Article
Oncology
Kun Wang, Theodoros Michelakos, Bing Wang, Zikun Shang, Albert B. DeLeo, Zhenfeng Duan, Francis J. Hornicek, Joseph H. Schwab, Xinhui Wang
Summary: This study demonstrates that DSF/Cu can increase the radiosensitivity of chondrosarcoma stem cells, potentially providing better treatment outcomes for chondrosarcoma patients requiring radiotherapy.
Article
Cell Biology
Lu Chen, Wujiang Gao, Chunli Sha, Meiling Yang, Li Lin, Taoqiong Li, Hong Wei, Qi Chen, Jie Xing, Mengxue Zhang, Shijie Zhao, Wenlin Xu, Yuefeng Li, Xiaolan Zhu
Summary: The E3 ligase SIAH1 is decreased in epithelial ovarian cancer (EOC) and negatively correlated with RPS3 levels. Overexpression of SIAH1 can suppress tumor cell growth, invasion, and cisplatin resistance by promoting RPS3 degradation and subsequent NF-kappa B inactivation.
Review
Biochemistry & Molecular Biology
Supattra Chaithongyot, Phatcharida Jantaree, Olga Sokolova, Michael Naumann
Summary: Gastric cancer is a major cause of cancer-related deaths globally, with environmental factors and dysregulation of the transcription factor nuclear factor kappa B (NF-kappa B) playing crucial roles in its development. NF-kappa B actively participates in tumor microenvironment cell crosstalk, with diverse effects on tumor cell and immune cell populations.
Article
Oncology
Taoqiong Li, Li Lin, Qin Liu, Wujiang Gao, Lu Chen, Chunli Sha, Qi Chen, Wenlin Xu, Yuefeng Li, Xiaolan Zhu
Summary: The study revealed that exosomal transfer of miR-429 enhances chemoresistance and proliferation of epithelial ovarian cancer cells. NF-κB promotes miR-429 expression, affecting the calcium-sensing receptor pathway and leading to drug resistance in cells.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Review
Cell Biology
Sepideh Mirzaei, Sam Saghari, Farzaneh Bassiri, Rasoul Raesi, Ali Zarrabi, Kiavash Hushmandi, Gautam Sethi, Vinay Tergaonkar
Summary: Metastasis of tumor cells is a significant challenge in cancer patients, and the activation of nuclear factor-kappaB (NF-kappa B) plays a crucial role in regulating the epithelial-to-mesenchymal transition (EMT). The activation of NF-kappa B enhances the invasive properties of tumor cells through inducing EMT mechanism, and this has been confirmed in various cancers.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Nikee Awasthee, Anusmita Shekher, Vipin Rai, Sumit S. Verma, Shruti Mishra, Anupam Dhasmana, Subash C. Gupta
Summary: Piperlongumine (PL, piplartine), an alkaloid derived from the Piper longum L. (long pepper) roots, has shown inhibitory effects on breast cancer cells and synergizes with doxorubicin. PL reduces migration and colony formation of cancer cells, induces apoptosis and DNA damage, and modulates the expression of certain genes. Additionally, PL alters tumor microenvironment pH and glucose metabolism. In vivo studies demonstrate that PL combined with doxorubicin can reduce tumor size, volume, and weight.
Article
Medicine, General & Internal
Hong Lin, Ruoxuan Ni, Dongdong Li, Mei Zhao, Yan Li, Kexin Li, Qiao Zhang, Changzhi Huang, Shengkai Huang
Summary: Long non-coding RNA MIR155HG plays a crucial role in promoting proliferation, migration, and chemoresistance of gastric cancer cells. It modulates the malignant phenotype of gastric cancer cells through regulation of the NF-κB and STAT3 signaling pathways. Moreover, overexpression of MIR155HG reduces the cytotoxicity and apoptosis induced by cisplatin and 5-FU in gastric cancer cells.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Wei Li, Tao Huang, Shenghan Xu, Bangwei Che, Ying Yu, Wenjun Zhang, Kaifa Tang
Summary: Tanshinone can target multiple pathways to inhibit the occurrence and development of prostate cancer, showing potential for the treatment of advanced PCa.
