标题
The Close Encounter Between Alpha-Synuclein and Mitochondria
作者
关键词
-
出版物
Frontiers in Neuroscience
Volume 12, Issue -, Pages -
出版商
Frontiers Media SA
发表日期
2018-06-07
DOI
10.3389/fnins.2018.00388
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- Striatal synapses, circuits, and Parkinson's disease
- (2018) Shenyu Zhai et al. CURRENT OPINION IN NEUROBIOLOGY
- On the Pathogenesis of Alzheimer's Disease: The MAM Hypothesis
- (2017) Estela Area-Gomez et al. FASEB JOURNAL
- Sodium butyrate rescues dopaminergic cells from alpha-synuclein-induced transcriptional deregulation and DNA damage
- (2017) Isabel Paiva et al. HUMAN MOLECULAR GENETICS
- Sideroflexin 3 is an α-synuclein-dependent mitochondrial protein that regulates synaptic morphology
- (2017) Inês S. Amorim et al. JOURNAL OF CELL SCIENCE
- Mechanism of α-synuclein translocation through a VDAC nanopore revealed by energy landscape modeling of escape time distributions
- (2017) David P. Hoogerheide et al. Nanoscale
- Cytosolic proteostasis through importing of misfolded proteins into mitochondria
- (2017) Linhao Ruan et al. NATURE
- Selective neuronal vulnerability in Parkinson disease
- (2017) D. James Surmeier et al. NATURE REVIEWS NEUROSCIENCE
- Dopamine oxidation mediates mitochondrial and lysosomal dysfunction in Parkinson’s disease
- (2017) Lena F. Burbulla et al. SCIENCE
- αSynuclein control of mitochondrial homeostasis in human-derived neurons is disrupted by mutations associated with Parkinson’s disease
- (2017) Victorio Martin Pozo Devoto et al. Scientific Reports
- Alpha-synuclein prevents the formation of spherical mitochondria and apoptosis under oxidative stress
- (2017) Stefanie Menges et al. Scientific Reports
- V63 and N65 of overexpressed α-synuclein are involved in mitochondrial dysfunction
- (2016) Huilin Zhang et al. BRAIN RESEARCH
- Mitochondria-associated ER membranes and Alzheimer disease
- (2016) Estela Area-Gomez et al. CURRENT OPINION IN GENETICS & DEVELOPMENT
- ALS/FTD‐associated FUS activates GSK‐3β to disrupt the VAPB–PTPIP51 interaction and ER–mitochondria associations
- (2016) Radu Stoica et al. EMBO REPORTS
- Mitochondrial dysfunction in Parkinson's disease
- (2016) Anindita Bose et al. JOURNAL OF NEUROCHEMISTRY
- Monomeric Alpha-Synuclein Exerts a Physiological Role on Brain ATP Synthase
- (2016) M. H. R. Ludtmann et al. JOURNAL OF NEUROSCIENCE
- Mitochondria-Associated Membranes (MAMs): Overview and Its Role in Parkinson’s Disease
- (2016) M. Rodríguez-Arribas et al. MOLECULAR NEUROBIOLOGY
- Interaction of α-synuclein with biomembranes in Parkinson's disease —role of cardiolipin
- (2016) Stephanie Ghio et al. PROGRESS IN LIPID RESEARCH
- α-Synuclein binds to TOM20 and inhibits mitochondrial protein import in Parkinson’s disease
- (2016) Roberto Di Maio et al. Science Translational Medicine
- Impairment of mitochondria dynamics by human A53T α-synuclein and rescue by NAP (davunetide) in a cell model for Parkinson’s disease
- (2016) T. Q. Melo et al. EXPERIMENTAL BRAIN RESEARCH
- α-Synuclein Shows High Affinity Interaction with Voltage-dependent Anion Channel, Suggesting Mechanisms of Mitochondrial Regulation and Toxicity in Parkinson Disease
- (2015) Tatiana K. Rostovtseva et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- A new role for α-synuclein in Parkinson's disease: Alteration of ER-mitochondrial communication
- (2015) Cristina Guardia-Laguarta et al. MOVEMENT DISORDERS
- Aggregated α-synuclein and complex I deficiency: exploration of their relationship in differentiated neurons
- (2015) A K Reeve et al. Cell Death & Disease
- Parkinson-causing α-synuclein missense mutations shift native tetramers to monomers as a mechanism for disease initiation
- (2015) Ulf Dettmer et al. Nature Communications
- Novel subcellular localization for α-synuclein: possible functional consequences
- (2015) Cristina Guardia-Laguarta et al. Frontiers in Neuroanatomy
- Mitochondrial Dysfunction andα-Synuclein Synaptic Pathology in Parkinson’s Disease: Who’s on First?
