Deacetylation of TFEB promotes fibrillar Aβ degradation by upregulating lysosomal biogenesis in microglia

TFEB Participates in the Aβ-Induced Pathogenesis of Alzheimer's Disease by Regulating the Autophagy-Lysosome Pathway

(2015) Yi-dan Zhang et al.   DNA AND CELL BIOLOGY

SIRT1 Deficiency in Microglia Contributes to Cognitive Decline in Aging and Neurodegeneration via Epigenetic Regulation of IL-1 

(2015) S.-H. Cho et al.   JOURNAL OF NEUROSCIENCE

Neuronal-Targeted TFEB Accelerates Lysosomal Degradation of APP, Reducing A  Generation and Amyloid Plaque Pathogenesis

(2015) Q. Xiao et al.   JOURNAL OF NEUROSCIENCE

Microglia constitute a barrier that prevents neurotoxic protofibrillar Aβ42 hotspots around plaques

(2015) Carlo Condello et al.   Nature Communications

Apolipoproteins E and J interfere with amyloid-beta uptake by primary human astrocytes and microgliain vitro

(2014) Sandra D. Mulder et al.   GLIA

Microglia receptors and their implications in the response to amyloid β for Alzheimer’s disease pathogenesis

(2014) Deborah Doens et al.   Journal of Neuroinflammation

Enhancing Astrocytic Lysosome Biogenesis Facilitates A  Clearance and Attenuates Amyloid Plaque Pathogenesis

(2014) Q. Xiao et al.   JOURNAL OF NEUROSCIENCE

SIRT1 in Neurodevelopment and Brain Senescence

(2014) A. Zara Herskovits et al.   NEURON

The emerging role of acetylation in the regulation of autophagy

(2013) Ágnes Bánréti et al.   Autophagy

Activation of lysosomal function in the course of autophagy via mTORC1 suppression and autophagosome-lysosome fusion

(2013) Jing Zhou et al.   CELL RESEARCH

Activated Cyclin-Dependent Kinase 5 Promotes Microglial Phagocytosis of Fibrillar β-Amyloid by Up-regulating Lipoprotein Lipase Expression

(2013) Yuanhui Ma et al.   MOLECULAR & CELLULAR PROTEOMICS

TFEB controls cellular lipid metabolism through a starvation-induced autoregulatory loop

(2013) Carmine Settembre et al.   NATURE CELL BIOLOGY

Signals from the lysosome: a control centre for cellular clearance and energy metabolism

(2013) Carmine Settembre et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

TFEB-mediated autophagy rescues midbrain dopamine neurons from  -synuclein toxicity

(2013) M. Decressac et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms Underlying the Rapid Peroxisome Proliferator-Activated Receptor- -Mediated Amyloid Clearance and Reversal of Cognitive Deficits in a Murine Model of Alzheimer's Disease

(2012) S. Mandrekar-Colucci et al.   JOURNAL OF NEUROSCIENCE

PGC-1  Rescues Huntington's Disease Proteotoxicity by Preventing Oxidative Stress and Promoting TFEB Function

(2012) T. Tsunemi et al.   Science Translational Medicine

SIRT1 controls lipolysis in adipocytes via FOXO1-mediated expression of ATGL

(2011) Partha Chakrabarti et al.   JOURNAL OF LIPID RESEARCH

Degradation of Alzheimer's amyloid fibrils by microglia requires delivery of ClC-7 to lysosomes

(2011) Amitabha Majumdar et al.   MOLECULAR BIOLOGY OF THE CELL

TFEB Links Autophagy to Lysosomal Biogenesis

(2011) C. Settembre et al.   SCIENCE

Clarifying lysosomal storage diseases

(2011) Mark L. Schultz et al.   TRENDS IN NEUROSCIENCES

RETRACTED: SIRT1 Suppresses β-Amyloid Production by Activating the α-Secretase Gene ADAM10

(2010) Gizem Donmez et al.   CELL

Amyloid-β–induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks

(2010) Jorge J Palop et al.   NATURE NEUROSCIENCE

Alzheimer's Disease

(2010) Henry W. Querfurth et al.   NEW ENGLAND JOURNAL OF MEDICINE

Decreased Clearance of CNS  -Amyloid in Alzheimer's Disease

(2010) K. G. Mawuenyega et al.   SCIENCE

Regulation of Autophagy by the p300 Acetyltransferase

(2009) In Hye Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Immune Activation in Brain Aging and Neurodegeneration: Too Much or Too Little?

(2009) Kurt M. Lucin et al.   NEURON

Dynamics of the Microglial/Amyloid Interaction Indicate a Role in Plaque Maintenance

(2008) T. Bolmont et al.   JOURNAL OF NEUROSCIENCE

Microglial Dysfunction and Defective  -Amyloid Clearance Pathways in Aging Alzheimer's Disease Mice

(2008) S. E. Hickman et al.   JOURNAL OF NEUROSCIENCE

Rapid appearance and local toxicity of amyloid-β plaques in a mouse model of Alzheimer’s disease

(2008) Melanie Meyer-Luehmann et al.   NATURE

Dietary supplementation with resveratrol reduces plaque pathology in a transgenic model of Alzheimer's disease

(2008) Saravanan S. Karuppagounder et al.   NEUROCHEMISTRY INTERNATIONAL

ApoE Promotes the Proteolytic Degradation of Aβ

(2008) Qingguang Jiang et al.   NEURON

A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy

(2008) I. H. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Degradation of fibrillar forms of Alzheimer's amyloid β-peptide by macrophages

(2007) Amitabha Majumdar et al.   NEUROBIOLOGY OF AGING