Review
Pharmacology & Pharmacy
Xiangning Cui, Yang Zhang, Yingdong Lu, Mi Xiang
Summary: Pulmonary diseases share common characteristics, such as ROS signaling and disruptions of proteostasis. ER stress plays a significant role in the pathogenesis of pulmonary diseases, and restoring ER proteostasis may be a potential therapeutic strategy.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Plant Sciences
Zalan Czekus, David Milodanovic, Peter Koprivanacz, Krisztina Bela, Maria F. Lopez-Climent, Aurelio Gomez-Cadenas, Peter Poor
Summary: In this study, the researchers investigated the effect of salicylic acid (SA) on glutathione metabolism under endoplasmic reticulum (ER) stress. They found that SA levels influenced the expression of UPR marker gene SlBiP and regulated the accumulation of reduced and oxidized glutathione. Additionally, SA also modulated the activities of glutathione reductase, dehydroascorbate reductase, and glutathione S-transferases in response to ER stress.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Article
Microbiology
Sang-Hun Son, Junghwan Lee, Soo-Na Cho, Ji-Ae Choi, Jaewhan Kim, Tam Doan Nguyen, Seong-Ahn Lee, Doyi Son, Chang-Hwa Song
Summary: Novel treatment strategies for tuberculosis (TB), such as host-directed therapeutics, may offer therapeutic options for patients with drug-resistant TB. This study revealed the role of Herp in mediating crosstalk between ER stress and ROS-mediated autophagy during H37Ra infection, suggesting its potential as a therapeutic target for Mycobacterium tuberculosis (Mtb) infection.
Article
Microbiology
Pei Sun, Jian Jin, Lixiang Wang, Jingjing Wang, Hongchao Zhou, Qi Zhang, Xingang Xu
Summary: The study demonstrated that PEDV infection induced ER stress and autophagy in Vero cells, with ROS acting as an upstream regulator. The unfolded protein response mediated by PERK and IRE1 pathways played a role in PEDV-induced autophagy. Inhibition of PERK and IRE1 pathways reversed PEDV-induced autophagy, suggesting a mechanism of ROS-dependent ER stress-mediated autophagy in Vero cells during PEDV infection.
VETERINARY MICROBIOLOGY
(2021)
Review
Medicine, General & Internal
Sandhya Chipurupalli, Unni Samavedam, Nirmal Robinson
Summary: The endoplasmic reticulum (ER) is crucial for protein synthesis, folding, sensing cellular stress and maintaining cellular homeostasis. The unfolded protein response (UPR) expands protein folding capacity, reduces protein synthesis, enhances ER-associated protein degradation (ERAD), and amplifies cytokine-mediated inflammatory responses. UPR also activates autophagy, which limits inflammation and provides cyto-protection by attenuating ER-stress.
FRONTIERS IN MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Sinan Xiong, Wee-Joo Chng, Jianbiao Zhou
Summary: In multiple myeloma, cells experience both endoplasmic reticulum stress and oxidative stress, leading to cell fate decision through common signaling pathways and inter-organelle communication, ultimately resulting in apoptosis. The mutual activation between endoplasmic reticulum stress and oxidative stress forms a self-perpetuating cycle, contributing to the understanding of MM pathogenesis and drug resistance. Research focusing on targeting redox signaling and endoplasmic reticulum stress responses is highlighted for future anti-myeloma therapy development.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Review
Pathology
Elmira Aboutalebi Vand Beilankouhi, Mir Amirhossein Sajadi, Iraj Alipourfard, Peyman Hassani, Mohammad Valilo, Reza Safaralizadeh
Summary: When misfolded or unfolded proteins accumulate in the endoplasmic reticulum (ER) due to stress, the unfolded protein response (UPR) is activated. This process is disrupted in various diseases including diabetes, neurodegenerative diseases, and cancers. The UPR activates specific signaling pathways in the ER, nucleus, and cytoplasm to restore cellular homeostasis, either promoting cell survival or apoptosis. Disturbance in this balance can lead to cancer.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Biochemistry & Molecular Biology
Babak Jahangiri, Ali Kian Saei, Patience O. Obi, Narjes Asghari, Shahrokh Lorzadeh, Shirin Hekmatirad, Marveh Rahmati, Fatemeh Velayatipour, Mohammad Hosseni Asghari, Ayesha Saleem, Mohammad Amin Moosavi
Summary: The exosomal release pathway and autophagy play crucial roles in maintaining cellular homeostasis and survival under stressful conditions. Dysregulation of the crosstalk between these pathways may contribute to the pathogenesis of various human diseases. A better understanding of their coordination and balance could improve our knowledge on disease mechanisms and treatment approaches.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Tsendsuren Tungalag, Kye Won Park, Dong Kwon Yang
Summary: Oxidative stress plays a significant role in the pathogenesis of heart diseases, and butein exhibits potential antioxidant effects in cardiomyocytes, providing protection against oxidative damage and suggesting its therapeutic potential for cardiac diseases.