- (2015) Michela Zaltieri et al. Parkinsons Disease
- α-Synuclein amino terminus regulates mitochondrial membrane permeability
- (2014) Jiamei Shen et al. BRAIN RESEARCH
- Calcium signaling in Parkinson’s disease
- (2014) Tito Calì et al. CELL AND TISSUE RESEARCH
- Alpha-Synuclein Binds to the Inner Membrane of Mitochondria in an α-Helical Conformation
- (2014) Marta Robotta et al. CHEMBIOCHEM
- Axon degeneration and PGC-1 -mediated protection in a zebrafish model of -synuclein toxicity
- (2014) K. C. O'Donnell et al. Disease Models & Mechanisms
- Soluble, Prefibrillar α-Synuclein Oligomers Promote Complex I-dependent, Ca2+-induced Mitochondrial Dysfunction
- (2014) Eric S. Luth et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- -Synuclein Is Localized to Mitochondria-Associated ER Membranes
- (2014) C. Guardia-Laguarta et al. JOURNAL OF NEUROSCIENCE
- Synucleins Regulate the Kinetics of Synaptic Vesicle Endocytosis
- (2014) K. J. Vargas et al. JOURNAL OF NEUROSCIENCE
- Abnormal alpha-synuclein reduces nigral voltage-dependent anion channel 1 in sporadic and experimental Parkinson's disease
- (2014) Yaping Chu et al. NEUROBIOLOGY OF DISEASE
- Region specific mitochondrial impairment in mice with widespread overexpression of alpha-synuclein
- (2014) Sudhakar Raja Subramaniam et al. NEUROBIOLOGY OF DISEASE
- ER–mitochondria associations are regulated by the VAPB–PTPIP51 interaction and are disrupted by ALS/FTD-associated TDP-43
- (2014) Radu Stoica et al. Nature Communications
- A 6.4 Mb Duplication of the α-Synuclein Locus Causing Frontotemporal Dementia and Parkinsonism
- (2014) Eleanna Kara et al. JAMA Neurology
- Voltage-dependent anion channel involved in the α-synuclein-induced dopaminergic neuron toxicity in rats
- (2013) Lingling Lu et al. ACTA BIOCHIMICA ET BIOPHYSICA SINICA
- The Parkinson’s Disease-Associated H50Q Mutation Accelerates α-Synuclein Aggregation in Vitro
- (2013) Dhiman Ghosh et al. BIOCHEMISTRY
- Enhanced parkin levels favor ER-mitochondria crosstalk and guarantee Ca2+ transfer to sustain cell bioenergetics
- (2013) Tito Calì et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- The Parkinson disease-related protein DJ-1 counteracts mitochondrial impairment induced by the tumour suppressor protein p53 by enhancing endoplasmic reticulum-mitochondria tethering
- (2013) D. Ottolini et al. HUMAN MOLECULAR GENETICS
- In VivoCross-linking Reveals Principally Oligomeric Forms of α-Synuclein and β-Synuclein in Neurons and Non-neural Cells
- (2013) Ulf Dettmer et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Assessing the Subcellular Dynamics of Alpha-synuclein Using Photoactivation Microscopy
- (2013) Susana Gonçalves et al. MOLECULAR NEUROBIOLOGY
- The mitochondrial permeability transition pore regulates Parkinson's disease development in mutant α-synuclein transgenic mice
- (2013) Lee J. Martin et al. NEUROBIOLOGY OF AGING
- α-Synuclein and Mitochondria: Partners in Crime?
