Article
Immunology
Anny Carolline Silva Oliveira, Luisa Rezende, Vladimir Gorshkov, Marcella Nunes Melo-Braga, Thiago Verano-Braga, Weslley Fernandes-Braga, Jorge Luis de Melo Guadalupe, Gustavo Batista de Menezes, Frank Kjeldsen, Helida Monteiro de Andrade, Luciana de Oliveira Andrade
Summary: Trypanosoma cruzi invades non-professional phagocytic cells by subverting their membrane repair process. Cells lacking LAMP1 and LAMP2 are less permissive to parasite invasion, but more prone to parasite intracellular multiplication. The ability of parasites to invade cells may differ depending on the intracellular environment.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Immunology
Luciana L. Soprano, Maximiliano R. Ferrero, Thomas Jacobs, Alicia S. Couto, Vilma G. Duschak
Summary: Chagas disease caused by Trypanosoma cruzi is still a major problem in Latin America. Glycoproteins containing sulfated N-linked oligosaccharides play important roles in molecular recognition. Mice immunized with C-T showed pathological effects, indicating the importance of sulfated antigens in the disease. Antibodies specific for sulfotopes may serve as biomarkers for predicting the progression of cardiac Chagas disease.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Microbiology
Melissa L. L. Sykes, Emily K. K. Kennedy, Vicky M. M. Avery
Summary: Chagas disease is caused by infection with the protozoan parasite, Trypanosoma cruzi. The disease causes a high number of deaths annually and is classified as one of the neglected tropical diseases. The drug discovery pipeline for Chagas disease faces challenges with few new candidates and high attrition rates.
Article
Biochemistry & Molecular Biology
Pablo Igor Ribeiro Franco, Jose Rodrigues do Carmo Neto, Marina Pacheco Miguel, Juliana Reis Machado, Mara Rubia Nunes Celes
Summary: This review summarizes the main molecular mechanisms of T. cruzi-related carcinogenesis and the mechanisms associated with tumor protection mediated by different parasite components.
Review
Immunology
Maria Gabriela Libisch, Natalia Rego, Carlos Robello
Summary: Chagas Disease is caused by the complex taxon T. cruzi, affecting nearly eight million people worldwide. T. cruzi has the ability to infect and interact with almost any nucleated cell, triggering molecular signaling cascades that depend on cell type, strain, and experimental variables. Host cell responses to infection, particularly in the respiratory chain and oxidative phosphorylation, vary depending on the T. cruzi strain and experimental model, while some responses remain consistent across strains, cell types, and conditions.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Genetics & Heredity
Hans Desale, Pierre Buekens, Jackeline Alger, Maria Luisa Cafferata, Emily Wheeler Harville, Claudia Herrera, Carine Truyens, Eric Dumonteil
Summary: The study assessed the epigenetic effects of in utero exposure to maternal Trypanosoma cruzi infection. By comparing the DNA methylation patterns of umbilical cord blood cells from uninfected babies with chagasic and uninfected mothers, a differential DNA methylation signature was identified. The genes affected are related to hematopoietic cell differentiation, immune response, and developmental disorders.
Article
Biochemistry & Molecular Biology
Naiara Dutra Barroso Gomes, Emanuel Paula Magalhaes, Lyanna Rodrigues Ribeiro, John Washington Cavalcante, Marcelo Morais Gomes Maia, Felipe Ramon Cunha da Silva, Arif Ali, Marcia Machado Marinho, Emmanuel Silva Marinho, Helcio Silva dos Santos, Alice Maria Costa Martins, Ramon Roseo Paula Pessoa Bezerra de Menezes
Summary: This study evaluated the activity of synthetic p-aminochalcones against T. cruzi and found that they have a trypanocidal effect by causing membrane damage and oxidative stress. Their mechanism of action may be related to inhibition of cruzain and TR.
