIV-infected patients on antiretroviral therapy

(2016) Carolina Gutiérrez et al.   AIDS

A Novel Toll-Like Receptor 9 Agonist, MGN1703, Enhances HIV-1 Transcription and NK Cell-Mediated Inhibition of HIV-1-Infected Autologous CD4+T Cells

(2016) Rasmus Offersen et al.   JOURNAL OF VIROLOGY

Enhanced clearance of HIV-1-infected cells by broadly neutralizing antibodies against HIV-1 in vivo

(2016) C.-L. Lu et al.   SCIENCE

Latency reversal and viral clearance to cure HIV-1

(2016) D. M. Margolis et al.   SCIENCE

Elimination of HIV-1-infected cells by broadly neutralizing antibodies

(2016) Timothée Bruel et al.   Nature Communications

Histone Deacetylase Inhibitors Enhance CD4 T Cell Susceptibility to NK Cell Killing but Reduce NK Cell Function

(2016) Matthew Pace et al.   PLoS Pathogens

HIV Latency-Reversing Agents Have Diverse Effects on Natural Killer Cell Function

(2016) Carolina Garrido et al.   Frontiers in Immunology

The Effect of Latency Reversal Agents on Primary CD8 + T Cells: Implications for Shock and Kill Strategies for Human Immunodeficiency Virus Eradication

(2016) Victoria E. Walker-Sperling et al.   EBioMedicine

Erratum: Corrigendum: The differential short- and long-term effects of HIV-1 latency-reversing agents on T cell function

(2016) G. Clutton et al.   Scientific Reports

Ex vivo analysis identifies effective HIV-1 latency–reversing drug combinations

(2015) Gregory M. Laird et al.   JOURNAL OF CLINICAL INVESTIGATION

In VivoActivation of Human NK Cells by Treatment with an Interleukin-15 Superagonist Potently Inhibits AcuteIn VivoHIV-1 Infection in Humanized Mice

(2015) Kieran Seay et al.   JOURNAL OF VIROLOGY

Innate Immune Activity Correlates with CD4 T Cell-Associated HIV-1 DNA Decline during Latency-Reversing Treatment with Panobinostat

(2015) Rikke Olesen et al.   JOURNAL OF VIROLOGY

Broad CTL response is required to clear latent HIV-1 due to dominance of escape mutations

(2015) Kai Deng et al.   NATURE

HIV reservoirs as obstacles and opportunities for an HIV cure

(2015) Tae-Wook Chun et al.   NATURE IMMUNOLOGY

An In-Depth Comparison of Latency-Reversing Agent Combinations in Various In Vitro and Ex Vivo HIV-1 Latency Models Identified Bryostatin-1+JQ1 and Ingenol-B+JQ1 to Potently Reactivate Viral Gene Expression

(2015) Gilles Darcis et al.   PLoS Pathogens

The Depsipeptide Romidepsin Reverses HIV-1 Latency In Vivo

(2015) Ole S. Søgaard et al.   PLoS Pathogens

Broadly Neutralizing Antibodies and Viral Inducers Decrease Rebound from HIV-1 Latent Reservoirs in Humanized Mice

(2014) Ariel Halper-Stromberg et al.   CELL

New ex vivo approaches distinguish effective and ineffective single agents for reversing HIV-1 latency in vivo

(2014) C Korin Bullen et al.   NATURE MEDICINE

Activation of HIV Transcription with Short-Course Vorinostat in HIV-Infected Patients on Suppressive Antiretroviral Therapy

(2014) Julian H. Elliott et al.   PLoS Pathogens

Histone Deacetylase Inhibitors Impair the Elimination of HIV-Infected Cells by Cytotoxic T-Lymphocytes

(2014) Richard Brad Jones et al.   PLoS Pathogens

Panobinostat, a histone deacetylase inhibitor, for latent-virus reactivation in HIV-infected patients on suppressive antiretroviral therapy: a phase 1/2, single group, clinical trial

(2014) Thomas A Rasmussen et al.   Lancet HIV

NK cell CD16 surface expression and function is regulated by a disintegrin and metalloprotease-17 (ADAM17)