Article
Integrative & Complementary Medicine
Shumeng Lin, Jing Wen, Xiao Xu, Jiamin Shi, Wen Zhang, Tiansheng Zheng, Yaqin Hou, Yanfei Zhang, Ziye Li, Kai Wang, Jing Jin, Liduo Yue, Baigenzhin Abay, Ming Li, Qingxi Yue, Lihong Fan
Summary: Amygdalin induces apoptosis of lung cancer cells through multiple mechanisms, including altered expression of apoptosis-related proteins, activation of NF kappa B-1 gene, and inhibition of NF kappa B signaling cascade. These findings reveal the potential of amygdalin as a therapeutic agent for lung cancer.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Qun Wang, Yun Huang, Min Jia, Dong Lu, Hong-Wei Zhang, Dan Huang, San-Hong Liu, Chao Lv
Summary: SPS-1, an active fraction from safflower polysaccharide, demonstrated strong antitumor effects in a mouse model of colorectal cancer by regulating the immune pathway and changing macrophage phenotype. It inhibited tumor growth, suppressed cell proliferation, induced apoptosis in CRC cells, and could potentially be used as a therapeutic option for CRC prevention and treatment.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Shifaa M. Abdin, Mai F. Tolba, Dana M. Zaher, Hany A. Omar
Summary: The inhibition of NF-kappa B activity can enhance the sensitivity of breast cancer cells to chemotherapy, particularly doxorubicin, by modulating multidrug resistance. Combined treatment with NF-kappa B inhibitors can sensitize resistant breast cancer cells to doxorubicin, by suppressing NF-kappa B activation and downregulating MDR efflux transporters.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Environmental Sciences
Ritesh Urade, Chon-Kit Chou, Han-Lin Chou, Bing-Hung Chen, Tsu-Nai Wang, Eing-Mei Tsai, Chun-Tzu Hung, Shyh-Jong Wu, Chien-Chih Chiu
Summary: This study found that plasticizers/phthalates, like DEHP, can interfere with the apoptosis and autophagy processes caused by CPT in non-small cell lung cancer cells, leading to increased chemoresistance.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Bingwu Liu, Xinfeng Yan, Zuojia Hou, Lei Zhang, Duwen Zhang
Summary: Bupivacaine inhibits colorectal cancer proliferation by suppressing cell viability, promoting apoptosis and autophagy, regulating the NF-kappa B signaling pathway, demonstrating potential therapeutic effects.
Review
Biochemistry & Molecular Biology
Ali Mussa, Hafeez Abiola Afolabi, Nazmul Huda Syed, Mustafa Talib, Ahmad Hafiz Murtadha, Khalid Hajissa, Noor Fatmawati Mokhtar, Rohimah Mohamud, Rosline Hassan
Summary: Breast cancer is the most common cancer type among women, and there is a need for a deeper understanding of its molecular etiology to develop more effective treatments. The activation of the pro-inflammatory transcription factor NF-κB is frequently observed in breast cancer and is associated with cell survival, metastasis, proliferation, and therapy resistance. Vitamin C has been found to regulate NF-κB activation and may be used as a natural pro-oxidant therapy for breast cancer treatment.
Review
Pharmacology & Pharmacy
Sandra Cotino-Najera, Luis A. Herrera, Guadalupe Dominguez-Gomez, Jose Diaz-Chavez
Summary: Cancer is a major cause of death worldwide, with cancer cells often developing resistance to treatment. This article explores the strategy of combining anticancer drugs with natural compounds to overcome resistance to chemotherapy and radiotherapy, focusing on the polyphenolic compound resveratrol and its ability to sensitize tumor cells to these treatments.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Sandra Jose, Sreevidya S. Devi, Anjana Sajeev, Sosmitha Girisa, Mohammed S. Alqahtani, Mohamed Abbas, Abdulrahman Alshammari, Gautam Sethi, Ajaikumar B. Kunnumakkara
Summary: Farnesoid X receptor (FXR) regulates genes involved in lipid, carbohydrate, and inflammatory processes. It is a possible tumor suppressor and its down-regulation is associated with various diseases. FXR agonism has been shown to improve survival in certain cancers, and the development of novel agonists could have therapeutic potential. Computer-aided drug design can be used to identify potential candidates, and alvimopan and montelukast were found to have strong binding affinity with FXR in this study.
