Insights Into Protein S-Palmitoylation in Synaptic Plasticity and Neurological Disorders: Potential and Limitations of Methods for Detection and Analysis

Polarized trafficking: the palmitoylation cycle distributes cytoplasmic proteins to distinct neuronal compartments

(2018) Elena Tortosa et al.   CURRENT OPINION IN CELL BIOLOGY

Roles of palmitoylation in axon growth, degeneration and regeneration

(2017) Sabrina M. Holland et al.   JOURNAL OF NEUROSCIENCE RESEARCH

The dopamine motive system: implications for drug and food addiction

(2017) Nora D. Volkow et al.   NATURE REVIEWS NEUROSCIENCE

Dynamic Palmitoylation Targets MAP6 to the Axon to Promote Microtubule Stabilization during Neuronal Polarization

(2017) Elena Tortosa et al.   NEURON

Lack of BACE1 S-palmitoylation reduces amyloid burden and mitigates memory deficits in transgenic mouse models of Alzheimer’s disease

(2017) Robert J. Andrew et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Global, site-specific analysis of neuronal protein S-acylation

(2017) Mark O. Collins et al.   Scientific Reports

Palmitoylation of the carboxyl-terminal tail of dopamine D 4 receptor is required for surface expression, endocytosis, and signaling

(2016) Xiaowei Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Palmitoylation on the carboxyl terminus tail is required for the selective regulation of dopamine D 2 versus D 3 receptors

(2016) Xiaowei Zhang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Expanding role of molecular chaperones in regulating α-synuclein misfolding; implications in Parkinson’s disease

(2016) Sandeep K. Sharma et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Palmitoylation of cdc42 Promotes Spine Stabilization and Rescues Spine Density Deficit in a Mouse Model of 22q11.2 Deletion Syndrome

(2016) E. Moutin et al.   CEREBRAL CORTEX

Bioorthogonal Chemical Reporters for Monitoring Unsaturated Fatty-Acylated Proteins

(2016) Emmanuelle Thinon et al.   CHEMBIOCHEM

Proteomic analysis of fatty-acylated proteins

(2016) Tao Peng et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

The role of palmitoylation and transmembrane domain in sorting of transmembrane adaptor proteins

(2016) Tomáš Chum et al.   JOURNAL OF CELL SCIENCE

Identification of PSD-95 Depalmitoylating Enzymes

(2016) Norihiko Yokoi et al.   JOURNAL OF NEUROSCIENCE

The residue at position 5 of the N-terminal region of Src and Fyn modulates their myristoylation, palmitoylation, and membrane interactions

(2016) Efrat Gottlieb-Abraham et al.   MOLECULAR BIOLOGY OF THE CELL

Palmitoylation in Alzheimer⿿s disease and other neurodegenerative diseases

(2016) Eunsil Cho et al.   PHARMACOLOGICAL RESEARCH

Palmitoylation regulates glutamate receptor distributions in postsynaptic densities through control of PSD95 conformation and orientation

(2016) Okunola Jeyifous et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mass-tag labeling reveals site-specific and endogenous levels of protein S-fatty acylation

(2016) Avital Percher et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Decreased protein S-palmitoylation in dorsolateral prefrontal cortex in schizophrenia

(2016) Anita L. Pinner et al.   SCHIZOPHRENIA RESEARCH

Control of Dendritic Spine Morphological and Functional Plasticity by Small GTPases

(2016) Kevin M. Woolfrey et al.   NEURAL PLASTICITY

Palmitoylated APP Forms Dimers, Cleaved by BACE1

(2016) Raja Bhattacharyya et al.   PLoS One

Enzymatic protein depalmitoylation by acyl protein thioesterases

(2015) David T.S. Lin et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Aberrant palmitoylation in Huntington disease

(2015) Shaun S. Sanders et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

X-exome sequencing of 405 unresolved families identifies seven novel intellectual disability genes

(2015) H Hu et al.   MOLECULAR PSYCHIATRY

Molecular Substrates of Altered Axonal Growth and Brain Connectivity in a Mouse Model of Schizophrenia

(2015) Jun Mukai et al.   NEURON

Palmitoylation of LIM Kinase-1 ensures spine-specific actin polymerization and morphological plasticity

(2015) Joju George et al.   eLife

S-palmitoylation regulates AMPA receptors trafficking and function: a novel insight into synaptic regulation and therapeutics

(2015) Jun Han et al.   Acta Pharmaceutica Sinica B

Effect of C-Terminal S-Palmitoylation on D2 Dopamine Receptor Trafficking and Stability

(2015) Brittany Ebersole et al.   PLoS One

The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease

(2014) Stefanie L. Butland et al.   HUMAN MOLECULAR GENETICS

Mutations in the X-linked Intellectual Disability Gene,zDHHC9, Alter Autopalmitoylation Activity by Distinct Mechanisms

(2014) David A. Mitchell et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Single-cell in situ imaging of palmitoylation in fatty-acylated proteins

(2014) Xinxin Gao et al.   Nature Protocols

Structural and Molecular Remodeling of Dendritic Spine Substructures during Long-Term Potentiation

