期刊
JOURNAL OF NEUROSCIENCE RESEARCH
卷 95, 期 8, 页码 1528-1539出版社
WILEY
DOI: 10.1002/jnr.24003
关键词
Protein trafficking; Retrograde Transport; Axon degeneration; Wallerian; DLK; Peripheral Neuropathy
资金
- NIH [R01NS094402]
- Shriners Hospitals for Children [85600]
The protein-lipid modification palmitoylation plays important roles in neurons, but most attention has focused on roles of this modification in the regulation of mature pre- and post-synapses. However, exciting recent findings suggest that palmitoylation is also critical for both the growth and integrity of neuronal axons and plays previously unappreciated roles in conveying axonal anterograde and retrograde signals. Here we review these emerging roles for palmitoylation in the regulation of axons in health and disease. (c) 2017 Wiley Periodicals, Inc.
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