BIOSCIENCE REPORTS
(2023)
Review
Biotechnology & Applied Microbiology
Milad Ashrafizadeh, Ali Zarrabi, Hassan Karimi-Maleh, Afshin Taheriazam, Sepideh Mirzaei, Mehrdad Hashemi, Kiavash Hushmandi, Pooyan Makvandi, Ehsan Nazarzadeh Zare, Esmaeel Sharifi, Arul Goel, Lingzhi Wang, Jun Ren, Yavuz Nuri Ertas, Alan Prem Kumar, Yuzhuo Wang, Navid Rabiee, Gautam Sethi, Zhaowu Ma
Summary: Nanomedicine has great potential in the treatment of bladder cancer, including improving drug efficacy, regulating gene expression, providing photodynamic and photothermal therapy, remodeling tumor microenvironment and infiltration of immune cells, timely diagnosis, and targeted therapy for bladder cancer.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Correction
Chemistry, Medicinal
Elina Khatoon, Mangala Hegde, Aviral Kumar, Uzini Devi Daimary, Gautam Sethi, Anupam Bishayee, Ajaikumar B. Kunnumakkara
ARCHIVES OF PHARMACAL RESEARCH
(2023)
Article
Oncology
Mangala Hegde, Nikunj Naliyadhara, Jyothsna Unnikrishnan, Mohammed S. Alqahtani, Mohamed Abbas, Sosmitha Girisa, Gautam Sethi, Ajaikumar B. Kunnumakkara
Summary: Metastasis is the main cause of cancer-related deaths, and despite advancements in treatment methods, it remains difficult to treat. Nanotechnology has shown promising applications in the diagnosis and treatment of metastatic cancer, with nanoparticles demonstrating the ability to target specific cells within metastatic regions. This review summarizes the current state of nanotechnology in the field and discusses its potential in various imaging techniques and combination therapies.
Review
Biochemistry & Molecular Biology
Mangala Hegde, Aviral Kumar, Sosmitha Girisa, Mohammed S. Alqahtani, Mohamed Abbas, Akul Goel, Kam Man Hui, Gautam Sethi, Ajaikumar B. Kunnumakkara
Summary: The hallmark of chronic inflammatory diseases is immune evasion, and exosomes play a critical role in immunomodulation and lipid metabolism during the development and progression of these diseases.
CYTOKINE & GROWTH FACTOR REVIEWS
(2023)
Review
Cell Biology
Wei Shi, Gautam Sethi
Summary: A novel form of cell death called ferroptosis, which is iron-dependent and nonapoptotic, is triggered by lipid peroxidation. The regulation of ferroptosis has been found to play a crucial role in various pathological processes, including cancer. Recent studies suggest that understanding and targeting ferroptosis may provide a potential therapeutic strategy for cancer management, especially in the context of resistance to standard chemoradiotherapy. Long noncoding RNAs (lncRNAs) have been implicated in tumorigenesis and have been identified as regulators of ferroptosis, presenting an exciting avenue for cancer therapy. However, further research is needed to fully understand the mechanisms and potential treatments involving lncRNAs in the context of ferroptosis.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Review
Chemistry, Medicinal
Milad Ashrafizadeh, Chakrabhavi D. Mohan, Shobith Rangappa, Ali Zarrabi, Kiavash Hushmandi, Alan Prem Kumar, Gautam Sethi, Kanchugarakoppal S. Rangappa
Summary: Gastrointestinal (GI) tumors are a major cause of death worldwide. STAT3 is an oncogenic transcription factor that promotes tumor progression, metastasis, and drug resistance. Recent research has shown that noncoding RNAs (ncRNAs) play a major role in regulating the STAT3 pathway. This article discusses the role of STAT3 signaling in promoting GI tumors and comprehensively explores the oncogenic and tumor suppressor functions of ncRNAs that modulate STAT3 signaling in GI cancers.
MEDICINAL RESEARCH REVIEWS
(2023)
Review
Chemistry, Medicinal
Hui Li Ang, Chakrabhavi Dhananjaya Mohan, Muthu K. Shanmugam, Hin Chong Leong, Pooyan Makvandi, Kanchugarakoppal S. Rangappa, Anupam Bishyaee, Alan Prem Kumar, Gautam Sethi
Summary: Epithelial-mesenchymal transition (EMT) is a crucial process in which epithelial cells transform into mesenchymal cells, playing a significant role in tumor progression and resistance to therapy. Various factors, such as signaling pathways, transcriptional regulators, noncoding RNAs, and epigenetic alterations, are involved in the regulation of EMT. However, despite preclinical data, there is a lack of clinical translation in targeting EMT therapeutically. This review discusses the role of these factors in EMT regulation, the contribution of EMT to drug resistance, and potential therapeutic interventions using natural products and nano-formulations as EMT blockers.
MEDICINAL RESEARCH REVIEWS
(2023)
Article
Chemistry, Medicinal
Naisarg Gamit, Manasi Patil, Soumya B. Sundrappa, S. Mohana Sundaram, Gautam Sethi, Arun Dharmarajan, Sudha Warrier
Summary: A reliable and efficient in vitro model using amniotic membrane-derived mesenchymal stem cells (AM-MSCs) has been developed for screening drugs for Alzheimer's disease (AD). This model can assess the neuroprotective ability of different drugs and quickly test a large number of potential compounds. The study found that the novel drugs probucol and NMJ-2 have protective effects against neurodegeneration.