(2014) Miquel Bosch et al.   NEURON

Palmitoylation of Gephyrin Controls Receptor Clustering and Plasticity of GABAergic Synapses

(2014) Borislav Dejanovic et al.   PLOS BIOLOGY

Expanding the clinical phenotype of patients with aZDHHC9mutation

(2013) Alice Masurel-Paulet et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Dual lipidation of the brain-specific Cdc42 isoform regulates its functional properties

(2013) Alexander Wirth et al.   BIOCHEMICAL JOURNAL

Chemical approaches for profiling dynamic palmitoylation

(2013) Brent R. Martin   BIOCHEMICAL SOCIETY TRANSACTIONS

Palmitoylation-dependent regulation of glutamate receptors and their PDZ domain-containing partners

(2013) Gareth M. Thomas et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Palmitoylation of serotonin receptors

(2013) Nataliya Gorinski et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Tracking Brain Palmitoylation Change: Predominance of Glial Change in a Mouse Model of Huntington’s Disease

(2013) Junmei Wan et al.   CHEMISTRY & BIOLOGY

Kainate Receptor Post-translational Modifications Differentially Regulate Association with 4.1N to Control Activity-dependent Receptor Endocytosis

(2013) Bryan A. Copits et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Local palmitoylation cycles define activity-regulated postsynaptic subdomains

(2013) Yuko Fukata et al.   JOURNAL OF CELL BIOLOGY

Palmitoylation of Amyloid Precursor Protein Regulates Amyloidogenic Processing in Lipid Rafts

(2013) R. Bhattacharyya et al.   JOURNAL OF NEUROSCIENCE

Resin-assisted enrichment of thiols as a general strategy for proteomic profiling of cysteine-based reversible modifications

(2013) Jia Guo et al.   Nature Protocols

Analysis of substrate specificity of human DHHC protein acyltransferases using a yeast expression system

(2012) Yusuke Ohno et al.   MOLECULAR BIOLOGY OF THE CELL

A proteomic approach identifies many novel palmitoylated proteins in Arabidopsis

(2012) Piers A. Hemsley et al.   NEW PHYTOLOGIST

Palmitoylation at Two Cysteine Clusters on the C-Terminus of GluN2A and GluN2B Differentially Control Synaptic Targeting of NMDA Receptors

(2012) Hayley A. Mattison et al.   PLoS One

Postsynaptic dysfunction is associated with spatial and object recognition memory loss in a natural model of Alzheimer's disease

(2012) A. O. Ardiles et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuronal β-amyloid generation is independent of lipid raft association of β-secretase BACE1: analysis with a palmitoylation-deficient mutant

(2012) Kazumi Motoki et al.   Brain and Behavior

The role of palmitoylation in directing dopamine D1 receptor internalization through selective endocytic routes

(2011) Michael M.C. Kong et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Protein palmitoylation and subcellular trafficking

(2011) Clara Aicart-Ramos et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

PSD-95-like membrane associated guanylate kinases (PSD-MAGUKs) and synaptic plasticity

(2011) Weifeng Xu   CURRENT OPINION IN NEUROBIOLOGY

Structural plasticity of dendritic spines

(2011) Miquel Bosch et al.   CURRENT OPINION IN NEUROBIOLOGY

Regulation of NMDA receptors by the tyrosine kinase Fyn

(2011) Catherine H. Trepanier et al.   FEBS Journal

Role of the CaMKII/NMDA Receptor Complex in the Maintenance of Synaptic Strength

(2011) M. Sanhueza et al.   JOURNAL OF NEUROSCIENCE

Mechanisms of polarized membrane trafficking in neurons — Focusing in on endosomes

(2011) Zofia M. Lasiecka et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Subcellular Golgi localization of stathmin family proteins is promoted by a specific set of DHHC palmitoyl transferases

(2011) Aurore D. Levy et al.   MOLECULAR BIOLOGY OF THE CELL

Global profiling of dynamic protein palmitoylation

(2011) Brent R Martin et al.   NATURE METHODS

GABAA Receptor Trafficking-Mediated Plasticity of Inhibitory Synapses

(2011) Bernhard Luscher et al.   NEURON

S-Nitrosylation and S-Palmitoylation Reciprocally Regulate Synaptic Targeting of PSD-95

(2011) Gary P.H. Ho et al.   NEURON

The Dynamic Modulation of GABAA Receptor Trafficking and Its Role in Regulating the Plasticity of Inhibitory Synapses

(2011) Mansi Vithlani et al.   PHYSIOLOGICAL REVIEWS

The prefrontal–limbic network in depression: A core pathology of synapse regression

(2011) M.R. Bennett   PROGRESS IN NEUROBIOLOGY

Putting proteins in their place: Palmitoylation in Huntington disease and other neuropsychiatric diseases