(2013) R. Romee et al.   BLOOD

Soluble ligands for the NKG2D receptor are released during HIV-1 infection and impair NKG2D expression and cytotoxicity of NK cells

(2013) Giulia Matusali et al.   FASEB JOURNAL

Immune activation and HIV persistence: implications for curative approaches to HIV infection

(2013) Nichole R. Klatt et al.   IMMUNOLOGICAL REVIEWS

ADAM17-Mediated Shedding of Fc RIIIA on Human NK Cells: Identification of the Cleavage Site and Relationship with Activation

(2013) L. Lajoie et al.   JOURNAL OF IMMUNOLOGY

Marine natural products: Bryostatins in preclinical and clinical studies

(2013) Peter Kollár et al.   PHARMACEUTICAL BIOLOGY

Stimulation of HIV-1-Specific Cytolytic T Lymphocytes Facilitates Elimination of Latent Viral Reservoir after Virus Reactivation

(2012) Liang Shan et al.   IMMUNITY

Virologically Suppressed HIV Patients Show Activation of NK Cells and Persistent Innate Immune Activation

(2012) G. F. Lichtfuss et al.   JOURNAL OF IMMUNOLOGY

Administration of vorinostat disrupts HIV-1 latency in patients on antiretroviral therapy

(2012) N. M. Archin et al.   NATURE

Shock and kill

(2012) Steven G. Deeks   NATURE

Immune-Correlates Analysis of an HIV-1 Vaccine Efficacy Trial

(2012) Barton F. Haynes et al.   NEW ENGLAND JOURNAL OF MEDICINE

HDAC inhibitors in HIV

(2011) Fiona Wightman et al.   IMMUNOLOGY AND CELL BIOLOGY

Expression and reactivation of HIV in a chemokine induced model of HIV latency in primary resting CD4+ T cells

(2011) Suha Saleh et al.   Retrovirology

ADAM17: a molecular switch to control inflammation and tissue regeneration

(2011) Jürgen Scheller et al.   TRENDS IN IMMUNOLOGY

Bryostatin Modulates Latent HIV-1 Infection via PKC and AMPK Signaling but Inhibits Acute Infection in a Receptor Independent Manner

(2010) Rajeev Mehla et al.   PLoS One

The HIV-1 Nef protein has a dual role in T cell receptor signaling in infected CD4+ T lymphocytes

(2010) Francesca Neri et al.   VIROLOGY

HIV-1 Vpr up-regulates expression of ligands for the activating NKG2D receptor and promotes NK cell-mediated killing

(2009) J. Richard et al.   BLOOD

Suberoylanilide Hydroxamic Acid Reactivates HIV from Latently Infected Cells

(2009) Xavier Contreras et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein Kinase C-  Is Required for NK Cell Activation and In Vivo Control of Tumor Progression

(2009) J. I. Aguilo et al.   JOURNAL OF IMMUNOLOGY

Matrix Metalloprotease Inhibitors Restore Impaired NK Cell-Mediated Antibody-Dependent Cellular Cytotoxicity in Human Immunodeficiency Virus Type 1 Infection

(2009) Q. Liu et al.   JOURNAL OF VIROLOGY

Synergistic Activation of HIV-1 Expression by Deacetylase Inhibitors and Prostratin: Implications for Treatment of Latent Infection

(2009) Sophie Reuse et al.   PLoS One

HIV-1 Vpr Triggers Natural Killer Cell–Mediated Lysis of Infected Cells through Activation of the ATR-Mediated DNA Damage Response

(2009) Jeffrey Ward et al.   PLoS Pathogens

NK cell-activating receptors require PKC-  for sustained signaling, transcriptional activation, and IFN-  secretion

(2008) I. Tassi et al.   BLOOD

Functions of natural killer cells

(2008) Eric Vivier et al.   NATURE IMMUNOLOGY

Lysis of Endogenously Infected CD4+ T Cell Blasts by rIL-2 Activated Autologous Natural Killer Cells from HIV-Infected Viremic Individuals

(2008) Manuela Fogli et al.   PLoS Pathogens