Cyclic AMP Pathway Suppress Autoimmune Neuroinflammation by Inhibiting Functions of Encephalitogenic CD4 T Cells and Enhancing M2 Macrophage Polarization at the Site of Inflammation

The Role of ERK Signaling in Experimental Autoimmune Encephalomyelitis

(2017) Katharina Birkner et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Puerarin inhibits M2 polarization and metastasis of tumor-associated macrophages from NSCLC xenograft model via inactivating MEK/ERK 1/2 pathway

(2017) Honggang Kang et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Differential induction of ATF3 and HO-1 in myeloid cells and keratinocytes via Dimethylfumarate or Cyclosporine A

(2017) Stefanie Müller et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Cyclic AMP signaling restricts activation and promotes maturation and antioxidant defenses in astrocytes

(2016) Sonia Paco et al.   BMC GENOMICS

Peripheral and central neuronal ATF3 precedes CD4+ T-cell infiltration in EAE

(2016) Noémie Frezel et al.   EXPERIMENTAL NEUROLOGY

Prostaglandin E2 promotes M2 polarization of macrophages via a cAMP/CREB signaling pathway and deactivates granulocytes in teleost fish

(2016) Jana Montero et al.   FISH & SHELLFISH IMMUNOLOGY

The Natural cAMP Elevating Compound Forskolin in Cancer Therapy: Is It Time?

(2016) Luigi Sapio et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Frontline Science: ATF3 is responsible for the inhibition of TNF-α release and the impaired migration of acute ethanol-exposed monocytes and macrophages

(2016) Chaojie Hu et al.   JOURNAL OF LEUKOCYTE BIOLOGY

A polarizing question: do M1 and M2 microglia exist?

(2016) Richard M Ransohoff   NATURE NEUROSCIENCE

Molecular Mechanisms for cAMP-Mediated Immunoregulation in T cells – Role of Anchored Protein Kinase A Signaling Units

(2016) Vanessa L. Wehbi et al.   Frontiers in Immunology

High-density lipoprotein inhibits human M1 macrophage polarization through redistribution of caveolin-1

(2015) Man K S Lee et al.   BRITISH JOURNAL OF PHARMACOLOGY

Curcumin Modulates Macrophage Polarization Through the Inhibition of the Toll-Like Receptor 4 Expression and its Signaling Pathways

(2015) Yaoyao Zhou et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Platelets Play Differential Role During the Initiation and Progression of Autoimmune NeuroinflammationNovelty and Significance

(2015) Sarah C. Starossom et al.   CIRCULATION RESEARCH

ATF3 Is a Key Regulator of Macrophage IFN Responses

(2015) Larisa I. Labzin et al.   JOURNAL OF IMMUNOLOGY

ERK Signaling Is Essential for Macrophage Development

(2015) Edward T. Richardson et al.   PLoS One

CREB pathway links PGE2 signaling with macrophage polarization

(2015) Bing Luan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

cAMP-responsive Element-binding Protein (CREB) and cAMP Co-regulate Activator Protein 1 (AP1)-dependent Regeneration-associated Gene Expression and Neurite Growth

(2014) Thong C. Ma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neuroinflammation and M2 microglia: the good, the bad, and the inflamed

(2014) Jonathan D Cherry et al.   Journal of Neuroinflammation

Role of MAPK signal pathways in differentiation process of M2 macrophages induced by high-ambient glucose and TGF-β1

(2014) Ning Su et al.   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

ROS play a critical role in the differentiation of alternatively activated macrophages and the occurrence of tumor-associated macrophages

(2013) Yan Zhang et al.   CELL RESEARCH

Polarization profiles of human M-CSF-generated macrophages and comparison of M1-markers in classically activated macrophages from GM-CSF and M-CSF origin

(2013) Marie Jaguin et al.   CELLULAR IMMUNOLOGY

Forskolin-inducible cAMP Pathway Negatively Regulates T-cell Proliferation by Uncoupling the Interleukin-2 Receptor Complex

(2013) Georgialina Rodriguez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IL-4 directly signals tissue-resident macrophages to proliferate beyond homeostatic levels controlled by CSF-1