Article
Medicine, Research & Experimental
Beatriz Delgado-Valero, Luci de la Fuente-Chavez, Ana Romero-Miranda, Maria Visitacion Bartolome, Bunty Ramchandani, Fabian Islas, Maria Luaces, Victoria Cachofeiro, Ernesto Martinez-Martinez
Summary: Myocardial infarction is associated with renal alterations, including fibrosis, inflammation, and oxidative stress, with endoplasmic reticulum stress playing a key role in these changes at the renal level. ER stress-related proteins in the kidney are linked to the detrimental effects of MI, highlighting the potential of targeting ER stress as a therapeutic strategy for renal alterations post-MI.
Review
Biochemistry & Molecular Biology
Peijun Zhu, Ting Li, Qingqing Li, Yawen Gu, Yuan Shu, Kaibo Hu, Leifeng Chen, Xiaogang Peng, Jie Peng, Liang Hao
Summary: Osteosarcoma, the most common malignant bone tumor, has a poor prognosis and low sensitivity to current treatment methods. Endoplasmic reticulum stress (ERS) has been found to play a role in regulating osteosarcoma proliferation, apoptosis, and chemoresistance through the unfolded protein response (UPR) pathway. Further research on the relationship between ERS and osteosarcoma could lead to the development of more effective treatment strategies.
Article
Plant Sciences
Xiao-Han Tang, Xin Li, Yan Zhou, Yu-Ting He, Zhi-Ying Wang, Xue Yang, Wei Wang, Kun Guo, Wei Zhang, Yue Sun, Hong-Qing Li, Xiao-Fang Li
Summary: This study reveals that GAAP1 and GAAP4 play redundant positive roles in regulating ER stress response in plants. They maintain proteostasis by inhibiting ROS accumulation through regulating glutathione content, thus enhancing cell viability and survival.
JOURNAL OF EXPERIMENTAL BOTANY
(2022)
Article
Cell Biology
Shaogui Wang, Xiaojuan Chao, Xiaoxiao Jiang, Tiantian Wang, Yssa Rodriguez, Ling Yang, Pal Pacher, Hong-Min Ni, Wen-Xing Ding
Summary: VMP1 plays a crucial role in the pathogenesis of pancreatitis by regulating autophagic degradation and ER stress, and its deficiency promotes inflammation and fibrosis. The study revealed the importance of VMP1 in modulating pancreatitis through the NFE2L2/Nrf2 pathway.
Review
Cell Biology
Haisen Li, Shengyi Sun
Summary: The endoplasmic reticulum (ER) is crucial for protein synthesis and quality control, utilizing chaperones and ER quality control pathways to maintain homeostasis. Accumulation of misfolded proteins in the ER can lead to toxic protein aggregates, causing ER storage diseases.
