Celastrol Attenuates the Invasion and Migration and Augments the Anticancer Effects of Bortezomib in a Xenograft Mouse Model of Multiple Myeloma

Ginkgolic Acid C 17:1, Derived from Ginkgo biloba Leaves, Suppresses Constitutive and Inducible STAT3 Activation through Induction of PTEN and SHP-1 Tyrosine Phosphatase

(2017) Seung Baek et al.   MOLECULES

Bone marrow micro-environment is a crucial player for myelomagenesis and disease progression

(2017) Patrizia Mondello et al.   Oncotarget

Multiple myeloma in the marrow: pathogenesis and treatments

(2016) Heather Fairfield et al.   Annals of the New York Academy of Sciences

A novel 4,6-disubstituted-1,2,4-triazolo-1,3,4-thiadiazole derivative inhibits tumor cell invasion and potentiates the apoptotic effect of TNFα by abrogating NF-κB activation cascade

(2016) Raghu Ningegowda et al.   APOPTOSIS

Targeting transcription factor STAT3 for cancer prevention and therapy

(2016) Edna Zhi Pei Chai et al.   PHARMACOLOGY & THERAPEUTICS

Bioactive natural products in cancer prevention and therapy: Progress and promise

(2016) Anupam Bishayee et al.   SEMINARS IN CANCER BIOLOGY

Cancer prevention and therapy through the modulation of transcription factors by bioactive natural compounds

(2016) Muthu K Shanmugam et al.   SEMINARS IN CANCER BIOLOGY

NF-κB in cancer therapy

(2015) Feng Li et al.   ARCHIVES OF TOXICOLOGY

Analysis of the intricate relationship between chronic inflammation and cancer

(2015) Edna Zhi Pei Chai et al.   BIOCHEMICAL JOURNAL

Ascochlorin, an isoprenoid antibiotic inhibits growth and invasion of hepatocellular carcinoma by targeting STAT3 signaling cascade through the induction of PIAS3

(2015) Xiaoyun Dai et al.   Molecular Oncology

Natural Bioactives in Cancer Treatment and Prevention

(2015) Yih-Shou Hsieh et al.   Biomed Research International

The Analysis of the Relationship between Multiple Myeloma Cells and Their Microenvironment

(2015) Artur Jurczyszyn et al.   Journal of Cancer

Thymoquinone overcomes chemoresistance and enhances the anticancer effects of bortezomib through abrogation of NF-κB regulated gene products in multiple myeloma xenograft mouse model

(2015) Kodappully Sivaraman Siveen et al.   Oncotarget

Drug resistance in multiple myeloma: latest findings and new concepts on molecular mechanisms

(2015) Jahangir Abdi et al.   Oncotarget

Novel Medicines and Strategies in Cancer Treatment and Prevention

(2014) Chih-Hsin Tang et al.   Biomed Research International

Natural Bioactives and Phytochemicals Serve in Cancer Treatment and Prevention

(2013) Shun-Fa Yang et al.   Evidence-based Complementary and Alternative Medicine

Current Therapeutic Strategy for Multiple Myeloma

(2013) Kenshi Suzuki   JAPANESE JOURNAL OF CLINICAL ONCOLOGY

Downregulation of ERK signaling impairs U2OS osteosarcoma cell migration in collagen matrix by suppressing MMP9 production

(2013) BARUN POUDEL et al.   Oncology Letters

Have drug combinations supplanted stem cell transplantation in myeloma?

(2012) A. Palumbo et al.   BLOOD

Proteasome inhibitors in multiple myeloma: 10 years later

(2012) P. Moreau et al.   BLOOD

Monoclonal Gammopathy of Undetermined Significance and Smoldering Multiple Myeloma: A Review of the Current Understanding of Epidemiology, Biology, Risk Stratification, and Management of Myeloma Precursor Disease

(2012) A. Agarwal et al.   CLINICAL CANCER RESEARCH

Cancer chemotherapy: A critical analysis of its 60 years of history

(2012) Darío Galmarini et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Combination chemotherapy increases cytotoxicity of multiple myeloma cells by modification of nuclear factor (NF)-κB activity

(2012) Kelley Salem et al.   EXPERIMENTAL HEMATOLOGY

Pathogenesis of Myeloma

(2011) Kenneth C. Anderson et al.   Annual Review of Pathology-Mechanisms of Disease

Celastrol inhibits tumor cell proliferation and promotes apoptosis through the activation of c-Jun N-terminal kinase and suppression of PI3 K/Akt signaling pathways

(2011) Radhamani Kannaiyan et al.   APOPTOSIS

Celastrol inhibits proliferation and induces chemosensitization through down-regulation of NF-κB and STAT3 regulated gene products in multiple myeloma cells

(2011) Radhamani Kannaiyan et al.   BRITISH JOURNAL OF PHARMACOLOGY

Mobilization of hematopoietic stem and progenitor cells using inhibitors of CXCR4 and VLA-4

(2011) M P Rettig et al.   LEUKEMIA

Targeting Cell Signaling and Apoptotic Pathways by Dietary Agents: Role in the Prevention and Treatment of Cancer

(2011) Muthu Shanmugam et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Targeting transcription factor NF-κB to overcome chemoresistance and radioresistance in cancer therapy

(2010) Feng Li et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Classical and/or alternative NF- B pathway activation in multiple myeloma

(2010) Y. N. Demchenko et al.   BLOOD

The Bcl-2 inhibitor ABT-263 enhances the response of multiple chemotherapeutic regimens in hematologic tumors in vivo

(2010) Scott Ackler et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Molecular targets of celastrol derived from Thunder of God Vine: Potential role in the treatment of inflammatory disorders and cancer

(2010) Radhamani Kannaiyan et al.   CANCER LETTERS

Natural Proteasome Inhibitor Celastrol Suppresses Androgen-Independent Prostate Cancer Progression by Modulating Apoptotic Proteins and NF-kappaB

(2010) Yao Dai et al.   PLoS One

Chemical and Pharmacological Studies of the Plants from GenusCelastrus

(2009) Xiao-Hui Su et al.   CHEMISTRY & BIODIVERSITY

Multiple myeloma

(2009) Marc S Raab et al.   LANCET

Prevalence of bortezomib-resistant constitutive NF-kappaB activity in mantle cell lymphoma

(2008) David T Yang et al.   Molecular Cancer

Bortezomib-Resistant Nuclear Factor- B Activity in Multiple Myeloma Cells

(2008) S. Markovina et al.   MOLECULAR CANCER RESEARCH