- (2013) Ken Nakamura Neurotherapeutics
- Adenine Nucleotide Translocase, Mitochondrial Stress, and Degenerative Cell Death
- (2013) Yaxin Liu et al. Oxidative Medicine and Cellular Longevity
- TOM40 Mediates Mitochondrial Dysfunction Induced by α-Synuclein Accumulation in Parkinson’s Disease
- (2013) Andreas Bender et al. PLoS One
- Modulation of the endoplasmic reticulum-mitochondria interface in Alzheimer's disease and related models
- (2013) L. Hedskog et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Upregulated function of mitochondria-associated ER membranes in Alzheimer disease
- (2012) Estela Area-Gomez et al. EMBO JOURNAL
- Mitochondrial dysfunction in Parkinson's disease: molecular mechanisms and pathophysiological consequences
- (2012) Nicole Exner et al. EMBO JOURNAL
- Selective binding of nuclear alpha-synuclein to the PGC1alpha promoter under conditions of oxidative stress may contribute to losses in mitochondrial function: Implications for Parkinson’s disease
- (2012) Almas Siddiqui et al. FREE RADICAL BIOLOGY AND MEDICINE
- α-Synuclein Controls Mitochondrial Calcium Homeostasis by Enhancing Endoplasmic Reticulum-Mitochondria Interactions
- (2012) Tito Calì et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- α-Synuclein in Central Nervous System and from Erythrocytes, Mammalian Cells, andEscherichia coliExists Predominantly as Disordered Monomer
- (2012) Bruno Fauvet et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- α-Synuclein Induces Alterations in Adult Neurogenesis in Parkinson Disease Models via p53-mediated Repression of Notch1
- (2012) Paula Desplats et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Alpha-synuclein impairs normal dynamics of mitochondria in cell and animal models of Parkinson’s disease
- (2012) Weilin Xie et al. JOURNAL OF NEUROCHEMISTRY
- Mitochondria-associated ER membranes in Alzheimer disease
- (2012) Eric A. Schon et al. MOLECULAR AND CELLULAR NEUROSCIENCE
- Extracellular signal-regulated kinase is involved in alpha-synuclein-induced mitochondrial dynamic disorders by regulating dynamin-like protein 1
- (2012) Ya-Xing Gui et al. NEUROBIOLOGY OF AGING
- Interaction of α-synuclein with vesicles that mimic mitochondrial membranes
- (2011) Imola G. Zigoneanu et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
- The mode of α-synuclein binding to membranes depends on lipid composition and lipid to protein ratio
- (2011) Volodymyr V. Shvadchak et al. FEBS LETTERS
- VAPB interacts with the mitochondrial protein PTPIP51 to regulate calcium homeostasis
- (2011) Kurt J. De Vos et al. HUMAN MOLECULAR GENETICS
- α-Synuclein overexpression impairs mitochondrial function by associating with adenylate translocator
- (2011) Yuangang Zhu et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Direct Membrane Association Drives Mitochondrial Fission by the Parkinson Disease-associated Protein α-Synuclein
- (2011) Ken Nakamura et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation
- (2011) Tim Bartels et al. NATURE
- Presenilin 2 modulates endoplasmic reticulum (ER)-mitochondria interactions and Ca2+ cross-talk
- (2011) E. Zampese et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A soluble -synuclein construct forms a dynamic tetramer
- (2011) W. Wang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- ER Tubules Mark Sites of Mitochondrial Division
- (2011) J. R. Friedman et al. SCIENCE
- Oxidative protein folding in the endoplasmic reticulum: Tight links to the mitochondria-associated membrane (MAM)
- (2010) Thomas Simmen et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
- The N-Terminus of the Intrinsically Disordered Protein α-Synuclein Triggers Membrane Binding and Helix Folding
- (2010) Tim Bartels et al. BIOPHYSICAL JOURNAL
- Developmental expression of sideroflexin family genes in Xenopus embryos
- (2010) Xiaojing Li et al. DEVELOPMENTAL DYNAMICS
- Inhibition of mitochondrial fusion by α-synuclein is rescued by PINK1, Parkin and DJ-1
- (2010) Frits Kamp et al. EMBO JOURNAL
- α-Synuclein induced membrane depolarization and loss of phosphorylation capacity of isolated rat brain mitochondria: Implications in Parkinson's disease