BIOORGANIC CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Fanny E. Eberhard, Sven Klimpel, Alessandra A. Guarneri, Nicholas J. Tobias
Summary: The study aimed to detect differences in the intestinal metabolome of the triatomine Rhodnius prolixus and predict exposure status to T. cruzi with high accuracies using logistic regression, a random forest classifier and a gradient boosting machine model. Important features for predicting exposure status and major metabolites for positive classification were identified, highlighting the complex interactions between triatomine vectors and parasites.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2021)
Article
Cardiac & Cardiovascular Systems
Maykon Tavares de Oliveira, Andre Schmidt, Maria Claudia da Silva, Eduardo Antonio Donadi, Joao Santana da Silva, Jose Antonio Marin-Neto
Summary: The study revealed that the blood parasite load in patients with CCC is highly variable and appears to be directly linked to the reduction of LVEF, an important prognostic indicator in CCC patients.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Microbiology
Eden R. Ferreira, Alexis Bonfim-Melo, Barbara A. Burleigh, Jaime A. Costales, Kevin M. Tyler, Renato A. Mortara
Summary: This study provides the first description of the coordinated mechanism by which T. cruzi escapes from host cells, involving remodeling of the host cell cytoskeleton and rupture of the host cell plasma membrane. The degradation of F-actin by parasite proteases plays a key role in triggering egress, which can be a potential target for novel therapeutic interventions.
Article
Immunology
Kayla J. J. Rayford, Ayorinde Cooley, Anthony W. W. Strode, Inmar Osi, Ashutosh Arun, Maria F. F. Lima, Smita Misra, Siddharth Pratap, Pius N. N. Nde
Summary: Trypanosoma cruzi is the cause of Chagas Disease, which has significant impacts on health and economics globally. This study investigates the dysregulation of a type of small noncoding RNA called piRNAs during early T. cruzi infection, and predicts their interactions with mRNA. The findings suggest that piRNAs play important roles in infection and pathogenesis, and could potentially be used as biomarkers and therapeutic targets for infectious diseases.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Immunology
Yves Carlier, Carine Truyens, Eric Muraille
Summary: This study discusses the potential role of antibody-dependent enhancement (ADE) in the trans-placental parasite transmission or the development of severe and fatal clinical forms of congenital/neonatal Chagas disease in newborns of T. cruzi-infected mothers. It highlights the importance of understanding how antibodies transmitted from infected pregnant women may influence the neonatal immune response to the parasite.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Maria Carmo P. Nunes, Lewis F. Buss, Jose Luiz P. Silva, Larissa Natany A. Martins, Claudia Di Lorenzo Oliveira, Clareci Silva Cardoso, Bruno Oliveira de Figueiredo Brito, Ariela Mota Ferreira, Lea Campos Oliveira, Ana Luiza Bierrenbach, Fabio Fernandes, Michael P. Busch, Viviane Tiemi Hotta, Luiz Mario Baptista Martinelli, Maria Carolina F. Almeida Soeiro, Adriana Brentegani, Vera M. C. Salemi, Marcia M. Menezes, Antonio Luiz P. Ribeiro, Ester Cerdeira Sabino
Summary: This study provides a comprehensive description of the natural history of T. cruzi seropositivity in a contemporary patient population, highlighting the central importance of anti-T. cruzi antibody titer as a marker of Chagas disease activity and risk of progression.
Article
Microbiology
Sergio Castaneda, Marina Munoz, Peter J. Hotez, Maria Elena Bottazzi, Alberto E. Paniz-Mondolfi, Kathryn M. Jones, Rojelio Mejia, Cristina Poveda, Juan David Ramirez
Summary: Chagas disease is caused by Trypanosoma cruzi and has a profound impact on the gastrointestinal tract. Alterations in the gut microbiome caused by the parasite may play a crucial role in host-parasite interactions and immune responses. Understanding this interaction could provide valuable insights into the pathophysiology of the disease and the development of new treatments.