(2011) Fiona B. Young et al.   PROGRESS IN NEUROBIOLOGY

DHHC palmitoyl transferases: substrate interactions and (patho)physiology

(2011) Jennifer Greaves et al.   TRENDS IN BIOCHEMICAL SCIENCES

The Postsynaptic Organization of Synapses

(2011) M. Sheng et al.   Cold Spring Harbor Perspectives in Biology

Global Analysis of Protein Palmitoylation in African Trypanosomes

(2010) Brian T. Emmer et al.   EUKARYOTIC CELL

Functional roles of short sequence motifs in the endocytosis of membrane receptors

(2010) Kailash et al.   Frontiers in Bioscience-Landmark

The intracellular dynamic of protein palmitoylation

(2010) Christine Salaun et al.   JOURNAL OF CELL BIOLOGY

Actin in dendritic spines: connecting dynamics to function

(2010) Pirta Hotulainen et al.   JOURNAL OF CELL BIOLOGY

Palmitoylation and depalmitoylation dynamics at a glance

(2010) Elizabeth Conibear et al.   JOURNAL OF CELL SCIENCE

Site-specific analysis of proteinS-acylation by resin-assisted capture

(2010) Michael T. Forrester et al.   JOURNAL OF LIPID RESEARCH

Fyn kinase contributes to tyrosine phosphorylation of the GABAA receptor γ2 subunit

(2010) Rachel Jurd et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Protein palmitoylation in neuronal development and synaptic plasticity

(2010) Yuko Fukata et al.   NATURE REVIEWS NEUROSCIENCE

Tandem fluorescence imaging of dynamic S-acylation and protein turnover

(2010) M. M. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Imaging the Lipidome: ω-Alkynyl Fatty Acids for Detection and Cellular Visualization of Lipid-Modified Proteins

(2009) Rami N. Hannoush et al.   ACS Chemical Biology

Constitutive Gs-mediated, but not G12-mediated, activity of the 5-hydroxytryptamine 5-HT7(a) receptor is modulated by the palmitoylation of its C-terminal domain

(2009) Elena Kvachnina et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Chemical tools for understanding protein lipidation in eukaryotes

(2009) Guillaume Charron et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Subunit-selective palmitoylation regulates the intracellular trafficking of AMPA receptor

(2009) Guang Yang et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Mobile DHHC palmitoylating enzyme mediates activity-sensitive synaptic targeting of PSD-95

(2009) Jun Noritake et al.   JOURNAL OF CELL BIOLOGY

Differential trafficking of Src, Lyn, Yes and Fyn is specified by the state of palmitoylation in the SH4 domain

(2009) I. Sato et al.   JOURNAL OF CELL SCIENCE

Palmitoylation of the synaptic vesicle fusion machinery

(2009) Gerald R. Prescott et al.   JOURNAL OF NEUROCHEMISTRY

Robust Fluorescent Detection of Protein Fatty-Acylation with Chemical Reporters

(2009) Guillaume Charron et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Proteome Scale Characterization of HumanS-Acylated Proteins in Lipid Raft-enriched and Non-raft Membranes

(2009) Wei Yang et al.   MOLECULAR & CELLULAR PROTEOMICS

The Hydrophobic Cysteine-rich Domain of SNAP25 Couples with Downstream Residues to Mediate Membrane Interactions and Recognition by DHHC Palmitoyl Transferases

(2009) Jennifer Greaves et al.   MOLECULAR BIOLOGY OF THE CELL

A systematic, large-scale resequencing screen of X-chromosome coding exons in mental retardation

(2009) Patrick S Tarpey et al.   NATURE GENETICS

Large-scale profiling of protein palmitoylation in mammalian cells

(2009) Brent R Martin et al.   NATURE METHODS

Regulation of AMPA receptor extrasynaptic insertion by 4.1N, phosphorylation and palmitoylation

(2009) Da-Ting Lin et al.   NATURE NEUROSCIENCE

Dual Palmitoylation of NR2 Subunits Regulates NMDA Receptor Trafficking

(2009) Takashi Hayashi et al.   NEURON

Anatomical and functional correlates in major depressive disorder: The contribution of neuroimaging studies

(2009) Silvia Rigucci et al.   WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY

Stimulation- and palmitoylation-dependent changes in oligomeric conformation of serotonin 5-HT1A receptorsi

(2008) Fritz Kobe et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Remodeling of Hippocampal Spine Synapses in the Rat Learned Helplessness Model of Depression

(2008) Tibor Hajszan et al.   BIOLOGICAL PSYCHIATRY

Neural palmitoyl-proteomics reveals dynamic synaptic palmitoylation

(2008) Rujun Kang et al.   NATURE

Strong association of de novo copy number mutations with sporadic schizophrenia

(2008) Bin Xu et al.   NATURE GENETICS

Palmitoylation-dependent neurodevelopmental deficits in a mouse model of 22q11 microdeletion

(2008) Jun Mukai et al.   NATURE NEUROSCIENCE

The Subspine Organization of Actin Fibers Regulates the Structure and Plasticity of Dendritic Spines

(2008) Naoki Honkura et al.   NEURON

Identification of palmitoylated mitochondrial proteins using a bio-orthogonal azido-palmitate analogue

(2007) Morris A. Kostiuk et al.   FASEB JOURNAL