- (2010) Kalpita Banerjee et al. FEBS LETTERS
- The Transgenic Overexpression of α-Synuclein and Not Its Related Pathology Associates with Complex I Inhibition
- (2010) Virginie Loeb et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Different sub-cellular localization of alpha-synuclein in the C57BL\6J mouse's central nervous system by two novel monoclonal antibodies
- (2010) G. Vivacqua et al. JOURNAL OF CHEMICAL NEUROANATOMY
- α-Synuclein Transgenic Mice Reveal Compensatory Increases in Parkinson's Disease-Associated Proteins DJ-1 and Parkin and Have Enhanced α-Synuclein and PINK1 Levels After Rotenone Treatment
- (2010) Sonia George et al. JOURNAL OF MOLECULAR NEUROSCIENCE
- Dynamic transport and localization of alpha-synuclein in primary hippocampal neurons
- (2010) Mong-Lin Yang et al. Molecular Neurodegeneration
- Mitochondrial alpha-synuclein accumulation impairs complex I function in dopaminergic neurons and results in increased mitophagy in vivo
- (2010) Shankar J. Chinta et al. NEUROSCIENCE LETTERS
- -Synuclein triple knockout mice reveal age-dependent neuronal dysfunction
- (2010) B. Greten-Harrison et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- -Synuclein Promotes SNARE-Complex Assembly in Vivo and in Vitro
- (2010) J. Burre et al. SCIENCE
- SR/ER–mitochondrial local communication: Calcium and ROS
- (2009) György Csordás et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
- Mitochondrial trafficking of APP and alpha synuclein: Relevance to mitochondrial dysfunction in Alzheimer's and Parkinson's diseases
- (2009) Latha Devi et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Alpha-synuclein overexpression and aggregation exacerbates impairment of mitochondrial functions by augmenting oxidative stress in human neuroblastoma cells
- (2009) Mordhwaj S. Parihar et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Curvature Dynamics of α-Synuclein Familial Parkinson Disease Mutants
- (2009) Jason D. Perlmutter et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The First N-terminal Amino Acids of α-Synuclein Are Essential for α-Helical Structure Formation In Vitro and Membrane Binding in Yeast
- (2009) Katherina Vamvaca et al. JOURNAL OF MOLECULAR BIOLOGY
- α-Synuclein is differentially expressed in mitochondria from different rat brain regions and dose-dependently down-regulates complex I activity
- (2009) Guangwei Liu et al. NEUROSCIENCE LETTERS
- Exogenous -synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells
- (2009) K. C. Luk et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- MAM: more than just a housekeeper
- (2009) Teruo Hayashi et al. TRENDS IN CELL BIOLOGY
- Gene expression profiling of substantia nigra dopamine neurons: further insights into Parkinson's disease pathology
- (2008) Filip Simunovic et al. BRAIN
- Semi-quantitative analysis of α-synuclein in subcellular pools of rat brain neurons: An immunogold electron microscopic study using a C-terminal specific monoclonal antibody
- (2008) Ling Zhang et al. BRAIN RESEARCH
- Mitochondrial association of alpha-synuclein causes oxidative stress
- (2008) M. S. Parihar et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Mitochondrial translocation of α-synuclein is promoted by intracellular acidification
- (2008) Nelson B. Cole et al. EXPERIMENTAL CELL RESEARCH
- Mitochondrial Import and Accumulation of α-Synuclein Impair Complex I in Human Dopaminergic Neuronal Cultures and Parkinson Disease Brain
- (2008) Latha Devi et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Parkin is recruited selectively to impaired mitochondria and promotes their autophagy
- (2008) Derek Narendra et al. JOURNAL OF CELL BIOLOGY
- Optical Reporters for the Conformation of -Synuclein Reveal a Specific Interaction with Mitochondria
- (2008) K. Nakamura et al. JOURNAL OF NEUROSCIENCE
- Proteomics Analysis Identifies Phosphorylation-dependent α-Synuclein Protein Interactions
- (2008) Melinda A. McFarland et al. MOLECULAR & CELLULAR PROTEOMICS
- Mitochondrial localization of alpha-synuclein protein in alpha-synuclein overexpressing cells
- (2008) Shaik Shavali et al. NEUROSCIENCE LETTERS
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now