DRUG DEVELOPMENT RESEARCH
(2023)
Article
Chemistry, Medicinal
Rajaghatta N. Suresh, Young Y. Jung, Chakrabhavi D. Mohan, Shalini V. Gowda, Kachigere B. Harsha, Kempegowda Mantelingu, Gautam Sethi, Kwang S. Ahn, Kanchugarakoppal S. Rangappa
Summary: In this study, new compounds called DTI were synthesized and found to exhibit selective cytotoxicity against gastric cancer cells. The cytotoxic effect was achieved by inhibiting the phosphorylation of STAT3 and STAT5, which are transcription factors involved in cancer development. Further investigation revealed that the inhibition of STAT proteins was mediated through the suppression of upstream kinases such as JAK1, JAK2, and Src. The involvement of tyrosine phosphatase and negative regulator PTP & epsilon;C in the DTI-induced STATs inhibition was also demonstrated. Overall, triazolyl-indolo-quinoxaline compounds like DTI show promise as inhibitors of the STAT3/STAT5 pathway in gastric cancer cells.
DRUG DEVELOPMENT RESEARCH
(2023)
Review
Chemistry, Medicinal
Bhagyalakshmi Nair, Jayaprakash K. Adithya, Gopika Chandrababu, P. K. Lakshmi, Joel Joy Koshy, Sreedharan Vilasini Manoj, D. B. Ambiliraj, Balachandran S. Vinod, Gautam Sethi, Lekshmi R. Nath
Summary: Keap1-Nrf2 is a crucial signaling cascade for promoting or preventing carcinogenesis. Nutraceuticals, as dietary agents with health benefits, show great potential as chemoprevention agents for cancer. This review systematically analyzes the role of 12 different nutraceuticals in modulating the Nrf2/Keap1 signaling mechanism. Although there is considerable preclinical evidence, further high-quality research is needed to validate the potential role of these nutraceuticals in Keap1-Nrf2 modulation.
PHYTOTHERAPY RESEARCH
(2023)
Article
Oncology
Yi Qin, Shengjun Xiong, Jun Ren, Gautam Sethi
Summary: Autophagy plays an important regulatory role in glioblastoma, and its dysregulation can lead to drug resistance and radioresistance. It also affects stem cell characteristics, overall growth, and metastasis. Therefore, autophagy is a promising target for glioblastoma therapy.
Article
Food Science & Technology
Mangala Hegde, Aviral Kumar, Sosmitha Girisa, Babu Santha Aswani, Ravichandran Vishwa, Gautam Sethi, Ajaikumar B. Kunnumakkara
Summary: Cancer is a complex disease with diverse characteristics and treatment responses. Overcoming the recurrence and resistance to therapy, as well as minimizing side effects, is crucial for improving the quality of life in cancer patients. This review explores the potential benefits of nanocurcumin, a nanotechnology-based formulation of the natural compound curcumin, in cancer treatment. Various types of curcumin nanoformulations are discussed, along with their anticancer activities and cellular mechanisms. The review also highlights the potential of nanocurcumin as a preventive or adjuvant therapy with conventional drugs.
Article
Oncology
Naveen Kumar, Gautam Sethi
Summary: Transformed cells acquire specific characteristics to become malignant. Telomerase, an enzyme complex, plays a significant role in maintaining telomere length. Its main component, TERT, interacts with various signaling molecules and promotes cancer hallmarks such as cell death resistance, sustained proliferation, angiogenesis activation, and metastasis. Understanding the role of telomerase in promoting cancer hallmarks is crucial for understanding the mechanism of cancer development and progression.
Review
Chemistry, Multidisciplinary
Hardeep Singh Tuli, Ruchira Joshi, Ginpreet Kaur, Vivek Kumar Garg, Katrin Sak, Mehmet Varol, Jagjit Kaur, Sulaiman Ali Alharbi, Tahani Awad Alahmadi, Diwakar Aggarwal, Kuldeep Dhama, Vivek Sheel Jaswal, Sonam Mittal, Gautam Sethi
Summary: Nanotechnology has led to the development of new materials (metal nanoparticles) that have specific applications in healthcare, particularly in the diagnosis and treatment of cancer. Metal nanoparticles can modulate molecular expression in the tumor microenvironment and have anti-cancer effects by inducing apoptosis and cell cycle arrest. They can also inhibit tumor angiogenesis, metastasis, and inflammation, thus preventing cancer proliferation.
JOURNAL OF NANOSTRUCTURE IN CHEMISTRY
(2023)