MICROBIOLOGY SPECTRUM
(2023)
Article
Immunology
Izadora Volpato Rossi, Maria Alice Ferreira Nunes, Bruna Sabatke, Hennrique Taborda Ribas, Sheila Maria Brochado Winnischofer, Augusto Savio Peixoto Ramos, Jameel Malhador Inal, Marcel Ivan Ramirez
Summary: Chagas disease is caused by Trypanosoma cruzi, which uses blood-feeding triatomine bugs to infect mammalian hosts. The parasite needs to evade the complement system and quickly invade cells for infection, achieved through the expression of different molecules and release of extracellular vesicles (EVs). Selecting a population of T. cruzi after exposure to human serum stress factors can lead to increased metacyclogenesis, resistance to complement-mediated lysis, and greater infectivity.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Biochemical Research Methods
Xueyun Zheng, Xing Zhang, Nathaniel S. Schocker, Ryan S. Renslow, Daniel J. Orton, Jamal Khamsi, Roger A. Ashmus, Igor C. Almeida, Keqi Tang, Catherine E. Costello, Richard D. Smith, Katja Michael, Erin S. Baker
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2017)
Article
Cell Biology
M. I. Ramirez, P. Deolindo, I. J. de Messias-Reason, Emma A. Arigi, H. Choi, I. C. Almeida, I. Evans-Osses
CELLULAR MICROBIOLOGY
(2017)
Article
Infectious Diseases
Faustino Torrico, Joaquim Gascon, Lourdes Ortiz, Cristina Alonso-Vega, Maria-Jesus Pinazo, Alejandro Schijman, Igor C. Almeida, Fabiana Alves, Nathalie Strub-Wourgaft, Isabela Ribeiro
LANCET INFECTIOUS DISEASES
(2018)
Article
Parasitology
Krishanthi S. Subramaniam, Victoria Austin, Nathaniel S. Schocker, Alba L. Montoya, Matthew S. Anderson, Roger A. Ashmus, Mina Mesri, Waleed Al-Salem, Igor C. Almeida, Katja Michael, Alvaro Acosta-Serrano
Article
Cardiac & Cardiovascular Systems
Hanan Qasim, Zubair A. Karim, Juan C. Silva-Espinoza, Fadi T. Khasawneh, Jose O. Rivera, Cameron C. Ellis, Stephanie L. Bauer, Igor C. Almeida, Fatima Z. Alshbool
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2018)
Article
Immunology
Susana Portillo, Brenda G. Zepeda, Eva Iniguez, Janet J. Olivas, Nasim H. Karimi, Otacilio C. Moreira, Alexandre F. Marques, Katja Michael, Rosa A. Maldonado, Igor C. Almeida
Article
Immunology
Trevor T. Duarte, Cameron C. Ellis, Brian Grajeda, Atasi De Chatterjee, Igor C. Almeida, Siddhartha Das
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Flavia Costa Mendonca-Natividade, Carla Duque Lopes, Rafael Ricci-Azevedo, Aline Sardinha-Silva, Camila Figueiredo Pinzan, Ana Claudia Paiva Alegre-Maller, Lilian L. Nohara, Alan B. Carneiro, Ademilson Panunto-Castelo, Igor C. Almeida, Maria Cristina Roque-Barreira
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Multidisciplinary Sciences
Haruka Toda, Miriam Diaz-Varela, Joan Segui-Barber, Wanlapa Roobsoong, Barbara Baro, Susana Garcia-Silva, Alicia Galiano, Melisa Gualdron-Lopez, Anne C. G. Almeida, Marcelo A. M. Brito, Gisely Cardoso de Melo, Iris Aparici-Herraiz, Carlos Castro-Cavadia, Wuelton Marcelo Monteiro, Eva Borras, Eduard Sabido, Igor C. Almeida, Jakub Chojnacki, Javier Martinez-Picado, Maria Calvo, Pilar Armengol, Jaime Carmona-Fonseca, Maria Fernanda Yasnot, Ricardo Lauzurica, Antonio Marcilla, Hector Peinado, Mary R. Galinski, Marcus V. G. Lacerda, Jetsumon Sattabongkot, Carmen Fernandez-Becerra, Hernando A. del Portillo
NATURE COMMUNICATIONS
(2020)
Article
Infectious Diseases
Julio Alonso-Padilla, Marcelo Abril, Belkisyole Alarcon de Noya, Igor C. Almeida, Andrea Angheben, Tania Araujo Jorge, Eric Chatelain, Monica Esteva, Joaquim Gascon, Mario J. Grijalva, Felipe Guhl, Alejandro Marcel Hasslocher-Moreno, Manuel Carlos Lopez, Alejandro Luquetti, Oscar Noya, Maria Jesus Pinazo, Janine M. Ramsey, Isabela Ribeiro, Andres Mariano Ruiz, Alejandro G. Schijman, Sergio Sosa-Estani, M. Carmen Thomas, Faustino Torrico, Maan Zrein, Albert Picado
PLOS NEGLECTED TROPICAL DISEASES
(2020)