Review
Biochemistry & Molecular Biology
Ruolei Wang, Lirong Liang, Misaki Matsumoto, Kazumi Iwata, Atsushi Umemura, Feng He
Summary: The imbalance between reactive oxygen species (ROS) production and clearance causes oxidative stress and plays a central role in regulating cell and tissue physiology and pathology. ROS can either stimulate cancer survival and growth or cause cell death depending on their concentration. The transcription factor NRF2 has dual roles in carcinogenesis, where short-term activation suppresses tissue injury, inflammation, and cancer initiation, while constitutive activation confers advantages for cancer cells' survival and growth. NRF2 hyperactivation, as an adaptive cancer phenotype, regulates multiple aspects of cancer development, metastasis, and resistance to anticancer therapy.
Article
Cell Biology
Mai Taniguchi, Satomi Nadanaka, Soichiro Tanakura, Shogo Sawaguchi, Sachiko Midori, Yumeto Kawai, Shogo Yamaguchi, Yui Shimada, Yuki Nakamura, Yasuyo Matsumura, Natsumi Fujita, Naoko Araki, Mayu Yamamoto, Masaya Oku, Sadao Wakabayashi, Hiroshi Kitagawa, Hiderou Yoshida
CELL STRUCTURE AND FUNCTION
(2015)
Review
Biochemistry & Molecular Biology
Kanae Sasaki, Hiderou Yoshida
JOURNAL OF BIOCHEMISTRY
(2015)
Review
Biochemistry & Molecular Biology
Daisuke Ariyasu, Hiderou Yoshida, Yukihiro Hasegawa
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2017)
Article
Cell Biology
Masaya Oku, Soichiro Tanakura, Aya Uemura, Miwa Sohda, Yoshio Misumi, Mai Taniguchi, Sadao Wakabayashi, Hiderou Yoshida
CELL STRUCTURE AND FUNCTION
(2011)
Article
Cell Biology
Ryota Komori, Mai Taniguchi, Yoshiaki Ichikawa, Aya Uemura, Masaya Oku, Sadao Wakabayashi, Kazuhiko Higuchi, Hiderou Yoshida
CELL STRUCTURE AND FUNCTION
(2012)
Article
Cell Biology
Aya Uemura, Mai Taniguchi, Yusaku Matsuo, Masaya Oku, Sadao Wakabayashi, Hiderou Yoshida
CELL STRUCTURE AND FUNCTION
(2013)
Article
Endocrinology & Metabolism
Daisuke Ariyasu, Hiderou Yoshida, Makoto Yamada, Yukihiro Hasegawa
Article
Biochemistry & Molecular Biology
Sadao Wakabayashi, Hiderou Yoshida
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2013)
Article
Chemistry, Medicinal
Mayu Kimura, Kanae Sasaki, Yosuke Fukutani, Hiderou Yoshida, Ikuroh Ohsawa, Masafumi Yohda, Kaori Sakurai
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2019)
Review
Biochemistry & Molecular Biology
Kanae Sasaki, Hiderou Yoshida
Review
Cell Biology
Kanae Sasaki, Hiderou Yoshida
CELL STRUCTURE AND FUNCTION
(2019)
Article
Cell Biology
Kanae Sasaki, Ryota Komori, Mai Taniguchi, Akie Shimaoka, Sachiko Midori, Mayu Yamamoto, Chiho Okuda, Ryuya Tanaka, Miyu Sakamoto, Sadao Wakabayashi, Hiderou Yoshida
CELL STRUCTURE AND FUNCTION
(2019)
Review
Cell Biology
Mai Taniguchi, Hiderou Yoshida
CELL STRUCTURE AND FUNCTION
(2017)
Article
Cell Biology
Mai Taniguchi, Kanae Sasaki-Osugi, Masaya Oku, Shogo Sawaguchi, Soichiro Tanakura, Yumeto Kawai, Sadao Wakabayashi, Hiderou Yoshida
CELL STRUCTURE AND FUNCTION
(2016)