Article
Multidisciplinary Sciences
Maike Bensberg, Olof Rundquist, Aida Selimovic, Cathrine Lagerwall, Mikael Benson, Mika Gustafsson, Hartmut Vogt, Antonio Lentini, Colm E. Nestor
Summary: TET2 silencing in T-ALL is associated with hypermethylation, and treatment with 5-azacytidine can reduce toxicity in TET2-silenced T-ALL cells, leading to stable re-expression of the TET2 gene.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Oncology
Aurora Taira, Kimmo Palin, Anna Kuosmanen, Niko Valimaki, Outi Kuittinen, Outi Kuismin, Eevi Kaasinen, Kristiina Rajamaki, Lauri A. Aaltonen
Summary: Recent studies have shown that vitamin C can enhance the demethylation activity of the TET2 gene and reduce DNA hypermethylation. This suggests that vitamin C may play a role in preventing hematological malignancies in individuals with TET2 dysfunction.
CLINICAL EPIGENETICS
(2023)
Article
Biochemistry & Molecular Biology
Yinglin Lu, Kai Shi, Haobin Wang, Heng Cao, Fan Li, Jing Zhou, Minli Yu, Debing Yu
Summary: Ascorbic acid and 5-AZA promote myogenic differentiation by regulating DNA demethylation and histone modification levels, with Tet2 playing a key role in this process.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Carlos C. Smith-Diaz, Nicholas J. Magon, Judith L. McKenzie, Mark B. Hampton, Margreet C. M. Vissers, Andrew B. Das
Summary: Loss-of-function mutations in TET2 are associated with AML, and ascorbate can potentially inhibit proliferation and promote differentiation in AML cells with mutations in both TET2 and TP53. However, the impact of ascorbate on targeted cytotoxic therapies like Prima-1(Met) seems minimal.
FRONTIERS IN ONCOLOGY
(2021)
Editorial Material
Hematology
Karen Keeshan
Summary: The study reveals the mechanistic basis for the development of acute myeloid leukemia (AML) mediated by HoxA9 and TRIB proteins, emphasizing their crucial roles in AML oncogenic activity. Further research is needed to explore the synergistic effect of HoxA9 and TRIB proteins in AML pathogenesis, as well as the impact of TRIB proteins on different AML phenotypes.
Article
Nutrition & Dietetics
Alessandro Maselli del Giudice, Ignazio La Mantia, Francesco Barbara, Silvana Ciccarone, Maria Sterpeta Ragno, Valentina de Robertis, Francesco Cariti, Michele Barbara, Luca D'Ascanio, Arianna Di Stadio
Summary: Elderly people are at high risk of infection and severe disease due to immune senescence. A supplement containing various nutrients was found to improve inflammatory levels and lymphocytes growth in elderly patients, although not to the same extent as young patients. Most patients reported feeling better after using the supplement.
Article
Biotechnology & Applied Microbiology
Tyler E. Miller, Caleb A. Lareau, Julia A. Verga, Erica A. K. DePasquale, Vincent Liu, Daniel Ssozi, Katalin Sandor, Yajie Yin, Leif S. Ludwig, Chadi A. El Farran, Duncan M. Morgan, Ansuman T. Satpathy, Gabriel K. Griffin, Andrew A. Lane, J. Christopher Love, Bradley E. Bernstein, Vijay G. Sankaran, Peter van Galen
Summary: The combination of single-cell transcriptomics and mitochondrial DNA variant detection is useful for establishing lineage relationships in primary human cells, but current methods are not suitable for analyzing complex tissues. In this study, researchers combined common 3' single-cell RNA-sequencing protocols with mitochondrial transcriptome enrichment to significantly increase coverage and enable high-confidence mutation detection. This method successfully identified skewed immune cell expansions in primary human clonal hematopoiesis.
NATURE BIOTECHNOLOGY
(2022)
Article
Hematology
Yasuhito Nannya, Magnus Tobiasson, Shinya Sato, Elsa Bernard, Shigeki Ohtake, June Takeda, Maria Creignou, Lanying Zhao, Manabu Kusakabe, Yuhei Shibata, Nobuhiko Nakamura, Mizuki Watanabe, Nobuhiro Hiramoto, Yusuke Shiozawa, Yuichi Shiraishi, Hiroko Tanaka, Kenichi Yoshida, Nobuyuki Kakiuchi, Hideki Makishima, Masahiro Nakagawa, Kensuke Usuki, Mitsumasa Watanabe, Kazunori Imada, Hiroshi Handa, Masataka Taguchi, Toru Kiguchi, Kazuma Ohyashiki, Takayuki Ishikawa, Akifumi Takaori-Kondo, Hisashi Tsurumi, Senji Kasahara, Shigeru Chiba, Tomoki Naoe, Satoru Miyano, Elli Papaemanuil, Yasushi Miyazaki, Eva Hellstrom-Lindberg, Seishi Ogawa
Summary: The study aims to investigate the effect of gene mutations on hematological response and overall survival (OS) in patients with myelodysplastic syndrome (MDS)-related diseases, particularly focusing on posttreatment clone size. A total of 449 patients were enrolled and analyzed for gene mutations in pretreatment and posttreatment bone marrow samples to assess the impact of mutations and posttreatment clone size on treatment outcomes.
Article
Oncology
Nicholas J. Short, Sangeetha Venugopal, Wei Qiao, Tapan M. Kadia, Farhad Ravandi, Walid Macaron, Courtney D. Dinardo, Naval Daver, Marina Konopleva, Gautam Borthakur, Elizabeth J. Shpall, Uday Popat, Richard E. Champlin, Rohtesh Mehta, Gheath Al-Atrash, Betul Oran, Elias Jabbour, Guillermo Garcia-Manero, Ghayas C. Issa, Guillermo Montalban-Bravo, Musa Yilmaz, Abhishek Maiti, Hagop Kantarjian
Summary: The optimal frontline treatment regimen for treated secondary acute myeloid leukemia (ts-AML) is uncertain. The use of hypomethylating agent (HMA) plus venetoclax-based regimen followed by hematopoietic stem cell transplantation (HSCT) may improve outcomes for ts-AML patients, particularly those with a non-adverse risk karyotype.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2022)
Review
Hematology
Firas El Chaer, Christopher S. Hourigan, Amer M. Zeidan
Summary: The European LeukemiaNet has recently updated the clinical and measurable residual disease testing guidelines for acute myeloid leukemia (AML) in 2022 and 2021 respectively. These updates provide new recommendations for classification, risk stratification, prognostication, monitoring, and response assessment in AML patients. Advances in understanding the genetic drivers of AML and its biology have led to the development of novel therapies and more complex clinical treatment guidelines.
Article
Multidisciplinary Sciences
Nayan Jain, Zeguo Zhao, Judith Feucht, Richard Koche, Archana Iyer, Anton Dobrin, Jorge Mansilla-Soto, Julie Yang, Yingqian Zhan, Michael Lopez, Gertrude Gunset, Michel Sadelain
Summary: Further advancements in cell engineering are necessary to improve the effectiveness of CAR and other T cell-based therapies. Disrupting TET2 can enhance T cell-mediated tumor rejection, but it also carries the risk of clonal expansions and tissue infiltration by CAR T cells.
Article
Oncology
Gabriele Greve, Julia Schueler, Bjoern A. Gruening, Bettina Berberich, Julia Stomper, Dennis Zimmer, Lea Gutenkunst, Ulrike Boenisch, Ruth Meier, Nadja Blagitko-Dorfs, Olga Grishina, Dietmar Pfeifer, Dieter Weichenhan, Christoph Plass, Michael Luebbert
Summary: This study investigated the therapeutic effects of hypomethylating agents on patients with acute myeloid leukemia/myelodysplastic syndrome, revealing that these agents can derepress genes in AML with chromosomal deletions and reactivate endogenous retroviruses, leading to improved survival rates for patients.
Article
Genetics & Heredity
Qiang Ma, Yixian Guo, Xiaoxi Lan, Guoxiang Wang, Wanling Sun
Summary: This study reported the co-existence of novel WT1 p.Arg370Pro and TET2 p.Asp1844Asn variants in a refractory and recurrent AML patient, which were only detectable genetic alteration in early recurrence. These variants were proven to be inherited from the patient's father and mother, and were subsequently replaced with donor-derived TET2 p.Asp1844Asn after allo-HSCT. The patient has remained in complete remission with regular follow-up.
BMC MEDICAL GENOMICS
(2021)
Article
Nutrition & Dietetics
Anitra C. Carr, Jens Lykkesfeldt
Summary: The study examines the relationship between vitamin C dose and concentration, specifically in relation to age and smoking status. It found that while vitamin C intake was similar across age groups, older individuals had significantly lower circulating vitamin C concentrations. This effect was more pronounced in non-smokers and suggests that older individuals may be more sensitive to low vitamin C intake, possibly due to the effects of long-term smoking and increased chronic disease prevalence.
Article
Nutrition & Dietetics
James W. W. Daily, Sunmin Park
Summary: This study aimed to identify factors that increase the risk of obesity and found that modulating nutrient intakes might help overcome a high genetic risk for obesity.