Article
Immunology
Andre Cronemberger-Andrade, Patricia Xander, Rodrigo Pedro Soares, Natalia Lima Pessoa, Marco Antonio Campos, Cameron C. Ellis, Brian Grajeda, Yifat Ofir-Birin, Igor Correia Almeida, Neta Regev-Rudzki, Ana Claudia Torrecilhas
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2020)
Article
Immunology
Nuria Cortes-Serra, Maria Tays Mendes, Clara Mazagatos, Joan Segui-Barber, Cameron C. Ellis, Cristina Ballart, Ana Garcia-Alvarez, Montserrat Gallego, Joaquim Gascon, Igor C. Almeida, Maria Jesus Pinazo, Carmen Fernandez-Becerra
EMERGING INFECTIOUS DISEASES
(2020)
Meeting Abstract
Chemistry, Multidisciplinary
Elisa Garcia Carvajal, Susana Portillo, Fikri Avci, Igor C. Almeida, Katja Michael
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2019)
Meeting Abstract
Public, Environmental & Occupational Health
Victoria Austin, Krishanthi Subramaniam, Alba Montoya, Nate Schocker, Katja Michaels, Igor Almeida, Alvaro Serrano
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2018)
Article
Cell Biology
Kleber Silva Ribeiro, Camilla Ioshida Vasconcellos, Rodrigo Pedro Soares, Maria Tays Mendes, Cameron C. Ellis, Marcela Aguilera-Flores, Igor Correia de Almeida, Sergio Schenkman, Leo Kei Iwai, Ana Claudia Torrecilhas
JOURNAL OF EXTRACELLULAR VESICLES
(2018)
Article
Parasitology
Kiswendsida Thierry Guiguemde, Patindoilba Marcel Sawadogo, Adama Zida, Apollinaire Kima, Roland Windtare Bougma, Mamadou Serme, Ibrahim Sangare, Clarisse Bougouma, Sanata Bamba
Summary: This study assessed the transmission of onchocerciasis in the Cascades region of Burkina Faso and found that the resumption of ivermectin treatment has significantly reduced the prevalence of the disease since 2011.
PARASITOLOGY INTERNATIONAL
(2024)
Article
Parasitology
K. D. Steffen, M. L. Gos, J. M. Unzaga, M. C. Venturini, R. O. Ariasc, G. More
Summary: The dynamics of anti-T. gondii antibodies and seroconversion in naturally infected goats from the last third of pregnancy to 100 days of lactation were evaluated, and their relationship with hematological and dehydration parameters was examined. The results showed that seroconversion occurred in goats of different physiological states and ages, and it was not related to hydration status.
PARASITOLOGY INTERNATIONAL
(2024)
Article
Parasitology
Maho Kotake, Yuho Watanabe, Naoki Itoh, Tomoyoshi Yoshinaga
Summary: This study examined the effects of light exposure on the theront excystment circadian rhythm in Cryptocaryon irritans. The results showed that light reception is essential for circadian rhythm entrainment and both light duration and temperature have an impact on the entrainment of circadian rhythm.
PARASITOLOGY INTERNATIONAL
(2024)
Review
Parasitology
Olivier Ndogo Eteme, Ernestine Nkwengoua Zondegoumba, Yasmin Saegusa Tadayozzi, Jessica Aparecida Serafim, Wendell Queiroz Leite, Mariane de Freitas Genari Severino, Eduardo Festozo Vicente
Summary: The high mortality rate caused by parasitic worms on their hosts is a major concern. Current drugs on the market are often toxic with numerous side effects, necessitating the search for new, more potent molecules. Medicinal plants have been found to contain a wide range of novel molecules that can effectively combat different types of helminths. This review provides an overview of the methods, activities, and mechanisms of action of cyclic peptides, specifically cyclotides, for treating helminthic infections.
PARASITOLOGY INTERNATIONAL
(2024)
Article
Parasitology
Lucas de Assis Silva Andrade, Carlos Nei Ortuzar-Ferreira, Mariana de Souza Oliveira, Sergian Vianna Cardozo, Viviane Moreira de Lima, Bruno Pereira Berto
Summary: A new species of Isospora Schneider, 1881 has been identified from V. chivi in Southeastern Brazil. Morphological and molecular analyses confirmed the identity of this new species.
PARASITOLOGY INTERNATIONAL
(2024)