HDAC6 Inhibition Promotes Transcription Factor EB Activation and Is Protective in Experimental Kidney Disease

Tubastatin A/ACY-1215 Improves Cognition in Alzheimer's Disease Transgenic Mice

(2018) Ling Zhang et al.   JOURNAL OF ALZHEIMERS DISEASE

Shifts in podocyte histone H3K27me3 regulate mouse and human glomerular disease

(2017) Syamantak Majumder et al.   JOURNAL OF CLINICAL INVESTIGATION

Janus Kinase 2 Regulates Transcription Factor EB Expression and Autophagy Completion in Glomerular Podocytes

(2017) Tamadher A. Alghamdi et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Protein misfolding in neurodegenerative diseases: implications and strategies

(2017) Patrick Sweeney et al.   Translational Neurodegeneration

The therapeutic hope for HDAC6 inhibitors in malignancy and chronic disease

(2016) S. N. Batchu et al.   CLINICAL SCIENCE

Activation of the transcription factor EB rescues lysosomal abnormalities in cystinotic kidney cells

(2016) Laura R. Rega et al.   KIDNEY INTERNATIONAL

Inhibition of histone deacetylase 6 activity reduces cyst growth in polycystic kidney disease

(2016) Liudmila Cebotaru et al.   KIDNEY INTERNATIONAL

Protein misfolding in the endoplasmic reticulum as a conduit to human disease

(2016) Miao Wang et al.   NATURE

The Autophagy–Lysosomal Pathway in Neurodegeneration: A TFEB Perspective

(2016) Heidi Martini-Stoica et al.   TRENDS IN NEUROSCIENCES

Deacetylation of TFEB promotes fibrillar Aβ degradation by upregulating lysosomal biogenesis in microglia

(2016) Jintao Bao et al.   Protein & Cell

Inhibition of HDAC3- and HDAC6-Promoted Survivin Expression Plays an Important Role in SAHA-Induced Autophagy and Viability Reduction in Breast Cancer Cells

(2016) Jane Ying-Chieh Lee et al.   Frontiers in Pharmacology

Endoplasmic reticulum stress in kidney function and disease

(2015) Mai Taniguchi et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Histone Deacetylase 6 (HDAC6) Promotes the Pro-survival Activity of 14-3-3ζ via Deacetylation of Lysines within the 14-3-3ζ Binding Pocket

(2015) Jeffrey B. Mortenson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cellular Mechanisms of Endoplasmic Reticulum Stress Signaling in Health and Disease. 2. Protein misfolding and ER stress

(2014) Joseph E. Chambers et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Mechanisms and biological functions of autophagy in diseased and ageing kidneys

(2014) Sophie Fougeray et al.   Nature Reviews Nephrology

Autophagy and the kidney: health and disease

(2014) Y. Takabatake et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Histone deacetylase 6 inhibition improves memory and reduces total tau levels in a mouse model of tau deposition

(2014) Maj-Linda Selenica et al.   Alzheimers Research & Therapy

Lysosomal basification and decreased autophagic flux in oxidatively stressed trabecular meshwork cells

(2013) Kristine Porter et al.   Autophagy

SQSTM1/p62 Interacts with HDAC6 and Regulates Deacetylase Activity

(2013) Jin Yan et al.   PLoS One

Histone deacetylase 10 promotes autophagy-mediated cell survival

(2013) I. Oehme et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB

(2012) Jose A. Martina et al.   Autophagy

Sequestosome 1/p62: across diseases

(2012) Thangiah Geetha et al.   BIOMARKERS

A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB

(2012) Carmine Settembre et al.   EMBO JOURNAL

The Transcription Factor TFEB Links mTORC1 Signaling to Transcriptional Control of Lysosome Homeostasis

(2012) A. Roczniak-Ferguson et al.   Science Signaling

Regulation of TFEB and V-ATPases by mTORC1

(2011) Samuel Peña-Llopis et al.   EMBO JOURNAL

Characterization of the CLEAR network reveals an integrated control of cellular clearance pathways

(2011) Michela Palmieri et al.   HUMAN MOLECULAR GENETICS

Histone deacetylase inhibition attenuates diabetes-associated kidney growth: potential role for epigenetic modification of the epidermal growth factor receptor

(2011) Richard E. Gilbert et al.   KIDNEY INTERNATIONAL

Fluorescent Microangiography Is a Novel and Widely Applicable Technique for Delineating the Renal Microvasculature

(2011) Andrew Advani et al.   PLoS One

TFEB Links Autophagy to Lysosomal Biogenesis

(2011) C. Settembre et al.   SCIENCE

HDAC6 controls autophagosome maturation essential for ubiquitin-selective quality-control autophagy

(2010) Joo-Yong Lee et al.   EMBO JOURNAL

Physiological significance of selective degradation of p62 by autophagy

(2010) Masaaki Komatsu et al.   FEBS LETTERS

The Microtubule-associated Histone Deacetylase 6 (HDAC6) Regulates Epidermal Growth Factor Receptor (EGFR) Endocytic Trafficking and Degradation

(2010) Ya-sheng Gao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rational Design and Simple Chemistry Yield a Superior, Neuroprotective HDAC6 Inhibitor, Tubastatin A

(2010) Kyle V. Butler et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1

(2010) Masaaki Komatsu et al.   NATURE CELL BIOLOGY

Nucleocytoplasmic Shuttling of p62/SQSTM1 and Its Role in Recruitment of Nuclear Polyubiquitinated Proteins to Promyelocytic Leukemia Bodies

(2009) Serhiy Pankiv et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Expression, Localization, and Function of the Thioredoxin System in Diabetic Nephropathy

(2009) A. Advani et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

A Gene Network Regulating Lysosomal Biogenesis and Function

(2009) Marco Sardiello et al.   SCIENCE

Regulation of Epidermal Growth Factor Receptor Trafficking by Lysine Deacetylase HDAC6

(2009) Y. Lissanu Deribe et al.   Science Signaling

Aggresome Formation and Neurodegenerative Diseases: Therapeutic Implications

(2008) L. Chin et al.   CURRENT MEDICINAL CHEMISTRY

Ref(2)P, theDrosophila melanogasterhomologue of mammalian p62, is required for the formation of protein aggregates in adult brain

(2008) Ioannis P. Nezis et al.   JOURNAL OF CELL BIOLOGY