(2013) Stephen J. Jenkins et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Shaping the Murine Macrophage Phenotype: IL-4 and Cyclic AMP Synergistically Activate the Arginase I Promoter

(2013) K. E. Sheldon et al.   JOURNAL OF IMMUNOLOGY

Sustained Activation of ERK1/2 MAPK in Oligodendrocytes and Schwann Cells Enhances Myelin Growth and Stimulates Oligodendrocyte Progenitor Expansion

(2013) A. Ishii et al.   JOURNAL OF NEUROSCIENCE

Platelets Recognize Brain-Specific Glycolipid Structures, Respond to Neurovascular Damage and Promote Neuroinflammation

(2013) Ilya Sotnikov et al.   PLoS One

IL-4/IL-13-Dependent and Independent Expression of miR-124 and Its Contribution to M2 Phenotype of Monocytic Cells in Normal Conditions and during Allergic Inflammation

(2013) Tatyana Veremeyko et al.   PLoS One

TGFβ signaling plays a critical role in promoting alternative macrophage activation

(2012) Dapeng Gong et al.   BMC IMMUNOLOGY

MicroRNAs are universal regulators of differentiation, activation, and polarization of microglia and macrophages in normal and diseased CNS

(2012) Eugene D. Ponomarev et al.   GLIA

Divergent requirement for Gαs and cAMP in the differentiation and inflammatory profile of distinct mouse Th subsets

(2012) Xiangli Li et al.   JOURNAL OF CLINICAL INVESTIGATION

Polar Opposites: Erk Direction of CD4 T Cell Subsets

(2012) C.-F. Chang et al.   JOURNAL OF IMMUNOLOGY

Detection of MicroRNAs in Microglia by Real-time PCR in Normal CNS and During Neuroinflammation

(2012) Tatiana Veremeyko et al.   Jove-Journal of Visualized Experiments

Cyclic AMP induces apoptosis in multiple myeloma cells and inhibits tumor development in a mouse myeloma model

(2011) Virginie Follin-Arbelet et al.   BMC CANCER

GM-CSF: the secret weapon in the TH17 arsenal

(2011) Mandy J McGeachy   NATURE IMMUNOLOGY

Infiltrating monocytes trigger EAE progression, but do not contribute to the resident microglia pool

(2011) Bahareh Ajami et al.   NATURE NEUROSCIENCE

Local Macrophage Proliferation, Rather than Recruitment from the Blood, Is a Signature of TH2 Inflammation

(2011) S. J. Jenkins et al.   SCIENCE

Gi/o Protein-Dependent and -Independent Actions of Pertussis Toxin (PTX)

(2011) Supachoke Mangmool et al.   Toxins

Gene expression analysis of cell death induction by Taurolidine in different malignant cell lines

(2010) Ansgar M Chromik et al.   BMC CANCER

How ERK1/2 activation controls cell proliferation and cell death: Is subcellular localization the answer?

(2010) Yohannes Mebratu et al.   CELL CYCLE

cAMP Modulates Macrophage Development by Suppressing M-CSF-Induced MAPKs Activation

(2010) Ning Zhu et al.   Cellular & Molecular Immunology

ATF3, an adaptive-response gene, enhances TGF  signaling and cancer-initiating cell features in breast cancer cells

(2010) X. Yin et al.   JOURNAL OF CELL SCIENCE

MicroRNA-124 promotes microglia quiescence and suppresses EAE by deactivating macrophages via the C/EBP-α–PU.1 pathway

(2010) Eugene D Ponomarev et al.   NATURE MEDICINE

Mucosal adjuvant activity of cholera toxin requires Th17 cells and protects against inhalation anthrax

(2010) S. K. Datta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of ERK MAPK Suppresses IL-23- and IL-1-Driven IL-17 Production and Attenuates Autoimmune Disease

(2009) C. F. Brereton et al.   JOURNAL OF IMMUNOLOGY

Elevated cyclic AMP and PDE4 inhibition induce chemokine expression in human monocyte-derived macrophages

(2009) A. L. Hertz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A CREB-C/EBP  cascade induces M2 macrophage-specific gene expression and promotes muscle injury repair

(2009) D. Ruffell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA